John M Scott

Summary

Affiliation: Trinity College
Country: Ireland

Publications

  1. ncbi request reprint Folate and vitamin B12
    J M Scott
    Department of Biochemistry, Trinity College, Dublin 2, Republic of Ireland
    Proc Nutr Soc 58:441-8. 1999
  2. ncbi request reprint Victor Herbert (1927-2002)
    John M Scott
    Biochemistry Department, Trinity College, Dublin 2, Ireland
    J Nutr 134:1678-80. 2004
  3. pmc Evaluation of common genetic variants in 82 candidate genes as risk factors for neural tube defects
    Faith Pangilinan
    Molecular Pathogenesis Section, Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
    BMC Med Genet 13:62. 2012
  4. doi request reprint Folic acid consumption throughout pregnancy: differentiation between trimesters
    John Scott
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    Ann Nutr Metab 59:46-9. 2011
  5. pmc Dietary and other lifestyle correlates of serum folate concentrations in a healthy adult population in Crete, Greece: a cross-sectional study
    Christos M Hatzis
    Preventive Medicine and Nutrition Clinic, Department of Social Medicine, Faculty of Medicine, University of Crete, P, O, Box 1352, 71110, Heraklion, Greece
    Nutr J 5:5. 2006
  6. pmc Folic acid fortification and public health: report on threshold doses above which unmetabolised folic acid appear in serum
    Mary Rose Sweeney
    Department of Clinical Medicine, Trinity College, Dublin, Ireland
    BMC Public Health 7:41. 2007
  7. doi request reprint Symposium on 'The challenge of translating nutrition research into public health nutrition'. Session 2: Personalised nutrition. Genetic variation and disease risk: new advances
    John Scott
    School of Biochemistry and Immunology, University of Dublin, Trinity College, Dublin 2, Republic of Ireland
    Proc Nutr Soc 68:113-21. 2009
  8. ncbi request reprint Confirmation of the R653Q polymorphism of the trifunctional C1-synthase enzyme as a maternal risk for neural tube defects in the Irish population
    Anne Parle-McDermott
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    Eur J Hum Genet 14:768-72. 2006
  9. ncbi request reprint Analysis of methionine synthase reductase polymorphisms for neural tube defects risk association
    Valerie B O'Leary
    Department of Biochemistry, Trinity College Dublin, Dublin, Ireland
    Mol Genet Metab 85:220-7. 2005
  10. ncbi request reprint Screening for new MTHFR polymorphisms and NTD risk
    Valerie B O'Leary
    Department of Biochemistry, Trinity College Dublin, Dublin, Ireland
    Am J Med Genet A 138:99-106. 2005

Collaborators

Detail Information

Publications64

  1. ncbi request reprint Folate and vitamin B12
    J M Scott
    Department of Biochemistry, Trinity College, Dublin 2, Republic of Ireland
    Proc Nutr Soc 58:441-8. 1999
    ..This process in turn produces a pseudo folate deficiency in such cells, preventing cell division and giving rise to an anaemia identical to that seen in folate deficiency...
  2. ncbi request reprint Victor Herbert (1927-2002)
    John M Scott
    Biochemistry Department, Trinity College, Dublin 2, Ireland
    J Nutr 134:1678-80. 2004
  3. pmc Evaluation of common genetic variants in 82 candidate genes as risk factors for neural tube defects
    Faith Pangilinan
    Molecular Pathogenesis Section, Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
    BMC Med Genet 13:62. 2012
    ..g., MTHFR rs1801133 (677 C > T) and MTHFD1 rs2236225 (R653Q)) have been found to increase NTD risk. We hypothesized that variants in additional folate/B12 pathway genes contribute to NTD risk...
  4. doi request reprint Folic acid consumption throughout pregnancy: differentiation between trimesters
    John Scott
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    Ann Nutr Metab 59:46-9. 2011
    ....
