John Vincent Reynolds

Summary

Affiliation: Trinity College
Country: Ireland

Publications

  1. pmc Long-term outcomes following neoadjuvant chemoradiotherapy for esophageal cancer
    John Vincent Reynolds
    Department of Surgery, Trinity Centre, St James s Hospital, and Trinity College Dublin, Dublin 8, Ireland
    Ann Surg 245:707-16. 2007
  2. pmc Expression of neuroepithelial transforming gene 1 is enhanced in oesophageal cancer and mediates an invasive tumour cell phenotype
    Conor Lahiff
    Gastrointestinal Unit, Mater University Hospital, Dublin 7, Ireland
    J Exp Clin Cancer Res 32:55. 2013
  3. doi request reprint Evolving progress in oncologic and operative outcomes for esophageal and junctional cancer: lessons from the experience of a high-volume center
    John V Reynolds
    Department of Surgery, St James s Hospital and Trinity College, Dublin, Ireland
    J Thorac Cardiovasc Surg 143:1130-1137.e1. 2012
  4. pmc Predicting the response of localised oesophageal cancer to neo-adjuvant chemoradiation
    Charles M Gillham
    Academic Unit of Clinical and Molecular Oncology, St James s Hospital, Dublin, Ireland
    World J Surg Oncol 5:97. 2007
  5. pmc Impact of solitary involved lymph node on outcome in localized cancer of the esophagus and esophagogastric junction
    Suzanne Rowley
    University Department of Surgery, Trinity College Centre for Health Sciences, St James Hospital and Trinity College, Dublin, 8, Ireland
    J Gastrointest Surg 11:493-9. 2007
  6. pmc The value of double balloon enteroscopy in diagnosing blue rubber bleb naevus syndrome: a case report
    Fardod O'Kelly
    Department of Clinical Surgery, Trinity Centre, St James s Hospital, Dublin 8, Ireland
    Cases J 3:29. 2010
  7. doi request reprint Multimodality therapy for adenocarcinoma of the esophagus, gastric cardia, and upper gastric third
    John V Reynolds
    Department of Surgery, Trinity Centre, St James s Hospital, Dublin 8, Ireland
    Recent Results Cancer Res 182:155-66. 2010
  8. ncbi request reprint Neoadjuvant chemoradiation may increase the risk of respiratory complications and sepsis after transthoracic esophagectomy
    John V Reynolds
    Department of Surgery, St James s Hospital and Trinity College, Dublin, Ireland
    J Thorac Cardiovasc Surg 132:549-55. 2006
  9. ncbi request reprint Modern oncologic and operative outcomes for oesophageal cancer treated with curative intent
    J V Reynolds
    Department of Surgery, St James s Hospital, James s St, Dublin 8
    Ir Med J 104:235-8. 2011
  10. pmc Visceral adiposity, insulin resistance and cancer risk
    Claire L Donohoe
    Department of Surgery, Trinity Centre for Health Sciences, Trinity College Dublin St James Hospital, Dublin 8, Ireland
    Diabetol Metab Syndr 3:12. 2011

Collaborators

  • Mohamed M M Abdel-Latif
  • L A Healy
  • Dermot O'Toole
  • Karl J Sweeney
  • Charles M Gillham
  • Michael Carey
  • James D Martin-Smith
  • Nicola Miller
  • Derek G Power
  • Malcolm R Kell
  • Chris Power
  • P Balfe
  • P J Byrne
  • N Ravi
  • Fardod O'Kelly
  • Claire L Donohoe
  • J M Howard
  • G P Pidgeon
  • Kheng Tian Lim
  • S Rowley
  • P Beddy
  • Narayanasamy Ravi
  • J M O'Riordan
  • E Mulligan
  • Conor Lahiff
  • D Kelleher
  • P W N Keeling
  • E D Mulligan
  • M Keogan
  • C L Donohoe
  • M Byrne
  • M Babar
  • J A McCullough
  • D P Ennis
  • Mary Aisling McMahon
  • Namita Jayaprakash
  • B Dunne
  • M Griffin
  • E Carton
  • L Walshe
  • Suzanne Rowley
  • J Butt
  • M J Kennedy
