J F Cryan

Summary

Affiliation: University College Cork
Country: Ireland

Publications

  1. ncbi request reprint Animal models of mood disorders: Recent developments
    John F Cryan
    Department of Pharmacology and Therapeutics, School of Pharmacy, University College Cork, Cork, Ireland
    Curr Opin Psychiatry 20:1-7. 2007
  2. ncbi request reprint Amyloid precursor protein knockdown by siRNA impairs spontaneous alternation in adult mice
    Yann Senechal
    Department of Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Lichtstrasse, Basel, Switzerland
    J Neurochem 102:1928-40. 2007
  3. doi request reprint Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
    John F Cryan
    Laboratory of Neurogastroenterology, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Nat Rev Neurosci 13:701-12. 2012
  4. pmc Tryptophan degradation in irritable bowel syndrome: evidence of indoleamine 2,3-dioxygenase activation in a male cohort
    Gerard Clarke
    Department of Psychiatry, University College Cork, Cork, Ireland
    BMC Gastroenterol 9:6. 2009
  5. ncbi request reprint Emerging use of non-viral RNA interference in the brain
    J F Cryan
    School of Pharmacy, Cavanagh Pharmacy Building, University College Cork, Cork, Ireland
    Biochem Soc Trans 35:411-5. 2007
  6. doi request reprint The microbiome-gut-brain axis: from bowel to behavior
    J F Cryan
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Neurogastroenterol Motil 23:187-92. 2011
  7. pmc The age of anxiety: role of animal models of anxiolytic action in drug discovery
    John F Cryan
    Neuropharmacology Research Group, School of Pharmacy, University College Cork, Cork, Ireland
    Br J Pharmacol 164:1129-61. 2011
  8. doi request reprint The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner
    G Clarke
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Mol Psychiatry 18:666-73. 2013
  9. doi request reprint 5-HT(2B) receptors modulate visceral hypersensitivity in a stress-sensitive animal model of brain-gut axis dysfunction
    S M O'Mahony
    Laboratory of Neurogastroenterology, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Neurogastroenterol Motil 22:573-8, e124. 2010
  10. doi request reprint Region specific decrease in glial fibrillary acidic protein immunoreactivity in the brain of a rat model of depression
    R D Gosselin
    Laboratory of Neurogastroenterology, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Neuroscience 159:915-25. 2009

Collaborators

Detail Information

Publications72

  1. ncbi request reprint Animal models of mood disorders: Recent developments
    John F Cryan
    Department of Pharmacology and Therapeutics, School of Pharmacy, University College Cork, Cork, Ireland
    Curr Opin Psychiatry 20:1-7. 2007
    ..This review focuses on the attempts to improve current paradigms and also illustrates examples where current paradigms are used to uncover novel molecular targets of antidepressants...
  2. ncbi request reprint Amyloid precursor protein knockdown by siRNA impairs spontaneous alternation in adult mice
    Yann Senechal
    Department of Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Lichtstrasse, Basel, Switzerland
    J Neurochem 102:1928-40. 2007
    ..These data suggest that acute knockdown of APP in adult mouse brain impairs hippocampus-dependent spatial working memory...
  3. doi request reprint Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
    John F Cryan
    Laboratory of Neurogastroenterology, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Nat Rev Neurosci 13:701-12. 2012
    ..Thus, the emerging concept of a microbiota-gut-brain axis suggests that modulation of the gut microbiota may be a tractable strategy for developing novel therapeutics for complex CNS disorders...
  4. pmc Tryptophan degradation in irritable bowel syndrome: evidence of indoleamine 2,3-dioxygenase activation in a male cohort
    Gerard Clarke
    Department of Psychiatry, University College Cork, Cork, Ireland
    BMC Gastroenterol 9:6. 2009
    ..In this study, we investigated tryptophan degradation in a male IBS cohort (n = 10) and control subjects (n = 26)...
  5. ncbi request reprint Emerging use of non-viral RNA interference in the brain
    J F Cryan
    School of Pharmacy, Cavanagh Pharmacy Building, University College Cork, Cork, Ireland
    Biochem Soc Trans 35:411-5. 2007
    ..Such tailoring of tools that deliver RNAi in the brain will significantly aid in our understanding of the complex pathophysiology of neuropsychiatric disorders where there is an immensely unmet medical need...
