Niamh M O'Boyle

Summary

Affiliation: Trinity College
Country: Ireland

Publications

  1. doi request reprint Analogues of the epoxy resin monomer diglycidyl ether of bisphenol F: effects on contact allergenic potency and cytotoxicity
    Niamh M O'Boyle
    Department of Chemistry and Molecular Biology, Dermatochemistry and Skin Allergy, University of Gothenburg, SE 412 96 Gothenburg, Sweden
    Chem Res Toxicol 25:2469-78. 2012
  2. doi request reprint Synthesis and biochemical activities of antiproliferative amino acid and phosphate derivatives of microtubule-disrupting β-lactam combretastatins
    Niamh M O'Boyle
    School of Pharmacy and Pharmaceutical Sciences, Centre for Synthesis and Chemical Biology, Trinity College Dublin, Dublin 2, Ireland
    Eur J Med Chem 62:705-21. 2013
  3. ncbi request reprint Designed multiple ligands for cancer therapy
    N M O'Boyle
    School of Pharmacy and Pharmaceutical Sciences, Panoz Institute, Trinity College Dublin, Dublin 2, Ireland
    Curr Med Chem 18:4722-37. 2011
  4. doi request reprint Lead identification of β-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90
    Niamh M O'Boyle
    School of Pharmacy and Pharmaceutical Sciences, Centre for Synthesis and Chemical Biology, Trinity College Dublin, Dublin 2, Ireland
    Bioorg Med Chem 19:6055-68. 2011
  5. doi request reprint Synthesis, biochemical and molecular modelling studies of antiproliferative azetidinones causing microtubule disruption and mitotic catastrophe
    Niamh M O'Boyle
    School of Pharmacy and Pharmaceutical Sciences, Centre for Synthesis and Chemical Biology, Trinity College Dublin, Dublin 2, Ireland
    Eur J Med Chem 46:4595-607. 2011
  6. doi request reprint Synthesis, evaluation and structural studies of antiproliferative tubulin-targeting azetidin-2-ones
    Niamh M O'Boyle
    School of Pharmacy and Pharmaceutical Sciences, Centre for Synthesis and Chemical Biology, Trinity College Dublin, Dublin 2, Ireland
    Bioorg Med Chem 19:2306-25. 2011
  7. doi request reprint Combretazet-3 a novel synthetic cis-stable combretastatin A-4-azetidinone hybrid with enhanced stability and therapeutic efficacy in colon cancer
    Lisa M Greene
    School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
    Oncol Rep 29:2451-8. 2013
  8. doi request reprint Synthesis and evaluation of azetidinone analogues of combretastatin A-4 as tubulin targeting agents
    Niamh M O'Boyle
    School of Pharmacy and Pharmaceutical Sciences, Centre for Synthesis and Chemical Biology, Trinity College Dublin, Dublin 2, Ireland
    J Med Chem 53:8569-84. 2010
  9. doi request reprint Novel cis-restricted β-lactam combretastatin A-4 analogues display anti-vascular and anti-metastatic properties in vitro
    Seema Maria Nathwani
    School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
    Oncol Rep 29:585-94. 2013
  10. doi request reprint The vascular targeting agent combretastatin-A4 and a novel cis-Restricted {beta}-Lactam Analogue, CA-432, induce apoptosis in human chronic myeloid leukemia cells and ex vivo patient samples including those displaying multidrug resistance
    Lisa M Greene
    School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    J Pharmacol Exp Ther 335:302-13. 2010

