K Tipton

Summary

Affiliation: Trinity College
Country: Ireland

Publications

  1. pmc GlycoForm and Glycologue: two software applications for the rapid construction and display of N-glycans from mammalian sources
    Andrew G McDonald
    School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    BMC Res Notes 3:173. 2010
  2. pmc ExplorEnz: a MySQL database of the IUBMB enzyme nomenclature
    Andrew G McDonald
    School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    BMC Biochem 8:14. 2007
  3. ncbi request reprint [Monoamine oxidase inhibitors and pressor response to dietary amines]
    K F Tipton
    Department of Biochemistry, Trinity College Dublin, Ireland
    Vopr Med Khim 43:494-503. 1997
  4. ncbi request reprint History of the enzyme nomenclature system
    K Tipton
    Department of Biochemistry, Trinity College, Dublin, Ireland
    Bioinformatics 16:34-40. 2000
  5. ncbi request reprint Monoamine oxidases: certainties and uncertainties
    Keith F Tipton
    Department of Biochemistry, Trinity College, Dublin 2, Ireland
    Curr Med Chem 11:1965-82. 2004
  6. ncbi request reprint It can be a complicated life being an enzyme
    K F Tipton
    Department of Biochemistry, Trinity College, Dublin 2, Ireland
    Biochem Soc Trans 31:711-5. 2003
  7. ncbi request reprint Modelling the roles of MAO and SSAO in glucose transport
    A McDonald
    Department of Biochemistry, School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    J Neural Transm 114:783-6. 2007
  8. doi request reprint Inhibition of bovine plasma semicarbazide-sensitive amine oxidase by caffeine
    A Olivieri
    School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    J Biochem Mol Toxicol 25:26-7. 2011
  9. ncbi request reprint Ceruloplasmin and what it might do
    J Healy
    Department of Biochemistry, School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    J Neural Transm 114:777-81. 2007
  10. ncbi request reprint Hydrogen peroxide derived from amine oxidation mediates the interaction between aminosugars and semicarbazide-sensitive amine oxidase
    J O'Sullivan
    School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    J Neural Transm 114:751-6. 2007

Collaborators

  • R K Porter
  • G P Davey
  • J Healy
  • C H Williams
  • Julie A Kelly
  • M B Youdim
  • Maria Grazia Giovannini
  • James P Hayes
  • Dietmar Schomburg
  • Andrew G McDonald
  • J F Gilmer
  • K Degtyarenko
  • R Apweiler
  • Masaaki Kotera
  • A Olivieri
  • Chiara Ballini
  • J O'Sullivan
  • Blanaid Mee
  • M O'SULLIVAN
  • Mercedes Unzeta
  • Michael O'Sullivan
  • Laura Della Corte
  • Wolfhardt Freinbichler
  • Denise Cornally
  • Zakia Ben Ramadan
  • Margherita Strolin Benedetti
  • Dermot Kelleher
  • Gary T M Henehan
  • Henry J Windle
  • Astrid Fleischmann
  • Jeff O'Sullivan
  • Jane A Irwin
  • Jeffrey O'Sullivan
  • O J P Joyce
  • M B O'Byrne
  • D H Fitzgerald
  • Martha Motherway
  • Maria Alessandra Colivicchi
  • Wolfgang Linert
  • Giancarlo Pepeu
  • Manuela Fattori
  • Marta Pazzagli
  • Maria A Colivicchi
  • Ciarán MacDonaill
  • Rhys Whomsley
  • Maria L Wrang
  • Renee Malone
  • Jesus Frias
  • Michael Darsow
  • Sinead Boyce
  • Michael I O'Sullivan
  • Kristian B Axelsen
  • Wolfgang Fleischmann
  • Amos Bairoch
  • M K Farmer
  • Maria Del Mar Hernandez
  • Jose Miguel Lizcano
  • Mary B MacDougall
  • Alun D McCarthy
  • W E McDevitt
  • Ivan Couée
  • Jane Irwin

