John A Baugh

Summary

Affiliation: University College Dublin
Country: Ireland

Publications

  1. pmc Modest elevation in BNP in asymptomatic hypertensive patients reflects sub-clinical cardiac remodeling, inflammation and extracellular matrix changes
    Dermot Phelan
    Heart Failure Unit, St Vincent s University Hospital, Elm Park, Dublin, Ireland
    PLoS ONE 7:e49259. 2012
  2. pmc Mechanical stretch up-regulates the B-type natriuretic peptide system in human cardiac fibroblasts: a possible defense against transforming growth factor-β mediated fibrosis
    Chris J Watson
    School of Medicine and Medical Science, The Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland
    Fibrogenesis Tissue Repair 5:9. 2012
  3. ncbi request reprint Macrophage migration inhibitory factor: a neuroendocrine modulator of chronic inflammation
    J A Baugh
    Department of Medicine and Therapeutics, The Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    J Endocrinol 179:15-23. 2003
  4. ncbi request reprint Dual regulation of macrophage migration inhibitory factor (MIF) expression in hypoxia by CREB and HIF-1
    John A Baugh
    School of Medicine and Medical Science, The Conway Institute for Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Biochem Biophys Res Commun 347:895-903. 2006
  5. pmc Hypoxia-induced DNA hypermethylation in human pulmonary fibroblasts is associated with Thy-1 promoter methylation and the development of a pro-fibrotic phenotype
    Claire M Robinson
    UCD School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Dublin 4, Ireland
    Respir Res 13:74. 2012
  6. doi request reprint Proteomic analysis of coronary sinus serum reveals leucine-rich α2-glycoprotein as a novel biomarker of ventricular dysfunction and heart failure
    Chris J Watson
    School of Medicine and Medical Science, St Vincent s University Hospital and the Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland
    Circ Heart Fail 4:188-97. 2011
  7. doi request reprint Can emerging biomarkers of myocardial remodelling identify asymptomatic hypertensive patients at risk for diastolic dysfunction and diastolic heart failure?
    Patrick Collier
    UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Eur J Heart Fail 13:1087-95. 2011
  8. doi request reprint Progression of left atrial volume index in a population at risk for heart failure: a substudy of the STOP-HF (St Vincent's Screening TO Prevent Heart Failure) trial
    Patrick Collier
    UCD Conway Institute of Biomolecular and Biomedical Research, Belfield, University College Dublin 4, Ireland
    Eur J Heart Fail 14:957-64. 2012
  9. ncbi request reprint Small interfering RNAs induce macrophage migration inhibitory factor production and proliferation in breast cancer cells via a double-stranded RNA-dependent protein kinase-dependent mechanism
    Michelle E Armstrong
    School of Medicine and Medical Science, College of Life Sciences, University College Dublin Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland
    J Immunol 180:7125-33. 2008
  10. ncbi request reprint Extracellular matrix sub-types and mechanical stretch impact human cardiac fibroblast responses to transforming growth factor beta
    Chris J Watson
    School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Ireland and
    Connect Tissue Res 55:248-56. 2014

