Donal J Brennan

Summary

Affiliation: University College Dublin
Country: Ireland

Publications

  1. pmc SOX11 expression correlates to promoter methylation and regulates tumor growth in hematopoietic malignancies
    Elin Gustavsson
    Department of Immunotechnology, Lund University, Lund, Sweden
    Mol Cancer 9:187. 2010
  2. pmc Expression of the RNA-binding protein RBM3 is associated with a favourable prognosis and cisplatin sensitivity in epithelial ovarian cancer
    Asa Ehlén
    Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Skane University Hospital, Malmo, Sweden
    J Transl Med 8:78. 2010
  3. pmc Increased androgen receptor expression in serous carcinoma of the ovary is associated with an improved survival
    Björn Nodin
    Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, and Skåne Regional Laboratories, Malmo, Sweden
    J Ovarian Res 3:14. 2010
  4. pmc Tumor-specific HMG-CoA reductase expression in primary premenopausal breast cancer predicts response to tamoxifen
    Donal J Brennan
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Breast Cancer Res 13:R12. 2011
  5. pmc Novel image analysis approach for quantifying expression of nuclear proteins assessed by immunohistochemistry: application to measurement of oestrogen and progesterone receptor levels in breast cancer
    Elton Rexhepaj
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Ireland
    Breast Cancer Res 10:R89. 2008
  6. pmc Prognostic impact of tumour-specific HMG-CoA reductase expression in primary breast cancer
    Signe Borgquist
    Center for Molecular Pathology, Department of Laboratory Medicine, Malmo University Hospital, Lund University, Malmo, Sweden
    Breast Cancer Res 10:R79. 2008
  7. pmc Homeobox transcription factor muscle segment homeobox 2 (Msx2) correlates with good prognosis in breast cancer patients and induces apoptosis in vitro
    Fiona Lanigan
    University College Dublin School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Breast Cancer Res 12:R59. 2010
  8. pmc The tumour suppressor SOX11 is associated with improved survival among high grade epithelial ovarian cancers and is regulated by reversible promoter methylation
    Sandra Sernbo
    Department of Immunotechnology, Lund University, Lund, Sweden
    BMC Cancer 11:405. 2011
  9. pmc Validation of cytoplasmic-to-nuclear ratio of survivin as an indicator of improved prognosis in breast cancer
    Elton Rexhepaj
    UCD Conway Institute, University College Dublin, Belfield, Ireland
    BMC Cancer 10:639. 2010
  10. pmc Up-regulation of cell cycle arrest protein BTG2 correlates with increased overall survival in breast cancer, as detected by immunohistochemistry using tissue microarray
    Elin Möllerström
    Department of Oncology, Institute of Clinical Sciences, Blå stråket 2, University of Gothenburg, SE 413 45 Goteborg, Sweden
    BMC Cancer 10:296. 2010

Collaborators

  • Karin Jirstrom
  • William M Gallagher
  • Mark P Hehir
  • Jenny Brändstedt
  • Sara Ek
  • Sami Kilpinen
  • Michael J Duffy
  • Elton Rexhepaj
  • Sandra Sernbo
  • Elin Gustavsson
  • Björn Nodin
  • Carl Ak Borrebaeck
  • Darran P O'Connor
  • Elin Möllerström
  • Asa Ehlén
  • Maria Prencipe
  • Jonas Manjer
  • Fiona Lanigan
  • Goran Landberg
  • Fredrik Ponten
  • Signe Borgquist
  • Frida Rydnert
  • Mark Lawler
  • Amanda McCann
  • Finian Martin
  • Per Karlsson
  • Barbara McGrogan
  • Ulla Delle
  • Szilard Nemes
  • Rowena Hughes
  • Antoinette S Perry
  • Patricia Fitzpatrick
  • Mathias Uhlen
  • Nooreldin Zendehrokh
  • Gabriela Gremel
  • Sallyann L O'Brien
  • Sine Phelan
  • Kristina Lövgren
  • Ian B Jeffrey
  • Fiona Furlong
  • Elise Nilsson
  • Anna Danielsson
  • Anikó Kovács
  • Maria Alvarado-Kristensson
  • Jenny A Watson
  • Elin Andersson
  • Mats Jerkeman
  • Jakob Eberhard
  • Michael Dictor
  • Toshima Parris
  • Khalil Helou
  • Aloysius McGoldrick
  • Anthony O'Grady
  • Elaine Kay
  • Amanda H McCann
  • Annika Jögi
  • Elaine W Kay
  • Peter Holloway
  • Lisa Rydén