Detail Information

Publications34

  1. pmc GlycoForm and Glycologue: two software applications for the rapid construction and display of N-glycans from mammalian sources
    Andrew G McDonald
    School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    BMC Res Notes 3:173. 2010
    ..Several tools exist for building such structures graphically, by selecting from a palette of symbols or sugar names, or else by specifying a structure in one of the chemical naming schemes currently available...
  2. pmc ExplorEnz: a MySQL database of the IUBMB enzyme nomenclature
    Andrew G McDonald
    School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    BMC Biochem 8:14. 2007
    ..The enzyme nomenclature is incorporated into many other resources, including the ExPASy-ENZYME, BRENDA and KEGG bioinformatics databases...
  3. ncbi request reprint [Monoamine oxidase inhibitors and pressor response to dietary amines]
    K F Tipton
    Department of Biochemistry, Trinity College Dublin, Ireland
    Vopr Med Khim 43:494-503. 1997
    ..Noncompetitive inhibitors might be expected to offer no safety advantage in this respect, whereas uncompetitive could actually exacerbate the pressor response...
  4. ncbi request reprint History of the enzyme nomenclature system
    K Tipton
    Department of Biochemistry, Trinity College, Dublin, Ireland
    Bioinformatics 16:34-40. 2000
    ..This account will consider the development of the enzyme nomenclature system, its benefits, shortcomings and future prospects...
  5. ncbi request reprint Monoamine oxidases: certainties and uncertainties
    Keith F Tipton
    Department of Biochemistry, Trinity College, Dublin 2, Ireland
    Curr Med Chem 11:1965-82. 2004
    ..This review concentrates on the dynamic aspects of our knowledge of the interactions of MAO with substrates and inhibitors and how it may collaborate with other enzymes, with particular emphasis on aspects that remain to be clarified...
  6. ncbi request reprint It can be a complicated life being an enzyme
    K F Tipton
    Department of Biochemistry, Trinity College, Dublin 2, Ireland
    Biochem Soc Trans 31:711-5. 2003
    ..Finally, the challenges posed by such multiplicity of functions for the interpretation of genetic deletion, in vivo inhibition and the development of functional protein databases are briefly considered...
  7. ncbi request reprint Modelling the roles of MAO and SSAO in glucose transport
    A McDonald
    Department of Biochemistry, School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    J Neural Transm 114:783-6. 2007
    ..This approach not only helps to establish the feasibility of this process but also allows behaviour prediction and the identification of further experimental approaches...
  8. doi request reprint Inhibition of bovine plasma semicarbazide-sensitive amine oxidase by caffeine
    A Olivieri
    School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    J Biochem Mol Toxicol 25:26-7. 2011
    ..Since caffeine contains an imidazole ring, it cannot be excluded that it might bind to an inhibitory imidazoline-binding site on SSAO...
  9. ncbi request reprint Ceruloplasmin and what it might do
    J Healy
    Department of Biochemistry, School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    J Neural Transm 114:777-81. 2007
    ..This account will consider the relative importance of these multiple functions in terms of the physiological roles of ceruloplasmin...
  10. ncbi request reprint Hydrogen peroxide derived from amine oxidation mediates the interaction between aminosugars and semicarbazide-sensitive amine oxidase
    J O'Sullivan
    School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    J Neural Transm 114:751-6. 2007
    ..These results suggest that the H(2)O(2) formed as a product of the SSAO-catalysed oxidation reaction is more efective in promoting the binding of amino sugars...
  11. ncbi request reprint Kinetic investigation of the specificity of porcine brain thyrotropin-releasing hormone-degrading ectoenzyme for thyrotropin-releasing hormone-like peptides
    J A Kelly
    Department of Biochemistry, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 275:16746-51. 2000
    ..5 micrometer) and Glp-Asn-Pro-7-amido-4-methyl coumarin (K(i) = 0.97 micrometer)...
  12. ncbi request reprint Inhibition of monoamine oxidase modulates the behaviour of semicarbazide-sensitive amine oxidase (SSAO)
    D H Fitzgerald
    School of Dentistry, Trinity College, Dublin, Ireland
    J Neural Transm 109:251-65. 2002
    ..These findings suggest a link between SSAO and cellular stress and may have importance in the context of the recent finding that tissue-SSAO is identical to a vascular adhesion protein (VAP1), involved in the process of inflammation...
