Derek W Morris

Summary

Affiliation: Trinity College
Country: Ireland

Publications

  1. ncbi request reprint Dysbindin (DTNBP1) and the biogenesis of lysosome-related organelles complex 1 (BLOC-1): main and epistatic gene effects are potential contributors to schizophrenia susceptibility
    Derek W Morris
    Neuropsychiatric Genetics Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College, Dublin, Ireland
    Biol Psychiatry 63:24-31. 2008
  2. ncbi request reprint No evidence for association of the dysbindin gene [DTNBP1] with schizophrenia in an Irish population-based study
    Derek W Morris
    Neuropsychiatric Genetics Group, Department of Genetics, Trinity College, 2, Dublin, Ireland
    Schizophr Res 60:167-72. 2003
  3. ncbi request reprint Confirming RGS4 as a susceptibility gene for schizophrenia
    Derek W Morris
    Neuropsychiatric Genetics Group, Department of Genetics, Trinity College, Dublin, Ireland
    Am J Med Genet B Neuropsychiatr Genet 125:50-3. 2004
  4. ncbi request reprint Chitinase-3-like 1 (CHI3L1) gene and schizophrenia: genetic association and a potential functional mechanism
    Mao Sheng Yang
    Neuropsychiatric Genetics Research Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College Dublin, Ireland
    Biol Psychiatry 64:98-103. 2008
  5. ncbi request reprint Investigation of the apolipoprotein-L (APOL) gene family and schizophrenia using a novel DNA pooling strategy for public database SNPs
    Kevin A McGhee
    Neuropsychiatric Genetics Group, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, James Street, Dublin 8, Ireland
    Schizophr Res 76:231-8. 2005
  6. ncbi request reprint Variance in neurocognitive performance is associated with dysbindin-1 in schizophrenia: a preliminary study
    Gary Donohoe
    Department of Psychology and Trinity Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
    Neuropsychologia 45:454-8. 2007
  7. doi request reprint Neural effects of the CSMD1 genome-wide associated schizophrenia risk variant rs10503253
    Emma J Rose
    Neuropsychiatric Genetics Group and Department of Psychiatry, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, Dublin, Ireland
    Am J Med Genet B Neuropsychiatr Genet 162:530-7. 2013
  8. pmc Non-random error in genotype calling procedures: implications for family-based and case-control genome-wide association studies
    Richard J L Anney
    Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, Dublin, Ireland
    Am J Med Genet B Neuropsychiatr Genet 147:1379-86. 2008
  9. ncbi request reprint Early visual processing deficits in dysbindin-associated schizophrenia
    Gary Donohoe
    Neuropsychiatric Genetics Group, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, Dublin, Ireland
    Biol Psychiatry 63:484-9. 2008
  10. doi request reprint Functional investigation of a schizophrenia GWAS signal at the CDC42 gene
    William P Gilks
    Neuropsychiatric Genetics Research Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland
    World J Biol Psychiatry 13:550-4. 2012

