Barry Boland

Summary

Affiliation: University College Dublin
Country: Ireland

Publications

  1. ncbi Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease
    Barry Boland
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, New York 10962, USA
    J Neurosci 28:6926-37. 2008
  2. ncbi Macroautophagy is not directly involved in the metabolism of amyloid precursor protein
    Barry Boland
    Laboratory for Neurodegenerative Research, School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Dublin 4, Ireland
    J Biol Chem 285:37415-26. 2010
  3. ncbi Neurofilament tail phosphorylation: identity of the RT-97 phosphoepitope and regulation in neurons by cross-talk among proline-directed kinases
    - Veeranna
    Center for Dementia Research, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York, USA
    J Neurochem 107:35-49. 2008
  4. ncbi gamma-secretase processing of APLP1 leads to the production of a p3-like peptide that does not aggregate and is not toxic to neurons
    Aedin M Minogue
    Laboratory for Neurodegenerative Research, The Conway Institute for Biomolecular and Biomedical Research, School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin 4, Republic of Ireland
    Brain Res 1262:89-99. 2009
  5. ncbi Calpain mediates calcium-induced activation of the erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease
    Takahide Kaji
    Center for Dementia Research, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York, USA
    Am J Pathol 165:795-805. 2004
  6. ncbi Abeta-mediated activation of the apoptotic cascade in cultured cortical neurones: a role for cathepsin-L
    Barry Boland
    Department of Physiology, Trinity College Neuroscience Institute, Trinity College, Dublin 2, Ireland
    Neurobiol Aging 25:83-91. 2004
  7. ncbi beta-Amyloid (1-40)-induced apoptosis of cultured cortical neurones involves calpain-mediated cleavage of poly-ADP-ribose polymerase
    Barry Boland
    Department of Physiology, Trinity College, Dublin 2, Ireland
    Neurobiol Aging 24:179-86. 2003
  8. ncbi Neuronal macroautophagy: from development to degeneration
    Barry Boland
    Department of Pharmacology, Oxford University, Oxford OX13QT, United Kingdom
    Mol Aspects Med 27:503-19. 2006

Collaborators

Detail Information

Publications8

  1. ncbi Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease
    Barry Boland
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, New York 10962, USA
    J Neurosci 28:6926-37. 2008
    ..Therapeutic modulation of autophagy in AD may, therefore, require targeting late steps in the autophagic pathway...
  2. ncbi Macroautophagy is not directly involved in the metabolism of amyloid precursor protein
    Barry Boland
    Laboratory for Neurodegenerative Research, School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Dublin 4, Ireland
    J Biol Chem 285:37415-26. 2010
    ..These data suggest that neuronal macroautophagy does not directly regulate APP metabolism but highlights the important anti-amyloidogenic role of lysosomal proteolysis in post-secretase APP-CTF catabolism...
  3. ncbi Neurofilament tail phosphorylation: identity of the RT-97 phosphoepitope and regulation in neurons by cross-talk among proline-directed kinases
    - Veeranna
    Center for Dementia Research, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York, USA
    J Neurochem 107:35-49. 2008
    ..The regulation of a single target by multiple protein kinases underscores the importance of monitoring other relevant kinases when the activity of a particular one is blocked...
  4. ncbi gamma-secretase processing of APLP1 leads to the production of a p3-like peptide that does not aggregate and is not toxic to neurons
    Aedin M Minogue
    Laboratory for Neurodegenerative Research, The Conway Institute for Biomolecular and Biomedical Research, School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin 4, Republic of Ireland
    Brain Res 1262:89-99. 2009
    ..Moreover, using two distinct experimental paradigms, we demonstrate that neither cell-derived nor chemically synthesized ALP-1 influences the oligomerization or aggregation of Abeta...
  5. ncbi Calpain mediates calcium-induced activation of the erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease
    Takahide Kaji
    Center for Dementia Research, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York, USA
    Am J Pathol 165:795-805. 2004
    ....
  6. ncbi Abeta-mediated activation of the apoptotic cascade in cultured cortical neurones: a role for cathepsin-L
    Barry Boland
    Department of Physiology, Trinity College Neuroscience Institute, Trinity College, Dublin 2, Ireland
    Neurobiol Aging 25:83-91. 2004
    ....
  7. ncbi beta-Amyloid (1-40)-induced apoptosis of cultured cortical neurones involves calpain-mediated cleavage of poly-ADP-ribose polymerase
    Barry Boland
    Department of Physiology, Trinity College, Dublin 2, Ireland
    Neurobiol Aging 24:179-86. 2003
    ..Thus, we propose that the stimulatory effect of beta-amyloid on Ca(2+) influx triggers calpain-mediated DNA fragmentation in cultured cortical neurones...
  8. ncbi Neuronal macroautophagy: from development to degeneration
    Barry Boland
    Department of Pharmacology, Oxford University, Oxford OX13QT, United Kingdom
    Mol Aspects Med 27:503-19. 2006
    ....