  13. ncbi request reprint L-lysine as a recognition molecule for the VAP-1 function of SSAO
    A Olivieri
    School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    J Neural Transm 114:747-9. 2007
    ..The possible implications of this in terms of the therapeutic uses of lysine are discussed...
  14. ncbi request reprint Immunolocalization of semicarbazide-sensitive amine oxidase in human dental pulp and its activity towards serotonin
    M O'SULLIVAN
    Department of Restorative Dentistry and Periodontology, School of Dental Science, Trinity College, Dublin 2, Ireland
    Arch Oral Biol 47:399-406. 2002
    ..The presence of SSAO in nerves in dental pulp appears to be unique. Tryptophan hydroxylase, a key enzyme in 5-HT synthesis, was also demonstrated in nerves and the odontoblast layer of human dental pulp...
  15. ncbi request reprint Oxidative phosphorylation by in situ synaptosomal mitochondria from whole brain of young and old rats
    O J P Joyce
    Department of Biochemistry, Trinity College Dublin, Dublin, Ireland
    J Neurochem 86:1032-41. 2003
    ..These in situ results may have important implications for the interpretation of theories that age-dependent impairment of mitochondrial energy production may result in increased susceptibility to neurodegeneration...
  16. ncbi request reprint Indirect measurement of mitochondrial proton leak and its application
    R K Porter
    Department of Biochemistry, Trinity College Dublin, Ireland
    Int J Obes Relat Metab Disord 23:S12-8. 1999
    ..It is proposed that the experimental system described here for measuring proton leak, is an ideal functional assay for determining whether the novel uncoupling proteins increase inner membrane permeability to protons...
  17. ncbi request reprint Complexities in the neurotoxic actions of 6-hydroxydopamine in relation to the cytoprotective properties of taurine
    J Hayes
    Department of Biochemistry, Trinity College, Dublin, Ireland
    Brain Res Bull 55:239-45. 2001
    ..Taurine, which is known to be neuroprotective in some other systems, only affords protection against some of these effects, thereby explaining its reported ineffectiveness against 6-hydroxydopamine toxicity...
  18. ncbi request reprint Inhibition of the neuronal isoform of nitric oxide synthase significantly attenuates 1-methyl-4-phenylpyridinium (MPP(+)) toxicity in vitro
    M B O'Byrne
    Department of Biochemistry, Trinity College, Dublin, Ireland
    J Neural Transm 109:585-96. 2002
    ..MK-801 afforded no significant protection of aminergic cells, although changes in LDH activity suggested that there may have been some protection of non-aminergic neurons affected by this, relatively high concentration of MPP(+)...
  19. pmc Structure-activity studies with high-affinity inhibitors of pyroglutamyl-peptidase II
    Julie A Kelly
    Department of Biochemistry, Trinity College Dublin, Dublin 2, Ireland
    Biochem J 389:569-76. 2005
    ..PPII inhibitors with this level of potency should find application in exploring the biological functions of TRH and PPII, and potentially provide a basis for development of novel therapeutics...
  20. ncbi request reprint The inhibition of semicarbazide-sensitive amine oxidase by aminohexoses
    Jeffrey O'Sullivan
    Department of Biochemistry, Trinity College, Dublin 2, Ireland
    Biochim Biophys Acta 1647:367-71. 2003
    ..These results suggest that the interactions between SSAO and aminohexoses are specific and, therefore, that the cell-adhesion functions and amine-recognition functions of VAP-1/SSAO may be interlinked...
  21. pmc IntEnz, the integrated relational enzyme database
    Astrid Fleischmann
    EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
    Nucleic Acids Res 32:D434-7. 2004
    ..IntEnz is supported by NC-IUBMB and contains enzyme data curated and approved by this committee. The database IntEnz is available at http://www.ebi.ac.uk/intenz...
  22. pmc Functional group and substructure searching as a tool in metabolomics
    Masaaki Kotera
    School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    PLoS ONE 3:e1537. 2008
    ....
  23. ncbi request reprint Species differences in the selective inhibition of monoamine oxidase (1-methyl-2-phenylethyl)hydrazine and its potentiation by cyanide
    Zakia Ben Ramadan
    Department of Biochemistry, Trinity College, Dublin, 2, Ireland
    Neurochem Res 32:1783-90. 2007
    ..The kinetic behaviour of cyanide activation was consistent with partial (non-essential) competitive activation in all cases...
