M J Rowan

Summary

Affiliation: Trinity College
Country: Ireland

Publications

  1. pmc Alzheimer's disease Aβ assemblies mediating rapid disruption of synaptic plasticity and memory
    Igor Klyubin
    Department of Pharmacology and Therapeutics, and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    Mol Brain 5:25. 2012
  2. pmc Synaptic plasticity in animal models of early Alzheimer's disease
    Michael J Rowan
    Department of Pharmacology and Therapeutics, Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland
    Philos Trans R Soc Lond B Biol Sci 358:821-8. 2003
  3. ncbi request reprint Mechanisms of the inhibitory effects of amyloid beta-protein on synaptic plasticity
    Michael J Rowan
    Trinity College Institute of Neuroscience, Department of Pharmacology and Therapeutics, Trinity College, Biotechnology Building, Dublin 2, Ireland
    Exp Gerontol 39:1661-7. 2004
  4. ncbi request reprint Synaptic plasticity disruption by amyloid beta protein: modulation by potential Alzheimer's disease modifying therapies
    M J Rowan
    Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland
    Biochem Soc Trans 33:563-7. 2005
  5. ncbi request reprint Synaptic memory mechanisms: Alzheimer's disease amyloid beta-peptide-induced dysfunction
    M J Rowan
    Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland
    Biochem Soc Trans 35:1219-23. 2007
  6. ncbi request reprint Presynaptic group II mGluR inhibition of short-term depression in the medial perforant path of the dentate gyrus in vitro
    J Kilbride
    Department of Physiology, Trinity College, Dublin 2, Ireland
    J Neurophysiol 85:2509-15. 2001
  7. ncbi request reprint Use-dependent effects of amyloidogenic fragments of (beta)-amyloid precursor protein on synaptic plasticity in rat hippocampus in vivo
    J H Kim
    Departments of Pharmacology, Trinity College, Dublin 2, Ireland
    J Neurosci 21:1327-33. 2001
  8. ncbi request reprint A role for protein kinase A and protein kinase M zeta in muscarinic acetylcholine receptor-initiated persistent synaptic enhancement in rat hippocampus in vivo
    J Hayes
    Department of Pharmacology and Therapeutics, Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland
    Neuroscience 151:604-12. 2008
  9. pmc NMDA receptor- and metabotropic glutamate receptor-dependent synaptic plasticity induced by high frequency stimulation in the rat dentate gyrus in vitro
    J Wu
    Department of Physiology, Trinity College, University of Dublin, Dublin 2, Ireland
    J Physiol 533:745-55. 2001
  10. ncbi request reprint Application of N-methyl-D-aspartate induces long-term potentiation in the medial perforant path and long-term depression in the lateral perforant path of the rat dentate gyrus in vitro
    A M Rush
    Department of Physiology, Trinity College, Dublin, Ireland
    Neurosci Lett 298:175-8. 2001