  6. doi request reprint The microbiome-gut-brain axis: from bowel to behavior
    J F Cryan
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Neurogastroenterol Motil 23:187-92. 2011
    ....
  7. pmc The age of anxiety: role of animal models of anxiolytic action in drug discovery
    John F Cryan
    Neuropharmacology Research Group, School of Pharmacy, University College Cork, Cork, Ireland
    Br J Pharmacol 164:1129-61. 2011
    ..It is clear that a better alignment of the interactions between basic and clinical scientists is needed if this is to change...
  8. doi request reprint The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner
    G Clarke
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Mol Psychiatry 18:666-73. 2013
    ....
  9. doi request reprint 5-HT(2B) receptors modulate visceral hypersensitivity in a stress-sensitive animal model of brain-gut axis dysfunction
    S M O'Mahony
    Laboratory of Neurogastroenterology, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Neurogastroenterol Motil 22:573-8, e124. 2010
    ..Thus we assessed the impact of a selective 5-HT(2B) receptor antagonist, RS-127445, on visceral hypersensitivity in a model of brain gut axis dysfunction the Wistar Kyoto (WKY) rat...
  10. doi request reprint Region specific decrease in glial fibrillary acidic protein immunoreactivity in the brain of a rat model of depression
    R D Gosselin
    Laboratory of Neurogastroenterology, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Neuroscience 159:915-25. 2009
    ..Moreover, they suggest that glial physiology may become a therapeutic target in depression and other stress-related conditions...
  11. doi request reprint Differential lipopolysaccharide-induced immune alterations in the hippocampus of two mouse strains: effects of stress
    C A Browne
    Neuropharmacology Research Group, Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland
    Neuroscience 225:237-48. 2012
    ..These data indicate altered central mRNA expression of tryptophan metabolising enzymes and immune activation in BALB/c mice compared to the normo-sensitive C57BL/6J strain...
  12. doi request reprint Differential stress-induced alterations of colonic corticotropin-releasing factor receptors in the Wistar Kyoto rat
    D O'Malley
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Neurogastroenterol Motil 22:301-11. 2010
    ..CONCLUSIONS & INFERENCES This study demonstrates that psychological and physical stressors alter colonic CRF receptor expression and further support a role for local colonic CRF signalling in stress-induced changes in GI function...
  13. doi request reprint The probiotic Bifidobacterium infantis 35624 displays visceral antinociceptive effects in the rat
    D P McKernan
    Laboratory of Neurogastroenterology, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Neurogastroenterol Motil 22:1029-35, e268. 2010
    ..In this study, we evaluated the efficacy of repeated treatment with three different probiotics in reducing visceral pain in visceral normosensitive (Sprague-Dawley [SD]) and visceral hypersensitive (Wistar-Kyoto [WKY]) rat strains...
  14. doi request reprint Characterisation of cationic amphiphilic cyclodextrins for neuronal delivery of siRNA: effect of reversing primary and secondary face modifications
    A M O'Mahony
    Pharmacodelivery Group, School of Pharmacy, University College Cork, Ireland
    Eur J Pharm Sci 47:896-903. 2012
    ..This was likely due to the differences in their chemical structures. The effective CD offers great potential as a novel non-toxic vector for neuronal siRNA delivery...
  15. pmc Enhanced peripheral toll-like receptor responses in psychosis: further evidence of a pro-inflammatory phenotype
    D P McKernan
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Transl Psychiatry 1:e36. 2011
    ..These data demonstrate that specific alterations in TLR agonist-mediated cytokine release contribute to the evidence of immune dysfunction in psychotic disorders...
  16. doi request reprint Review article: probiotics for the treatment of irritable bowel syndrome--focus on lactic acid bacteria
    G Clarke
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Aliment Pharmacol Ther 35:403-13. 2012
    ..The withdrawal, due to adverse events, of a number of pharmacological agents that were approved for the treatment of IBS has left a therapeutic vacuum for patients suffering from the disorder...
  17. doi request reprint BDNF expression in the hippocampus of maternally separated rats: does Bifidobacterium breve 6330 alter BDNF levels?
