Luke A O'Neill

Summary

Affiliation: Trinity College
Country: Ireland

Publications

  1. pmc Blockade of Toll-like receptor 2 prevents spontaneous cytokine release from rheumatoid arthritis ex vivo synovial explant cultures
    Sinéad Nic An Ultaigh
    Department of Rheumatology, St Vincent s University Hospital, Dublin Academic Medical Centre, Elm Park, Dublin 4, Ireland
    Arthritis Res Ther 13:R33. 2011
  2. doi request reprint Cardiolipin and the Nlrp3 inflammasome
    Luke A J O'Neill
    School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland Electronic address
    Cell Metab 18:610-2. 2013
  3. doi request reprint The history of Toll-like receptors - redefining innate immunity
    Luke A J O'Neill
    School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
    Nat Rev Immunol 13:453-60. 2013
  4. doi request reprint Metabolism of inflammation limited by AMPK and pseudo-starvation
    Luke A J O'Neill
    School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland
    Nature 493:346-55. 2013
  5. doi request reprint "Transflammation": when innate immunity meets induced pluripotency
    Luke A J O'Neill
    School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Pearse Street, Trinity College Dublin, Dublin 2, Ireland Electronic address
    Cell 151:471-3. 2012
  6. pmc Toll-like receptors and NOD-like receptors in rheumatic diseases
    William J McCormack
    OPSONA Therapeutics Ltd, Institute of Molecular Medicine, Trinity Centre for Health Sciences, St James Hospital, Dublin 8, Ireland
    Arthritis Res Ther 11:243. 2009
  7. doi request reprint Primer: Toll-like receptor signaling pathways--what do rheumatologists need to know?
    Luke A J O'Neill
    School of Biochemistry and Immunology at Trinity College Dublin, Ireland
    Nat Clin Pract Rheumatol 4:319-27. 2008
  8. doi request reprint Boosting the brain's ability to block inflammation via microRNA-132
    Luke A J O'Neill
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Immunity 31:854-5. 2009
  9. doi request reprint Innate immunity: squelching anti-viral signalling with NLRX1
    Luke A J O'Neill
    School of Biochemistry and Immunology, Trinity College Dublin, Ireland
    Curr Biol 18:R302-4. 2008
  10. doi request reprint The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress
    Luke A J O'Neill
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    Immunol Rev 226:10-8. 2008

Collaborators

Detail Information

Publications61

  1. pmc Blockade of Toll-like receptor 2 prevents spontaneous cytokine release from rheumatoid arthritis ex vivo synovial explant cultures
    Sinéad Nic An Ultaigh
    Department of Rheumatology, St Vincent s University Hospital, Dublin Academic Medical Centre, Elm Park, Dublin 4, Ireland
    Arthritis Res Ther 13:R33. 2011
    ..The aim of this study was to examine the effect of blocking Toll-like receptor 2 (TLR2) in rheumatoid arthritis (RA) synovial cells...
  2. doi request reprint Cardiolipin and the Nlrp3 inflammasome
    Luke A J O'Neill
    School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland Electronic address
    Cell Metab 18:610-2. 2013
    ..Cardiolipin is thus a hydrophobic danger signal that, upon translocation to the outer mitochondrial membrane, activates Nlrp3, promoting inflammation. ..
  3. doi request reprint The history of Toll-like receptors - redefining innate immunity
    Luke A J O'Neill
    School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
    Nat Rev Immunol 13:453-60. 2013
    ..TLRs have a central role in immunity - in this Timeline article, we describe the landmark findings that gave rise to this important field of research...
  4. doi request reprint Metabolism of inflammation limited by AMPK and pseudo-starvation
    Luke A J O'Neill
    School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland
    Nature 493:346-55. 2013
    ..Altered metabolism may thus participate in the signal-directed programs that promote or inhibit inflammation...