Collaborators

Detail Information

Publications38

  1. pmc Alzheimer's disease Aβ assemblies mediating rapid disruption of synaptic plasticity and memory
    Igor Klyubin
    Department of Pharmacology and Therapeutics, and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    Mol Brain 5:25. 2012
    ..The same principle appears to apply to other synaptotoxic amyloidogenic proteins including tau, α-synuclein and prion protein...
  2. pmc Synaptic plasticity in animal models of early Alzheimer's disease
    Michael J Rowan
    Department of Pharmacology and Therapeutics, Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland
    Philos Trans R Soc Lond B Biol Sci 358:821-8. 2003
    ..Having identified the active species of Abeta that can play havoc with synaptic plasticity, it is hoped that new ways of targeting early AD can be developed...
  3. ncbi request reprint Mechanisms of the inhibitory effects of amyloid beta-protein on synaptic plasticity
    Michael J Rowan
    Trinity College Institute of Neuroscience, Department of Pharmacology and Therapeutics, Trinity College, Biotechnology Building, Dublin 2, Ireland
    Exp Gerontol 39:1661-7. 2004
    ..These mechanistic studies provide a plausible explanation for the sensitivity of hippocampus-dependent memory to impairment in the early preclinical stages of Alzheimer's disease...
  4. ncbi request reprint Synaptic plasticity disruption by amyloid beta protein: modulation by potential Alzheimer's disease modifying therapies
    M J Rowan
    Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland
    Biochem Soc Trans 33:563-7. 2005
    ....
  5. ncbi request reprint Synaptic memory mechanisms: Alzheimer's disease amyloid beta-peptide-induced dysfunction
    M J Rowan
    Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland
    Biochem Soc Trans 35:1219-23. 2007
    ..Taken together, this research lends support to therapeutic trials of drugs antagonizing synaptic plasticity-disrupting actions of Abeta oligomers in preclinical AD...
  6. ncbi request reprint Presynaptic group II mGluR inhibition of short-term depression in the medial perforant path of the dentate gyrus in vitro
    J Kilbride
    Department of Physiology, Trinity College, Dublin 2, Ireland
    J Neurophysiol 85:2509-15. 2001
    ..Activation of presynaptically located group II mGluR increased the frequency at which the EPSP per unit time plateaued up to 30-50 Hz...
  7. ncbi request reprint Use-dependent effects of amyloidogenic fragments of (beta)-amyloid precursor protein on synaptic plasticity in rat hippocampus in vivo
    J H Kim
    Departments of Pharmacology, Trinity College, Dublin 2, Ireland
    J Neurosci 21:1327-33. 2001
    ..This will result in a profound disruption of information processing dependent on hippocampal synaptic plasticity...
  8. ncbi request reprint A role for protein kinase A and protein kinase M zeta in muscarinic acetylcholine receptor-initiated persistent synaptic enhancement in rat hippocampus in vivo
    J Hayes
    Department of Pharmacology and Therapeutics, Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland
    Neuroscience 151:604-12. 2008
    ..These findings are strong evidence that antagonism of M2 muscarinic ACh receptors in vivo induces an NMDA receptor-independent persistent synaptic enhancement that requires activation of both PKA and PKM zeta...
  9. pmc NMDA receptor- and metabotropic glutamate receptor-dependent synaptic plasticity induced by high frequency stimulation in the rat dentate gyrus in vitro
    J Wu
    Department of Physiology, Trinity College, University of Dublin, Dublin 2, Ireland
    J Physiol 533:745-55. 2001
    ..6. Quantal analysis involving minimal stimulation demonstrated that the mGluR-dependent LTD induction was associated with a decrease in potency and an increase in failure rate...
  10. ncbi request reprint Application of N-methyl-D-aspartate induces long-term potentiation in the medial perforant path and long-term depression in the lateral perforant path of the rat dentate gyrus in vitro
    A M Rush
    Department of Physiology, Trinity College, Dublin, Ireland
    Neurosci Lett 298:175-8. 2001
    ..Bath perfusion of NMDA (10 microM, 5 min) resulted in induction of long-term potentiation in the medial perforant path, and induction of long-term depression in the lateral perforant path...
  11. ncbi request reprint Developmental dependence, the role of the kinases p38 MAPK and PKC, and the involvement of tumor necrosis factor-R1 in the induction of mGlu-5 LTD in the dentate gyrus
    Q Wang
    Department of Physiology, Trinity College, Dublin 2, Ireland
    Neuroscience 144:110-8. 2007
    ..Evidence for the involvement of tumor necrosis factor-receptor 1 (TNF-R1) in the induction of mGluR-LTD was presented in the present study, with both HFS-mGluR-LTD and DHPG-LTD being absent in mutant mice null for TNF-R1...
  12. ncbi request reprint Activation of group II metabotropic glutamate receptors results in long-term potentiation following preconditioning stimulation in the dentate gyrus
    A M Rush
    Department of Physiology, Trinity College, Dublin, Ireland
    Neuroscience 105:335-41. 2001
    ....
  13. ncbi request reprint Activation of group-II metabotropic glutamate receptors blocks induction of long-term potentiation and depotentiation in area CA1 of the rat in vivo
    C Holscher