Detail Information

Publications35

  1. ncbi request reprint Dysbindin (DTNBP1) and the biogenesis of lysosome-related organelles complex 1 (BLOC-1): main and epistatic gene effects are potential contributors to schizophrenia susceptibility
    Derek W Morris
    Neuropsychiatric Genetics Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College, Dublin, Ireland
    Biol Psychiatry 63:24-31. 2008
    ....
  2. ncbi request reprint No evidence for association of the dysbindin gene [DTNBP1] with schizophrenia in an Irish population-based study
    Derek W Morris
    Neuropsychiatric Genetics Group, Department of Genetics, Trinity College, 2, Dublin, Ireland
    Schizophr Res 60:167-72. 2003
    ..No evidence was found to suggest an association between the DTNBP1 gene and schizophrenia in our sample. Possible reasons for these findings are discussed...
  3. ncbi request reprint Confirming RGS4 as a susceptibility gene for schizophrenia
    Derek W Morris
    Neuropsychiatric Genetics Group, Department of Genetics, Trinity College, Dublin, Ireland
    Am J Med Genet B Neuropsychiatr Genet 125:50-3. 2004
    ..The same haplotype is in excess in the Caucasian schizophrenia sample used by Chowdari et al. [2002: Hum Mol Genet 11: 1373-1380]. This study provides further support for the contribution of RGS4 to schizophrenia susceptibility...
  4. ncbi request reprint Chitinase-3-like 1 (CHI3L1) gene and schizophrenia: genetic association and a potential functional mechanism
    Mao Sheng Yang
    Neuropsychiatric Genetics Research Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College Dublin, Ireland
    Biol Psychiatry 64:98-103. 2008
    ..Gene expression data and association analyses in two Chinese samples implicate chitinase 3-like 1 (CHI3L1), a cellular survival gene, in schizophrenia susceptibility...
  5. ncbi request reprint Investigation of the apolipoprotein-L (APOL) gene family and schizophrenia using a novel DNA pooling strategy for public database SNPs
    Kevin A McGhee
    Neuropsychiatric Genetics Group, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, James Street, Dublin 8, Ireland
    Schizophr Res 76:231-8. 2005
    ..We found no evidence to support the hypothesis that genetic variation at the APOL genes contributes to SZ susceptibility in our sample...
  6. ncbi request reprint Variance in neurocognitive performance is associated with dysbindin-1 in schizophrenia: a preliminary study
    Gary Donohoe
    Department of Psychology and Trinity Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
    Neuropsychologia 45:454-8. 2007
    ..Our study suggests that the increased risk for schizophrenia associated with dysbindin may be partly mediated by its influence on pre-frontal function...
  7. doi request reprint Neural effects of the CSMD1 genome-wide associated schizophrenia risk variant rs10503253
    Emma J Rose
    Neuropsychiatric Genetics Group and Department of Psychiatry, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, Dublin, Ireland
    Am J Med Genet B Neuropsychiatr Genet 162:530-7. 2013
    ..e., executive function); with the relatively deleterious effects of the identified "A" risk allele on brain activity possibly constituting part of the mechanism by which CSMD1 increases schizophrenia risk...
  8. pmc Non-random error in genotype calling procedures: implications for family-based and case-control genome-wide association studies
    Richard J L Anney
    Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, Dublin, Ireland
    Am J Med Genet B Neuropsychiatr Genet 147:1379-86. 2008
    ..The family-based association simulations show close to nominal type-I error at 4% genotype missingness. These findings have important implications to study design, quality-control procedures and reporting of findings in GWAS...
  9. ncbi request reprint Early visual processing deficits in dysbindin-associated schizophrenia
    Gary Donohoe
    Neuropsychiatric Genetics Group, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, Dublin, Ireland
    Biol Psychiatry 63:484-9. 2008
    ..We investigated P1 performance, a component of early visual processing on which both patients and their relatives show deficits, in carriers and noncarriers of a known dysbindin risk haplotype...
  10. doi request reprint Functional investigation of a schizophrenia GWAS signal at the CDC42 gene
    William P Gilks
    Neuropsychiatric Genetics Research Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland
    World J Biol Psychiatry 13:550-4. 2012
    ..Reduced expression of CDC42 in schizophrenia has previously been reported. Our objective was to test whether the associated SNP affected CDC42 expression...
  11. ncbi request reprint Genome-wide schizophrenia variant at MIR137 does not impact white matter microstructure in healthy participants
    Sinead Kelly