  5. doi request reprint "Transflammation": when innate immunity meets induced pluripotency
    Luke A J O'Neill
    School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Pearse Street, Trinity College Dublin, Dublin 2, Ireland Electronic address
    Cell 151:471-3. 2012
    ..A surprising link between innate immunity and nuclear reprogramming is reported by Lee et al.; this discovery may boost the efficiency of stem cell production...
  6. pmc Toll-like receptors and NOD-like receptors in rheumatic diseases
    William J McCormack
    OPSONA Therapeutics Ltd, Institute of Molecular Medicine, Trinity Centre for Health Sciences, St James Hospital, Dublin 8, Ireland
    Arthritis Res Ther 11:243. 2009
    ..These findings present new therapeutic opportunities, possibly allowing for the replacement of biologics with small molecule inhibitors...
  7. doi request reprint Primer: Toll-like receptor signaling pathways--what do rheumatologists need to know?
    Luke A J O'Neill
    School of Biochemistry and Immunology at Trinity College Dublin, Ireland
    Nat Clin Pract Rheumatol 4:319-27. 2008
    ..Inhibition of TLR4, TLR7 and TLR9 has produced intriguing results, which indicate that TLRs and their signaling pathways might indeed have great potential as novel targets for the treatment of inflammatory joint disease...
  8. doi request reprint Boosting the brain's ability to block inflammation via microRNA-132
    Luke A J O'Neill
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Immunity 31:854-5. 2009
    ..In this issue of Immunity, Shaked et al. (2009) describe how miR-132 mediates an anti-inflammatory effect via the targeting of acetylcholinesterase, leading to an increase in the neurotransmitter acetylcholine...
  9. doi request reprint Innate immunity: squelching anti-viral signalling with NLRX1
    Luke A J O'Neill
    School of Biochemistry and Immunology, Trinity College Dublin, Ireland
    Curr Biol 18:R302-4. 2008
    ..Recent work has identified that NLRX1, a member of another class of innate immune receptors, sequesters MAVS away from RIG-I and thereby prevents mitochondrial anti-viral immunity...
  10. doi request reprint The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress
    Luke A J O'Neill
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    Immunol Rev 226:10-8. 2008
    ..This area has therefore proved very fruitful in terms of improving our knowledge of the molecular basis for innate immunity and inflammation, and we can anticipate further discoveries in the coming years...
  11. pmc Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer
    Luke A J O'Neill
    School of Biochemistry and Immunology, Trinity College Dublin, Ireland
    Pharmacol Rev 61:177-97. 2009
    ..Here we review these recent advances and speculate about whether manipulating TLRs is likely to be successful in fighting off different diseases...
  12. doi request reprint When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction
    Luke A J O'Neill
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Immunity 29:12-20. 2008
    ..These recent findings emphasize the importance of considering TLR signaling in the context of other signaling pathways, as is likely to occur in vivo during infection and inflammation...
  13. doi request reprint DNA makes RNA makes innate immunity
    Luke A J O'Neill
    School of Biochemistry and Immunology, Trinity College Dublin, College Green, Dublin 2, Ireland
    Cell 138:428-30. 2009
    ..Chiu et al. (2009) now implicate cytosolic DNA-dependent RNA polymerase III as the DNA sensor linking DNA release by pathogenic bacteria and viruses in the host cell cytosol to IFN-beta production and innate immunity...
  14. doi request reprint Sensing and signaling in antiviral innate immunity
    Luke A J O'Neill
    Immunology Research Centre, School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Curr Biol 20:R328-33. 2010
    ..Furthermore, new complexities in the signaling pathways activated by these receptors continue to be revealed. Together, these new insights are leading to therapeutically useful information in the fight against viruses...
  15. doi request reprint Stopping sepsis by targeting sphingosine kinase 1
    Luke A J O'Neill
    School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    Sci Transl Med 2:36ps29. 2010
    ....
  16. doi request reprint Counter-regulation in the IKK family
    Luke A J O'Neill
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    Biochem J 434:e1-2. 2011
    ....