    Department of Pharmacology and Therapeutics, Trinity College, Dublin, Ireland
    Eur J Pharmacol 322:155-63. 1997
    ..It is concluded that activation of group-II metabotropic glutamate receptors can block both high-frequency stimulation-induced long term potentiation and low-frequency stimulation-induced depotentiation in the CA1 area in vivo...
  14. ncbi request reprint Synaptically stimulated induction of group I metabotropic glutamate receptor-dependent long-term depression and depotentiation is inhibited by prior activation of metabotropic glutamate receptors and protein kinase C
    J Wu
    Department of Physiology, Trinity College, Dublin 2, Ireland
    Neuroscience 123:507-14. 2004
    ....
  15. ncbi request reprint Muscarinic acetylcholine receptor-dependent induction of persistent synaptic enhancement in rat hippocampus in vivo
    S Li
    Department of Pharmacology and Therapeutics, Biotechnology Building, Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland
    Neuroscience 144:754-61. 2007
    ..The present studies provide evidence for the rapid induction of a persistent potentiation at hippocampal glutamatergic synapses by endogenous ACh in vivo following disinhibition of inhibitory M2 muscarinic autoreceptors...
  16. ncbi request reprint L-AP4 (L-(+)-2-amino-4-phosphonobutyric acid) induced impairment of spatial learning in the rat is antagonized by MAP4 ((S)-2-amino-2-methyl-4-phosphonobutanoic acid)
    C Holscher
    Department of Pharmacology and Therapeutics, Trinity College Dublin, Ireland
    Behav Brain Res 81:69-79. 1996
    ..Neither latency in the visible-platform test nor behavior in the open field was affected. We conclude that L-AP4 sensitive metabotropic glutamate receptors play a selective role in learning and memory formation of the rat...
  17. ncbi request reprint Mechanisms underlying the inhibition of long-term potentiation by preconditioning stimulation in the hippocampus in vitro
    B Gisabella
    Department of Physiology, Trinity College, Dublin 2, Ireland
    Neuroscience 121:297-305. 2003
    ..We conclude that the preconditioning inhibition of LTP induction is a complex process which involves activation of NMDAR, group I and group II mGluR, and intracellular cascades activating PKC and p38 MAP kinase...
  18. ncbi request reprint Early spatial memory deficit induced by 2,5-hexanedione in the rat
    R Carney
    Department of Pharmacology and Therapeutics, Zoology Building, Trinity College, University of Dublin, Dublin 2, Ireland
    Toxicol Lett 128:107-15. 2002
    ..Thus 2,5-HD may mediate some of the cognitive effects of hexacarbons and these changes can occur prior to the development of motor symptoms...
  19. ncbi request reprint An NMDAR-independent LTP mediated by group II metabotropic glutamate receptors and p42/44 MAP kinase in the dentate gyrus in vitro
    JianQun Wu
    Department of Physiology, Trinity College, Dublin 2, Ireland
    Neuropharmacology 46:311-7. 2004
    ..The NMDAR-independent LTP induced by HFS was mediated via activation of p42/44 MAP kinase as it was blocked by the selective inhibitor PD98059...
  20. ncbi request reprint Alpha v integrins mediate beta-amyloid induced inhibition of long-term potentiation
    Qinwen Wang
    Department of Physiology, Trinity College, Dublin 2, Ireland
    Neurobiol Aging 29:1485-93. 2008
    ..These studies indicate that alpha v integrins may be important mediators of synaptic dysfunction prior to neurodegeneration in Alzheimer's disease...
  21. ncbi request reprint Beta-amyloid blocks high frequency stimulation induced LTP but not nicotine enhanced LTP
    Philip J Welsby
    Department of Physiology, Trinity College, Dublin 2, Ireland
    Neuropharmacology 53:188-95. 2007
    ..We postulate that nicotine-enhanced LTP has certain different mechanisms to that of control LTP which results in a resistance to inhibition by Abeta...
  22. ncbi request reprint Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
    Dominic M Walsh
    Department of Neurology, Harvard Medical School and Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Nature 416:535-9. 2002
    ....
  23. doi request reprint Involvement of group I mGluRs in LTP induced by strong high frequency stimulation in the dentate gyrus in vitro
    JianQun Wu
    Department of Physiology, Trinity College, Dublin 2, Ireland
    Neurosci Lett 436:235-8. 2008
    ..These studies demonstrate that the large amplitude LTP induced by strong stimulation involves additional mechanisms to the LTP induced by brief HFS, in particular involving activation of mGluR5 and RyR-sensitive Ca stores...
  24. pmc Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization
    Igor Klyubin
    Institute of Neuroscience and Department of Pharmacology and Therapeutics, Trinity College, Dublin 2, Ireland
    J Neurosci 28:4231-7. 2008
    ..Abeta monomer isolated from human CSF did not affect long-term potentiation. These results strongly support a strategy of passive immunization against soluble Abeta oligomers in early Alzheimer's disease...
  25. pmc Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
    Ganesh M Shankar
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Med 14:837-42. 2008
    ..We conclude that soluble Abeta oligomers extracted from Alzheimer's disease brains potently impair synapse structure and function and that dimers are the smallest synaptotoxic species...