Detail Information

Publications16

  1. pmc SOX11 expression correlates to promoter methylation and regulates tumor growth in hematopoietic malignancies
    Elin Gustavsson
    Department of Immunotechnology, Lund University, Lund, Sweden
    Mol Cancer 9:187. 2010
    ..SOX11 has been shown to prevent gliomagenesis in vivo but the causes and consequences of aberrant expression of SOX11 outside the CNS remain unexplained...
  2. pmc Expression of the RNA-binding protein RBM3 is associated with a favourable prognosis and cisplatin sensitivity in epithelial ovarian cancer
    Asa Ehlén
    Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Skane University Hospital, Malmo, Sweden
    J Transl Med 8:78. 2010
    ..The aim of this study was to examine the prognostic value of RBM3 mRNA and protein expression in epithelial ovarian cancer (EOC) and the cisplatin response upon RBM3 depletion in a cisplatin-sensitive ovarian cancer cell line...
  3. pmc Increased androgen receptor expression in serous carcinoma of the ovary is associated with an improved survival
    Björn Nodin
    Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, and Skåne Regional Laboratories, Malmo, Sweden
    J Ovarian Res 3:14. 2010
    ..Altered androgen hormone homeostasis and androgen receptor (AR) activity have been implicated in ovarian carcinogenesis but the relationship between AR expression in ovarian cancer and clinical outcome remains unclear...
  4. pmc Tumor-specific HMG-CoA reductase expression in primary premenopausal breast cancer predicts response to tamoxifen
    Donal J Brennan
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Breast Cancer Res 13:R12. 2011
    ..Here, the predictive value of HMG-CoAR expression in relation to tamoxifen response was examined...
  5. pmc Novel image analysis approach for quantifying expression of nuclear proteins assessed by immunohistochemistry: application to measurement of oestrogen and progesterone receptor levels in breast cancer
    Elton Rexhepaj
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Ireland
    Breast Cancer Res 10:R89. 2008
    ..In the present article we describe the development of a novel approach for automatically quantifying oestrogen receptor (ER) and progesterone receptor (PR) protein expression assessed by IHC in primary breast cancer...
  6. pmc Prognostic impact of tumour-specific HMG-CoA reductase expression in primary breast cancer
    Signe Borgquist
    Center for Molecular Pathology, Department of Laboratory Medicine, Malmo University Hospital, Lund University, Malmo, Sweden
    Breast Cancer Res 10:R79. 2008
    ..In the present study, we examined the prognostic value of HMG-CoAR expression in a large cohort of primary breast cancer patients with long-term follow up...
  7. pmc Homeobox transcription factor muscle segment homeobox 2 (Msx2) correlates with good prognosis in breast cancer patients and induces apoptosis in vitro
    Fiona Lanigan
    University College Dublin School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Breast Cancer Res 12:R59. 2010
    ..However, the clinical implications of Msx2 expression in breast cancer are unclear. The aims of this study were to investigate the potential clinical value of Msx2 as a breast cancer biomarker and to clarify its functional role in vitro...
  8. pmc The tumour suppressor SOX11 is associated with improved survival among high grade epithelial ovarian cancers and is regulated by reversible promoter methylation
    Sandra Sernbo
    Department of Immunotechnology, Lund University, Lund, Sweden
    BMC Cancer 11:405. 2011
    ....
  9. pmc Validation of cytoplasmic-to-nuclear ratio of survivin as an indicator of improved prognosis in breast cancer
    Elton Rexhepaj
    UCD Conway Institute, University College Dublin, Belfield, Ireland
    BMC Cancer 10:639. 2010
    ..Here, we validate survivin CNR in a separate and extended cohort. Furthermore, we present new data suggesting that a low CNR may predict outcome in tamoxifen-treated patients...
  10. pmc Up-regulation of cell cycle arrest protein BTG2 correlates with increased overall survival in breast cancer, as detected by immunohistochemistry using tissue microarray
    Elin Möllerström
    Department of Oncology, Institute of Clinical Sciences, Blå stråket 2, University of Gothenburg, SE 413 45 Goteborg, Sweden
    BMC Cancer 10:296. 2010
    ..The aim of this study was to characterize the expression of the corresponding proteins in breast carcinoma and to determine their correlation with clinical outcome...
  11. pmc Tumour-specific HMG-CoAR is an independent predictor of recurrence free survival in epithelial ovarian cancer
    Donal J Brennan
    Dept of Obstetrics and Gynaecology, National Maternity Hospital, Holles Street, Dublin 2, Ireland
    BMC Cancer 10:125. 2010
    ..In the present study, the prognostic value of HMG-CoAR expression was examined in tumours from a cohort of patients with primary epithelial ovarian cancer...
  12. doi request reprint The transcription factor Sox11 is a prognostic factor for improved recurrence-free survival in epithelial ovarian cancer
    Donal J Brennan
    Department of Obstetrics and Gynaecology, National Maternity Hospital, Holles Street Dublin 2, Ireland
    Eur J Cancer 45:1510-7. 2009
    ..Current prognostic molecular markers for epithelial ovarian cancer (EOC) are insufficient. The aim of the current study was to investigate the role of Sox11 in EOC...
  13. ncbi request reprint MAD2 downregulation in hypoxia is independent of promoter hypermethylation
    Maria Prencipe
    UCD School of Medicine and Medical Science SMMS, University College Dublin, Belfield, Dublin, Ireland
    Cell Cycle 9:2856-65. 2010
    ..Moreover, MAD2 downregulation could play a central role in the induction of chemoresistance in hypoxia, a key tumour microenvironment associated with chemoresistance...
  14. pmc Identification of a myometrial molecular profile for dystocic labor
    Donal J Brennan
    National Maternity Hospital, Dublin, Ireland
    BMC Pregnancy Childbirth 11:74. 2011
    ..The most common indication for cesarean section (CS) in nulliparous women is dystocia secondary to ineffective myometrial contractility. The aim of this study was to identify a molecular profile in myometrium associated with dystocic labor...
  15. doi request reprint Maternal and fetal cocaine- and amphetamine-regulated transcript in diabetic and non-diabetic pregnancy
    Mark P Hehir
    UCD Obstetrics and Gynaecology, School of Medicine and Medical Science, University College Dublin, National Maternity Hospital, Dublin, Ireland
    Gynecol Endocrinol 28:682-5. 2012
    ..332) (p = 0.001) irrespective of diabetes. Serum CART can be detected in both diabetic and non-diabetic human pregnancy and may play an important role in body mass regulation in pregnancy...
  16. doi request reprint The singleton, cephalic, nulliparous woman after 36 weeks of gestation: contribution to overall cesarean delivery rates
    Donal J Brennan
    National Maternity Hospital, Dublin, Ireland
    Obstet Gynecol 117:273-9. 2011
    ..To examine the contribution of singleton, cephalic, term (37 weeks or later) nulliparous cesarean rates to overall cesarean incidence in a single institution during a 35-year period...