  • D Hollywood
  • M MacGuill
  • F M Smith
  • A Jabbar
  • G S A McDonald
  • P M Lawlor
  • N Keeling
  • Z Mahmood
  • E M Connolly
  • A A Raouf
  • D Evoy
  • Padraic MacMathuna
  • Peter Doran
  • Eoin Cotter
  • Graham Pidgeon
  • Rory Casey
  • David Murray
  • B M Ryan
  • A Raouf
  • Mai Nguyen
  • Sarah Geagan Murray
  • Suzanne L Doyle
  • Nicole Chen
  • Brian J Mehigan
  • Jessica Cook
  • Paul H McCormick
  • Fardziana Zaki
  • P Lawler
  • J Howard
  • B White
  • J Lysaght
  • C de Blacam
  • Nasir Mahmud
  • B J Manning
  • A Murphy
  • C McMahon
  • S G Maher
  • A M Mongan
  • N Millar
  • P Byrne
  • M T Keogan
  • J S O'Donnell
  • S Murphy
  • D Ennis
  • M Knox
  • Fiachra Cooke
  • T Moran

Detail Information

Publications54

  1. pmc Long-term outcomes following neoadjuvant chemoradiotherapy for esophageal cancer
    John Vincent Reynolds
    Department of Surgery, Trinity Centre, St James s Hospital, and Trinity College Dublin, Dublin 8, Ireland
    Ann Surg 245:707-16. 2007
    ..We present and analyze long-term outcomes following multimodal therapy for esophageal cancer, in particular the relative impact of histomorphologic tumor regression and nodal status...
  2. pmc Expression of neuroepithelial transforming gene 1 is enhanced in oesophageal cancer and mediates an invasive tumour cell phenotype
    Conor Lahiff
    Gastrointestinal Unit, Mater University Hospital, Dublin 7, Ireland
    J Exp Clin Cancer Res 32:55. 2013
    ..We aimed to investigate whether NET1 plays a functional role in oesophageal cancer (OAC) and its pre-malignant phenotype Barrett's oesophagus...
  3. doi request reprint Evolving progress in oncologic and operative outcomes for esophageal and junctional cancer: lessons from the experience of a high-volume center
    John V Reynolds
    Department of Surgery, St James s Hospital and Trinity College, Dublin, Ireland
    J Thorac Cardiovasc Surg 143:1130-1137.e1. 2012
    ..An objective analysis of factors that underpin current benchmarks within high-volume centers has not been performed...
  4. pmc Predicting the response of localised oesophageal cancer to neo-adjuvant chemoradiation
    Charles M Gillham
    Academic Unit of Clinical and Molecular Oncology, St James s Hospital, Dublin, Ireland
    World J Surg Oncol 5:97. 2007
    ..abstract:..
  5. pmc Impact of solitary involved lymph node on outcome in localized cancer of the esophagus and esophagogastric junction
    Suzanne Rowley
    University Department of Surgery, Trinity College Centre for Health Sciences, St James Hospital and Trinity College, Dublin, 8, Ireland
    J Gastrointest Surg 11:493-9. 2007
    ..The presence of a solitary involved lymph node has a negative impact on survival compared with node-negative disease, but it is associated with significantly improved overall survival compared with all other nodal groups...
  6. pmc The value of double balloon enteroscopy in diagnosing blue rubber bleb naevus syndrome: a case report
    Fardod O'Kelly
    Department of Clinical Surgery, Trinity Centre, St James s Hospital, Dublin 8, Ireland
    Cases J 3:29. 2010
    ....
  7. doi request reprint Multimodality therapy for adenocarcinoma of the esophagus, gastric cardia, and upper gastric third
    John V Reynolds
    Department of Surgery, Trinity Centre, St James s Hospital, Dublin 8, Ireland
    Recent Results Cancer Res 182:155-66. 2010
    ..In this review, we assess the level of recommendations from the major published trials and -discuss new trials and approaches...