    E O'Sullivan
    University College Cork, Alimentary Pharmabiotic Centre, College Road, Cork, Ireland
    Benef Microbes 2:199-207. 2011
    ..While B. breve 6330 influenced BDNF in normal animals, it had no significant effect on BDNF in those which were maternally separated. We have demonstrated that an orally administered probiotic can influence hippocampal BDNF...
  18. doi request reprint High-fat diet selectively protects against the effects of chronic social stress in the mouse
    B C Finger
    Food for Health Ireland, University College Cork, Cork, Ireland
    Neuroscience 192:351-60. 2011
    ..Moreover, these results illustrate the strong influence of dietary components on stress-induced psychological factors and thereby emphasize the importance of the brain-gut-axis as a point of future therapeutic intervention...
  19. doi request reprint Lithium augmentation of the effects of desipramine in a mouse model of treatment-resistant depression: a role for hippocampal cell proliferation
    O F O'Leary
    Department of Anatomy and Neuroscience, University College Cork, Ireland
    Neuroscience 228:36-46. 2013
    ..Moreover, since BALB/cOLaHsd mice respond to lithium plus desipramine but not to either drug alone, they may become useful in the development of a mouse model of treatment-refractory depression for which there is an unmet need...
  20. doi request reprint Colorectal distension-induced prefrontal cortex activation in the Wistar-Kyoto rat: implications for irritable bowel syndrome
    S M Gibney
    Laboratory of Neurogastroenterology, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Neuroscience 165:675-83. 2010
    ....
  21. doi request reprint Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses
    Siobhain M O'Mahony
    Alimentary Pharmabiotic Centre, Cork, Ireland
    Biol Psychiatry 65:263-7. 2009
    ..This makes the identification of the neurobiological substrates that are affected by adverse experiences in early life invaluable...
  22. doi request reprint Irritable bowel syndrome: towards biomarker identification
    Gerard Clarke
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Trends Mol Med 15:478-89. 2009
    ..The successful identification of biomarkers is critical to progressing our understanding of IBS and addressing the unmet therapeutic needs of this debilitating condition...
  23. doi request reprint Verapamil in treatment resistant depression: a role for the P-glycoprotein transporter?
    Gerard Clarke
    Department of Psychiatry, Biosciences Institute, University College Cork, Cork, Ireland
    Hum Psychopharmacol 24:217-23. 2009
    ..In this study we examined the hypothesis that the antidepressant-like effects of verapamil are mediated through its blockade of the Pgp transporter in the blood brain barrier (BBB)...
  24. pmc Marked elevations in pro-inflammatory polyunsaturated fatty acid metabolites in females with irritable bowel syndrome
    Gerard Clarke
    Department of Psychiatry, University College Cork, Cork, Ireland
    J Lipid Res 51:1186-92. 2010
    ..Together, our data identifies a novel proinflammatory mechanism in irritable bowel syndrome and also suggests that elevated arachidonic acid levels in plasma may serve as putative biological markers in this condition...
  25. doi request reprint Alterations in colonic corticotropin-releasing factor receptors in the maternally separated rat model of irritable bowel syndrome: differential effects of acute psychological and physical stressors
    Dervla O'Malley
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Peptides 31:662-70. 2010
    ..This study demonstrates that acute stressors alter colonic CRF receptor expression in a manner that is determined by the underlying stress sensitivity of the subject...
  26. doi request reprint Chain reactions: early-life stress alters the metabolic profile of plasma polyunsaturated fatty acids in adulthood
    Gerard Clarke
    Department of Psychiatry, University College Cork, Cork, Ireland Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Behav Brain Res 205:319-21. 2009
    ..Our results identify a proinflammatory PUFA profile as a persistent consequence of early-life stress and suggest new avenues of investigation in stress-related disorders...
  27. doi request reprint Maternal separation as a model of brain-gut axis dysfunction
    Siobhain M O'Mahony
    Alimentary Pharmabiotic Centre, Biosciences Institute, University College Cork, Cork, Ireland
    Psychopharmacology (Berl) 214:71-88. 2011
    ..Accumulating evidence suggest that stress, especially in early life, is a predisposing factor to IBS...
  28. doi request reprint Little things on which happiness depends: microRNAs as novel therapeutic targets for the treatment of anxiety and depression
    R M O'Connor
    School of Pharmacy, University College Cork, Cork, Ireland
    Mol Psychiatry 17:359-76. 2012
    ....