  24. ncbi request reprint Interactions of the neurotoxin 6-hydroxydopamine with glyceraldehyde-3-phosphate dehydrogenase
    James P Hayes
    Department of Biochemistry, Trinity College, Dublin 2, Ireland
    Toxicol Lett 128:197-206. 2002
    ..Since GAPDH is an essential enzyme in glycolysis and also plays a role in apoptotic cell death, these results suggest that the effects on this enzyme may contribute to the neurotoxicity of 6-OHDA...
  25. ncbi request reprint The therapeutic potential of monoamine oxidase inhibitors
    Moussa B H Youdim
    Technion Rappaport Family Faculty of Medicine, Eve Topf and US National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases
    Nat Rev Neurosci 7:295-309. 2006
    ..We evaluate these arguments in the light of what we know, and still have to learn, of the structure, function and genetics of the monoamine oxidases and the disparate actions of their inhibitors...
  26. ncbi request reprint Semicarbazide-sensitive amine oxidases in pig dental pulp
    Michael O'Sullivan
    Department of Restorative Dentistry and Periodontology, Dublin Dental School and Hospital, Lincoln Place, Dublin 2, Ireland
    Biochim Biophys Acta 1647:333-6. 2003
    ..These two forms also differ in their thermostabilities at 60 and 70 degrees C, although this thermal inactivation is partly reversible...
  27. doi request reprint Aldo-keto reductase from Helicobacter pylori--role in adaptation to growth at acid pH
    Denise Cornally
    School of Food Science and Environmental Health, Dublin Institute of Technology, Ireland
    FEBS J 275:3041-50. 2008
    ..pylori demonstrated that HpAKR is required for growth under acidic conditions, suggesting an important role for this enzyme in adaptation to growth in the gastric mucosa. This AKR is a member of a hitherto little-studied class...
  28. doi request reprint Purification of glutamate dehydrogenase from liver and brain
    Martha Motherway
    Department of Biochemistry Trinity College, Dublin, Ireland
    Curr Protoc Protein Sci . 2002
    ..Procedures for the synthesis of GTP-Sepharose and bis-NAD+ are described and the ancillary procedures, including the assay of GDH activity and the determination of protein concentration, are also presented...
  29. doi request reprint Extracellular levels of brain aspartate, glutamate and GABA during an inhibitory avoidance response in the rat
    Chiara Ballini
    Dipartimento di Farmacologia Preclinica e Clinica M Aiazzi Mancini, Universita degli Studi di Firenze, Viale G Pieraccini, Firenze, Italia
    J Neurochem 106:1035-43. 2008
    ....
  30. doi request reprint Validation of a robust and sensitive method for detecting hydroxyl radical formation together with evoked neurotransmitter release in brain microdialysis
    Wolfhardt Freinbichler
    Institute for Applied Synthetic Chemistry, Vienna University of Technology, Vienna, Austria
    J Neurochem 105:738-49. 2008
    ..The in vitro results in the Fenton system (Fe2+ + H2O2) indicate a mechanism whereby TA2- forms a primary complex with Fe2+ followed by an intramolecular hydroxylation accompanied by intramolecular electron transfer...
  31. ncbi request reprint Amine oxidases and monooxygenases in the in vivo metabolism of xenobiotic amines in humans: has the involvement of amine oxidases been neglected?
    Margherita Strolin Benedetti
    UCB Pharma, Non Clinical Development, Nanterre, France
    Fundam Clin Pharmacol 21:467-80. 2007
    ..However, for some drugs on the market, the involvement of MAOs in their in vivo metabolism in humans has been demonstrated recently, among these drugs citalopram, sertraline and the triptans are examples that can be mentioned...
  32. ncbi request reprint Semicarbazide-sensitive amine oxidases: enzymes with quite a lot to do
    Jeff O'Sullivan
    Department of Biochemistry, Trinity College, Dublin 2, Ireland
    Neurotoxicology 25:303-15. 2004
    ..This review considers what is known about the activities and potential functions of this hardworking protein...
  33. ncbi request reprint Affinity precipitation methods
    Jane A Irwin
    Department of Veterinary Physiology and Biochemistry, University College Dublin, Ireland
    Methods Mol Biol 244:205-23. 2004
  34. ncbi request reprint Characterization of cinnamyl alcohol dehydrogenase of Helicobacter pylori. An aldehyde dismutating enzyme
    Blanaid Mee
    School of Food Science and Environmental Health, Dublin Institute of Technology, Ireland
    FEBS J 272:1255-64. 2005
    ..This dismutation reaction has not been shown previously for this class of alcohol dehydrogenase and provides the bacterium with a means of reducing aldehyde concentration within the cell...