Gerald H Tomkin

Summary

Affiliation: Trinity College
Country: Ireland

Publications

  1. ncbi The intestine as a regulator of cholesterol homeostasis in diabetes
    Gerald H Tomkin
    Diabetes Institute of Ireland, Beacon Clinic Dublin, and Blackrock Clinic Dublin, Department of Medicine, Trinity College, Dublin, Ireland
    Atheroscler Suppl 9:27-32. 2008
  2. ncbi Atherosclerosis, diabetes and lipoproteins
    Gerald H Tomkin
    Diabetes Institute of Ireland, Beacon Clinic, Dublin 18, Ireland
    Expert Rev Cardiovasc Ther 8:1015-29. 2010
  3. ncbi Targets for intervention in dyslipidemia in diabetes
    Gerald H Tomkin
    Department of Diabetes and Endocrinology, Trinity College Dublin, Dublin, Ireland
    Diabetes Care 31:S241-8. 2008
  4. ncbi Dyslipidaemia--hepatic and intestinal cross-talk
    Gerald H Tomkin
    Trinity College Dublin and Diabetes Institute of Ireland, Beacon Hospital, Sandyford, Clontra, Quinns Road, Shankill Co, Dublin, Ireland
    Atheroscler Suppl 11:5-9. 2010
  5. ncbi The effect of antidiabetic drugs on genes regulating lipid metabolism
    Gerald H Tomkin
    Diabetes Institute of Ireland, Beacon Hospital, Dublin, Ireland
    Curr Opin Lipidol 20:10-6. 2009
  6. ncbi Ezetimibe - new anti-atherogenic properties?
    Gerald H Tomkin
    Diabetes Institute of Ireland, Beacon Clinic, Dublin, Ireland
    Br J Pharmacol 156:1216-7. 2009
  7. ncbi Intestinal microsomal triglyceride transfer protein in type 2 diabetic and non-diabetic subjects: the relationship to triglyceride-rich postprandial lipoprotein composition
    Catherine Phillips
    Department of Diabetes and Endocrinology, Trinity College Dublin and The Adelaide and Meath Hospital, Diabetes Research Foundation, Clontra, Shankill, Dublin, Ireland
    Atherosclerosis 187:57-64. 2006
  8. ncbi Defective chylomicron synthesis as a cause of delayed particle clearance in diabetes?
    Catherine Phillips
    Department of Clinical Medicine, Trinity College, Dublin, Ireland
    Int J Exp Diabetes Res 3:171-8. 2002
  9. ncbi Genes that affect cholesterol synthesis, cholesterol absorption, and chylomicron assembly: the relationship between the liver and intestine in control and streptozotosin diabetic rats
    Sean Lally
    Department of Diabetes and Endocrinology, Trinity College, Dublin 18, Ireland
    Metabolism 56:430-8. 2007
  10. ncbi Intestinal rather than hepatic microsomal triglyceride transfer protein as a cause of postprandial dyslipidemia in diabetes
    Catherine Phillips
    Department of Clinical Medicine, Trinity College, Dublin, Ireland
    Metabolism 51:847-52. 2002