  8. ncbi request reprint Neoadjuvant chemoradiation may increase the risk of respiratory complications and sepsis after transthoracic esophagectomy
    John V Reynolds
    Department of Surgery, St James s Hospital and Trinity College, Dublin, Ireland
    J Thorac Cardiovasc Surg 132:549-55. 2006
    ..The role of neoadjuvant chemotherapy and radiation therapy before resection in esophageal cancer remains controversial. Operative risks may be increased, but this has not been systematically addressed in published trials or reports...
  9. ncbi request reprint Modern oncologic and operative outcomes for oesophageal cancer treated with curative intent
    J V Reynolds
    Department of Surgery, St James s Hospital, James s St, Dublin 8
    Ir Med J 104:235-8. 2011
    ..An in-hospital postoperative mortality rate of less than 2 per cent, and 5-year survival of between 35 and 42% is consistent with benchmarks from international series...
  10. pmc Visceral adiposity, insulin resistance and cancer risk
    Claire L Donohoe
    Department of Surgery, Trinity Centre for Health Sciences, Trinity College Dublin St James Hospital, Dublin 8, Ireland
    Diabetol Metab Syndr 3:12. 2011
    ..abstract:..
  11. pmc Management of synchronous adenocarcinoma of the esophago-gastric junction and ampulla of Vater: case report of a surgically challenging condition
    Namita Jayaprakash
    Department of Clinical Surgery, Trinity Centre, Trinity College Dublin and St James s Hospital, Dublin 8, Ireland
    Patient Saf Surg 3:23. 2009
    ..Patient returned to a good quality of life at six-month follow up with no further gastrointestinal symptoms or evidence of disease recurrence...
  12. pmc Endoscopic T-tube placement in the management of lye-induced esophageal perforation: Case report of a safe treatment strategy
    Mary Aisling McMahon
    Department of Clinical Surgery, Trinity Centre, Trinity College Dublin and St, James s Hospital, Dublin 8, Ireland
    Patient Saf Surg 3:19. 2009
    ..We report herein a case of lye-induced esophageal perforation managed successfully by employing endoscopic T-tube placement with a successful outcome...
  13. doi request reprint Fast-track protocols in colorectal surgery
    Claire L Donohoe
    Department of Surgery, Trinity Centre for Health Sciences, Trinity College Dublin St James Hospital, Dublin 8, Ireland
    Surgeon 9:95-103. 2011
    ..Acceptance of FTS protocols by all members of the multi-disciplinary team and a change in organisational structure to accommodate structured peri-operative care, are imperative to implementation...
  14. doi request reprint Diet, obesity and cancer
    J V Reynolds
    Department of Surgery, Trinity Centre for Health Sciences, Trinity College Dublin St James Hospital, Dublin 8, Ireland
    Ir J Med Sci 180:521-7. 2011
    ..This review seeks to summarise the current evidence pertaining to dietary factors and cancer incidence and progression...
  15. ncbi request reprint Prospective evaluation of quality of life in patients with localized oesophageal cancer treated by multimodality therapy or surgery alone
    J V Reynolds
    Department of Surgery, St James s Hospital and Trinity College Dublin, Dublin, Ireland
    Br J Surg 93:1084-90. 2006
    ..This prospective non-randomized study evaluated HRQL in patients treated by preoperative chemotherapy and radiation therapy followed by surgery (multimodal therapy) or by surgery alone...
  16. doi request reprint Differential pathologic variables and outcomes across the spectrum of adenocarcinoma of the esophagogastric junction
    John V Reynolds
    Department of Surgery, St James s Hospital and Trinity College Dublin, Trinity Center, Dublin 8, Ireland
    World J Surg 34:2821-9. 2010
    ..The origin of AEG tumors, esophageal or gastric, and their biology remain controversial, particularly for AEG type II (cardia) tumors...
