A M Molloy

Summary

Affiliation: Trinity College
Country: Ireland

Publications

  1. doi request reprint Genetic aspects of folate metabolism
    Anne M Molloy
    School of Medicine, Trinity College Dublin, Dublin 2, Ireland
    Subcell Biochem 56:105-30. 2012
  2. pmc Evaluation of common genetic variants in 82 candidate genes as risk factors for neural tube defects
    Faith Pangilinan
    Molecular Pathogenesis Section, Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
    BMC Med Genet 13:62. 2012
  3. pmc Genotyping of a tri-allelic polymorphism by a novel melting curve assay in MTHFD1L: an association study of nonsyndromic Cleft in Ireland
    Stefano Minguzzi
    Nutritional Genomics Group, School of Biotechnology, Dublin City University, Dublin, Ireland
    BMC Med Genet 13:29. 2012
  4. ncbi request reprint Choline and homocysteine interrelations in umbilical cord and maternal plasma at delivery
    Anne M Molloy
    Department of Clinical Medicine and the National Human Genome Research Institute, The National Institutes of Health, Bethesda, MD, USA
    Am J Clin Nutr 82:836-42. 2005
  5. ncbi request reprint Effects of folate and vitamin B12 deficiencies during pregnancy on fetal, infant, and child development
    Anne M Molloy
    School of Medicine, Trinity College Dublin, Ireland
    Food Nutr Bull 29:S101-11; discussion S112-5. 2008
  6. ncbi request reprint Genetic variation and nutritional requirements
    Anne M Molloy
    Department of Biochemistry, Trinity College Dublin, Dublin, Ireland
    World Rev Nutr Diet 93:153-63. 2004
  7. ncbi request reprint Folate and homocysteine interrelationships including genetics of the relevant enzymes
    Anne M Molloy
    Department of Clinical Medicine, Trinity College Dublin, Ireland
    Curr Opin Lipidol 15:49-57. 2004
  8. doi request reprint The search for genetic polymorphisms in the homocysteine/folate pathway that contribute to the etiology of human neural tube defects
    Anne M Molloy
    School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    Birth Defects Res A Clin Mol Teratol 85:285-94. 2009
  9. doi request reprint Maternal vitamin B12 status and risk of neural tube defects in a population with high neural tube defect prevalence and no folic Acid fortification
    Anne M Molloy
    Schools of Medicine, Trinity College Dublin, School of Medicine, Dublin 2, Ireland
    Pediatrics 123:917-23. 2009
  10. doi request reprint Lack of association between folate-receptor autoantibodies and neural-tube defects
    Anne M Molloy
    School of Medicine, Trinity College, Dublin, Ireland
    N Engl J Med 361:152-60. 2009