Collaborators

Detail Information

Publications13

  1. ncbi The intestine as a regulator of cholesterol homeostasis in diabetes
    Gerald H Tomkin
    Diabetes Institute of Ireland, Beacon Clinic Dublin, and Blackrock Clinic Dublin, Department of Medicine, Trinity College, Dublin, Ireland
    Atheroscler Suppl 9:27-32. 2008
    ..In conclusion, diabetes is associated with considerable dysfunction of the intestine leading to abnormal chylomicron composition which may play a major part in the premature development of atherosclerosis...
  2. ncbi Atherosclerosis, diabetes and lipoproteins
    Gerald H Tomkin
    Diabetes Institute of Ireland, Beacon Clinic, Dublin 18, Ireland
    Expert Rev Cardiovasc Ther 8:1015-29. 2010
    ..Postprandial studies are difficult to carry out, which is one reason why large studies have not so far been performed. The important new findings in chylomicron metabolism suggest new treatments for the future...
  3. ncbi Targets for intervention in dyslipidemia in diabetes
    Gerald H Tomkin
    Department of Diabetes and Endocrinology, Trinity College Dublin, Dublin, Ireland
    Diabetes Care 31:S241-8. 2008
    ..More successful treatment of diabetic dyslipidemia is essential if we are to reduce the burden of cardiovascular disease so commonly found in diabetes...
  4. ncbi Dyslipidaemia--hepatic and intestinal cross-talk
    Gerald H Tomkin
    Trinity College Dublin and Diabetes Institute of Ireland, Beacon Hospital, Sandyford, Clontra, Quinns Road, Shankill Co, Dublin, Ireland
    Atheroscler Suppl 11:5-9. 2010
    ....
  5. ncbi The effect of antidiabetic drugs on genes regulating lipid metabolism
    Gerald H Tomkin
    Diabetes Institute of Ireland, Beacon Hospital, Dublin, Ireland
    Curr Opin Lipidol 20:10-6. 2009
    ..The purpose of this review is to explore the recent literature...
  6. ncbi Ezetimibe - new anti-atherogenic properties?
    Gerald H Tomkin
    Diabetes Institute of Ireland, Beacon Clinic, Dublin, Ireland
    Br J Pharmacol 156:1216-7. 2009
    ..Whether these results in a rabbit model of atherosclerosis can be translated into human atherosclerosis awaits further studies...
  7. ncbi Intestinal microsomal triglyceride transfer protein in type 2 diabetic and non-diabetic subjects: the relationship to triglyceride-rich postprandial lipoprotein composition
    Catherine Phillips
    Department of Diabetes and Endocrinology, Trinity College Dublin and The Adelaide and Meath Hospital, Diabetes Research Foundation, Clontra, Shankill, Dublin, Ireland
    Atherosclerosis 187:57-64. 2006
    ..Since the MTP promoter region has a sterol response element the effect of statins on intestinal MTP mRNA was analysed...
  8. ncbi Defective chylomicron synthesis as a cause of delayed particle clearance in diabetes?
    Catherine Phillips
    Department of Clinical Medicine, Trinity College, Dublin, Ireland
    Int J Exp Diabetes Res 3:171-8. 2002
    ..Thus, diabetes resulted in the production of an increased number of lipid- and apo E-deficient chylomicron particles. These alterations account, in part, for the delay in clearance of these particles...
  9. ncbi Genes that affect cholesterol synthesis, cholesterol absorption, and chylomicron assembly: the relationship between the liver and intestine in control and streptozotosin diabetic rats
    Sean Lally
    Department of Diabetes and Endocrinology, Trinity College, Dublin 18, Ireland
    Metabolism 56:430-8. 2007
    ..01). In conclusion, fasting intestinal gene expression reflects the fed state. In diabetes, intestinal and hepatic gene expression correlates with abnormalities in chylomicron and VLDL cholesterol...
  10. ncbi Intestinal rather than hepatic microsomal triglyceride transfer protein as a cause of postprandial dyslipidemia in diabetes
    Catherine Phillips
    Department of Clinical Medicine, Trinity College, Dublin, Ireland
    Metabolism 51:847-52. 2002
    ..005). There was no difference in MTP activity or mRNA expression in the liver. This study suggests that MTP may play an important role in the postprandial dyslipidemia of diabetes...
  11. ncbi Low density lipoprotein non-esterified fatty acids and lipoprotein lipase in diabetes
    Catherine Phillips
    Department of Diabetes and Endocrinology, Trinity College Dublin, Ireland
    Atherosclerosis 181:109-14. 2005
    ....
  12. ncbi Albiglutide, an albumin-based fusion of glucagon-like peptide 1 for the potential treatment of type 2 diabetes
    Gerald H Tomkin
    Beacon Hospital, Diabetes Institute of Ireland, Dublin 18, Ireland
    Curr Opin Mol Ther 11:579-88. 2009
    ..Albiglutide represents a promising new drug for the treatment of patients with T2DM; the results of long-term trials are awaited with interest...
  13. ncbi The chylomicron: relationship to atherosclerosis
    Gerald H Tomkin
    Diabetes Institute of Ireland, Beacon Clinic, Sandyford, Dublin 18, Ireland
    Int J Vasc Med 2012:784536. 2012
    ..This paper will discuss cholesterol absorption and synthesis, chylomicron formation, and the effect of postprandial lipoproteins on factors involved in atherosclerosis...