Detail Information

Publications12

  1. doi request reprint Analogues of the epoxy resin monomer diglycidyl ether of bisphenol F: effects on contact allergenic potency and cytotoxicity
    Niamh M O'Boyle
    Department of Chemistry and Molecular Biology, Dermatochemistry and Skin Allergy, University of Gothenburg, SE 412 96 Gothenburg, Sweden
    Chem Res Toxicol 25:2469-78. 2012
    ..In contrast, it was found that the cytotoxicity in monolayer cell culture was dependent not only on the presence of epoxide groups but also on other structural features...
  2. doi request reprint Synthesis and biochemical activities of antiproliferative amino acid and phosphate derivatives of microtubule-disrupting β-lactam combretastatins
    Niamh M O'Boyle
    School of Pharmacy and Pharmaceutical Sciences, Centre for Synthesis and Chemical Biology, Trinity College Dublin, Dublin 2, Ireland
    Eur J Med Chem 62:705-21. 2013
    ..Due to their aqueous solubility and potent biochemical effects, these compounds are promising candidates for further development as microtubule-disrupting agents...
  3. ncbi request reprint Designed multiple ligands for cancer therapy
    N M O'Boyle
    School of Pharmacy and Pharmaceutical Sciences, Panoz Institute, Trinity College Dublin, Dublin 2, Ireland
    Curr Med Chem 18:4722-37. 2011
    ..The review also provides brief commentaries on the biological processes and proteins that are currently targeted in cancer therapy and the potential for dual or triple targeting of these with designed multiple ligands...
  4. doi request reprint Lead identification of β-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90
    Niamh M O'Boyle
    School of Pharmacy and Pharmaceutical Sciences, Centre for Synthesis and Chemical Biology, Trinity College Dublin, Dublin 2, Ireland
    Bioorg Med Chem 19:6055-68. 2011
    ..6 μM, 14.5 μM, and 22.1 μM, respectively. The binding affinity displayed by these compounds positions them as lead compounds for the design of future inhibitors of heat shock protein 90 based on the β-lactam and imine templates...
  5. doi request reprint Synthesis, biochemical and molecular modelling studies of antiproliferative azetidinones causing microtubule disruption and mitotic catastrophe
    Niamh M O'Boyle
    School of Pharmacy and Pharmaceutical Sciences, Centre for Synthesis and Chemical Biology, Trinity College Dublin, Dublin 2, Ireland
    Eur J Med Chem 46:4595-607. 2011
    ..Additionally, mitotic catastrophe for combretastatin A-4 and for 26 was demonstrated in breast cancer cells for the first time, as evidenced by the formation of giant, multinucleated cells...
  6. doi request reprint Synthesis, evaluation and structural studies of antiproliferative tubulin-targeting azetidin-2-ones
    Niamh M O'Boyle
    School of Pharmacy and Pharmaceutical Sciences, Centre for Synthesis and Chemical Biology, Trinity College Dublin, Dublin 2, Ireland
    Bioorg Med Chem 19:2306-25. 2011
    ..37 μM) confirmed that the molecular target of this series of compounds is tubulin. These novel 3-(thienyl) β-lactam antiproliferative agents are useful scaffolds for the development of tubulin-targeting drugs...
  7. doi request reprint Combretazet-3 a novel synthetic cis-stable combretastatin A-4-azetidinone hybrid with enhanced stability and therapeutic efficacy in colon cancer
    Lisa M Greene
    School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
    Oncol Rep 29:2451-8. 2013
    ..Our results suggest that combretastatin-azetidinone hybrids represent an effective novel therapy for the treatment of combretastatin resistant carcinomas...
  8. doi request reprint Synthesis and evaluation of azetidinone analogues of combretastatin A-4 as tubulin targeting agents
    Niamh M O'Boyle
    School of Pharmacy and Pharmaceutical Sciences, Centre for Synthesis and Chemical Biology, Trinity College Dublin, Dublin 2, Ireland
    J Med Chem 53:8569-84. 2010
    ..These novel β-lactam compounds are identified as potentially useful scaffolds for the further development of antitumor agents that target tubulin...
  9. doi request reprint Novel cis-restricted β-lactam combretastatin A-4 analogues display anti-vascular and anti-metastatic properties in vitro
    Seema Maria Nathwani
    School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
    Oncol Rep 29:585-94. 2013
    ....
  10. doi request reprint The vascular targeting agent combretastatin-A4 and a novel cis-Restricted {beta}-Lactam Analogue, CA-432, induce apoptosis in human chronic myeloid leukemia cells and ex vivo patient samples including those displaying multidrug resistance
    Lisa M Greene
    School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    J Pharmacol Exp Ther 335:302-13. 2010
    ..In summary, synthetic intrinsically stable analogs of CA-4 that display significant clinical potential as antileukemic agents have been designed and synthesized...
  11. doi request reprint The vascular targeting agent Combretastatin-A4 directly induces autophagy in adenocarcinoma-derived colon cancer cells
    Lisa M Greene
    School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    Biochem Pharmacol 84:612-24. 2012
    ..Results presented within demonstrate that autophagy is a novel response to combretastatin exposure and may be manipulated to enhance the therapeutic efficacy of this class of vascular targeting agents...
  12. ncbi request reprint Epoxy resin monomers with reduced skin sensitizing potency
    Niamh M O'Boyle
    Department of Chemistry and Molecular Biology, Dermatochemistry and Skin Allergy, University of Gothenburg, SE 412 96 Gothenburg, Sweden
    Chem Res Toxicol 27:1002-10. 2014
    ....