  5. pmc Dietary and other lifestyle correlates of serum folate concentrations in a healthy adult population in Crete, Greece: a cross-sectional study
    Christos M Hatzis
    Preventive Medicine and Nutrition Clinic, Department of Social Medicine, Faculty of Medicine, University of Crete, P, O, Box 1352, 71110, Heraklion, Greece
    Nutr J 5:5. 2006
    ..The study aimed at examining the distribution and determinants of serum folate concentrations in a healthy adult population in Crete, Greece...
  6. pmc Folic acid fortification and public health: report on threshold doses above which unmetabolised folic acid appear in serum
    Mary Rose Sweeney
    Department of Clinical Medicine, Trinity College, Dublin, Ireland
    BMC Public Health 7:41. 2007
    ..The aim of this study was to capture the short-term effect of folic acid fortification on unmetabolised folic acid in serum after chronic consumption of folic acid...
  7. doi request reprint Symposium on 'The challenge of translating nutrition research into public health nutrition'. Session 2: Personalised nutrition. Genetic variation and disease risk: new advances
    John Scott
    School of Biochemistry and Immunology, University of Dublin, Trinity College, Dublin 2, Republic of Ireland
    Proc Nutr Soc 68:113-21. 2009
    ..All three approaches carry the certainty that significant associations will be found by statistical chance, for which correction must be made. This latter issue is helped by large numbers and by independent replication cohorts...
  8. ncbi request reprint Confirmation of the R653Q polymorphism of the trifunctional C1-synthase enzyme as a maternal risk for neural tube defects in the Irish population
    Anne Parle-McDermott
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    Eur J Hum Genet 14:768-72. 2006
    ..We have established that the MTHFD1 1958G>A polymorphism has a significant role in influencing a mother's risk of having an NTD-affected pregnancy in the Irish population...
  9. ncbi request reprint Analysis of methionine synthase reductase polymorphisms for neural tube defects risk association
    Valerie B O'Leary
    Department of Biochemistry, Trinity College Dublin, Dublin, Ireland
    Mol Genet Metab 85:220-7. 2005
    ..The frequencies of I22M and K350R differed significantly between the two groups (p = 0.0005 and p = 0.0001, respectively). Our findings do not support an important role for these MTRR variants in NTDs...
  10. ncbi request reprint Screening for new MTHFR polymorphisms and NTD risk
    Valerie B O'Leary
    Department of Biochemistry, Trinity College Dublin, Dublin, Ireland
    Am J Med Genet A 138:99-106. 2005
    ..This is the first NTD association study of both R594Q and the novel P39P. The association with NTD risk reported for these SNPs is driven by the linkage disequilibrium with the A222V (677C->T) NTD risk factor...
  11. doi request reprint Maternal vitamin B12 status and risk of neural tube defects in a population with high neural tube defect prevalence and no folic Acid fortification
    Anne M Molloy
    Schools of Medicine, Trinity College Dublin, School of Medicine, Dublin 2, Ireland
    Pediatrics 123:917-23. 2009
    ..Our objective was to quantify the effect of low B(12) status on neural tube defect risk in a high-prevalence, unfortified population...
  12. ncbi request reprint Reduced folate carrier polymorphisms and neural tube defect risk
    Valerie B O'Leary
    Department of Biochemistry, Trinity College Dublin, Ireland
    Mol Genet Metab 87:364-9. 2006
    ..The previously unstudied 61 bp tandem repeat, however, has a possible protective NTD effect in our Irish population. This requires confirmation in other studies...
  13. ncbi request reprint The MTHFR 1298CC and 677TT genotypes have opposite associations with red cell folate levels
    Anne Parle-McDermott
    School of Biochemistry and Immunology, Trinity College Dublin, Ireland
    Mol Genet Metab 88:290-4. 2006
    ..Thus, these two common polymorphisms change a metabolic phenotype in opposite directions suggesting that their cancer protective associations are by different mechanisms...
  14. ncbi request reprint Polymorphisms within the vitamin B12 dependent methylmalonyl-coA mutase are not risk factors for neural tube defects
    Anne Parle-McDermott
    Department of Biochemistry, Trinity College Dublin, Dublin, Ireland
    Mol Genet Metab 80:463-8. 2003
    ..002; H532R, P</=0.001; V671I, P=0.006). In conclusion, common variants in the mutase gene do not appear to be risk factors for NTDs but their allele frequencies are significantly different between ethnic groups...