    Neuropsychiatric Genetics Group, Department of Psychiatry, Trinity Centre for Health Sciences, St James s Hospital, Dublin 8, Ireland Trinity College Institute for Neuroscience, Trinity College Dublin, Ireland
    Neurosci Lett 574:6-10. 2014
    ....
  12. pmc Development of strategies for SNP detection in RNA-seq data: application to lymphoblastoid cell lines and evaluation using 1000 Genomes data
    Emma M Quinn
    TrinSeq and Neuropsychiatric Genetics Research Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland
    PLoS ONE 8:e58815. 2013
    ..If RNA-seq is applied to disease tissue samples and assuming that genes carrying mutations relevant to disease biology are being expressed, a very high proportion of these mutations can be detected...
  13. doi request reprint Social cognition in bipolar disorder versus schizophrenia: comparability in mental state decoding deficits
    Gary Donohoe
    Neuropsychiatric Genetics Research Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland
    Bipolar Disord 14:743-8. 2012
    ....
  14. doi request reprint Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility
    C O'Dushlaine
    Department of Psychiatry, Trinity College Dublin, Dublin, Ireland
    Mol Psychiatry 16:286-92. 2011
    ..Similar pathways have also emerged from a pathway analysis of autism, suggesting that mechanisms involved in neuronal cell adhesion may contribute broadly to neurodevelopmental psychiatric phenotypes...
  15. doi request reprint Analysis of the hexanucleotide repeat expansion and founder haplotype at C9ORF72 in an Irish psychosis case-control sample
    Ciara Fahey
    Neuropsychiatric Genetics Research Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland
    Neurobiol Aging 35:1510.e1-5. 2014
    ..714, p < 0.001). Our study provides further evidence to bolster the claim that carriers of the repeat expansion at C9ORF72 arose from a single common founder...
  16. pmc Mutation of Semaphorin-6A disrupts limbic and cortical connectivity and models neurodevelopmental psychopathology
    Annette E Rünker
    Smurfit Institute of Genetics and Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
    PLoS ONE 6:e26488. 2011
    ..The biological data presented here also make these genes plausible candidates to explain human linkage findings for schizophrenia and autism...
  17. pmc First implication of STRA6 mutations in isolated anophthalmia, microphthalmia, and coloboma: a new dimension to the STRA6 phenotype
    Jillian Casey
    School of Medicine and Medical Science, University College Dublin, Belfield, Dublin, Ireland
    Hum Mutat 32:1417-26. 2011
    ..G304K patients. The current study demonstrates that STRA6 mutations can cause isolated eye malformations in addition to the congenital anomalies observed in MWS...
  18. doi request reprint Evidence for cis-acting regulation of ANK3 and CACNA1C gene expression
    Emma M Quinn
    Neuropsychiatric Genetics Research Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College Dublin, Ireland
    Bipolar Disord 12:440-5. 2010
    ..We investigated whether, instead of affecting protein function, these risk variants might impact on gene regulation affecting expression...
  19. pmc Multiplex target enrichment using DNA indexing for ultra-high throughput SNP detection
    Elaine M Kenny
    Trinity Genome Sequencing Laboratory, Neuropsychiatric Genetics Research Group, Department of Psychiatry, Institute of Molecular Medicine, Trinity College Dublin, Ireland
    DNA Res 18:31-8. 2011
    ..Within a single experiment, this method can sequence the exonic regions of hundreds of genes in tens of samples for sequence and structural variation using as little as 1 μg of input DNA per sample...
  20. pmc The psychosis susceptibility gene ZNF804A: associations, functions, and phenotypes
    Gary Donohoe
    Department of Psychiatry, Trinity College Dublin, Trinity Health Sciences Building, St James s Hospital, Dublin 8, Ireland
    Schizophr Bull 36:904-9. 2010
    ..We conclude that ZNF804A is robustly, if modestly, associated with schizophrenia risk, with much work still remaining to elucidate its role in schizophrenia biology...
  21. doi request reprint Influence of NOS1 on verbal intelligence and working memory in both patients with schizophrenia and healthy control subjects
    Gary Donohoe
    Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity Health Sciences Bldg, St James s Hospital, Dublin 8, Ireland
    Arch Gen Psychiatry 66:1045-54. 2009
    ..Human and animal studies have implicated the gene NOS1 in both cognition and schizophrenia susceptibility...
  22. doi request reprint Effects of MIR137 on fronto-amygdala functional connectivity
    Omar Mothersill
    Neuropsychiatric Genetics Group, Department of Psychiatry, Trinity College Dublin, Ireland Trinity College Institute for Neuroscience, Trinity College Dublin, Ireland
    Neuroimage 90:189-95. 2014