  17. doi request reprint MicroRNAs: the fine-tuners of Toll-like receptor signalling
    Luke A O'Neill
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    Nat Rev Immunol 11:163-75. 2011
    ..miRNAs are also proving to be an important link between the innate and adaptive immune systems, and their dysregulation might have a role in the pathogenesis of inflammatory diseases...
  18. doi request reprint A critical role for citrate metabolism in LPS signalling
    Luke A J O'Neill
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland Email
    Biochem J 438:e5-6. 2011
    ..This somewhat unexpected role for citrate in LPS action adds to a growing literature on the role for metabolism in the regulation of signalling in inflammation...
  19. ncbi request reprint The powerstroke and camshaft of the RIG-I antiviral RNA detection machine
    Luke A J O'Neill
    Immunology Research Centre, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland
    Cell 147:259-61. 2011
    ..2011) and Luo et al. (2011) reveal the structure of RIG-I, and in combination with functional analyses, they show how RIG-I recognizes viral RNA to initiate signaling and a type I interferon response...
  20. ncbi request reprint TAMpering with toll-like receptor signaling
    Luke A J O'Neill
    School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    Cell 131:1039-41. 2007
    ..2007) uncover a complex negative feedback mechanism to limit TLR signaling involving the Tyro3/Axl/Mer (TAM) family of receptor tyrosine kinases, which induce expression of the inhibitory proteins SOCS1 and SOCS3...
  21. ncbi request reprint The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
    Luke A J O'Neill
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Nat Rev Immunol 7:353-64. 2007
    ..These new insights allow for a detailed description of the function of the five TIR-domain-containing adaptors in the initiation of TLR signalling...
  22. ncbi request reprint The Toll-IL-1 receptor adaptor family grows to five members
    Luke A J O'Neill
    Cytokine Research Group, Department of Biochemistry, Trinity College, Dublin, Ireland
    Trends Immunol 24:286-90. 2003
    ..It is probable that differential use of adaptors will help explain the distinct pathways activated by TLRs during host defence...
  23. ncbi request reprint Toll-like receptor signal transduction and the tailoring of innate immunity: a role for Mal?
    Luke A J O'Neill
    Dept of Biochemistry, Trinity College, Dublin, Ireland
    Trends Immunol 23:296-300. 2002
    ..These findings may ultimately explain how dendritic cells control specific T-cell responses...
  24. ncbi request reprint The role of MyD88-like adapters in Toll-like receptor signal transduction
    L A J O'Neill
    Department of Biochemistry, Trinity College Dublin, Ireland
    Biochem Soc Trans 31:643-7. 2003
    ..However, signals that separate Mal from MyD88 have yet to emerge, although biochemical differences between the two proteins imply that each will have a specific function...
  25. ncbi request reprint Mal and MyD88: adapter proteins involved in signal transduction by Toll-like receptors
    Luke A J O'Neill
    Department of Biochemistry, Trinity College Dublin, Ireland
    J Endotoxin Res 9:55-9. 2003
    ..Future studies on Mal will reveal specificities in signal transduction by different TLRs, which may ultimately provide molecular explanations for specificities in the innate immune response to infection...
  26. ncbi request reprint How Toll-like receptors signal: what we know and what we don't know
    Luke A J O'Neill
    School of Biochemistry and Immunology, Trinity College Dublin, Ireland
    Curr Opin Immunol 18:3-9. 2006
    ..Selective targeting of pathways by anti-inflammatory glucocorticoids also indicates the potential for modulating TLR signalling therapeutically...
  27. ncbi request reprint Targeting signal transduction as a strategy to treat inflammatory diseases
    Luke A J O'Neill
    School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    Nat Rev Drug Discov 5:549-63. 2006
    ..The challenge is to place a value on one target relative to another, and to devise strategies to modulate them...