Collaborators

Detail Information

Publications21

  1. pmc Modest elevation in BNP in asymptomatic hypertensive patients reflects sub-clinical cardiac remodeling, inflammation and extracellular matrix changes
    Dermot Phelan
    Heart Failure Unit, St Vincent s University Hospital, Elm Park, Dublin, Ireland
    PLoS ONE 7:e49259. 2012
    ....
  2. pmc Mechanical stretch up-regulates the B-type natriuretic peptide system in human cardiac fibroblasts: a possible defense against transforming growth factor-β mediated fibrosis
    Chris J Watson
    School of Medicine and Medical Science, The Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland
    Fibrogenesis Tissue Repair 5:9. 2012
    ..abstract:..
  3. ncbi request reprint Macrophage migration inhibitory factor: a neuroendocrine modulator of chronic inflammation
    J A Baugh
    Department of Medicine and Therapeutics, The Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    J Endocrinol 179:15-23. 2003
    ....
  4. ncbi request reprint Dual regulation of macrophage migration inhibitory factor (MIF) expression in hypoxia by CREB and HIF-1
    John A Baugh
    School of Medicine and Medical Science, The Conway Institute for Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Biochem Biophys Res Commun 347:895-903. 2006
    ..Given the importance of MIF in inflammatory and malignant diseases these data reveal a HIF-1-mediated pathway as a potential therapeutic target for suppression of MIF expression in hypoxic tissues...
  5. pmc Hypoxia-induced DNA hypermethylation in human pulmonary fibroblasts is associated with Thy-1 promoter methylation and the development of a pro-fibrotic phenotype
    Claire M Robinson
    UCD School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Dublin 4, Ireland
    Respir Res 13:74. 2012
    ..As it has been reported that hypoxia suppresses Thy-1 expression during lung development we also studied the effect of hypoxia on Thy-1 promoter methylation and gene expression...
  6. doi request reprint Proteomic analysis of coronary sinus serum reveals leucine-rich α2-glycoprotein as a novel biomarker of ventricular dysfunction and heart failure
    Chris J Watson
    School of Medicine and Medical Science, St Vincent s University Hospital and the Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland
    Circ Heart Fail 4:188-97. 2011
    ..Our aim was to discover differentially expressed disease-associated proteins that identify patients with ventricular dysfunction and HF...
  7. doi request reprint Can emerging biomarkers of myocardial remodelling identify asymptomatic hypertensive patients at risk for diastolic dysfunction and diastolic heart failure?
    Patrick Collier
    UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Eur J Heart Fail 13:1087-95. 2011
    ....
  8. doi request reprint Progression of left atrial volume index in a population at risk for heart failure: a substudy of the STOP-HF (St Vincent's Screening TO Prevent Heart Failure) trial
    Patrick Collier
    UCD Conway Institute of Biomolecular and Biomedical Research, Belfield, University College Dublin 4, Ireland
    Eur J Heart Fail 14:957-64. 2012
    ..The aim of this study was to investigate clinical characteristics and serological biomarkers in a cohort with risk factors for HF and evidence of serial atrial dilatation...
  9. ncbi request reprint Small interfering RNAs induce macrophage migration inhibitory factor production and proliferation in breast cancer cells via a double-stranded RNA-dependent protein kinase-dependent mechanism
    Michelle E Armstrong
    School of Medicine and Medical Science, College of Life Sciences, University College Dublin Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland
    J Immunol 180:7125-33. 2008
    ..In conclusion, this study highlights the potential biological consequences of off-target, nonspecific effects of siRNAs and underlines the safety concerns regarding the use of siRNAs in the treatment of human diseases, such as cancer...
  10. ncbi request reprint Extracellular matrix sub-types and mechanical stretch impact human cardiac fibroblast responses to transforming growth factor beta
    Chris J Watson
    School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Ireland and
    Connect Tissue Res 55:248-56. 2014
    ..These findings may give insight into the impact of selective pathological deposition of extracellular matrix proteins within different disease states and how these could impact the fibrotic environment...
  11. doi request reprint Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype
    Chris J Watson
    School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Hum Mol Genet 23:2176-88. 2014
    ..Targeting up-regulated expression of DNMTs in ischemic heart disease may prove to be a valuable therapeutic approach. ..
  12. doi request reprint Macrophage migration inhibitory factor enzymatic activity, lung inflammation, and cystic fibrosis
    Huzaifa Adamali
    School of Medicine and Medical Science, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland
    Am J Respir Crit Care Med 186:162-9. 2012
    ..We previously demonstrated that individual patients with cystic fibrosis (CF) who are genetically predisposed to be high MIF producers develop accelerated end-organ injury...
  13. ncbi request reprint Role of proteomics in the investigation of pulmonary fibrosis
    Praveen Govender
    University College Dublin, School of Medicine and Medical Science, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    Expert Rev Proteomics 4:379-88. 2007
    ....
  14. pmc Epigenetics within the matrix: a neo-regulator of fibrotic disease
    Claire M Robinson
    The Conway Institute, School of Medicine and Medical Science, University College Dublin, Dublin, Ireland
    Epigenetics 7:987-93. 2012
    ..Specifically, the roles of DNA methylation and histone modifications in fibrotic disease will be discussed...
  15. doi request reprint Natural history of markers of collagen turnover in patients with early diastolic dysfunction and impact of eplerenone
    George J Mak
    St Vincent s University Hospital, Dublin, Ireland
    J Am Coll Cardiol 54:1674-82. 2009
    ..This study was designed to evaluate the impact of eplerenone on collagen turnover in preserved systolic function heart failure (HFPSF)...
  16. ncbi request reprint Cystic fibrosis, disease severity, and a macrophage migration inhibitory factor polymorphism
    Barry J Plant
    F R C P I, Department of Medicine and Therapeutics, The Education Research Centre, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    Am J Respir Crit Care Med 172:1412-5. 2005
    ..Studies have shown that MIF knockout mice have less aggressive Pseudomonas infection (compared with wild-type)...
  17. ncbi request reprint Nuclear transcription of long hairpin RNA triggers innate immune responses
    Michael P Gantier
    School of Medicine and Medical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, and St Vincent s University Hospital, Dublin, Ireland
    J Interferon Cytokine Res 27:789-97. 2007
    ..With growing concerns about the complexity of cytoplasmic detection of dsRNAs by the innate immune machinery, this work highlights the need for closer scrutiny when using lhRNAs as potential antiviral agents...
  18. ncbi request reprint Sarcoidosis and MIF gene polymorphism: a case-control study in an Irish population
    B J Plant
    The Conway Institute of Biomolecular and Biomedical Research, School of Medicine and Medical Science, University College of Dublin, Dublin, Ireland
    Eur Respir J 29:325-9. 2007
    ....
  19. ncbi request reprint Macrophage migration inhibitory factor is associated with aneurysmal expansion
    Jie Hong Pan
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California San Francisco, 90 Medical Center Way, San Francisco, CA 94143, USA
    J Vasc Surg 37:628-35. 2003
    ..The correlation and contribution of MIF to these human diseases remain unknown, although a recent rabbit study showed expression of this cytokine in atherosclerotic lesions...
  20. ncbi request reprint A role for macrophage migration inhibitory factor in the neonatal respiratory distress syndrome
    Katharine A Kevill
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 180:601-8. 2008
    ..03). This study demonstrates for the first time a role for MIF in lung maturation, and supports a protective role for MIF in newborn lung disease...
  21. ncbi request reprint Macrophage migration inhibitory factor
    John A Baugh
    Picower Institute for Medical Research, Manhasset, NY 11030, USA
    Crit Care Med 30:S27-35. 2002
    ..This review discusses the pathogenic role of MIF in inflammatory disease and highlights the novel structural, functional, and mechanistic properties of MIF...