  17. ncbi request reprint Margin involvement and outcome in oesophageal carcinoma: a 10-year experience in a specialist unit
    E D Mulligan
    Department of Surgery, St James s Hospital, James s Street, Dublin 8, Ireland
    Eur J Surg Oncol 30:313-7. 2004
    ..We questioned whether the benefit of a multimodal approach in oesophageal carcinoma is due to reduced resection margin involvement and whether multimodal therapy alters the disease course when margins are involved...
  18. ncbi request reprint Loss of Bcl-2 expression in Barrett's dysplasia and adenocarcinoma is associated with tumor progression and worse survival but not with response to neoadjuvant chemoradiation
    A A Raouf
    Department of Surgery, St James s Hospital and Trinity College, Dublin, Ireland
    Dis Esophagus 16:17-23. 2003
    ....
  19. pmc A pathological study of tumour regression in oesophageal adenocarcinoma treated with preoperative chemoradiotherapy
    B Dunne
    Department of Histopathology, St James's Hospital, Dublin 8, Ireland
    J Clin Pathol 54:841-5. 2001
    ..Although there are as yet no reliable predictors of response to treatment, patients who are identified at diagnosis as having negative loco-regional lymph nodes should benefit considerably from this treatment approach...
  20. pmc Spontaneous and inducible apoptosis in oesophageal adenocarcinoma
    A Raouf
    The Department of Clinical Surgery, Trinity Centre for Health Sciences, Trinity College Dublin, St James s Hospital, Dublin 8, Ireland
    Br J Cancer 85:1781-6. 2001
    ..Assessment of the tumours proliferation activity by Ki-67 expression might identify patients who are at risk of developing metastatic disease...
  21. ncbi request reprint Gastric myoelectrical activity post-chemoradiotherapy and esophagectomy: a prospective study using subscapular surface recording
    P M Lawlor
    GI Function Unit, St James Hospital, Dublin 8, Ireland
    Dis Esophagus 17:76-80. 2004
    ..Surgery causes a depression in dominant frequency with a reduced incidence of normogastria at 3 months and 6 months but with a tendency towards normality at 12 months...
  22. pmc Long-term activation of the pro-coagulant response after neoadjuvant chemoradiation and major cancer surgery
    M Byrne
    Department of Surgery, St James s Hospital, Trinity College, Dublin 8, Ireland
    Br J Cancer 102:73-9. 2010
    ..The aim of this study was to examine the markers of pro-coagulation response and VTE risk in an exemplar multimodal model of pre-operative combination chemotherapy and radiation therapy, followed by complex cancer surgery...
  23. pmc Management of gastro-bronchial fistula complicating a subtotal esophagectomy: a case report
    James D Martin-Smith
    Department of Clinical Surgery, St James s Hospital and Trinity College Dublin, Dublin, Ireland
    BMC Surg 9:20. 2009
    ..The development of a fistula between the tracheobronchial tree and the gastric conduit post esophagectomy is a rare and often fatal complication...
  24. ncbi request reprint Proinflammatory cytokine and nuclear factor kappa-B expression along the inflammation-metaplasia-dysplasia-adenocarcinoma sequence in the esophagus
    J M O'Riordan
    University Department of Surgery, St James s Hospital, The Dublin Molecular Medicine Centre, Trinity College, Dublin, Ireland
    Am J Gastroenterol 100:1257-64. 2005
    ..The molecular events that characterize the pathway from inflammation to metaplasia to dysplasia and adenocarcinoma are poorly understood...
  25. doi request reprint Health-related quality of life assessment at presentation may predict complications and early relapse in patients with localized cancer of the esophagus
    L A Healy
    Department of Clinical Nutrition, St James s Hospital, Dublin, Ireland
    Dis Esophagus 21:522-8. 2008
    ....
  26. ncbi request reprint Vitamin C enhances chemosensitization of esophageal cancer cells in vitro
    M M M Abdel-Latif
    Department of Surgery, Trinity Centre for Health Sciences, St James s Hospital, Dublin, Ireland
    J Chemother 17:539-49. 2005
    ..The data suggest that vitamin C supplementation may improve the efficacy of chemotherapy for esophageal cancer...
