Research Topics
| Geraldine ButlerSummaryAffiliation: University College Dublin Country: Ireland Publications
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Detail Information
Publications
Fungal sex and pathogenesisGeraldine Butler
UCD School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Dublin 4, Ireland
Clin Microbiol Rev 23:140-59. 2010..I provide an overview of how sex is suppressed in different species and discuss the potential associations with pathogenesis...- Evolution of pathogenicity and sexual reproduction in eight Candida genomesGeraldine Butler
UCD School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
Nature 459:657-62. 2009..Analysis of the CUG leucine-to-serine genetic-code change reveals that 99% of ancestral CUG codons were erased and new ones arose elsewhere. Lastly, we revise the Candida albicans gene catalogue, identifying many new genes... - Chromosomal G + C content evolution in yeasts: systematic interspecies differences, and GC-poor troughs at centromeresDenise B Lynch
Conway Institute of Biomedical and Biomolecular Sciences, University College Dublin, Belfield, Dublin 4, Ireland
Genome Biol Evol 2:572-83. 2010.... - Conserved and divergent roles of Bcr1 and CFEM proteins in Candida parapsilosis and Candida albicansChen Ding
School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin, Ireland
PLoS ONE 6:e28151. 2011..parapsilosis. Our data suggest that the role of the CFEM family in iron acquisition is conserved between C. albicans and C. parapsilosis, but their role in biofilm formation is not... - Evidence of recent interkingdom horizontal gene transfer between bacteria and Candida parapsilosisDavid A Fitzpatrick
School of Biomolecular and Biomedical Science, Conway Institute, University College, Dublin, Belfield, Dublin 4, Ireland
BMC Evol Biol 8:181. 2008..We refer to these as CTG species because they translate the CTG codon as serine rather than leucine, and share a recent common ancestor... - Evolution of mating within the Candida parapsilosis species groupSixiang Sai
UCD School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin 4, Ireland
Eukaryot Cell 10:578-87. 2011..It is therefore likely either that mating of C. orthopsilosis takes place under certain unidentified conditions or that the mating pathway has been adapted for other functions, such as cross-species communication... - Candida albicans transcription factor Ace2 regulates metabolism and is required for filamentation in hypoxic conditionsSiobhan M Mulhern
UCD School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
Eukaryot Cell 5:2001-13. 2006..We suggest that filamentation is induced in wild-type cells by reducing respiration (using low oxygen or respiratory drugs) and that mutants with increased respiratory activity fail to undergo filamentation under these conditions... - Regulation of the hypoxic response in Candida albicansJohn M Synnott
Conway Institute, University College Dublin, Ireland
Eukaryot Cell 9:1734-46. 2010..albicans is complex and is signaled both via lowered sterol levels and other unstudied mechanisms. We also show that induction of filamentation under hypoxic conditions requires the Ras1- and Cdc35-dependent pathway... - Analysis of gene evolution and metabolic pathways using the Candida Gene Order BrowserDavid A Fitzpatrick
UCD School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
BMC Genomics 11:290. 2010..Saccharomyces cerevisiae is also included as a reference genome... - A genome sequence survey shows that the pathogenic yeast Candida parapsilosis has a defective MTLa1 allele at its mating type locusMary E Logue
Department of Biochemistry, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
Eukaryot Cell 4:1009-17. 2005..It is therefore likely that all (or at least the majority) of C. parapsilosis isolates have a mating pathway that is either defective or substantially different from that of C. albicans... 
The Candida albicans CaACE2 gene affects morphogenesis, adherence and virulenceMary T Kelly
Department of Biochemistry, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
Mol Microbiol 53:969-83. 2004..The CaAce2 protein is localized to the daughter nucleus of large budded cells at the end of mitosis. C. albicans Ace2p therefore plays a major role in morphogenesis and adherence and resembles S. cerevisiae Ace2p in function...- Development of a gene knockout system in Candida parapsilosis reveals a conserved role for BCR1 in biofilm formationChen Ding
UCD School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
Eukaryot Cell 6:1310-9. 2007..parapsilosis does not generate true hyphae and that BCR1 regulates the expression of many hypha-specific adhesins in C. albicans... - Using RNA-seq to determine the transcriptional landscape and the hypoxic response of the pathogenic yeast Candida parapsilosisAlessandro Guida
School of Medicine and Medical Science, Conway Institute, UniversityCollege Dublin, Belfield, Dublin 4, Ireland
BMC Genomics 12:628. 2011..The transcriptional response of C. parapsilosis to hypoxic (low oxygen) conditions, such as those encountered in the host, is also relatively unexplored... - A fungal phylogeny based on 42 complete genomes derived from supertree and combined gene analysisDavid A Fitzpatrick
School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
BMC Evol Biol 6:99. 2006..As a tool for future comparative, phylogenomic and phylogenetic studies, we used both supertrees and concatenated alignments to infer relationships between 42 species of fungi for which complete genome sequences are available... - Sequence and analysis of the genome of the pathogenic yeast Candida orthopsilosisAlessandro Riccombeni
School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin, Ireland
PLoS ONE 7:e35750. 2012..orthopsilosis but not C. parapsilosis, and has a patchy distribution in Candida species. Our results suggest that the difference in virulence between C. parapsilosis and C. orthopsilosis may be associated with expansion of gene families... - Transcriptional response of Candida parapsilosis following exposure to farnesolTristan Rossignol
UCD School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
Antimicrob Agents Chemother 51:2304-12. 2007..There is no effect on expression of C. parapsilosis orthologs of genes involved in hyphal growth in C. albicans. Farnesol therefore differs significantly in its effects on C. parapsilosis and C. albicans... - Phenotype switching affects biofilm formation by Candida parapsilosisSean F Laffey
Department of Biochemistry, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
Microbiology 151:1073-81. 2005..The smooth phenotype, however, grows significantly faster than the others. The quorum-sensing molecule farnesol inhibits formation of biofilms by the crepe, concentric and crater phenotypes... - Evolution of the MAT locus and its Ho endonuclease in yeast speciesGeraldine Butler
Department of Biochemistry, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland
Proc Natl Acad Sci U S A 101:1632-7. 2004.... - Genomic differences between Candida glabrata and Saccharomyces cerevisiae around the MRPL28 and GCN3 lociDavid W Walsh
Department of Biochemistry and Conway Institute of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin 4, Ireland
Yeast 19:991-4. 2002..cerevisiae chromosome XI (including GCN3) followed by a four-gene cluster similar to chromosome XV (including HIS3). A small-scale rearrangement of gene order has occurred in the chromosome XI-like section...