Genomes and Genes
Christine M Costello
Affiliation: University College Dublin
- Lung-selective gene responses to alveolar hypoxia: potential role for the bone morphogenetic antagonist gremlin in pulmonary hypertensionChristine M Costello
School of Medicine and Medical Science, UCD Conway Institute of Biomolecular and Biomedical Sciences, University College Dublin, Dublin, Ireland
Am J Physiol Lung Cell Mol Physiol 295:L272-84. 2008..This gives new insights into the mechanisms of pulmonary hypertension and vascular loss in chronic lung disease and identifies gremlin 1 as a potentially important mediator of vascular changes in hypoxic pulmonary hypertension...
- A role for the CXCL12 receptor, CXCR7, in the pathogenesis of human pulmonary vascular diseaseChristine M Costello
UCD School of Medicine and Medical Science, Conway Institute, University College Dublin 4, Ireland
Eur Respir J 39:1415-24. 2012..Our findings demonstrate that CXCR7 has a critical but previously unrecognised role to play in endothelial cell proliferation, suggesting that CXCR7-mediated signalling may be functionally important in pulmonary vascular diseases...
- Can Zipf's law be adapted to normalize microarrays?Tim Lu
Department of Medicine, Christian Albrechts University, Kiel, Germany
BMC Bioinformatics 6:37. 2005..A computationally simple and intuitively appealing technique based on this observation is presented...
- Role of gremlin in the lung: development and diseaseChristine M Costello
School of Medicine and Medical Science, UCD Conway Institute of Biomolecular and Biomedical Sciences, University College Dublin, Dublin 4, Ireland
Am J Respir Cell Mol Biol 42:517-23. 2010..The purpose of this article is to review this evidence, consider the potential mechanisms and multicellular actions by which gremlin contributes to disease pathogenesis, and suggest future avenues of research...
- Gremlin plays a key role in the pathogenesis of pulmonary hypertensionEdwina Cahill
University College Dublin, School of Medicine and Medical Sciences, Belfield, Dublin 4, Ireland
Circulation 125:920-30. 2012..Subsequently, it was demonstrated that BMP signaling was also reduced in common forms of pulmonary hypertension, including hypoxic pulmonary hypertension; however, the mechanism of this reduction has not previously been elucidated...
- Hypoxia selectively activates the CREB family of transcription factors in the in vivo lungMartin O Leonard
University College Dublin, School of Medicine and Medical Science, and Conway Institute of Biomolecular and Biomedical Research, Dublin, Ireland
Am J Respir Crit Care Med 178:977-83. 2008..The pulmonary vascular changes in response to hypoxia, both structural and functional, are unique to this circulation...
- Placenta growth factor and vascular endothelial growth factor B expression in the hypoxic lungMichelle Sands
School of Medicine and Medical Science, Conway Institute of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin, Ireland
Respir Res 12:17. 2011..The aim of this study was to examine the expression of placenta growth factor (PlGF) and VEGFB during the development of hypoxic pulmonary angiogenesis and their functional effects on the pulmonary endothelium...
- Inhibition of Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulationJean-Marc Hyvelin
Department of Physiology, University College, Earlsfort Terrace, Dublin 2, Ireland
Circ Res 97:185-91. 2005..Rho kinase also mediated hypoxia-induced capillary angiogenesis, a previously unrecognized but potentially important adaptive response...
- Dissection of the inflammatory bowel disease transcriptome using genome-wide cDNA microarraysChristine M Costello
Institute for Clinical Molecular Biology, University Hospital Schleswig Holstein, Christian-Albrechts University of Kiel, Kiel, Germany
PLoS Med 2:e199. 2005..The multiple unknown genes identified may stimulate new research in the fields of barrier mechanisms and cell signalling in the context of IBD, and ultimately new therapeutic approaches...