Gerard Clarke

Summary

Affiliation: University College Cork
Country: Ireland

Publications

  1. pmc A Distinct Profile of Tryptophan Metabolism along the Kynurenine Pathway Downstream of Toll-Like Receptor Activation in Irritable Bowel Syndrome
    Gerard Clarke
    Alimentary Pharmabiotic Centre, University College Cork Cork, Ireland
    Front Pharmacol 3:90. 2012
  2. doi request reprint The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner
    G Clarke
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Mol Psychiatry 18:666-73. 2013
  3. doi request reprint Review article: probiotics for the treatment of irritable bowel syndrome--focus on lactic acid bacteria
    G Clarke
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Aliment Pharmacol Ther 35:403-13. 2012
  4. pmc Marked elevations in pro-inflammatory polyunsaturated fatty acid metabolites in females with irritable bowel syndrome
    Gerard Clarke
    Department of Psychiatry, University College Cork, Cork, Ireland
    J Lipid Res 51:1186-92. 2010
  5. doi request reprint Irritable bowel syndrome: towards biomarker identification
    Gerard Clarke
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Trends Mol Med 15:478-89. 2009
  6. doi request reprint Chain reactions: early-life stress alters the metabolic profile of plasma polyunsaturated fatty acids in adulthood
    Gerard Clarke
    Department of Psychiatry, University College Cork, Cork, Ireland Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Behav Brain Res 205:319-21. 2009
  7. doi request reprint Verapamil in treatment resistant depression: a role for the P-glycoprotein transporter?
    Gerard Clarke
    Department of Psychiatry, Biosciences Institute, University College Cork, Cork, Ireland
    Hum Psychopharmacol 24:217-23. 2009
  8. pmc Tryptophan degradation in irritable bowel syndrome: evidence of indoleamine 2,3-dioxygenase activation in a male cohort
    Gerard Clarke
    Department of Psychiatry, University College Cork, Cork, Ireland
    BMC Gastroenterol 9:6. 2009
  9. doi request reprint Differential visceral nociceptive, behavioural and neurochemical responses to an immune challenge in the stress-sensitive Wistar Kyoto rat strain
    Siobhain M O' Mahony
    Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland
    Behav Brain Res 253:310-7. 2013
  10. ncbi request reprint Human P-glycoprotein differentially affects antidepressant drug transport: relevance to blood-brain barrier permeability
    Fionn E O'Brien
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Int J Neuropsychopharmacol 16:2259-72. 2013

