Christine M Costello

Summary

Affiliation: University College Dublin
Country: Ireland

Publications

  1. doi Lung-selective gene responses to alveolar hypoxia: potential role for the bone morphogenetic antagonist gremlin in pulmonary hypertension
    Christine M Costello
    School of Medicine and Medical Science, UCD Conway Institute of Biomolecular and Biomedical Sciences, University College Dublin, Dublin, Ireland
    Am J Physiol Lung Cell Mol Physiol 295:L272-84. 2008
  2. doi A role for the CXCL12 receptor, CXCR7, in the pathogenesis of human pulmonary vascular disease
    Christine M Costello
    UCD School of Medicine and Medical Science, Conway Institute, University College Dublin 4, Ireland
    Eur Respir J 39:1415-24. 2012
  3. pmc Can Zipf's law be adapted to normalize microarrays?
    Tim Lu
    Department of Medicine, Christian Albrechts University, Kiel, Germany
    BMC Bioinformatics 6:37. 2005
  4. doi Role of gremlin in the lung: development and disease
    Christine M Costello
    School of Medicine and Medical Science, UCD Conway Institute of Biomolecular and Biomedical Sciences, University College Dublin, Dublin 4, Ireland
    Am J Respir Cell Mol Biol 42:517-23. 2010
  5. doi Gremlin plays a key role in the pathogenesis of pulmonary hypertension
    Edwina Cahill
    University College Dublin, School of Medicine and Medical Sciences, Belfield, Dublin 4, Ireland
    Circulation 125:920-30. 2012
  6. pmc Hypoxia selectively activates the CREB family of transcription factors in the in vivo lung
    Martin O Leonard
    University College Dublin, School of Medicine and Medical Science, and Conway Institute of Biomolecular and Biomedical Research, Dublin, Ireland
    Am J Respir Crit Care Med 178:977-83. 2008
  7. pmc Placenta growth factor and vascular endothelial growth factor B expression in the hypoxic lung
    Michelle Sands
    School of Medicine and Medical Science, Conway Institute of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin, Ireland
    Respir Res 12:17. 2011
  8. ncbi Inhibition of Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation
    Jean Marc Hyvelin
    Department of Physiology, University College, Earlsfort Terrace, Dublin 2, Ireland
    Circ Res 97:185-91. 2005
  9. pmc Dissection of the inflammatory bowel disease transcriptome using genome-wide cDNA microarrays
    Christine M Costello
    Institute for Clinical Molecular Biology, University Hospital Schleswig Holstein, Christian Albrechts University of Kiel, Kiel, Germany
    PLoS Med 2:e199. 2005

Collaborators

Detail Information

Publications9

  1. doi Lung-selective gene responses to alveolar hypoxia: potential role for the bone morphogenetic antagonist gremlin in pulmonary hypertension
    Christine M Costello
    School of Medicine and Medical Science, UCD Conway Institute of Biomolecular and Biomedical Sciences, University College Dublin, Dublin, Ireland
    Am J Physiol Lung Cell Mol Physiol 295:L272-84. 2008
    ..This gives new insights into the mechanisms of pulmonary hypertension and vascular loss in chronic lung disease and identifies gremlin 1 as a potentially important mediator of vascular changes in hypoxic pulmonary hypertension...
  2. doi A role for the CXCL12 receptor, CXCR7, in the pathogenesis of human pulmonary vascular disease
    Christine M Costello
    UCD School of Medicine and Medical Science, Conway Institute, University College Dublin 4, Ireland
    Eur Respir J 39:1415-24. 2012
    ..Our findings demonstrate that CXCR7 has a critical but previously unrecognised role to play in endothelial cell proliferation, suggesting that CXCR7-mediated signalling may be functionally important in pulmonary vascular diseases...
  3. pmc Can Zipf's law be adapted to normalize microarrays?
    Tim Lu
    Department of Medicine, Christian Albrechts University, Kiel, Germany
    BMC Bioinformatics 6:37. 2005
    ..A computationally simple and intuitively appealing technique based on this observation is presented...
  4. doi Role of gremlin in the lung: development and disease
    Christine M Costello
    School of Medicine and Medical Science, UCD Conway Institute of Biomolecular and Biomedical Sciences, University College Dublin, Dublin 4, Ireland
    Am J Respir Cell Mol Biol 42:517-23. 2010
    ..The purpose of this article is to review this evidence, consider the potential mechanisms and multicellular actions by which gremlin contributes to disease pathogenesis, and suggest future avenues of research...
  5. doi Gremlin plays a key role in the pathogenesis of pulmonary hypertension
    Edwina Cahill
    University College Dublin, School of Medicine and Medical Sciences, Belfield, Dublin 4, Ireland
    Circulation 125:920-30. 2012
    ..Subsequently, it was demonstrated that BMP signaling was also reduced in common forms of pulmonary hypertension, including hypoxic pulmonary hypertension; however, the mechanism of this reduction has not previously been elucidated...
  6. pmc Hypoxia selectively activates the CREB family of transcription factors in the in vivo lung
    Martin O Leonard
    University College Dublin, School of Medicine and Medical Science, and Conway Institute of Biomolecular and Biomedical Research, Dublin, Ireland
    Am J Respir Crit Care Med 178:977-83. 2008
    ..The pulmonary vascular changes in response to hypoxia, both structural and functional, are unique to this circulation...
  7. pmc Placenta growth factor and vascular endothelial growth factor B expression in the hypoxic lung
    Michelle Sands
    School of Medicine and Medical Science, Conway Institute of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin, Ireland
    Respir Res 12:17. 2011
    ..The aim of this study was to examine the expression of placenta growth factor (PlGF) and VEGFB during the development of hypoxic pulmonary angiogenesis and their functional effects on the pulmonary endothelium...
  8. ncbi Inhibition of Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation
    Jean Marc Hyvelin
    Department of Physiology, University College, Earlsfort Terrace, Dublin 2, Ireland
    Circ Res 97:185-91. 2005
    ..Rho kinase also mediated hypoxia-induced capillary angiogenesis, a previously unrecognized but potentially important adaptive response...
  9. pmc Dissection of the inflammatory bowel disease transcriptome using genome-wide cDNA microarrays
    Christine M Costello
    Institute for Clinical Molecular Biology, University Hospital Schleswig Holstein, Christian Albrechts University of Kiel, Kiel, Germany
    PLoS Med 2:e199. 2005
    ..cDNA microarrays can be used to decipher gene regulation events at a genome-wide level and to identify novel unknown genes that might be involved in perpetuating inflammatory disease progression...