Research Topics
Genomes and Genes | Derek W MorrisSummaryAffiliation: Trinity College Country: Ireland Publications
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Publications
Dysbindin (DTNBP1) and the biogenesis of lysosome-related organelles complex 1 (BLOC-1): main and epistatic gene effects are potential contributors to schizophrenia susceptibilityDerek W Morris
Neuropsychiatric Genetics Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College, Dublin, Ireland
Biol Psychiatry 63:24-31. 2008....- No evidence for association of the dysbindin gene [DTNBP1] with schizophrenia in an Irish population-based studyDerek W Morris
Neuropsychiatric Genetics Group, Department of Genetics, Trinity College, 2, Dublin, Ireland
Schizophr Res 60:167-72. 2003..No evidence was found to suggest an association between the DTNBP1 gene and schizophrenia in our sample. Possible reasons for these findings are discussed... - Confirming RGS4 as a susceptibility gene for schizophreniaDerek W Morris
Neuropsychiatric Genetics Group, Department of Genetics, Trinity College, Dublin, Ireland
Am J Med Genet B Neuropsychiatr Genet 125:50-3. 2004..The same haplotype is in excess in the Caucasian schizophrenia sample used by Chowdari et al. [2002: Hum Mol Genet 11: 1373-1380]. This study provides further support for the contribution of RGS4 to schizophrenia susceptibility... 
Chitinase-3-like 1 (CHI3L1) gene and schizophrenia: genetic association and a potential functional mechanismMao Sheng Yang
Neuropsychiatric Genetics Research Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College Dublin, Ireland
Biol Psychiatry 64:98-103. 2008..Gene expression data and association analyses in two Chinese samples implicate chitinase 3-like 1 (CHI3L1), a cellular survival gene, in schizophrenia susceptibility...- Investigation of the apolipoprotein-L (APOL) gene family and schizophrenia using a novel DNA pooling strategy for public database SNPsKevin A McGhee
Neuropsychiatric Genetics Group, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, James Street, Dublin 8, Ireland
Schizophr Res 76:231-8. 2005..We found no evidence to support the hypothesis that genetic variation at the APOL genes contributes to SZ susceptibility in our sample... - Variance in neurocognitive performance is associated with dysbindin-1 in schizophrenia: a preliminary studyGary Donohoe
Department of Psychology and Trinity Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
Neuropsychologia 45:454-8. 2007..Our study suggests that the increased risk for schizophrenia associated with dysbindin may be partly mediated by its influence on pre-frontal function... 
Non-random error in genotype calling procedures: implications for family-based and case-control genome-wide association studiesRichard J L Anney
Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, Dublin, Ireland
Am J Med Genet B Neuropsychiatr Genet 147:1379-86. 2008..The family-based association simulations show close to nominal type-I error at 4% genotype missingness. These findings have important implications to study design, quality-control procedures and reporting of findings in GWAS...- Early visual processing deficits in dysbindin-associated schizophreniaGary Donohoe
Neuropsychiatric Genetics Group, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, Dublin, Ireland
Biol Psychiatry 63:484-9. 2008..We investigated P1 performance, a component of early visual processing on which both patients and their relatives show deficits, in carriers and noncarriers of a known dysbindin risk haplotype... - Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibilityC O'Dushlaine
Department of Psychiatry, Trinity College Dublin, Dublin, Ireland
Mol Psychiatry 16:286-92. 2011..Similar pathways have also emerged from a pathway analysis of autism, suggesting that mechanisms involved in neuronal cell adhesion may contribute broadly to neurodevelopmental psychiatric phenotypes... - Functional investigation of a schizophrenia GWAS signal at the CDC42 geneWilliam P Gilks
Neuropsychiatric Genetics Research Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland
World J Biol Psychiatry 13:550-4. 2012..Reduced expression of CDC42 in schizophrenia has previously been reported. Our objective was to test whether the associated SNP affected CDC42 expression... - First implication of STRA6 mutations in isolated anophthalmia, microphthalmia, and coloboma: a new dimension to the STRA6 phenotypeJillian Casey
School of Medicine and Medical Science, University College Dublin, Belfield, Dublin, Ireland
Hum Mutat 32:1417-26. 2011..G304K patients. The current study demonstrates that STRA6 mutations can cause isolated eye malformations in addition to the congenital anomalies observed in MWS... - Mutation of Semaphorin-6A disrupts limbic and cortical connectivity and models neurodevelopmental psychopathologyAnnette E Rünker
Smurfit Institute of Genetics and Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
PLoS ONE 6:e26488. 2011..The biological data presented here also make these genes plausible candidates to explain human linkage findings for schizophrenia and autism... - Evidence for cis-acting regulation of ANK3 and CACNA1C gene expressionEmma M Quinn
Neuropsychiatric Genetics Research Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College Dublin, Ireland
Bipolar Disord 12:440-5. 2010..We investigated whether, instead of affecting protein function, these risk variants might impact on gene regulation affecting expression... - Multiplex target enrichment using DNA indexing for ultra-high throughput SNP detectionElaine M Kenny
