Liam Nestor

Summary

Affiliation: Trinity College Institute for Neuroscience, Trinity College Dublin
Location: Dublin, Ireland
Summary:
Researcher in cognitive neuroscience, investigating drugs of addiction (e.g., cannabis, nicotine) on neural networks using functional MRI (fMRI). Particular interest in using fMRI to map the impact of pharmacological agents upon neural networks potentially disrupted in addiction.
Publications:
Liam J. Nestor, Dara G. Ghahremani, John Monterosso, and Edythe D. London (2011). Prefrontal hypoactivation during cognitive control in early abstinent methamphetamine-dependent subjects. Psychiatry Research: Neuroimaging, 194(3), 287-95

Liam Nestor, Ella McCabe, Jennifer Jones, Luke Clancy, Hugh Garavan (2011). Differences in “bottom-up” and “top-down” neural activity in current and former cigarette smokers: Evidence for neural substrates which may promote nicotine abstinence through increased cognitive control. Neuroimage, 56(4), 2258-2275.

Zorick, T., Nestor, L., Miotto, K., Sugar, C., Hellemann, G., Scanlon, G., et al. (2010). Withdrawal symptoms in abstinent methamphetamine-dependent subjects. Addiction, 105(10), 1809-1818.

Azizian, A., Nestor, L. J., Payer, D., Monterosso, J. R., Brody, A. L., & London, E. D. (2010). Smoking reduces conflict-related anterior cingulate activity in abstinent cigarette smokers performing a Stroop task. Neuropsychopharmacology, 35(3), 775-782.

Nestor, L., Hester, R., & Garavan, H. (2010). Increased ventral striatal BOLD activity during non-drug reward anticipation in cannabis users. Neuroimage, 49(1), 1133-1143.

Roberts, G. M., Nestor, L., & Garavan, H. (2009). Learning and memory deficits in ecstasy users and their neural correlates during a face-learning task. Brain Res, 1292, 71-81.

Hester, R., Nestor, L., & Garavan, H. (2009). Impaired error awareness and anterior cingulate cortex hypoactivity in chronic cannabis users. Neuropsychopharmacology, 34(11), 2450-2458.

Nestor, L., Roberts, G., Garavan, H., & Hester, R. (2008). Deficits in learning and memory: parahippocampal hyperactivity and frontocortical hypoactivity in cannabis users. Neuroimage, 40(3), 1328-1339.

Lintzeris, N., Mitchell, T. B., Bond, A. J., Nestor, L., & Strang, J. (2007). Pharmacodynamics of diazepam co-administered with methadone or buprenorphine under high dose conditions in opioid dependent patients. Drug Alcohol Depend, 91(2-3), 187-194.

Lintzeris, N., Mitchell, T. B., Bond, A., Nestor, L., & Strang, J. (2006). Interactions on mixing diazepam with methadone or buprenorphine in maintenance patients. J Clin Psychopharmacol, 26(3), 274-283.

Newton, T. F., De La Garza, R., 2nd, Kalechstein, A. D., & Nestor, L. (2005). Cocaine and methamphetamine produce different patterns of subjective and cardiovascular effects. Pharmacol Biochem Behav, 82(1), 90-97.

Newton, T. F., Kalechstein, A. D., Hardy, D. J., Cook, I. A., Nestor, L., Ling, W., et al. (2004). Association between quantitative EEG and neurocognition in methamphetamine-dependent volunteers. Clin Neurophysiol, 115(1), 194-198.

Publications

  1. ncbi Association between quantitative EEG and neurocognition in methamphetamine-dependent volunteers
    Thomas F Newton
    Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute, UCLA School of Medicine, Room A7 372, 760 Westwood Plaza, Los Angeles, CA 90024, USA
    Clin Neurophysiol 115:194-8. 2004
  2. ncbi Smoking reduces conflict-related anterior cingulate activity in abstinent cigarette smokers performing a Stroop task
    Allen Azizian
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
    Neuropsychopharmacology 35:775-82. 2010
  3. ncbi Increased ventral striatal BOLD activity during non-drug reward anticipation in cannabis users
    Liam Nestor
    School of Psychology and Institute of Neuroscience, Trinity College Dublin, Ireland
    Neuroimage 49:1133-43. 2010
  4. ncbi Learning and memory deficits in ecstasy users and their neural correlates during a face-learning task
    Gloria M P Roberts
    School of Psychology and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    Brain Res 1292:71-81. 2009
  5. ncbi Impaired error awareness and anterior cingulate cortex hypoactivity in chronic cannabis users
    Robert Hester
    Department of Psychology, University of Melbourne, Melbourne, Victoria, Australia
    Neuropsychopharmacology 34:2450-8. 2009
  6. ncbi Deficits in learning and memory: parahippocampal hyperactivity and frontocortical hypoactivity in cannabis users
    Liam Nestor
    Department of Psychology and Institute of Neuroscience, Trinity College, University of Dublin, Ireland
    Neuroimage 40:1328-39. 2008
  7. ncbi Pharmacodynamics of diazepam co-administered with methadone or buprenorphine under high dose conditions in opioid dependent patients
    Nicholas Lintzeris
    National Addiction Centre, Institute of Psychiatry, Kings College London, and South London and Maudsley NHS Trust, P O Box 48, 4 Windsor Walk, Denmark Hill, London SE5 8AF, United Kingdom
    Drug Alcohol Depend 91:187-94. 2007
  8. ncbi Interactions on mixing diazepam with methadone or buprenorphine in maintenance patients
    Nicholas Lintzeris
    National Addiction Center, Institute of Psychiatry, King s College London, London, England
    J Clin Psychopharmacol 26:274-83. 2006
  9. ncbi Cocaine and methamphetamine produce different patterns of subjective and cardiovascular effects
    Thomas F Newton
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Semel Institute for Neuroscience and Human Behavior, Room A7 372, 740 Westwood Plaza, Los Angeles, CA 90024, USA
    Pharmacol Biochem Behav 82:90-7. 2005
  10. ncbi Withdrawal symptoms in abstinent methamphetamine-dependent subjects
    Todd Zorick
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Addiction 105:1809-18. 2010

