Donal J Brennan

Summary

Affiliation: University College Dublin
Country: Ireland

Publications

  1. pmc Identification of a myometrial molecular profile for dystocic labor
    Donal J Brennan
    National Maternity Hospital, Dublin, Ireland
    BMC Pregnancy Childbirth 11:74. 2011
  2. pmc SOX11 expression correlates to promoter methylation and regulates tumor growth in hematopoietic malignancies
    Elin Gustavsson
    Department of Immunotechnology, Lund University, Lund, Sweden
    Mol Cancer 9:187. 2010
  3. pmc Expression of the RNA-binding protein RBM3 is associated with a favourable prognosis and cisplatin sensitivity in epithelial ovarian cancer
    Asa Ehlén
    Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Skane University Hospital, Malmo, Sweden
    J Transl Med 8:78. 2010
  4. pmc Increased androgen receptor expression in serous carcinoma of the ovary is associated with an improved survival
    Björn Nodin
    Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, and Skåne Regional Laboratories, Malmo, Sweden
    J Ovarian Res 3:14. 2010
  5. pmc Tumor-specific HMG-CoA reductase expression in primary premenopausal breast cancer predicts response to tamoxifen
    Donal J Brennan
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Breast Cancer Res 13:R12. 2011
  6. pmc Prognostic impact of tumour-specific HMG-CoA reductase expression in primary breast cancer
    Signe Borgquist
    Center for Molecular Pathology, Department of Laboratory Medicine, Malmo University Hospital, Lund University, Malmo, Sweden
    Breast Cancer Res 10:R79. 2008
  7. pmc The tumour suppressor SOX11 is associated with improved survival among high grade epithelial ovarian cancers and is regulated by reversible promoter methylation
    Sandra Sernbo
    Department of Immunotechnology, Lund University, Lund, Sweden
    BMC Cancer 11:405. 2011
  8. pmc Up-regulation of cell cycle arrest protein BTG2 correlates with increased overall survival in breast cancer, as detected by immunohistochemistry using tissue microarray
    Elin Möllerström
    Department of Oncology, Institute of Clinical Sciences, Blå stråket 2, University of Gothenburg, SE 413 45 Goteborg, Sweden
    BMC Cancer 10:296. 2010
  9. pmc Tumour-specific HMG-CoAR is an independent predictor of recurrence free survival in epithelial ovarian cancer
    Donal J Brennan
    Dept of Obstetrics and Gynaecology, National Maternity Hospital, Holles Street, Dublin 2, Ireland
    BMC Cancer 10:125. 2010
  10. doi Increased claudin-4 expression is associated with poor prognosis and high tumour grade in breast cancer
    Fiona Lanigan
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland
    Int J Cancer 124:2088-97. 2009