  28. ncbi request reprint Therapeutic targeting of Toll-like receptors for inflammatory and infectious diseases
    Luke A J O'Neill
    Cytokine Research Group, Department of Biochemistry, Trinity College Dublin, Ireland
    Curr Opin Pharmacol 3:396-403. 2003
    ..As we learn more about TLR signal transduction, more options are presenting themselves for pharmacological targeting...
  29. ncbi request reprint The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense
    L A O'Neill
    Department of Biochemistry and Biotechnology Institute, Trinity College, Dublin, Ireland
    Sci STKE 2000:re1. 2000
    ..The signaling proteins activated are also conserved across species. This receptor superfamily therefore represents an ancient signaling system that is a critical determinant of the innate immune and inflammatory responses...
  30. ncbi request reprint The Toll/interleukin-1 receptor domain: a molecular switch for inflammation and host defence
    L O'Neill
    Department of Biochemistry, Trinity College Dublin, Ireland
    Biochem Soc Trans 28:557-63. 2000
    ..This receptor superfamily therefore appears to play a central role in inflammation and host defence against infection, pointing to the TIR domain as a critical molecular player in the innate immune response...
  31. ncbi request reprint Signal transduction pathways activated by the IL-1 receptor/toll-like receptor superfamily
    L A J O'Neill
    Department of Biochemistry, Trinity College Dublin, Ireland
    Curr Top Microbiol Immunol 270:47-61. 2002
    ..Future studies on TLR signalling may reveal hitherto unsuspected specificities in the innate immune response to infection...
  32. pmc Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence
    Julianne Stack
    Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Exp Med 201:1007-18. 2005
    ..Importantly, VV lacking the A46R gene was attenuated in a murine intranasal model, demonstrating the importance of A46R for VV virulence...
  33. doi request reprint MicroRNAs and the resolution phase of inflammation in macrophages
    Muhammad M Alam
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    Eur J Immunol 41:2482-5. 2011
    ..Importantly, their dysregualtion may be important for chronic inflammation, which in turn can lead to autoimmunity and cancer, as discussed in this Viewpoint...
  34. doi request reprint Viral evasion and subversion of pattern-recognition receptor signalling
    Andrew G Bowie
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Nat Rev Immunol 8:911-22. 2008
    ....
  35. ncbi request reprint The role of Toll-like receptors in the host response to viruses
    Andrew G Bowie
    Department of Biochemistry, Trinity College, Dublin 2, Ireland
    Mol Immunol 42:859-67. 2005
    ..Secondly, TLRs trigger anti-viral signalling pathways leading to the induction of the interferon response. Thirdly, viral immune strategies employed against TLRs have been identified...
  36. doi request reprint Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule
    Tatyana Lysakova-Devine
    Immunology Research Centre, School of Biochemistry and Immunology, Trinity College Dublin, Ireland
    J Immunol 185:4261-71. 2010
    ..Overall, we demonstrate for the first time disruption of a specific TLR signaling pathway by a short virally derived peptide...
  37. ncbi request reprint Viral inhibition of IL-1- and neutrophil elastase-induced inflammatory responses in bronchial epithelial cells
    Tomas P Carroll
    Respiratory Research Division, Royal College of Surgeons in Ireland, Education and Research Center, Beaumont Hospital, Dublin, Ireland
    J Immunol 175:7594-601. 2005
    ..These findings identify vaccinia virus proteins as possible therapeutic agents for the manifestations of several inflammatory lung diseases...
  38. doi request reprint Insights from vaccinia virus into Toll-like receptor signalling proteins and their regulation by ubiquitin: role of IRAK-2
    Andrew G Bowie
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Biochem Soc Trans 36:449-52. 2008
    ..Further, I demonstrate how understanding one molecular mechanism whereby vaccinia virus inhibits NF-kappaB activation has led to a revealing of a key role for IRAK-2 in TRAF-6-mediated NF-kappaB activation...