Collaborators

Detail Information

Publications28

  1. pmc A Distinct Profile of Tryptophan Metabolism along the Kynurenine Pathway Downstream of Toll-Like Receptor Activation in Irritable Bowel Syndrome
    Gerard Clarke
    Alimentary Pharmabiotic Centre, University College Cork Cork, Ireland
    Front Pharmacol 3:90. 2012
    ..Furthermore, these studies implicate the modulation of TLRs as means through which aberrant tryptophan metabolism along the kynurenine pathway can be controlled, a novel potential therapeutic strategy in this and other disorders...
  2. doi request reprint The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner
    G Clarke
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Mol Psychiatry 18:666-73. 2013
    ....
  3. doi request reprint Review article: probiotics for the treatment of irritable bowel syndrome--focus on lactic acid bacteria
    G Clarke
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Aliment Pharmacol Ther 35:403-13. 2012
    ..The withdrawal, due to adverse events, of a number of pharmacological agents that were approved for the treatment of IBS has left a therapeutic vacuum for patients suffering from the disorder...
  4. pmc Marked elevations in pro-inflammatory polyunsaturated fatty acid metabolites in females with irritable bowel syndrome
    Gerard Clarke
    Department of Psychiatry, University College Cork, Cork, Ireland
    J Lipid Res 51:1186-92. 2010
    ..Together, our data identifies a novel proinflammatory mechanism in irritable bowel syndrome and also suggests that elevated arachidonic acid levels in plasma may serve as putative biological markers in this condition...
  5. doi request reprint Irritable bowel syndrome: towards biomarker identification
    Gerard Clarke
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Trends Mol Med 15:478-89. 2009
    ..The successful identification of biomarkers is critical to progressing our understanding of IBS and addressing the unmet therapeutic needs of this debilitating condition...
  6. doi request reprint Chain reactions: early-life stress alters the metabolic profile of plasma polyunsaturated fatty acids in adulthood
    Gerard Clarke
    Department of Psychiatry, University College Cork, Cork, Ireland Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Behav Brain Res 205:319-21. 2009
    ..Our results identify a proinflammatory PUFA profile as a persistent consequence of early-life stress and suggest new avenues of investigation in stress-related disorders...
  7. doi request reprint Verapamil in treatment resistant depression: a role for the P-glycoprotein transporter?
    Gerard Clarke
    Department of Psychiatry, Biosciences Institute, University College Cork, Cork, Ireland
    Hum Psychopharmacol 24:217-23. 2009
    ..In this study we examined the hypothesis that the antidepressant-like effects of verapamil are mediated through its blockade of the Pgp transporter in the blood brain barrier (BBB)...
  8. pmc Tryptophan degradation in irritable bowel syndrome: evidence of indoleamine 2,3-dioxygenase activation in a male cohort
    Gerard Clarke
    Department of Psychiatry, University College Cork, Cork, Ireland
    BMC Gastroenterol 9:6. 2009
    ..In this study, we investigated tryptophan degradation in a male IBS cohort (n = 10) and control subjects (n = 26)...
  9. doi request reprint Differential visceral nociceptive, behavioural and neurochemical responses to an immune challenge in the stress-sensitive Wistar Kyoto rat strain
    Siobhain M O' Mahony
    Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland
    Behav Brain Res 253:310-7. 2013
    ..This implies that heightened stress-susceptibility in vulnerable populations may compromise the coordinated CNS response to peripheral immune activation. ..
  10. ncbi request reprint Human P-glycoprotein differentially affects antidepressant drug transport: relevance to blood-brain barrier permeability
    Fionn E O'Brien
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Int J Neuropsychopharmacol 16:2259-72. 2013
    ..Moreover, the present results highlight that other antidepressants may not be transported substrates of human P-gp...
  11. doi request reprint Differential stress-induced alterations in tryptophan hydroxylase activity and serotonin turnover in two inbred mouse strains
    Caroline A Browne
    Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland
    Neuropharmacology 60:683-91. 2011
    ..Together these data highlight the differential serotonergic response of BALB/c and C57BL/6J mice to acute and chronic restraint stress and may offer insight into the observed differences in their stress-related phenotypes...
  12. doi request reprint The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat
    Lieve Desbonnet
    Department of Psychiatry and Alimentary Pharmacobiotic Centre, Biosciences Institute, University College Cork, Cork, Ireland
    J Psychiatr Res 43:164-74. 2008
    ..However, these findings are preliminary and further investigation into the precise mechanisms involved, is warranted...
  13. doi request reprint An effective dietary method for chronic tryptophan depletion in two mouse strains illuminates a role for 5-HT in nesting behaviour
    Caroline A Browne
    Neuropharmacology Research Group, Department of Pharmacology and Therapeutics, University College Cork, Ireland
    Neuropharmacology 62:1903-15. 2012
    ..This study demonstrates significant alterations in the levels of tryptophan, serotonin turnover and behaviour following chronic dietary tryptophan depletion...
  14. doi request reprint Alterations in prefrontal cortical serotonin and antidepressant-like behavior in a novel C3H/HeJxDBA/2J recombinant inbred mouse strain
    Caroline A Browne
    Neuropharmacology Research Group, Department of Pharmacology and Therapeutics, University College Cork, Ireland
    Behav Brain Res 236:283-8. 2013
    ..These data implicate serotonergic modulation in the mPFC in the maintenance of antidepressant-like behavior in a highly fearful mouse strain...