Collaborators

Detail Information

Publications30

  1. pmc Identification of a myometrial molecular profile for dystocic labor
    Donal J Brennan
    National Maternity Hospital, Dublin, Ireland
    BMC Pregnancy Childbirth 11:74. 2011
    ..The most common indication for cesarean section (CS) in nulliparous women is dystocia secondary to ineffective myometrial contractility. The aim of this study was to identify a molecular profile in myometrium associated with dystocic labor...
  2. pmc SOX11 expression correlates to promoter methylation and regulates tumor growth in hematopoietic malignancies
    Elin Gustavsson
    Department of Immunotechnology, Lund University, Lund, Sweden
    Mol Cancer 9:187. 2010
    ..SOX11 has been shown to prevent gliomagenesis in vivo but the causes and consequences of aberrant expression of SOX11 outside the CNS remain unexplained...
  3. pmc Expression of the RNA-binding protein RBM3 is associated with a favourable prognosis and cisplatin sensitivity in epithelial ovarian cancer
    Asa Ehlén
    Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Skane University Hospital, Malmo, Sweden
    J Transl Med 8:78. 2010
    ..The aim of this study was to examine the prognostic value of RBM3 mRNA and protein expression in epithelial ovarian cancer (EOC) and the cisplatin response upon RBM3 depletion in a cisplatin-sensitive ovarian cancer cell line...
  4. pmc Increased androgen receptor expression in serous carcinoma of the ovary is associated with an improved survival
    Björn Nodin
    Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, and Skåne Regional Laboratories, Malmo, Sweden
    J Ovarian Res 3:14. 2010
    ..Altered androgen hormone homeostasis and androgen receptor (AR) activity have been implicated in ovarian carcinogenesis but the relationship between AR expression in ovarian cancer and clinical outcome remains unclear...
  5. pmc Tumor-specific HMG-CoA reductase expression in primary premenopausal breast cancer predicts response to tamoxifen
    Donal J Brennan
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Breast Cancer Res 13:R12. 2011
    ..Here, the predictive value of HMG-CoAR expression in relation to tamoxifen response was examined...
  6. pmc Prognostic impact of tumour-specific HMG-CoA reductase expression in primary breast cancer
    Signe Borgquist
    Center for Molecular Pathology, Department of Laboratory Medicine, Malmo University Hospital, Lund University, Malmo, Sweden
    Breast Cancer Res 10:R79. 2008
    ..In the present study, we examined the prognostic value of HMG-CoAR expression in a large cohort of primary breast cancer patients with long-term follow up...
  7. pmc The tumour suppressor SOX11 is associated with improved survival among high grade epithelial ovarian cancers and is regulated by reversible promoter methylation
    Sandra Sernbo
    Department of Immunotechnology, Lund University, Lund, Sweden
    BMC Cancer 11:405. 2011
    ....
  8. pmc Up-regulation of cell cycle arrest protein BTG2 correlates with increased overall survival in breast cancer, as detected by immunohistochemistry using tissue microarray
    Elin Möllerström
    Department of Oncology, Institute of Clinical Sciences, Blå stråket 2, University of Gothenburg, SE 413 45 Goteborg, Sweden
    BMC Cancer 10:296. 2010
    ..The aim of this study was to characterize the expression of the corresponding proteins in breast carcinoma and to determine their correlation with clinical outcome...
  9. pmc Tumour-specific HMG-CoAR is an independent predictor of recurrence free survival in epithelial ovarian cancer
    Donal J Brennan
    Dept of Obstetrics and Gynaecology, National Maternity Hospital, Holles Street, Dublin 2, Ireland
    BMC Cancer 10:125. 2010
    ..In the present study, the prognostic value of HMG-CoAR expression was examined in tumours from a cohort of patients with primary epithelial ovarian cancer...
  10. doi Increased claudin-4 expression is associated with poor prognosis and high tumour grade in breast cancer
    Fiona Lanigan
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland
    Int J Cancer 124:2088-97. 2009
    ..We conclude that high levels of claudin-4 protein are associated with adverse outcome in breast cancer patients, including the subgroup of patients treated with adjuvant tamoxifen...
  11. pmc Validation of cytoplasmic-to-nuclear ratio of survivin as an indicator of improved prognosis in breast cancer
    Elton Rexhepaj
    UCD Conway Institute, University College Dublin, Belfield, Ireland
    BMC Cancer 10:639. 2010
    ..Here, we validate survivin CNR in a separate and extended cohort. Furthermore, we present new data suggesting that a low CNR may predict outcome in tamoxifen-treated patients...
  12. doi JAM-A expression positively correlates with poor prognosis in breast cancer patients
    Elaine A McSherry
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Ireland
    Int J Cancer 125:1343-51. 2009
    ..Our results are consistent with a previously unreported role for JAM-A overexpression as a possible mechanism contributing to progression in primary breast cancer; and a potential therapeutic target...
  13. doi miR-187 is an independent prognostic factor in breast cancer and confers increased invasive potential in vitro
    Laoighse Mulrane
    UCD Schools of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Ireland
    Clin Cancer Res 18:6702-13. 2012
    ..Here, we describe an integrated bioinformatics, functional analysis, and translational pathology approach to identify novel miRNAs involved in breast cancer progression...
  14. pmc Novel image analysis approach for quantifying expression of nuclear proteins assessed by immunohistochemistry: application to measurement of oestrogen and progesterone receptor levels in breast cancer
    Elton Rexhepaj
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Ireland
    Breast Cancer Res 10:R89. 2008
    ..In the present article we describe the development of a novel approach for automatically quantifying oestrogen receptor (ER) and progesterone receptor (PR) protein expression assessed by IHC in primary breast cancer...
  15. doi Altered cytoplasmic-to-nuclear ratio of survivin is a prognostic indicator in breast cancer
    Donal J Brennan
    UCD School of Biomolecular and Biomedical Science and UCD School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    Clin Cancer Res 14:2681-9. 2008
    ..Quantitative determination of survivin expression using image analysis offers the opportunity to develop alternative scoring models for survivin immunohistochemistry. Here, we present such a model...
  16. ncbi CENP-F expression is associated with poor prognosis and chromosomal instability in patients with primary breast cancer
    Sallyann L O'Brien