  15. ncbi request reprint The 19-bp deletion polymorphism in intron-1 of dihydrofolate reductase (DHFR) may decrease rather than increase risk for spina bifida in the Irish population
    Anne Parle-McDermott
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    Am J Med Genet A 143:1174-80. 2007
    ..5-fold) associated with the 19-bp intron deletion polymorphism, but this was not significant. In conclusion, the DHFR intron 19-bp deletion allele may be a protective NTD genetic factor by increasing DHFR mRNA levels in pregnant women...
  16. ncbi request reprint Analysis of the MTHFR 1298A-->C and 677C-->T polymorphisms as risk factors for neural tube defects
    Anne Parle-McDermott
    Department of Biochemistry, Trinity College Dublin, Dublin, Ireland
    J Hum Genet 48:190-3. 2003
    ..Our findings do not support a role for the 1298A-->C polymorphism in NTDs (OR 0.85 (95% CI 0.49-1.47), p= 0.55), nor do we observe a combined effect with the 677C-->T polymorphism...
  17. doi request reprint Unmetabolized folic acid prevalence is widespread in the older Irish population despite the lack of a mandatory fortification program
    Andrew Boilson
    UCD School of Public Health, Physiotherapy and Population Science, University College Dublin, Dublin, Ireland
    Am J Clin Nutr 96:613-21. 2012
    ..The safety issues include concerns about the masking of vitamin B-12 deficiency and potential cancer acceleration, both of which may be of concern for the elderly population...
  18. ncbi request reprint MTHFD1 R653Q polymorphism is a maternal genetic risk factor for severe abruptio placentae
    Anne Parle-McDermott
    Department of Biochemistry, Trinity College Dublin, Dublin, Ireland
    Am J Med Genet A 132:365-8. 2005
    ..We conclude that women who are 'QQ' homozygote for the MTHFD1 1258G --> A (R653Q) polymorphism are almost three times more likely to develop severe abruptio placentae during their pregnancy than women who are 'RQ' or 'RR.'..
  19. ncbi request reprint A polymorphism in the MTHFD1 gene increases a mother's risk of having an unexplained second trimester pregnancy loss
    Anne Parle-McDermott
    Department of Biochemistry, Trinity College Dublin, Dublin, Ireland
    Mol Hum Reprod 11:477-80. 2005
    ..Neither showed evidence of significantly affecting the maternal risk of having a second trimester pregnancy loss. In conclusion, the MTHFD1 1958AA genotype may be an important maternal risk factor to consider during pregnancy...
  20. ncbi request reprint Analysis of the human folate receptor beta gene for an association with neural tube defects
    Valerie B O'Leary
    Department of Biochemistry, Trinity College Dublin, Dublin, Ireland
    Mol Genet Metab 79:129-33. 2003
    ..Highly significant allele frequency differences were observed between populations. In conclusion, SNP rs651646 within the FRbeta gene is polymorphic but is not associated with neural tube defects within the Irish population...
  21. pmc Genotyping of a tri-allelic polymorphism by a novel melting curve assay in MTHFD1L: an association study of nonsyndromic Cleft in Ireland
    Stefano Minguzzi
    Nutritional Genomics Group, School of Biotechnology, Dublin City University, Dublin, Ireland
    BMC Med Genet 13:29. 2012
    ..This required the development of a new melting curve assay to genotype the technically challenging MTHFD1L triallelic deletion/insertion polymorphism (rs3832406)...
  22. ncbi request reprint Effects of folate and vitamin B12 deficiencies during pregnancy on fetal, infant, and child development
    Anne M Molloy
    School of Medicine, Trinity College Dublin, Ireland
    Food Nutr Bull 29:S101-11; discussion S112-5. 2008
    ..However, the implications of starting pregnancy and lactation with low vitamin B12 status have not been sufficiently researched...