  29. pmc Inhibition of P-glycoprotein enhances transport of imipramine across the blood-brain barrier: microdialysis studies in conscious freely moving rats
    F E O'Brien
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Br J Pharmacol 166:1333-43. 2012
    ..Therefore, the present study aimed to investigate the effect of P-gp inhibition on the transport of the tricyclic antidepressant imipramine and its active metabolite desipramine across the BBB...
  30. doi request reprint Altered peripheral toll-like receptor responses in the irritable bowel syndrome
    D P McKernan
    Alimentary Pharmabiotic Centre, University College Cork, Ireland
    Aliment Pharmacol Ther 33:1045-52. 2011
    ..The immune system is a critical regulator of the brain-gut axis. Toll-like receptors (TLRs) are pattern recognition molecules regulating innate immunity...
  31. doi request reprint Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression
    L Desbonnet
    Department of Psychiatry, University College Cork, Cork, Ireland
    Neuroscience 170:1179-88. 2010
    ..These findings point to a more influential role for bifidobacteria in neural function, and suggest that probiotics may have broader therapeutic applications than previously considered...
  32. doi request reprint Distinct alterations in colonic morphology and physiology in two rat models of enhanced stress-induced anxiety and depression-like behaviour
    Dervla O'Malley
    Laboratory of Neurogastroenterology, Alimentary Pharmabiotic Centre, Biosciences Institute, University College Cork, Cork, Ireland
    Stress 13:114-22. 2010
    ..This study provides evidence of altered colonic function and morphology in two animal models with a heightened response to stress...
  33. pmc Antipsychotics and the gut microbiome: olanzapine-induced metabolic dysfunction is attenuated by antibiotic administration in the rat
    K J Davey
    1 Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland 2 School of Pharmacy, University College Cork, Cork, Ireland
    Transl Psychiatry 3:e309. 2013
    ..These results suggest that the gut microbiome has a role in the cycle of metabolic dysfunction associated with olanzapine, and could represent a novel therapeutic target for preventing antipsychotic-induced metabolic disease...
  34. doi request reprint Increased sensitivity to the effects of chronic social defeat stress in an innately anxious mouse strain
    H M Savignac
    Laboratory of Neurogastroenterology, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Neuroscience 192:524-36. 2011
    ..These data suggest different coping strategies to social interaction stress between the two mouse strains. The genetic basis of this stress-resilience/susceptibility warrants further investigation...
  35. pmc A novel role for the metabotropic glutamate receptor-7: modulation of faecal water content and colonic electrolyte transport in the mouse
    M Julio-Pieper
    Alimentary Pharmabiotic Centre, University College Cork, Ireland
    Br J Pharmacol 160:367-75. 2010
    ..This present study investigated the expression and possible functional role of mGlu(7) receptors in the mouse colon...
  36. doi request reprint "Killing the Blues": a role for cellular suicide (apoptosis) in depression and the antidepressant response?
    Declan P McKernan
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Prog Neurobiol 88:246-63. 2009
    ....
  37. doi request reprint Riluzole normalizes early-life stress-induced visceral hypersensitivity in rats: role of spinal glutamate reuptake mechanisms
    Romain Daniel Gosselin
    Laboratory of Neurogastroenterology, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Gastroenterology 138:2418-25. 2010
    ..Because alterations in spinal non-neuronal (astrocytic) glutamate reuptake are suspected to participate in chronic pain, we asked whether such processes occur in visceral hypersensitivity...
  38. doi request reprint Comparison of hippocampal metabotropic glutamate receptor 7 (mGlu7) mRNA levels in two animal models of depression
    Cliona M O'Mahony
    Neuropharmacology Research Group, Dept of Pharmacology and Therapeutics, University College Cork, Ireland
    Neurosci Lett 482:137-41. 2010
    ....
  39. doi request reprint Melancholic microbes: a link between gut microbiota and depression?
    T G Dinan
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Neurogastroenterol Motil 25:713-9. 2013
    ..Further studies require appropriately phenotyped patients with depression and/or IBS using a judicious use of techniques including functional imaging and in depth microbial pyrosequencing. ..