  39. doi request reprint TRIM-ing down Tolls
    Andrew G Bowie
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Nat Immunol 9:348-50. 2008
  40. doi request reprint Evaluating the role of Toll-like receptors in diseases of the central nervous system
    Michael Carty
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Biochem Pharmacol 81:825-37. 2011
    ..This review aims to examine the recent literature on TLRs in the CNS thus demonstrating their importance in a range of infectious and non-infectious diseases of the brain...
  41. ncbi request reprint IRAK-4: a new drug target in inflammation, sepsis, and autoimmunity
    Claudia Wietek
    Department of Biochemistry, Trinity College, Dublin 2, Ireland
    Mol Interv 2:212-5. 2002
  42. doi request reprint miR-107: a toll-like receptor-regulated miRNA dysregulated in obesity and type II diabetes
    Niamh H Foley
    School of Biochemistry and Immunology, Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland
    J Leukoc Biol 92:521-7. 2012
    ..If this process is impaired, disease, such as T2D, might persist. This review aims to discuss a possible link between the molecular phenomena of obesity and inflammation and the role that miR-107 may contribute to these processes...
  43. ncbi request reprint Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NFkappaB activation by lipopolysaccharide
    Sarah L Doyle
    Department of Biochemistry and Biotechnology Institute, Trinity College, Dublin 2, Ireland
    J Biol Chem 280:23496-501. 2005
    ..This study therefore reveals a novel function for Btk. It is required for the signaling pathway activated by TLR4, which culminates in phosphorylation of p65 on serine 536 promoting transactivation by NFkappaB...
  44. doi request reprint A trio of microRNAs that control Toll-like receptor signalling
    Susan R Quinn
    School of Biochemistry and Immunology, Trinity College Dublin, Ireland
    Int Immunol 23:421-5. 2011
    ..In this review, we focus in on a trio of miRNA which have proven to be key in many immune and inflammatory pathways; miR-155, miR-21 and miR-146...
  45. ncbi request reprint Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptors
    Gary DiPerna
    Viral Immune Evasion Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Biol Chem 279:36570-8. 2004
    ..Furthermore, N1L inhibited IRF3 signaling, which is also regulated by TBK1. These studies define a role for N1L as an immunomodulator of innate immunity by targeting components of NF-kappaB and IRF3 signaling pathways...
  46. doi request reprint Activation of host pattern recognition receptors by viruses
    Kiva Brennan
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Curr Opin Microbiol 13:503-7. 2010
    ..Another novel mechanism of viral DNA recognition unveiled, leading to proinflammatory cytokine production, involves the PYHIN family member AIM2...
  47. pmc Nuclear factor κB2 p52 protein has a role in antiviral immunity through IκB kinase epsilon-dependent induction of Sp1 protein and interleukin 15
    Sarah L Doyle
    Immunology Research Centre, Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 288:25066-75. 2013
    ..Our study identifies NFκB2 as a target for IKKε in antiviral immunity and describes, for the first time, a role for NFκB2 in the regulation of gene expression in response to viral infection. ..
  48. pmc Detecting microRNA activity from gene expression data
    Stephen F Madden
    School of Medicine and Medical Science, Conway Institute, University College Dublin, Dublin, Ireland
    BMC Bioinformatics 11:257. 2010
    ..In this study we used predicted miRNA-gene interactions to analyse mRNA gene expression microarray data to predict miRNAs associated with particular diseases or conditions...
  49. ncbi request reprint The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling
    Michael Carty
    School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    Nat Immunol 7:1074-81. 2006
    ..Thus, the fifth mammalian TIR adaptor SARM is a negative regulator of Toll-like receptor signaling...
  50. ncbi request reprint Modulation of innate immune signalling pathways by viral proteins
    Orla Mulhern
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    Adv Exp Med Biol 666:49-63. 2009
    ..In this chapter we outline the signalling pathways that respond to viral infection and the various methods that viruses utilize to evade detection and modulate the innate immune response to favour their survival...