  23. doi request reprint The search for genetic polymorphisms in the homocysteine/folate pathway that contribute to the etiology of human neural tube defects
    Anne M Molloy
    School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    Birth Defects Res A Clin Mol Teratol 85:285-94. 2009
    ..Although moving forward is exciting, it is humbling that the most important result-prevention of NTDs by maternal folic acid supplementation-was achieved years ago, the direct result of Smithells' groundbreaking studies...
  24. ncbi request reprint Maternal and fetal plasma homocysteine concentrations at birth: the influence of folate, vitamin B12, and the 5,10-methylenetetrahydrofolate reductase 677C-->T variant
    Anne M Molloy
    Department of Clinical Medicine, Trinity College Dublin, Ireland
    Am J Obstet Gynecol 186:499-503. 2002
    ..The purpose of this study was to determine the nutritional and genetic factors that influence fetal plasma homocysteine concentrations...
  25. doi request reprint Lack of association between folate-receptor autoantibodies and neural-tube defects
    Anne M Molloy
    School of Medicine, Trinity College, Dublin, Ireland
    N Engl J Med 361:152-60. 2009
    ..We sought to confirm this finding in an Irish population, which traditionally has had a high prevalence of neural-tube defects...
  26. ncbi request reprint Postprandial serum folic acid response to multiple doses of folic acid in fortified bread
    Mary R Sweeney
    Department of Clinical Medicine, University of Dublin, Trinity College, Dublin, Ireland
    Br J Nutr 95:145-51. 2006
    ..Approaches to optimise folic acid intake in target populations as part of a universal fortification strategy should take into consideration the potential hazard of over-exposure in groups consuming high amounts of flour-based products...
  27. doi request reprint A dose-finding trial of the effect of long-term folic acid intervention: implications for food fortification policy
    Paula Tighe
    Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland and Biochemistry and Immunology, Trinity College, Dublin, Ireland
    Am J Clin Nutr 93:11-8. 2011
    ..The lowest dose of folic acid required to achieve effective reductions in homocysteine is controversial but important for food fortification policy given recent concerns about the potential adverse effects of overexposure to this vitamin...
  28. pmc Impact of the MTHFR C677T polymorphism on risk of neural tube defects: case-control study
    Peadar N Kirke
    Child Health Epidemiology Division, Health Research Board, Dublin 2, Ireland
    BMJ 328:1535-6. 2004
  29. ncbi request reprint Reduced folate status is common and increases disease risk. It can be corrected by daily ingestion of supplements or fortification
    John M Scott
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Novartis Found Symp 282:105-17; discussion 117-22, 212-8. 2007
    ..The level for such fortification is suboptimal for NTD prevention, because of fear of overexposure in the elderly. Thus even fortified communities require advice to take supplements for optimum NTD prevention...
  30. ncbi request reprint Evidence of unmetabolised folic acid in cord blood of newborn and serum of 4-day-old infants
    Mary R Sweeney
    Department of Clinical Medicine, University of Dublin, Trinity College, Dublin, Ireland
    Br J Nutr 94:727-30. 2005
    ..This would also be the case in infants exposed to unmetabolised folic acid as a result of formula feeding...
  31. pmc Persistent circulating unmetabolised folic acid in a setting of liberal voluntary folic acid fortification. Implications for further mandatory fortification?
    Mary R Sweeney
    UCD School of Public Health and Population Science, University College Dublin, and Coombe Women s and Infant s Hospital, Dublin, Ireland
    BMC Public Health 9:295. 2009
    ..A secondary aim was to predict the increase in circulatory unmetabolised folic acid levels after fortification...
  32. ncbi request reprint Choline and homocysteine interrelations in umbilical cord and maternal plasma at delivery
    Anne M Molloy
    Department of Clinical Medicine and the National Human Genome Research Institute, The National Institutes of Health, Bethesda, MD, USA
    Am J Clin Nutr 82:836-42. 2005
    ..Choline, via betaine, is an important folate-independent source of methyl groups for remethylating homocysteine in liver...
