A S Perry
Affiliation: Trinity College
- Gene expression and epigenetic discovery screen reveal methylation of SFRP2 in prostate cancerAntoinette S Perry
Prostate Molecular Oncology, Department of Clinical Medicine, Institute of Molecular Medicine, Trinity College Dublin, Ireland
Int J Cancer 132:1771-80. 2013..45, HB = 0.47, and BPH = 0.12). We show that SFRP2 hypermethylation is a common event in prostate cancer. SFRP2 methylation in combination with other epigenetic markers may be a useful biomarker of prostate cancer...
- In silico mining identifies IGFBP3 as a novel target of methylation in prostate cancerA S Perry
Department of Haematology and Academic Unit of Clinical and Molecular Oncology, Institute of Molecular Medicine, St James s Hospital and Trinity College Dublin, Ireland
Br J Cancer 96:1587-94. 2007..Evaluation of further relevant genes could contribute towards a methylation signature of this disease...
- The epigenome as a therapeutic target in prostate cancerAntoinette S Perry
Prostate Molecular Oncology, Trinity Centre for Health Sciences, St James s Hospital, Dublin 8, Ireland
Nat Rev Urol 7:668-80. 2010..Reactivation of tumor-suppressor genes by demethylating agents and histone deacetylase inhibitors could be a potential treatment option for patients with advanced disease...
- The emergence of DNA methylation as a key modulator of aberrant cell death in prostate cancerT M Murphy
Prostate Cancer Research Group, Institute of Molecular Medicine, Trinity College Dublin, Ireland
Endocr Relat Cancer 15:11-25. 2008..We also introduce the concept of an 'apoptotic methylation signature' for prostate cancer and evaluate its potential in a diagnostic, prognostic and therapeutic setting...