  40. pmc Click-modified cyclodextrins as nonviral vectors for neuronal siRNA delivery
    A M O'Mahony
    Pharmacodelivery Group, School of Pharmacy, University College Cork, Ireland
    ACS Chem Neurosci 3:744-52. 2012
    ..To our knowledge, this is the first time that a modified CD has been used as a safe and efficacious vector for siRNA delivery into neuronal cells...
  41. doi request reprint GABAB receptors and depression. Current status
    John F Cryan
    School of Pharmacy, Department of Pharmacology and Therapeutics, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Adv Pharmacol 58:427-51. 2010
    ..Therefore, while further research is necessary, it is suggested that GABA(B) receptor antagonists may represent a new class of antidepressant compounds...
  42. pmc Toll-like receptor mRNA expression is selectively increased in the colonic mucosa of two animal models relevant to irritable bowel syndrome
    Declan P McKernan
    Laboratory of Neurogastroenterology, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    PLoS ONE 4:e8226. 2009
    ..It was our hypothesis that innate immune receptor expression may be changed in the gastrointestinal tract of animals with stress-induced IBS-like symptoms...
  43. doi request reprint Restraint stress-induced brain activation patterns in two strains of mice differing in their anxiety behaviour
    Cliona M O'Mahony
    Neuropharmacology Research Group, University College Cork, Cork, Ireland
    Behav Brain Res 213:148-54. 2010
    ..The lower levels of stress-induced activity in high anxiety BALB/c mice, possibly indicate a circuit dysregulation at the cortico-limbic level in response to stress...
  44. doi request reprint Colonic soluble mediators from the maternal separation model of irritable bowel syndrome activate submucosal neurons via an interleukin-6-dependent mechanism
    Dervla O'Malley
    School of Pharmacy, Cavanagh Pharmacy Bldg, University College Cork, Cork, Ireland
    Am J Physiol Gastrointest Liver Physiol 300:G241-52. 2011
    ....
  45. doi request reprint Exciting times beyond the brain: metabotropic glutamate receptors in peripheral and non-neural tissues
    Marcela Julio-Pieper
    Laboratory of Neurogastroenterology, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Pharmacol Rev 63:35-58. 2011
    ..This review summarizes the new potential roles of mGlu receptors and raises the possibility of novel pharmacological targets for various disorders...
  46. doi request reprint Leptin-deficient mice retain normal appetitive spatial learning yet exhibit marked increases in anxiety-related behaviours
    Beate C Finger
    School of Pharmacy, Cavanagh Pharmacy Building, University College Cork, Cork, Ireland
    Psychopharmacology (Berl) 210:559-68. 2010
    ..Leptin, encoded by the ob gene, plays an important part in the energy homeostasis and is critical for the development of obesity...
  47. doi request reprint Metabotropic glutamate receptor 7: at the interface of cognition and emotion
    Richard M O'Connor
    School of Pharmacy, University College Cork, Cork, Ireland
    Eur J Pharmacol 639:123-31. 2010
    ....
  48. pmc Neurochemical and behavioral consequences of widespread gene knockdown in the adult mouse brain by using nonviral RNA interference
    Deepak R Thakker
    Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH 4002 Basel, Switzerland
    Proc Natl Acad Sci U S A 101:17270-5. 2004
    ..Application of this nonviral RNAi approach may accelerate target validation for neuropsychiatric disorders that involve a complex interplay of gene(s) from various brain regions...
  49. ncbi request reprint The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice
    John F Cryan
    Psychiatry Program, Neuroscience Research, The Novartis Institutes for BioMedical Research WSJ 386 344, Novartis Pharma AG, CH 4002 Basel, Switzerland
    Neurosci Biobehav Rev 29:571-625. 2005
    ..Taken together, we conclude that the tail suspension test is a useful test for assessing the behavioural effects of antidepressant compounds and other pharmacological and genetic manipulations relevant to depression...
  50. ncbi request reprint Global down-regulation of gene expression in the brain using RNA interference, with emphasis on monoamine transporters and GPCRs: implications for target characterization in psychiatric and neurological disorders
    Daniel Hoyer
    Psychiatry Program, Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
    J Recept Signal Transduct Res 26:527-47. 2006
    ..Application of this non-viral RNAi approach may accelerate target validation for neuropsychiatric disorders that involve a complex interplay of gene(s) from various brain regions...