  33. doi request reprint The discovery of vitamin B(12)
    John M Scott
    School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Dublin, Ireland jscott tcd ie
    Ann Nutr Metab 61:239-45. 2012
    ..Vitamin B(12) is still the subject of intense research and, in particular, its role in preventing these irreversible neurological lesions remains unclear...
  34. ncbi request reprint Elevated plasma homocysteine in early pregnancy: a risk factor for the development of nonsevere preeclampsia
    Amanda M Cotter
    Department of Biochemistry, Trinity College Dublin and Coombe Women s Hospital, Dublin, Ireland
    Am J Obstet Gynecol 189:391-4; discussion 394-6. 2003
    ..The aim of this study was to determine whether an elevated plasma homocysteine in early pregnancy is also associated with the development of nonsevere preeclampsia...
  35. ncbi request reprint MTRR and MTHFR polymorphism: link to Down syndrome?
    Valerie B O'Leary
    Department of Biochemistry, Trinity College, Dublin, Ireland
    Am J Med Genet 107:151-5. 2002
    ..Women who have both the MTRR and MTHFR variant genotypes are also at increased risk of producing offspring with Down syndrome...
  36. ncbi request reprint Folate, vitamin B12 and birth defects
    J M Scott
    Biochemistry Department, Trinity College Dublin, Ireland
    Forum Nutr 56:45-9. 2003
    ..Some studies indicate a positive protection while others are negative. There are also conflicting reports as to whether or not the C677T variant of MTHFR increases risk. This is to be contrasted with NTDs where it clearly does...
  37. ncbi request reprint Screening for vitamin B-12 and folate deficiency in older persons
    Robert Clarke
    Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 77:1241-7. 2003
    ..Folate deficiency also results in elevated tHcy. Measurement of these metabolites can be used to screen for functional vitamin B-12 or folate deficiency...
  38. ncbi request reprint Effect of a voluntary food fortification policy on folate, related B vitamin status, and homocysteine in healthy adults
    Leane Hoey
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, United Kingdom
    Am J Clin Nutr 86:1405-13. 2007
    ..Thus, it is virtually nonexistent in Europe, albeit many countries allow food fortification on a voluntary basis...
  39. doi request reprint Evidence for sex differences in the determinants of homocysteine concentrations
    Anna Stanisławska-Sachadyn
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Mol Genet Metab 93:355-62. 2008
    ..Among females, smokers (regardless of MTHFR genotype) appear to be at the highest risk, and to be the most vulnerable to a single factor (i.e. RBC folate) that is associated with homocysteine raising effects...
  40. pmc Construction of a high resolution linkage disequilibrium map to evaluate common genetic variation in TP53 and neural tube defect risk in an Irish population
    Faith Pangilinan
    Molecular Pathogenesis Section, Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland 20892 8004, USA
    Am J Med Genet A 146:2617-25. 2008
    ..86 [1.16-2.96], P = 0.01) and the TT genotype of rs1614984 (RR = 0.58 [0.37-0.91], P = 0.02). As multiple comparisons were made, these cannot be considered definitive positive findings and additional investigation is required...
  41. pmc Homocysteine concentration, related B vitamins, and betaine in pregnant women recruited to the Seychelles Child Development Study
    Julie Mw Wallace
    Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, Coleraine, United Kingdom
    Am J Clin Nutr 87:391-7. 2008
    ..Both folate and betaine are important predictors of total homocysteine (tHcy) during pregnancy. However, studies to date have only been undertaken in populations with Western dietary patterns...
  42. doi request reprint Folate and vitamin B12 status in relation to cognitive impairment and anaemia in the setting of voluntary fortification in the UK
    Robert Clarke
    Clinical Trial Service Unit, University of Oxford, Oxford, UK
    Br J Nutr 100:1054-9. 2008
    ..88)). There was no evidence of modification by high folate status of the associations of low B12 with anaemia or cognitive impairment in the setting of voluntary fortification, but periodic surveys are needed to monitor fortification...
  43. doi request reprint Intake and status of folate and related B-vitamins: considerations and challenges in achieving optimal status
    Helene McNulty
    The Northern Ireland Centre for Food and Health NICHE, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland
    Br J Nutr 99:S48-54. 2008
    ..Finally, there is evidence that riboflavin status is generally low in the UK population, and particularly so in younger women; this warrants further investigation...