  27. doi request reprint Metabolic syndrome, central obesity and insulin resistance are associated with adverse pathological features in postmenopausal breast cancer
    L A Healy
    Department of Clinical Nutrition, St James s Hospital and Trinity College Dublin, Ireland
    Clin Oncol (R Coll Radiol) 22:281-8. 2010
    ..These features may cluster in the so-called metabolic syndrome. The relevance of metabolic syndrome to the biology of breast cancer is unknown, and this was the focus of the present study...
  28. ncbi request reprint Comparison of two fractionation regimens in the multimodal therapy of cancer of the esophagus
    L Walshe
    Department of Surgery, St James s Hospital, and Academic Unit of Clinical and Medical Oncology, Trinity College Dublin, Dublin, Ireland
    Dis Esophagus 20:217-24. 2007
    ..There were no significant differences observed between treatment groups, but a trend toward improved efficacy appeared with the increased dose per fraction...
  29. ncbi request reprint Activated nuclear factor-kappa B and cytokine profiles in the esophagus parallel tumor regression following neoadjuvant chemoradiotherapy
    M M M Abdel-Latif
    Department of Clinical Surgery, Trinity Centre for Health Sciences, St James s Hospital, Dublin, Ireland
    Dis Esophagus 18:246-52. 2005
    ..The study suggests that monitoring of molecular and cytokine patterns in patients undergoing this neoadjuvant regimen may help subselect the cohort that derives most benefit from the multimodal approach...
  30. doi request reprint Localized adenocarcinoma of the esophagogastric junction--is there a standard of care?
    D G Power
    Department of Medical Oncology, St James s Hospital, Dublin, Ireland
    Cancer Treat Rev 36:400-9. 2010
    ..Rectal cancer provides an analogous paradigm in this regard. As systemic disease is the primary cause of mortality chemosensitivity should be determined early...
  31. ncbi request reprint Factors influencing the development of Barrett's epithelium in the esophageal remnant postesophagectomy
    J M O'Riordan
    University Department of Surgery, St James Hospital, Dublin 8, Ireland
    Am J Gastroenterol 99:205-11. 2004
    ....
  32. ncbi request reprint Clinicopathologic factors predicting complete pathological response to neoadjuvant chemoradiotherapy in esophageal cancer
    M MacGuill
    Division of Upper Gastrointestinal Surgery, Clinical Medicine, and Academic Unit of Clinical and Medical Oncology, St James s Hospital and Trinity College Dublin, Dublin, Ireland
    Dis Esophagus 19:273-6. 2006
    ..A simpler explanation is that the existing dose and treatment schedule for combination chemoradiotherapy is suboptimal in patients with larger tumors...
  33. doi request reprint Quality of life and survival in patients treated with radical chemoradiation alone for oesophageal cancer
    C M Gillham
    Academic Unit of Clinical and Molecular Oncology, Trinity Centre, St James s Hospital, Dublin, Ireland
    Clin Oncol (R Coll Radiol) 20:227-33. 2008
    ..To report cancer-specific and health-related quality-of-life outcomes in patients undergoing radical chemoradiation (CRT) alone for oesophageal cancer...
  34. pmc An unusual presentation of Boerhaave Syndrome: a case report
    Fardod O'Kelly
    Department of Clinical Surgery, Trinity Centre, Trinity College Dublin and St James s Hospital Dublin 8 Ireland
    Cases J 2:8000. 2009
    ..We present a unique case of Boerhaave Syndrome that may highlight the spectrum of barotrauma from a Mallory-Weiss tear to full-thickness perforation. In this case, perforation only became evident following air insufflation at endoscopy...
  35. doi request reprint Associations between leptin and adiponectin receptor upregulation, visceral obesity and tumour stage in oesophageal and junctional adenocarcinoma
    J M Howard
    Department of Surgery, Trinity College Dublin and St James s Hospital, Dublin, Ireland
    Br J Surg 97:1020-7. 2010
    ..Altered circulating adipocytokines may be important. This study aimed to identify pathways through which visceral fat impacts on tumour biology...