  51. doi request reprint Mal, more than a bridge to MyD88
    Nicholas J Bernard
    Trinity Biomedical Sciences Institute, Trinity College, Dublin 2, Ireland
    IUBMB Life 65:777-86. 2013
    ....
  52. doi request reprint Tribbles 3: a novel regulator of TLR2-mediated signaling in response to Helicobacter pylori lipopolysaccharide
    Sinead M Smith
    Department of Clinical Medicine, Trinity College Dublin, Dublin 8, Ireland
    J Immunol 186:2462-71. 2011
    ..pylori LPS. Thus, modulation of TRIB3 by H. pylori and/or its products may be an important mechanism during H. pylori-associated pathogenesis...
  53. ncbi request reprint IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination
    Sinead E Keating
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 282:33435-43. 2007
    ..Further, IRAK-2 loss-of-function mutants, which could not activate NFkappaB, were incapable of promoting TRAF6 ubiquitination. Thus we propose that IRAK-2 plays a more central role than IRAK-1 in TLR signaling to NFkappaB...
  54. pmc IFI16 is an innate immune sensor for intracellular DNA
    Leonie Unterholzner
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    Nat Immunol 11:997-1004. 2010
    ..IFI16 (p204) is the first PYHIN protein to our knowledge shown to be involved in IFN-β induction. Thus, the PYHIN proteins IFI16 and AIM2 form a new family of innate DNA sensors we call 'AIM2-like receptors' (ALRs)...
  55. pmc Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation
    Martina Schröder
    Viral Immune Evasion Group, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    EMBO J 27:2147-57. 2008
    ..Therefore, this study shows for the first time the involvement of a DEAD box helicase in TBK1/IKKepsilon-mediated IRF activation and Ifnb promoter induction...
  56. ncbi request reprint TLR3 in antiviral immunity: key player or bystander?
    Martina Schröder
    Viral Immune Evasion Group, Department of Biochemistry, Trinity College Dublin, College Green, Dublin 2, Ireland
    Trends Immunol 26:462-8. 2005
    ..Also, recent research concerning the expression profile of TLR3, its evasion by viruses and a potential role in crosspriming is addressed, which reveals a clearer appreciation of the contribution of TLR3 to antiviral immunity...
  57. ncbi request reprint Vaccinia virus protein A52R activates p38 mitogen-activated protein kinase and potentiates lipopolysaccharide-induced interleukin-10
    Geraldine Maloney
    Viral Immune Evasion Group, School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 280:30838-44. 2005
    ..A52R-mediated enhancement of TLR-induced IL-10 may be important to virulence, given the role of IL-10 in immunoregulation...
  58. ncbi request reprint The interplay between viruses and innate immune signaling: recent insights and therapeutic opportunities
    Leonie Unterholzner
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Biochem Pharmacol 75:589-602. 2008
    ..Further, the viral proteins themselves or derivatives of them may be of use therapeutically to curtail inflammation and autoimmunity...
  59. doi request reprint Unexpected roles for DEAD-box protein 3 in viral RNA sensing pathways
    Orla Mulhern
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Eur J Immunol 40:933-5. 2010
    ..This further emphasises the importance of DDX3 in anti-viral immunity, and is consistent with the idea that viruses target DDX3 for immune evasion...
  60. ncbi request reprint Viral appropriation of apoptotic and NF-kappaB signaling pathways
    Andrew G Bowie
    Viral Immune Evasion Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Cell Biochem 91:1099-108. 2004
    ..Here, modulation of apoptotic and NF-kappaB signal transduction pathways are examined as examples of common pathways appropriated in contrasting ways by herpesviruses and poxviruses...
  61. doi request reprint Characterisation of viral proteins that inhibit Toll-like receptor signal transduction
    Julianne Stack
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Methods Mol Biol 517:217-35. 2009
    ..Again, complexes recovered from the beads are analysed by Western blotting...