  44. doi request reprint An insertion/deletion polymorphism of the dihydrofolate reductase (DHFR) gene is associated with serum and red blood cell folate concentrations in women
    Anna Stanisławska-Sachadyn
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA, 19104 6084, USA
    Hum Genet 123:289-95. 2008
    ....
  45. ncbi request reprint Impaired functioning of thermolabile methylenetetrahydrofolate reductase is dependent on riboflavin status: implications for riboflavin requirements
    Helene McNulty
    Northern Ireland Centre for Diet and Health, University of Ulster, Coleraine, United Kingdom
    Am J Clin Nutr 76:436-41. 2002
    ..A reduction in MTHFR activity, as occurs in the homozygous state for the 677C-->T (so-called thermolabile) enzyme variant (TT genotype), is associated with an increase in plasma total homocysteine (tHcy)...
  46. pmc A polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase is a maternal genetic risk factor for neural tube defects: report of the Birth Defects Res
    Lawrence C Brody
    Genome Technology Branch, National Human Genome Research Institute, Bethesda, MD, USA
    Am J Hum Genet 71:1207-15. 2002
    ..003). We conclude that genetic variation in the MTHFD1 gene is associated with an increase in the genetically determined risk that a woman will bear a child with NTD and that the gene may be associated with decreased embryo survival...
  47. ncbi request reprint Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults
    Leo A J Kluijtmans
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Blood 101:2483-8. 2003
    ..These data underscore the potential benefits that may be gained by improving the dietary status of young adults, and provide support for the implementation of folate/B-vitamin food fortification programs...
  48. ncbi request reprint The short-term bioavailabilities of [6S]-5-methyltetrahydrofolate and folic acid are equivalent in men
    Kristina Pentieva
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, Northern Ireland BT52 1SA
    J Nutr 134:580-5. 2004
    ..Supplementation with the natural folate derivative could have all the beneficial effects associated with FA, but without the potential disadvantage of masking the anemia of vitamin B-12 deficiency...
  49. ncbi request reprint The 5,10-methylenetetrahydrofolate reductase C677T polymorphism interacts with smoking to increase homocysteine
    Karen S Brown
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Atherosclerosis 174:315-22. 2004
    ..We propose that hyperhomocysteinemia in MTHFR 677TT homozygote smokers is the consequence of mild intracellular folate deficiency caused by a smoking-related reduction of NOS3 activity that is exacerbated when serum folate is low...
  50. ncbi request reprint Maternal homocysteine before conception and throughout pregnancy predicts fetal homocysteine and birth weight
    Michelle M Murphy
    Unit of Preventive Medicine and Public Health, Rovira i Virgili University, Reus, Spain
    Clin Chem 50:1406-12. 2004
    ..Increased homocysteine has been associated with pregnancy complications...
  51. ncbi request reprint A common insertion/deletion polymorphism of the thymidylate synthase (TYMS) gene is a determinant of red blood cell folate and homocysteine concentrations
    Carmel Kealey
    Department of Pharmacology, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Hum Genet 116:347-53. 2005
    ....
  52. ncbi request reprint Evaluation of transcobalamin II polymorphisms as neural tube defect risk factors in an Irish population
    Deborah A Swanson
    Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Birth Defects Res A Clin Mol Teratol 73:239-44. 2005
    ..TCII levels are altered in the amniotic fluid of pregnancies affected by NTDs. Given this evidence, inherited variants in genes involved in vitamin B(12) trafficking such as TCII are candidate NTD risk factors...
  53. ncbi request reprint Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C->T polymorphism
    Helene McNulty
    Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland
    Circulation 113:74-80. 2006
    ....