  36. ncbi request reprint Major upper gastrointestinal surgery is associated with an antigen-dependent proinflammatory T cell response
    K J Sweeney
    Department of Clinical Surgery, St James s Hospital and Trinity College Dublin, Dublin 8, Ireland
    Br J Surg 92:989-95. 2005
    ..This study involved a detailed analysis of T cell function in a consecutive cohort of patients undergoing such surgery...
  37. doi request reprint Lack of differential pattern in central adiposity and metabolic syndrome in Barrett's esophagus and gastroesophageal reflux disease
    L A Healy
    Department of Clinical Surgery, St James Hospital and Trinity College, Dublin, Ireland
    Dis Esophagus 23:386-91. 2010
    ..In BE, the importance of obesity and the metabolic syndrome in disease progression merits further study...
  38. ncbi request reprint Pathological and molecular predictors of the response of rectal cancer to neoadjuvant radiochemotherapy
    F M Smith
    University Department of Surgery, St James s Hospital, Dublin, Ireland
    Eur J Surg Oncol 32:55-64. 2006
    ..A neoadjuvant regimen is increasingly the gold standard in rectal cancer management and the aim of this review was to highlight predictive markers currently assessed and evaluate their clinical utility...
  39. doi request reprint Pilot translational study of dietary vitamin C supplementation in Barrett's esophagus
    M Babar
    Department of Clinical Surgery, Trinity Centre for Health Sciences, St James s Hospital, Dublin, Ireland
    Dis Esophagus 23:271-6. 2010
    ..Dietary vitamin C supplementation may down-regulate pro-inflammatory markers in a subset of Barrett's patients. Further studies with larger numbers of endpoints will be needed to further evaluate this effect...
  40. pmc A common p73 polymorphism is associated with a reduced incidence of oesophageal carcinoma
    B M Ryan
    Department of Clinical Medicine and Gastroenterology, St James s Hospital and Trinity College, Dublin 8, Ireland
    Br J Cancer 85:1499-503. 2001
    ..Clinically, this observation could have implications in aiding identification of high-risk Barrett's oesophagus patients...
  41. pmc Endocinch therapy for gastro-oesophageal reflux disease: a one year prospective follow up
    Z Mahmood
    Department of Clinical Medicine, Trinity College, St James s Hospital, Dublin, Ireland
    Gut 52:34-9. 2003
    ..Recently, BARD developed Endocinch, a device used to place sutures just below the oesophagogastric junction (OGJ) to treat GORD...
  42. doi request reprint Association of visceral adiposity with oesophageal and junctional adenocarcinomas
    P Beddy
    Department of Radiology, St James Hospital and Trinity College Dublin, Dublin, Ireland
    Br J Surg 97:1028-34. 2010
    ..This study compared abdominal fat composition in patients with oesophageal/junctional adenocarcinoma with that in patients with oesophageal squamous cell carcinoma and gastric adenocarcinoma, and in controls...
  43. doi request reprint Building a bioresource for esophageal research: lessons from the early experience of an academic medical center
    D P Ennis
    Department of Surgery, Trinity Centre for Health Sciences, St James s Hospital, Trinity College Dublin, Ireland
    Dis Esophagus 23:1-7. 2010
    ..The development and expansion of such repositories, at local and national levels, is required to enable leading academic medical centers and their investigators to provide optimal and molecularly guided care to their patients...
  44. pmc (18)FDG uptake during induction chemoradiation for oesophageal cancer fails to predict histomorphological tumour response
    C M Gillham
    Academic Unit of Clinical and Molecular Oncology, Trinity College Dublin, Trinity Centre, St James s Hospital, Dublin, Republic of Ireland
    Br J Cancer 95:1174-9. 2006
    ..This may reflect an inflammatory effect of radiation that obscures tumour-specific metabolic changes at this time. This assessment may have limited application in predicting response to multimodal regimens for oesophageal cancer...
