M Clyne

Summary

Affiliation: University College Dublin
Country: Ireland

Publications

  1. pmc The interaction of Helicobacter pylori with the adherent mucus gel layer secreted by polarized HT29-MTX-E12 cells
    Brendan Dolan
    University College Dublin, School of Medicine and Medical Science, Dublin, Ireland
    PLoS ONE 7:e47300. 2012
  2. pmc Molecular mechanisms of gastric epithelial cell adhesion and injection of CagA by Helicobacter pylori
    Steffen Backert
    University College Dublin, School of Biomolecular and Biomedical Sciences, Science Center West, Belfield Campus, Dublin 4, Ireland
    Cell Commun Signal 9:28. 2011
  3. ncbi Bacterial factors that mediate colonization of the stomach and virulence of Helicobacter pylori
    Marguerite Clyne
    UCD School of Medicine and Medical Science, The Children s Research Ctr, Our Lady s Children s Hospital Crumlin, Dublin, Ireland
    FEMS Microbiol Lett 268:135-43. 2007
  4. pmc Adherence of isogenic flagellum-negative mutants of Helicobacter pylori and Helicobacter mustelae to human and ferret gastric epithelial cells
    M Clyne
    Department of Paediatrics and The Conway Institute of Molecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Infect Immun 68:4335-9. 2000
  5. pmc Helicobacter pylori infection of human and murine primary gastric cells
    Marguerite Clyne
    The Children s Research Centre, Our Lady s Hospital for Sick Children, Crumlin, Dublin 12, Ireland
    Infect Immun 72:5464-9. 2004
  6. pmc Helicobacter pylori interacts with the human single-domain trefoil protein TFF1
    Marguerite Clyne
    Children s Research Centre, Our Lady s Hospital for Sick Children, Dublin 12, Ireland
    Proc Natl Acad Sci U S A 101:7409-14. 2004
  7. ncbi Adherence of Helicobacter pylori to the gastric mucosa
    M Clyne
    Department of Paediatrics, University College Dublin, Children s Research Centre, Our Lady s Hospital for Sick Children, Crumlin, Ireland
    Can J Gastroenterol 11:243-8. 1997
  8. ncbi Absence of effect of Lewis A and Lewis B expression on adherence of Helicobacter pylori to human gastric cells
    M Clyne
    Department of Paediatrics, University College Dublin, The Childrens Research Centre, Our Lady s Hospital for Sick Children, Crumlin, Ireland
    Gastroenterology 113:72-80. 1997
  9. pmc In vitro evaluation of the role of antibodies against Helicobacter pylori in inhibiting adherence of the organism to gastric cells
    M Clyne
    Department of Paediatrics, University College Dublin, Ireland
    Gut 40:731-8. 1997
  10. pmc Antigastric autoantibodies in ferrets naturally infected with Helicobacter mustelae
    T O Cróinín
    The Children s Research Centre, Our Lady s Hospital for Sick Children, Crumlin, Ireland
    Infect Immun 69:2708-13. 2001