  54. ncbi request reprint Association between the NAT1 1095C > A polymorphism and homocysteine concentration
    Anna Stanisławska-Sachadyn
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6084, USA
    Am J Med Genet A 140:2374-7. 2006
  55. ncbi request reprint The pregnancy-related decrease in fasting plasma homocysteine is not explained by folic acid supplementation, hemodilution, or a decrease in albumin in a longitudinal study
    Michelle M Murphy
    Unit of Preventive Medicine, Rovira i Virgili University, Reus, Spain
    Am J Clin Nutr 76:614-9. 2002
    ..Previous reports suggested that this is due to folic acid supplementation, hemodilution, or a decrease in albumin. However, these hypotheses have not been tested in a longitudinal study...
  56. ncbi request reprint Detection of vitamin B12 deficiency in older people by measuring vitamin B12 or the active fraction of vitamin B12, holotranscobalamin
    Robert Clarke
    Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom
    Clin Chem 53:963-70. 2007
    ..Concentrations of this active component, carried on holotranscobalamin (holoTC), may be of greater relevance than total vitamin B(12)...
  57. ncbi request reprint The effect of different cooking methods on folate retention in various foods that are amongst the major contributors to folate intake in the UK diet
    Derek J McKillop
    Northern Ireland Centre for Food and Health NICHE, University of Ulster, Coleraine, BT52 1SA, Northern Ireland, UK
    Br J Nutr 88:681-8. 2002
    ..Thus, public health efforts to increase folate intake in order to improve folate status should incorporate practical advice on cooking...
  58. ncbi request reprint Protocol for the production of concentrated extracts of food folate for use in human bioavailability studies
    Derek J McKillop
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, Northern Ireland BT52 1SA
    J Agric Food Chem 51:4382-8. 2003
    ..Neither the mono- to polyglutamate ratio nor the distribution of the main folate derivatives was altered during processing, making these extracts suitable for use in human bioavailability studies...
  59. ncbi request reprint Facts and recommendations about total homocysteine determinations: an expert opinion
    Helga Refsum
    Department of Pharmacology, University of Oxford, Oxford OX1 3QT, UK
    Clin Chem 50:3-32. 2004
    ....
  60. ncbi request reprint The effect of docosahexaenoic acid and folic acid supplementation on placental apoptosis and proliferation
    Mario Klingler
    Dr von Hauner Children s Hospital, Ludwig Maximilians University of Munich, Munich, Germany
    Br J Nutr 96:182-90. 2006
    ..A defined combination of DHA and 5-MTHF may, however, affect placental proliferation...
  61. ncbi request reprint The rate of intestinal absorption of natural food folates is not related to the extent of folate conjugation
    Derek J McKillop
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, United Kingdom
    Am J Clin Nutr 84:167-73. 2006
    ..Evidence is conflicting as to whether the bioavailability of food folates is influenced by the extent of their conjugation...
  62. ncbi request reprint Determining bioavailability of food folates in a controlled intervention study
    Mary P Hannon-Fletcher
    Northern Ireland Centre for Food and Health and the School of Hotel, Leisure, and Tourism, University of Ulster, Coleraine, United Kingdom
    Am J Clin Nutr 80:911-8. 2004
    ..However, many published reports on folate bioavailability are problematic because of several confounding factors...
  63. ncbi request reprint Homocysteine is lower in the third trimester of pregnancy in women with enhanced folate status from continued folic acid supplementation
    Valerie A Holmes
    Northern Ireland Centre for Food and Health NICHE, School of Biomedical Sciences, University of Ulster, Coleraine, UK
    Clin Chem 51:629-34. 2005
    ..Low folate status is associated with an increased concentration of plasma total homocysteine (tHcy), a risk factor associated with pregnancy complications such as preeclampsia...
  64. ncbi request reprint Longitudinal study of the effect of pregnancy on maternal and fetal cobalamin status in healthy women and their offspring
    Michelle M Murphy
    Unitat de Medicina Preventiva i Salut Pública, IRCIS, Facultat de Medicina i Ciencies de la Salut, Universitat Rovira i Virgili, Reus, 43201 Spain
    J Nutr 137:1863-7. 2007
    ..707, 0.682, respectively; P < 0.01). The moderate increases observed in the cobalamin biomarker, MMA, during pregnancy may indicate a functional depletion in intracellular cobalamin status...