  51. ncbi request reprint Concomitant deficits in working memory and fear extinction are functionally dissociated from reduced anxiety in metabotropic glutamate receptor 7-deficient mice
    Zsuzsanna Callaerts-Vegh
    Laboratory of Biological Psychology, Department of Psychology, University of Leuven, B 3000 Leuven, Belgium
    J Neurosci 26:6573-82. 2006
    ..It appears to depend on glutamatergic and higher-level brain functions similar to those involved in spatial working memory but functionally dissociated from those that mediate constitutional responses in anxiety tests...
  52. ncbi request reprint GABAB receptor antagonist-mediated antidepressant-like behavior is serotonin-dependent
    David A Slattery
    Neuroscience Research, Novartis Institutes for BioMedical Research WSJ 386 344, Novartis, Basel, CH 4002, Switzerland
    J Pharmacol Exp Ther 312:290-6. 2005
    ..Together, these data demonstrate that GABA(B) receptor antagonists via an interaction with the serotonergic system display antidepressant-like properties and therefore represent a novel approach for the treatment of depression...
  53. ncbi request reprint Non-nicotinic neuropharmacological strategies for nicotine dependence: beyond bupropion
    John F Cryan
    Neuroscience Disease Area, The Novartis Institutes for BioMedical Research, WSJ 386 344Novartis Pharma AG CH 4002, Basel, Switzerland
    Drug Discov Today 8:1025-34. 2003
    ....
  54. ncbi request reprint Withdrawal from chronic amphetamine induces depressive-like behavioral effects in rodents
    John F Cryan
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
    Biol Psychiatry 54:49-58. 2003
    ....
  55. ncbi request reprint Antidepressant and anxiolytic-like effects in mice lacking the group III metabotropic glutamate receptor mGluR7
    John F Cryan
    Nervous System Research, Novartis Institutes for BioMedical Sciences, Novartis Pharma AG, Basel, Switzerland
    Eur J Neurosci 17:2409-17. 2003
    ..Therefore, drugs acting at mGluR7 may provide novel treatments for psychiatric disorders such as depression and anxiety...
  56. ncbi request reprint Assessing antidepressant activity in rodents: recent developments and future needs
    John F Cryan
    Neuromodulation Unit, Nervous System Research, Novartis Pharma AG, WSJ 386 344, CH 4002 Basel, Switzerland
    Trends Pharmacol Sci 23:238-45. 2002
    ....
  57. ncbi request reprint cAMP response element-binding protein is essential for the upregulation of brain-derived neurotrophic factor transcription, but not the behavioral or endocrine responses to antidepressant drugs
    Alana C Conti
    Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6084, USA
    J Neurosci 22:3262-8. 2002
    ....
  58. ncbi request reprint Noradrenergic lesions differentially alter the antidepressant-like effects of reboxetine in a modified forced swim test
    John F Cryan
    Department of Psychiatry, University of Pennsylvania, 538A Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Eur J Pharmacol 436:197-205. 2002
    ..Taken together, these data suggest that forebrain regions innervated by these two distinct noradrenergic pathways exert opposing influences on the behavioral response to reboxetine in the rat forced swim test...
  59. ncbi request reprint Evaluation of reward processes in an animal model of depression
    David A Slattery
    Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
    Psychopharmacology (Berl) 190:555-68. 2007
    ..Deficits in reward function, which underlie anhedonia, can be readily assessed in animals. Therefore, anhedonia may serve as an endophenotype for understanding the neural circuitry and molecular pathways underlying depression...
  60. ncbi request reprint Antidepressant-like effects of the novel, selective, 5-HT2C receptor agonist WAY-163909 in rodents
    Sharon Rosenzweig-Lipson
    Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
    Psychopharmacology (Berl) 192:159-70. 2007
    ..Activation of one or more of the serotonin (5-HT) receptors may play a role in mediating the antidepressant effects of SSRIs...
  61. ncbi request reprint Genetic and pharmacological evidence of a role for GABA(B) receptors in the modulation of anxiety- and antidepressant-like behavior
    Cedric Mombereau
    Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
    Neuropsychopharmacology 29:1050-62. 2004
    ....