Collaborators

Detail Information

Publications16

  1. pmc The interaction of Helicobacter pylori with the adherent mucus gel layer secreted by polarized HT29-MTX-E12 cells
    Brendan Dolan
    University College Dublin, School of Medicine and Medical Science, Dublin, Ireland
    PLoS ONE 7:e47300. 2012
    ..pylori LPS is critical for this interaction to occur. HT29-MTX-E12 cells are a useful system with which to study the interaction of bacteria with mucosal surfaces and the effect of such interactions on mediating colonization...
  2. pmc Molecular mechanisms of gastric epithelial cell adhesion and injection of CagA by Helicobacter pylori
    Steffen Backert
    University College Dublin, School of Biomolecular and Biomedical Sciences, Science Center West, Belfield Campus, Dublin 4, Ireland
    Cell Commun Signal 9:28. 2011
    ..The contribution of these interactions to H. pylori colonization and pathogenesis is discussed...
  3. ncbi Bacterial factors that mediate colonization of the stomach and virulence of Helicobacter pylori
    Marguerite Clyne
    UCD School of Medicine and Medical Science, The Children s Research Ctr, Our Lady s Children s Hospital Crumlin, Dublin, Ireland
    FEMS Microbiol Lett 268:135-43. 2007
    ..In this review, some of the bacterial factors that mediate colonization of the gastric mucosa and play a role in the pathogenesis of this organism have been considered...
  4. pmc Adherence of isogenic flagellum-negative mutants of Helicobacter pylori and Helicobacter mustelae to human and ferret gastric epithelial cells
    M Clyne
    Department of Paediatrics and The Conway Institute of Molecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Infect Immun 68:4335-9. 2000
    ..pylori or H. mustelae to gastric epithelial cells. However, genes involved in the regulation of H. pylori flagellar biosynthesis may also regulate the production of an adhesin...
  5. pmc Helicobacter pylori infection of human and murine primary gastric cells
    Marguerite Clyne
    The Children s Research Centre, Our Lady s Hospital for Sick Children, Crumlin, Dublin 12, Ireland
    Infect Immun 72:5464-9. 2004
    ..Identification of an easily available animal model of infection in which the organism adheres to gastric mucosal cells would enhance studies of the virulence of H. pylori...
  6. pmc Helicobacter pylori interacts with the human single-domain trefoil protein TFF1
    Marguerite Clyne
    Children s Research Centre, Our Lady s Hospital for Sick Children, Dublin 12, Ireland
    Proc Natl Acad Sci U S A 101:7409-14. 2004
    ..This interaction may underline the previously unexplained tropism of this organism for gastric tissue and its colocalization with the gastric mucin MUC5AC...
  7. ncbi Adherence of Helicobacter pylori to the gastric mucosa
    M Clyne
    Department of Paediatrics, University College Dublin, Children s Research Centre, Our Lady s Hospital for Sick Children, Crumlin, Ireland
    Can J Gastroenterol 11:243-8. 1997
    ..Topics discussed are the mechanism of H pylori adherence; in vitro and in vivo models of H pylori infection; and adherence and potential adhesins and receptors for H pylori...
  8. ncbi Absence of effect of Lewis A and Lewis B expression on adherence of Helicobacter pylori to human gastric cells
    M Clyne
    Department of Paediatrics, University College Dublin, The Childrens Research Centre, Our Lady s Hospital for Sick Children, Crumlin, Ireland
    Gastroenterology 113:72-80. 1997
    ..The aim of this study was to determine the effect of expression of Lewis a and Lewis b on binding of H. pylori to primary gastric cells...
  9. pmc In vitro evaluation of the role of antibodies against Helicobacter pylori in inhibiting adherence of the organism to gastric cells
    M Clyne
    Department of Paediatrics, University College Dublin, Ireland
    Gut 40:731-8. 1997
    ..Once Helicobacter pylori infection is established, it is difficult to eradicate despite a persistent systemic and local immune response. It is not known whether immunisation can be used to prevent H pylori infection in humans...
  10. pmc Antigastric autoantibodies in ferrets naturally infected with Helicobacter mustelae
    T O Cróinín
    The Children s Research Centre, Our Lady s Hospital for Sick Children, Crumlin, Ireland
    Infect Immun 69:2708-13. 2001
    ..In conclusion, ferrets naturally infected with H. mustelae generate antibodies that react with parietal cells, but these autoantibodies are not due to molecular mimicry...
  11. ncbi Helicobacter pylori lipopolysaccharide interacts with TFF1 in a pH-dependent manner
    Emer P Reeves
    University College Dublin School of Medicine and Medical Science, The Children s Research Centre, Our Lady s Children s Hospital, Dublin, Ireland
    Gastroenterology 135:2043-54, 2054.e1-2. 2008
    ..We aimed to characterize the interaction of H. pylori with TFF1 and to assess the role of this interaction in mediating colonization...
  12. pmc Campylobacter jejuni cocultured with epithelial cells reduces surface capsular polysaccharide expression
    N Corcionivoschi
    The Children s Research Centre, Our Lady s Children s Hospital, Crumlin, Dublin 12, Ireland
    Infect Immun 77:1959-67. 2009
    ..C. jejuni alters its surface polysaccharides when cocultured with epithelial cells, suggesting the existence of a cross talk mechanism that modulates CPS expression during infection...
  13. ncbi Campylobacter upsaliensis exerts a cytolethal distending toxin effect on HeLa cells and T lymphocytes
    A Mooney
    Children's Research Centre, Our Lady's Hospital for Sick Children and Department of Paediatrics, The Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Crumlin, Dublin 12, Ireland
    Microbiology 147:735-43. 2001
    ..Using a combination of Annexin V/PI staining and TUNEL assay, cytodistended HeLa cells were shown to undergo apoptotic cell death. These data provide the first insights into the virulence mechanisms of this novel enteropathogen...
  14. doi Purified chicken intestinal mucin attenuates Campylobacter jejuni pathogenicity in vitro
    Abofu Alemka
    School of Medicine and Medical Science, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    J Med Microbiol 59:898-903. 2010
    ..jejuni pathogenicity. In conclusion, differences in the composition of chicken and human intestinal mucin may contribute to the differential outcome of Campylobacter infection of these hosts...
  15. ncbi Campylobacter jejuni adhere to and invade chicken intestinal epithelial cells in vitro
    Catherine M Byrne
    The Children s Research Centre, Our Lady s Children s Hospital, Crumlin, Dublin 12, Ireland
    Microbiology 153:561-9. 2007
    ..Chicken mucus, but not intestinal mucus of human origin, significantly reduced infection of primary human intestinal cells. Avian mucus appears to inhibit Campylobacter from interacting with epithelial cell surfaces...
  16. pmc Probiotic colonization of the adherent mucus layer of HT29MTXE12 cells attenuates Campylobacter jejuni virulence properties
    Abofu Alemka
    School of Medicine and Medical Science, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Infect Immun 78:2812-22. 2010
    ..These results demonstrate the potential for E12 cells as a model of mucosal pathogenesis and provide a rationale for the further investigation of probiotics as prophylaxis against human campylobacteriosis...