Detail Information

Publications10

  1. ncbi Association between quantitative EEG and neurocognition in methamphetamine-dependent volunteers
    Thomas F Newton
    Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute, UCLA School of Medicine, Room A7 372, 760 Westwood Plaza, Los Angeles, CA 90024, USA
    Clin Neurophysiol 115:194-8. 2004
    ..Exposure to methamphetamine is associated with long-lasting reductions in markers for dopaminergic neurons in preclinical models and in humans. These changes may be associated with alterations in brain electrical activity and in cognition...
  2. ncbi Smoking reduces conflict-related anterior cingulate activity in abstinent cigarette smokers performing a Stroop task
    Allen Azizian
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
    Neuropsychopharmacology 35:775-82. 2010
    ..Resumption of smoking may enhance cognitive control in smokers, involving a reduction in ACC response conflict activity together with improvement in conflict resolution involving the dorsolateral prefrontal cortex...
  3. ncbi Increased ventral striatal BOLD activity during non-drug reward anticipation in cannabis users
    Liam Nestor
    School of Psychology and Institute of Neuroscience, Trinity College Dublin, Ireland
    Neuroimage 49:1133-43. 2010
    ....
  4. ncbi Learning and memory deficits in ecstasy users and their neural correlates during a face-learning task
    Gloria M P Roberts
    School of Psychology and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    Brain Res 1292:71-81. 2009
    ..These ecstasy-specific effects may be related to the vulnerability of isocortical and allocortical regions to the neurotoxic effects of ecstasy...
  5. ncbi Impaired error awareness and anterior cingulate cortex hypoactivity in chronic cannabis users
    Robert Hester
    Department of Psychology, University of Melbourne, Melbourne, Victoria, Australia
    Neuropsychopharmacology 34:2450-8. 2009
    ....
  6. ncbi Deficits in learning and memory: parahippocampal hyperactivity and frontocortical hypoactivity in cannabis users
    Liam Nestor
    Department of Psychology and Institute of Neuroscience, Trinity College, University of Dublin, Ireland
    Neuroimage 40:1328-39. 2008
    ..Hypoactivity in frontal and temporal cortices, and relative hyperactivity in the parahippocampus identify functional deficits and compensatory processes in cannabis users...
  7. ncbi Pharmacodynamics of diazepam co-administered with methadone or buprenorphine under high dose conditions in opioid dependent patients
    Nicholas Lintzeris
    National Addiction Centre, Institute of Psychiatry, Kings College London, and South London and Maudsley NHS Trust, P O Box 48, 4 Windsor Walk, Denmark Hill, London SE5 8AF, United Kingdom
    Drug Alcohol Depend 91:187-94. 2007
    ..Benzodiazepine abuse is common among methadone- and buprenorphine-maintained patients; however interactions between these drugs under high dose conditions have not been adequately examined under controlled conditions...
  8. ncbi Interactions on mixing diazepam with methadone or buprenorphine in maintenance patients
    Nicholas Lintzeris
    National Addiction Center, Institute of Psychiatry, King s College London, London, England
    J Clin Psychopharmacol 26:274-83. 2006
    ..Diazepam may significantly alter the response to opioid substitution treatment with methadone or buprenorphine...
  9. ncbi Cocaine and methamphetamine produce different patterns of subjective and cardiovascular effects
    Thomas F Newton
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Semel Institute for Neuroscience and Human Behavior, Room A7 372, 740 Westwood Plaza, Los Angeles, CA 90024, USA
    Pharmacol Biochem Behav 82:90-7. 2005
    ..We predict that these differences may impact drug use and relapse patterns, and may have implications in medications development for these addictive disorders...
  10. ncbi Withdrawal symptoms in abstinent methamphetamine-dependent subjects
    Todd Zorick
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Addiction 105:1809-18. 2010
    ..g. depression, psychosis) persist beyond a month of abstinence...