  62. pmc Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitors
    John F Cryan
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 101:8186-91. 2004
    ..These data show that NE plays an important role in mediating acute behavioral and neurochemical actions of many antidepressants, including most SSRIs...
  63. ncbi request reprint Metabotropic glutamate receptor subtype 7 ablation causes dysregulation of the HPA axis and increases hippocampal BDNF protein levels: implications for stress-related psychiatric disorders
    Kayo Mitsukawa
    Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
    Neuropsychopharmacology 31:1112-22. 2006
    ..We conclude that genetic ablation of mGluR7 in mice interferes at multiple sites in the neuronal circuitry and molecular pathways implicated in affective disorders...
  64. ncbi request reprint Interfering with the brain: use of RNA interference for understanding the pathophysiology of psychiatric and neurological disorders
    Deepak R Thakker
    Psychiatry Program, Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
    Pharmacol Ther 109:413-38. 2006
    ....
  65. pmc GABA(B) receptor-positive modulation decreases selective molecular and behavioral effects of cocaine
    Loic Lhuillier
    Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
    Neuropsychopharmacology 32:388-98. 2007
    ..Further investigation of GABA(B) receptor-positive modulation as a novel therapeutic strategy for the treatment of cocaine dependence and possibly other drugs of abuse is therefore warranted...
  66. ncbi request reprint Behavioral evaluation of mice deficient in GABA(B(1)) receptor isoforms in tests of unconditioned anxiety
    Laura H Jacobson
    Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4002 Basel, Switzerland
    Psychopharmacology (Berl) 190:541-53. 2007
    ..Recent findings indicate specific roles for these isoforms in conditioned fear responses, although their influence on behavior in tests of unconditioned anxiety is unknown...
  67. ncbi request reprint Differential behavioral effects of the antidepressants reboxetine, fluoxetine, and moclobemide in a modified forced swim test following chronic treatment
    John F Cryan
    Department of Psychiatry, University of Pennsylvania, 538A Clinical Research Building, Philadelphia, PA 19104, USA
    Psychopharmacology (Berl) 182:335-44. 2005
    ..However, few studies have compared the effects of short- and long-term antidepressant treatment on behaviors in the test, despite the need to treat patients chronically to produce clinical effects...
  68. ncbi request reprint Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test
    John F Cryan
    Department of Psychiatry and Pharmacology, University of Pennsylvania, 538A Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Neurosci Biobehav Rev 29:547-69. 2005
    ..Finally, a physiological model of performance in the rat FST has been proposed involving the regulation of 5-HT transmission by corticotropin releasing factor (CRF)...
  69. pmc Differential compartmentalization and distinct functions of GABAB receptor variants
    Rejan Vigot
    Department of Clinical Biological Sciences, Institute of Physiology, Pharmazentrum, University of Basel, CH 4056 Basel, Switzerland
    Neuron 50:589-601. 2006
    ..The constitutive absence of GABAB1a but not GABAB1b results in impaired synaptic plasticity and hippocampus-dependent memory, emphasizing molecular differences in synaptic GABAB functions...
  70. ncbi request reprint Don't worry 'B' happy!: a role for GABA(B) receptors in anxiety and depression
    John F Cryan
    Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
    Trends Pharmacol Sci 26:36-43. 2005
    ..These include mice that lack functional GABA(B) receptors, and novel positive modulators of the GABA(B) receptor. In this review, we discuss evidence that points to a role of GABA(B) receptors in anxiety and depression...
  71. ncbi request reprint Redistribution of GABAB(1) protein and atypical GABAB responses in GABAB(2)-deficient mice
    Martin Gassmann
    Pharmazentrum, Department of Clinical Biological Sciences, University of Basel, CH 4056 Basel, Switzerland
    J Neurosci 24:6086-97. 2004
    ..It is therefore possible that functional GABAB receptors exist in neurons that naturally lack GABAB(2) subunits...
  72. ncbi request reprint The ascent of mouse: advances in modelling human depression and anxiety
    John F Cryan
    Neuroscience Research, Novartis Institutes for BioMedical Research, Basel CH 4055, Switzerland
    Nat Rev Drug Discov 4:775-90. 2005
    ..Here, we assess the current status of research into developing appropriate tests for assessing such behaviours...