  45. doi request reprint Outcomes in achalasia from a surgical unit where pneumatic dilatation is first-line therapy
    J M Howard
    Department of Surgery, St James s Hospital, Dublin, Ireland
    Dis Esophagus 23:465-72. 2010
    ..This study suggests that pneumatic dilatation is a safe and effective approach as first-line therapy in patients with newly diagnosed achalasia...
  46. ncbi request reprint Management of gastric lymphoma
    P Balfe
    Department of Surgery, Pathology and Medical Oncology, St James s Hospital and Trinity Colle Dublin, Ireland
    Surgeon 6:262-5. 2008
    ..The aim of this report is to highlight the variety of treatment regimens deployed, the outcomes achieved and to present a modern management approach for this enigmatic tumour...
  47. ncbi request reprint The Rossetti-Nissen fundoplication--effective in managing gastro-oesophageal reflux disease
    P J Byrne
    Trinity College Dublin, St James s Hospital, Ireland
    Surgeon 6:19-24. 2008
    ....
  48. doi request reprint Obesity and gastrointestinal cancer
    C L Donohoe
    Department of Surgery, Trinity Centre for Health Sciences, Trinity College Dublin St James Hospital, Dublin 8, Ireland
    Br J Surg 97:628-42. 2010
    ..There is emerging evidence of a strong association between obesity and gastrointestinal cancer. This review summarizes the evidence from an epidemiological and pathophysiological perspective...
  49. ncbi request reprint D2 lymphadenectomy in the management of gastric cancer
    J A McCullough
    Department of Surgery, St James s Hospital, Dublin, Ireland
    Ir J Med Sci 172:132-5. 2003
    ....
  50. ncbi request reprint Management of gastrointestinal stromal tumours: a single-centre experience
    J Butt
    University Department of Surgery, St James Hospital and Trinity College, Dublin 8, Ireland
    Ir J Med Sci 176:157-60. 2007
    ..The advent of imatinib, a tyrosine kinase inhibitor, has presented a novel and effective therapy in advanced disease. The aim of this study was to present the experience and outcomes of a single centre...
  51. pmc Stab to second intercostal space: a bubbling extrapleural wound
    A Jabbar
    St James Hospital, Dublin, Ireland
    Emerg Med J 22:916-8. 2005
    ..The following day, swelling and discharge indicated oesophageal damage, which was later confirmed by gastrografin swallow. With conservative management in hospital for 2 weeks, he made a full recovery and was discharged...
  52. ncbi request reprint Gastrointestinal stromal tumours
    E M Connolly
    Department of Surgery, St James Hospital and Trinity College Dublin, Dublin 8, Ireland
    Br J Surg 90:1178-86. 2003
    ..GISTs are notoriously unresponsive to chemotherapy and, until the recent introduction of the KIT inhibitor imatinib, there has been no effective therapy for advanced, metastatic disease...
  53. ncbi request reprint Impaired visceral sensitivity to acid reflux in patients with Barrett's esophagus. The role of esophageal motility*
    P J Byrne
    University Departments of Surgery and Medicine, St James s Hospital, Dublin 8, and Trinity College Dublin, Ireland
    Dis Esophagus 16:199-203. 2003
    ..Normal motility in Barrett's esophagus is associated with the poorest sensitivity and the presence of increased acid exposure is required in order to achieve sensitivity levels comparable with GERD patients...
  54. ncbi request reprint Superiority of anti-reflux stent compared with conventional stents in the palliative management of patients with cancer of the lower esophagus and esophago-gastric junction: results of a randomized clinical trial
    C Power
    Departments of Surgery and Gastrointestinal Physiology, Trinity Center for Health Sciences, St James s Hospital, Trinity College Dublin, Dublin 8, Ireland
    Dis Esophagus 20:466-70. 2007
    ..Anti-reflux stents, however, controlled symptomatic and physiologically relevant reflux and should therefore be considered as optimal palliation in this cohort...