  26. doi request reprint Soluble amyloid-beta peptides potently disrupt hippocampal synaptic plasticity in the absence of cerebrovascular dysfunction in vivo
    Neng Wei Hu
    Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland
    Brain 131:2414-24. 2008
    ..This strongly indicates that early cognitive deficits can be caused by soluble Abeta independently of deleterious effects on cerebrovascular dynamics...
  27. ncbi request reprint Overcoming the effects of stress on synaptic plasticity in the intact hippocampus: rapid actions of serotonergic and antidepressant agents
    Alison C Shakesby
    Department of Pharmacology and Therapeutics, Trinity College, Dublin 2, Ireland
    J Neurosci 22:3638-44. 2002
    ..These findings show that antidepressants have rapid and powerful interactions with the mechanisms controlling the persistence of the block of LTP by inescapable stress...
  28. ncbi request reprint Group I metabotropic glutamate receptor (mGluR)-dependent long-term depression mediated via p38 mitogen-activated protein kinase is inhibited by previous high-frequency stimulation and activation of mGluRs and protein kinase C in the rat dentate gyrus in
    Anthony M Rush
    Department of Physiology, Trinity College, Dublin 2, Ireland
    J Neurosci 22:6121-8. 2002
    ....
  29. ncbi request reprint Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well a
    Qinwen Wang
    Department of Physiology and Pharmacology, Trinity College, Dublin 2, Ireland
    J Neurosci 24:3370-8. 2004
    ..These studies provide evidence that the Abeta-mediated inhibition of LTP induction involves stimulation of the kinases JNK, Cdk5, and p38 MAPK after the activation of both the Abeta receptor(s) and mGluR5...
  30. ncbi request reprint Soluble Arctic amyloid beta protein inhibits hippocampal long-term potentiation in vivo
    Igor Klyubin
    Trinity College Institute of Neuroscience, and Department of Pharmacology and Therapeutics, Trinity College, Dublin 2, Ireland
    Eur J Neurosci 19:2839-46. 2004
    ....
  31. ncbi request reprint Endogenous acetylcholine lowers the threshold for long-term potentiation induction in the CA1 area through muscarinic receptor activation: in vivo study
    Saak V Ovsepian
    Department of Pharmacology and Therapeutics, Biotechnology Building, Trinity College, Dublin 2, Ireland
    Eur J Neurosci 20:1267-75. 2004
    ....
  32. ncbi request reprint Dopamine-dependent facilitation of LTP induction in hippocampal CA1 by exposure to spatial novelty
    Shaomin Li
    Department of Pharmacology and Therapeutics, Biotechnology Building, Trinity College, Dublin 2, Ireland
    Nat Neurosci 6:526-31. 2003
    ..Furthermore, the facilitation was dependent on activation of D1/D5 receptors. These findings support an important role for dopamine-regulated synaptic plasticity in the storage of unpredicted information in the CA1 area...
  33. ncbi request reprint Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo
    Igor Klyubin
    Trinity College Institute of Neuroscience, Department of Pharmacology and Therapeutics, Trinity College, Dublin 2, Ireland
    Nat Med 11:556-61. 2005
    ....
  34. ncbi request reprint Presynaptic group III mGluR modulation of short-term plasticity in the lateral perforant path of the dentate gyrus in vitro
    Anthony M Rush
    Department of Physiology, Trinity College, Dublin 2, Ireland
    Brain Res 952:38-43. 2002
    ..Short-term facilitation became prominent at high stimulation frequencies as short-term depression was inhibited by activation of group III mGluR. Activation of group III mGluR also shifted the limiting frequency to higher values...
  35. ncbi request reprint Beta-amyloid inhibition of long-term potentiation is mediated via tumor necrosis factor
    Qinwen Wang
    Department of Physiology, Trinity College, Dublin 2, Ireland
    Eur J Neurosci 22:2827-32. 2005
    ..The inhibition of LTP by TNFalpha involved activation of group I metabotropic glutamate receptor and p38 MAP kinase, identical to that for the Abeta-mediated inhibition of LTP induction...
  36. ncbi request reprint Beta-amyloid-mediated inhibition of NMDA receptor-dependent long-term potentiation induction involves activation of microglia and stimulation of inducible nitric oxide synthase and superoxide
    Qinwen Wang
    Department of Physiology, Trinity College, Dublin 2, Ireland
    J Neurosci 24:6049-56. 2004
    ....
  37. ncbi request reprint Performance- and task-dependent effects of the dopamine D1/D5 receptor agonist SKF 38393 on learning and memory in the rat
    Francesco Amico
    Department of Pharmacology and Therapeutics, Trinity College, Dublin 2, Ireland
    Eur J Pharmacol 577:71-7. 2007
    ..These results suggest that dopamine D(1)/D(5) receptor activation has performance- and task-dependent effects on cognitive function...
  38. ncbi request reprint Long-term potentiation is mediated by multiple kinase cascades involving CaMKII or either PKA or p42/44 MAPK in the adult rat dentate gyrus in vitro
    JianQun Wu
    Department of Physiology, Trinity College, Dublin 2, Ireland
    J Neurophysiol 95:3519-27. 2006
    ..Thus LTP is mediated by either of two parallel cascades, one involving CaMKII and the other PKA or MAPK. Moreover, these cascades are active for a certain period after the induction stimulus...