  15. doi request reprint Chronic stress-induced alterations in mouse colonic 5-HT and defecation responses are strain dependent
    Marcela Julio-Pieper
    Laboratory of Neurogastroenterology, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Stress 15:218-26. 2012
    ..In addition, C57BL/6 mice emerge as a relevant model for studying GI alterations induced by chronic stress...
  16. doi request reprint The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram
    Fionn E O'Brien
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland Pharmacodelivery Group, School of Pharmacy, University College Cork, Cork, Ireland Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland
    Behav Brain Res 261:17-25. 2014
    ....
  17. doi request reprint Gut memories: towards a cognitive neurobiology of irritable bowel syndrome
    Paul J Kennedy
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Neurosci Biobehav Rev 36:310-40. 2012
    ..We conclude that each factor addressed could significantly impinge on central nervous system function, supporting the view that future research efforts must be directed towards a detailed assessment of cognitive function in IBS...
  18. ncbi request reprint A review of ketamine in affective disorders: current evidence of clinical efficacy, limitations of use and pre-clinical evidence on proposed mechanisms of action
    Marie Naughton
    Department of Psychiatry, University College Cork, Western Road, Cork City, Cork, Ireland Electronic address
    J Affect Disord 156:24-35. 2014
    ....
  19. doi request reprint Strain differences in the neurochemical response to chronic restraint stress in the rat: relevance to depression
    Cliona M O'Mahony
    Neuropharmacology Research Group, Dept of Pharmacology and Therapeutics, University College Cork, Cork, Ireland
    Pharmacol Biochem Behav 97:690-9. 2011
    ..Together these data show that there are specific strain-dependent changes in neurotransmitter and neurotrophin levels in response to chronic stress which may predispose WKY animals to a depressive-like phenotype...
  20. doi request reprint Enhanced cholinergic-mediated increase in the pro-inflammatory cytokine IL-6 in irritable bowel syndrome: role of muscarinic receptors
    Timothy G Dinan
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Am J Gastroenterol 103:2570-6. 2008
    ..We tested the hypothesis that the pro-inflammatory cytokine profile in IBS is driven by the cholinergic system and determined if the responses are mediated by muscarinic receptors...
  21. ncbi request reprint The impact of microbiota on brain and behavior: mechanisms & therapeutic potential
    Yuliya E Borre
    Laboratory of Neurogastroenterology, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Adv Exp Med Biol 817:373-403. 2014
    ..Thus, the concept of a microbiome-brain-gut axis is emerging, suggesting microbiota-modulating strategies may be a tractable therapeutic approach for developing novel treatments for CNS disorders. ..
  22. pmc P-glycoprotein inhibition increases the brain distribution and antidepressant-like activity of escitalopram in rodents
    Fionn E O'Brien
    1 Alimentary Pharmabiotic Center, University College Cork, Cork, Ireland 2 Pharmacodelivery Group, School of Pharmacy, University College Cork, Cork, Ireland 3 Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland
    Neuropsychopharmacology 38:2209-19. 2013
    ....
  23. doi request reprint Menstrual cycle influences Toll-like receptor responses
    Una Dennison
    Department of Psychiatry, University College Cork, Cork, Ireland
    Neuroimmunomodulation 19:171-9. 2012
    ..Human studies have shown changes in endometrial TLR expression during the menstrual cycle and during pregnancy. Our objective was to measure peripheral TLR activity over the course of the menstrual cycle...
  24. doi request reprint The microbiome: stress, health and disease
    Rachel D Moloney
    Laboratory of Neurogastroenterology, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Mamm Genome 25:49-74. 2014
    ....
  25. doi request reprint Biological and psychological markers of stress in humans: focus on the Trier Social Stress Test
    Andrew P Allen
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland Department of Psychiatry, University College Cork, Cork, Ireland
    Neurosci Biobehav Rev 38:94-124. 2014
    ..Our analysis suggests that multiple readouts are necessary to derive maximum information; this strategy will enhance our understanding of the psychobiology of stress and provide the means to assess novel therapeutic agents. ..
  26. ncbi request reprint An isocratic high performance liquid chromatography method for the determination of GABA and glutamate in discrete regions of the rodent brain
    Gerard Clarke
    Alimentary Pharmabiotic Centre and Department of Psychiatry, University College Cork, Cork, Ireland
    J Neurosci Methods 160:223-30. 2007
    ..Successful application of the method to a maternal deprivation study has identified the hippocampus and the brainstem as possible sites of long-term alteration in this paradigm...
  27. pmc Dynamic 5-HT2C receptor editing in a mouse model of obesity
    Harriet Schellekens
    Food for Health Ireland, University College Cork, Cork, Ireland
    PLoS ONE 7:e32266. 2012
    ..The differential 5-HT(1A), 5-HT(1B) and 5-HT(6) receptor expression and altered 5-HT(2C) receptor editing profile reported here is poised to have important consequences for the development of novel anti-obesity therapies...
  28. pmc Brain-gut-microbe communication in health and disease
    Sue Grenham
    Laboratory of Neurogastroenterology, Alimentary Pharmabiotic Centre, University College Cork Cork, Ireland
    Front Physiol 2:94. 2011
    ..Despite the considerable challenges that lie ahead, this is an exciting area of research and one that is destined to remain the center of focus for some time to come...