    UCD School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    Int J Cancer 120:1434-43. 2007
    ..036) and overall survival (p=0.040). In conclusion, we identified CENP-F as a biomarker associated with poor outcome in breast cancer and showed several novel associations of biological significance...
  17. ncbi CA IX is an independent prognostic marker in premenopausal breast cancer patients with one to three positive lymph nodes and a putative marker of radiation resistance
    Donal J Brennan
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College, Dublin, and Department of Pathology and Laboratory Medicine, St Vincent s University Hospital, Ireland
    Clin Cancer Res 12:6421-31. 2006
    ..We examined the potential prognostic and predictive role of CA IX in premenopausal breast cancer patients...
  18. pmc Homeobox transcription factor muscle segment homeobox 2 (Msx2) correlates with good prognosis in breast cancer patients and induces apoptosis in vitro
    Fiona Lanigan
    University College Dublin School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Breast Cancer Res 12:R59. 2010
    ..However, the clinical implications of Msx2 expression in breast cancer are unclear. The aims of this study were to investigate the potential clinical value of Msx2 as a breast cancer biomarker and to clarify its functional role in vitro...
  19. ncbi Contribution of DNA and tissue microarray technology to the identification and validation of biomarkers and personalised medicine in breast cancer
    Donal J Brennan
    UCD School of Biomolecular and Biomedical Science, University College Dublin, Belfield, and Department of Pathology and Laboratory Medicine, St Vincent s University Hospital, Dublin 4, Ireland
    Cancer Genomics Proteomics 4:121-34. 2007
    ..Here, we review the role of DNA microarrays and tissue microarrays in the validation of biomarkers in breast cancer, with emphasis on their potential application to determine mode of personalised therapy in the future...
  20. pmc Systematic antibody generation and validation via tissue microarray technology leading to identification of a novel protein prognostic panel in breast cancer
    Patrick C O Leary
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute of Biomolecular and Biomedical Science, University College Dublin, Dublin 4, Ireland
    BMC Cancer 13:175. 2013
    ....
  21. doi The transcription factor Sox11 is a prognostic factor for improved recurrence-free survival in epithelial ovarian cancer
    Donal J Brennan
    Department of Obstetrics and Gynaecology, National Maternity Hospital, Holles Street Dublin 2, Ireland
    Eur J Cancer 45:1510-7. 2009
    ..Current prognostic molecular markers for epithelial ovarian cancer (EOC) are insufficient. The aim of the current study was to investigate the role of Sox11 in EOC...
  22. doi Antibody-based proteomics: fast-tracking molecular diagnostics in oncology
    Donal J Brennan
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Nat Rev Cancer 10:605-17. 2010
    ..In this Review, we discuss the current status of antibody-based proteomics and its contribution to the development of new assays that are crucial for the realization of individualized cancer therapy...
  23. doi The singleton, cephalic, nulliparous woman after 36 weeks of gestation: contribution to overall cesarean delivery rates
    Donal J Brennan
    National Maternity Hospital, Dublin, Ireland
    Obstet Gynecol 117:273-9. 2011
    ..To examine the contribution of singleton, cephalic, term (37 weeks or later) nulliparous cesarean rates to overall cesarean incidence in a single institution during a 35-year period...
  24. ncbi Breast cancer proteomics: clinical perspectives
    Thomas Y K Lau
    UCD Conway Institute, UCD School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin 4, Ireland
    Expert Opin Biol Ther 7:209-19. 2007
    ..It aims to analyse the complex circuitry of the breast cancer proteome. Here, the authors review how breast cancer proteomics has progressed so far, with emphasis on its potential application to clinically relevant scenarios...
  25. ncbi Survivin: a promising tumor biomarker
    Michael J Duffy
    Department of Pathology and Laboratory Medicine, St Vincent s University Hospital, Dublin 4, Ireland
    Cancer Lett 249:49-60. 2007
    ..Furthermore, assays for the measurement of survivin should be simplified, standardized and evaluated in external quality assurance schemes...
  26. doi Comparative analysis of international cesarean delivery rates using 10-group classification identifies significant variation in spontaneous labor
    Donal J Brennan
    National Maternity Hospital, Dublin, Ireland
    Am J Obstet Gynecol 201:308.e1-8. 2009
    ..Cesarean section (CS) rates continue to rise throughout the developed world. The aim of this study was to highlight variations in obstetric populations and practices and to identify variations in CS rates in different institutions...
  27. doi Maternal and fetal cocaine- and amphetamine-regulated transcript in diabetic and non-diabetic pregnancy
    Mark P Hehir
    UCD Obstetrics and Gynaecology, School of Medicine and Medical Science, University College Dublin, National Maternity Hospital, Dublin, Ireland
    Gynecol Endocrinol 28:682-5. 2012
    ..332) (p = 0.001) irrespective of diabetes. Serum CART can be detected in both diabetic and non-diabetic human pregnancy and may play an important role in body mass regulation in pregnancy...
  28. doi Natural history, management, and outcomes of peripartum cardiomyopathy: an Irish single-center cohort study
    Stephen J Horgan
    Department of Cardiology, Mater Misericordiae University Hospital and University College Dublin, Dublin, Ireland
    J Matern Fetal Neonatal Med 26:161-5. 2013
    ..To describe the natural history, management and outcomes of peripartum cardiomyopathy (PPCM) in an unselected Northern European population...
  29. ncbi MAD2 downregulation in hypoxia is independent of promoter hypermethylation
    Maria Prencipe
    UCD School of Medicine and Medical Science SMMS, University College Dublin, Belfield, Dublin, Ireland
    Cell Cycle 9:2856-65. 2010
    ..Moreover, MAD2 downregulation could play a central role in the induction of chemoresistance in hypoxia, a key tumour microenvironment associated with chemoresistance...
  30. ncbi Application of DNA microarray technology in determining breast cancer prognosis and therapeutic response
    Donal J Brennan
    Conway Institute of Biomolecular and Biomedical Research, Department of Pharmacology, Centre for Molecular Medicine, University College Dublin, Dublin 4, Ireland
    Expert Opin Biol Ther 5:1069-83. 2005
    ..The most recent data supporting the integration of various publicly available data sets is also reviewed in detail...