Trinity Genome Sequencing Laboratory, Neuropsychiatric Genetics Research Group, Department of Psychiatry, Institute of Molecular Medicine, Trinity College Dublin, Ireland
DNA Res 18:31-8. 2011..Within a single experiment, this method can sequence the exonic regions of hundreds of genes in tens of samples for sequence and structural variation using as little as 1 μg of input DNA per sample... - The psychosis susceptibility gene ZNF804A: associations, functions, and phenotypesGary Donohoe
Department of Psychiatry, Trinity College Dublin, Trinity Health Sciences Building, St James s Hospital, Dublin 8, Ireland
Schizophr Bull 36:904-9. 2010..We conclude that ZNF804A is robustly, if modestly, associated with schizophrenia risk, with much work still remaining to elucidate its role in schizophrenia biology... - Influence of NOS1 on verbal intelligence and working memory in both patients with schizophrenia and healthy control subjectsGary Donohoe
Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity Health Sciences Bldg, St James s Hospital, Dublin 8, Ireland
Arch Gen Psychiatry 66:1045-54. 2009..Human and animal studies have implicated the gene NOS1 in both cognition and schizophrenia susceptibility... - Avian resistance to Campylobacter jejuni colonization is associated with an intestinal immunogene expression signature identified by mRNA sequencingSarah Connell
Smurfit Institute of Genetics, University of Dublin, Trinity College, Dublin, Ireland
PLoS ONE 7:e40409. 2012.... - Social cognition in bipolar disorder versus schizophrenia: comparability in mental state decoding deficitsGary Donohoe
Neuropsychiatric Genetics Research Group, Department of Psychiatry and Institute of Molecular Medicine Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
Bipolar Disord 14:743-8. 2012..An important direction for further research will be to establish to what extent these deficits affect social and occupational functioning as a potential target for therapeutic intervention... - A NOS1 variant implicated in cognitive performance influences evoked neural responses during a high density EEG study of early visual perceptionTherese O'Donoghue
Neuropsychiatric Genetics Group and Department of Psychiatry, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, Dublin 8, Ireland
Hum Brain Mapp 33:1202-11. 2012..Whether this variant is also associated with variation in early sensory processing remains unclear... - Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophreniaNadine Norton
Department of Psychological Medicine, Wales School of Medicine, Heath Park, Cardiff CF14 4XN, Wales, UK
Am J Med Genet B Neuropsychiatr Genet 141:96-101. 2006.... - Evaluation of a susceptibility gene for schizophrenia: genotype based meta-analysis of RGS4 polymorphisms from thirteen independent samplesMichael E Talkowski
Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 60:152-62. 2006..Yet, similar to other SCZ candidate genes, studies have been inconsistent with respect to the associated alleles... - Neurocognition and suicidal behaviour in an Irish population with major psychotic disordersJeanne-Marie Nangle
Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, Ireland
Schizophr Res 85:196-200. 2006..In particular, the preservation of higher executive function may influence the ability to initiate and plan suicidal behaviour... - Analysis of high-resolution HapMap of DTNBP1 (Dysbindin) suggests no consistency between reported common variant associations and schizophreniaMousumi Mutsuddi
Psychiatric Disease Initiative, Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA
Am J Hum Genet 79:903-9. 2006..Evidence of association is, at present, equivocal and unsatisfactory. The new dense map of the region may be valuable in more-comprehensive follow-up studies... - Rare chromosomal deletions and duplications increase risk of schizophreniaJennifer L Stone
Nature 455:237-41. 2008..Our results provide strong support for a model of schizophrenia pathogenesis that includes the effects of multiple rare structural variants, both genome-wide and at specific loci... - Variation in DNA repair genes XRCC3, XRCC4, XRCC5 and susceptibility to myelomaPatrick J Hayden
Durkan Leukaemia Laboratories, Department of Haematology, Institute of Molecular Medicine, Trinity College Dublin, Ireland
Hum Mol Genet 16:3117-27. 2007..015). This SNP is located in the 3'-UTR of XRCC5. Overall, these data provide support for the hypothesis that common variation in the genes encoding DNA repair proteins contributes to susceptibility to myeloma... - An assessment of the Irish population for large-scale genetic mapping studies involving epilepsy and other complex diseasesColm T O'Dushlaine
Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, Ireland
Eur J Hum Genet 16:176-83. 2008..This analysis therefore confirms that the genetic architecture of the Irish population is well suited to the study of complex traits and that tSNPs selected using the HapMap data can be confidently applied to the Irish population... - Universal, robust, highly quantitative SNP allele frequency measurement in DNA poolsNadine Norton
Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
Hum Genet 110:471-8. 2002..Our assay conditions are generalisable, universal, robust and, therefore, for the first time, permit high-throughput association analysis at a realistic cost... - Variance in facial recognition performance associated with BDNF in schizophreniaGary Donohoe
Am J Med Genet B Neuropsychiatr Genet 144:578-9. 2007