    ..Following this evidence, we investigated the effects of MIR137 genotype on neuronal activity during face processing...
  23. pmc Delineating the genetic heterogeneity of ALS using targeted high-throughput sequencing
    Kevin P Kenna
    Smurfit Institute of Genetics, Trinity College, Dublin, Ireland
    J Med Genet 50:776-83. 2013
    ..Over 100 genes have been implicated in the aetiology of amyotrophic lateral sclerosis (ALS). A detailed understanding of their independent and cumulative contributions to disease burden may help guide various clinical and research efforts...
  24. pmc Avian resistance to Campylobacter jejuni colonization is associated with an intestinal immunogene expression signature identified by mRNA sequencing
    Sarah Connell
    Smurfit Institute of Genetics, University of Dublin, Trinity College, Dublin, Ireland
    PLoS ONE 7:e40409. 2012
    ....
  25. pmc Identification of mechanosensitive genes during skeletal development: alteration of genes associated with cytoskeletal rearrangement and cell signalling pathways
    Rebecca A Rolfe
    Department of Zoology, School of Natural Sciences, Trinity College Dublin, Dublin, Ireland
    BMC Genomics 15:48. 2014
    ..We used Microarray and RNA sequencing analysis tools to identify differentially expressed genes between muscle-less and control embryonic (TS23) humerus tissue...
  26. doi request reprint A NOS1 variant implicated in cognitive performance influences evoked neural responses during a high density EEG study of early visual perception
    Therese O'Donoghue
    Neuropsychiatric Genetics Group and Department of Psychiatry, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, Dublin 8, Ireland
    Hum Brain Mapp 33:1202-11. 2012
    ..Whether this variant is also associated with variation in early sensory processing remains unclear...
  27. ncbi request reprint Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia
    Nadine Norton
    Department of Psychological Medicine, Wales School of Medicine, Heath Park, Cardiff CF14 4XN, Wales, UK
    Am J Med Genet B Neuropsychiatr Genet 141:96-101. 2006
    ....
  28. pmc Evaluation of a susceptibility gene for schizophrenia: genotype based meta-analysis of RGS4 polymorphisms from thirteen independent samples
    Michael E Talkowski
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 60:152-62. 2006
    ..Yet, similar to other SCZ candidate genes, studies have been inconsistent with respect to the associated alleles...
  29. ncbi request reprint Neurocognition and suicidal behaviour in an Irish population with major psychotic disorders
    Jeanne Marie Nangle
    Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, Ireland
    Schizophr Res 85:196-200. 2006
    ..Our aim was to examine the relationship between neurocognitive variables and suicidal behaviour in patients with schizophrenia and schizoaffective disorder...
  30. pmc Analysis of high-resolution HapMap of DTNBP1 (Dysbindin) suggests no consistency between reported common variant associations and schizophrenia
    Mousumi Mutsuddi
    Psychiatric Disease Initiative, Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA
    Am J Hum Genet 79:903-9. 2006
    ..Evidence of association is, at present, equivocal and unsatisfactory. The new dense map of the region may be valuable in more-comprehensive follow-up studies...
  31. ncbi request reprint Variation in DNA repair genes XRCC3, XRCC4, XRCC5 and susceptibility to myeloma
    Patrick J Hayden
    Durkan Leukaemia Laboratories, Department of Haematology, Institute of Molecular Medicine, Trinity College Dublin, Ireland
    Hum Mol Genet 16:3117-27. 2007
    ..015). This SNP is located in the 3'-UTR of XRCC5. Overall, these data provide support for the hypothesis that common variation in the genes encoding DNA repair proteins contributes to susceptibility to myeloma...
  32. ncbi request reprint An assessment of the Irish population for large-scale genetic mapping studies involving epilepsy and other complex diseases
    Colm T O'Dushlaine
    Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, Ireland
    Eur J Hum Genet 16:176-83. 2008
    ..This analysis therefore confirms that the genetic architecture of the Irish population is well suited to the study of complex traits and that tSNPs selected using the HapMap data can be confidently applied to the Irish population...
  33. ncbi request reprint Universal, robust, highly quantitative SNP allele frequency measurement in DNA pools
    Nadine Norton
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Hum Genet 110:471-8. 2002
    ..Our assay conditions are generalisable, universal, robust and, therefore, for the first time, permit high-throughput association analysis at a realistic cost...
  34. ncbi request reprint Variance in facial recognition performance associated with BDNF in schizophrenia
    Gary Donohoe
    Am J Med Genet B Neuropsychiatr Genet 144:578-9. 2007