Collaborators

Detail Information

Publications51

  1. doi request reprint Genetic aspects of folate metabolism
    Anne M Molloy
    School of Medicine, Trinity College Dublin, Dublin 2, Ireland
    Subcell Biochem 56:105-30. 2012
    ..It is thus becoming clear that genetic aspects of folate metabolism are wide-ranging and may touch on events as disparate as prenatal imprinting to cancer susceptibility. This chapter will review the current knowledge in this area...
  2. pmc Evaluation of common genetic variants in 82 candidate genes as risk factors for neural tube defects
    Faith Pangilinan
    Molecular Pathogenesis Section, Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
    BMC Med Genet 13:62. 2012
    ..g., MTHFR rs1801133 (677 C > T) and MTHFD1 rs2236225 (R653Q)) have been found to increase NTD risk. We hypothesized that variants in additional folate/B12 pathway genes contribute to NTD risk...
  3. pmc Genotyping of a tri-allelic polymorphism by a novel melting curve assay in MTHFD1L: an association study of nonsyndromic Cleft in Ireland
    Stefano Minguzzi
    Nutritional Genomics Group, School of Biotechnology, Dublin City University, Dublin, Ireland
    BMC Med Genet 13:29. 2012
    ..This required the development of a new melting curve assay to genotype the technically challenging MTHFD1L triallelic deletion/insertion polymorphism (rs3832406)...
  4. ncbi request reprint Choline and homocysteine interrelations in umbilical cord and maternal plasma at delivery
    Anne M Molloy
    Department of Clinical Medicine and the National Human Genome Research Institute, The National Institutes of Health, Bethesda, MD, USA
    Am J Clin Nutr 82:836-42. 2005
    ..Choline, via betaine, is an important folate-independent source of methyl groups for remethylating homocysteine in liver...
  5. ncbi request reprint Effects of folate and vitamin B12 deficiencies during pregnancy on fetal, infant, and child development
    Anne M Molloy
    School of Medicine, Trinity College Dublin, Ireland
    Food Nutr Bull 29:S101-11; discussion S112-5. 2008
    ..However, the implications of starting pregnancy and lactation with low vitamin B12 status have not been sufficiently researched...
  6. ncbi request reprint Genetic variation and nutritional requirements
    Anne M Molloy
    Department of Biochemistry, Trinity College Dublin, Dublin, Ireland
    World Rev Nutr Diet 93:153-63. 2004
  7. ncbi request reprint Folate and homocysteine interrelationships including genetics of the relevant enzymes
    Anne M Molloy
    Department of Clinical Medicine, Trinity College Dublin, Ireland
    Curr Opin Lipidol 15:49-57. 2004
    ..In many instances these risks are manifested through elevated plasma homocysteine. This review focuses on current research into the contribution of genetic variability to folate status and disease predisposition...
  8. doi request reprint The search for genetic polymorphisms in the homocysteine/folate pathway that contribute to the etiology of human neural tube defects
    Anne M Molloy
    School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    Birth Defects Res A Clin Mol Teratol 85:285-94. 2009
    ..Although moving forward is exciting, it is humbling that the most important result-prevention of NTDs by maternal folic acid supplementation-was achieved years ago, the direct result of Smithells' groundbreaking studies...
  9. doi request reprint Maternal vitamin B12 status and risk of neural tube defects in a population with high neural tube defect prevalence and no folic Acid fortification
    Anne M Molloy
    Schools of Medicine, Trinity College Dublin, School of Medicine, Dublin 2, Ireland
    Pediatrics 123:917-23. 2009
    ..Our objective was to quantify the effect of low B(12) status on neural tube defect risk in a high-prevalence, unfortified population...
  10. doi request reprint Lack of association between folate-receptor autoantibodies and neural-tube defects
    Anne M Molloy
    School of Medicine, Trinity College, Dublin, Ireland
    N Engl J Med 361:152-60. 2009
    ..We sought to confirm this finding in an Irish population, which traditionally has had a high prevalence of neural-tube defects...
  11. ncbi request reprint Folate bioavailability and health
    Anne M Molloy
    Department of Clinical Medicine, Trinity College Dublin, Dublin 2, Ireland
    Int J Vitam Nutr Res 72:46-52. 2002
    ....
  12. ncbi request reprint Methylenetetrahydrofolate reductase thermolabile variant and oral clefts
    J L Mills
    National Institute of Child Health and Human Development, Bethesda, Maryland 20852, USA
    Am J Med Genet 86:71-4. 1999
    ..Am. J. Med. Genet. 86:71-74, 1999. Published 1999 Wiley-Liss, Inc...
  13. ncbi request reprint Folates and prevention of disease
    A M Molloy
    Department of Clinical Medicine, Trinity College Dublin, Ireland
    Public Health Nutr 4:601-9. 2001
    ..While it is hard to determine if this is cause or effect, there is little doubt that if it were true then low dose folic acid intervention would be highly effective...
  14. ncbi request reprint MTRR and MTHFR polymorphism: link to Down syndrome?
    Valerie B O'Leary
    Department of Biochemistry, Trinity College, Dublin, Ireland
    Am J Med Genet 107:151-5. 2002
    ..Women who have both the MTRR and MTHFR variant genotypes are also at increased risk of producing offspring with Down syndrome...
  15. doi request reprint Transcobalamin II receptor polymorphisms are associated with increased risk for neural tube defects
    F Pangilinan
    Molecular Pathogenesis Section, Genome Technology Branch, National Human Genome Research Institute, 50 South Drive, Bethesda, MD 20892 8004, USA
    J Med Genet 47:677-85. 2010
    ..The transcobalamin II receptor (TCblR) mediates uptake of cobalamin into cells. Inherited variants in the TCblR gene as NTD risk factors were evaluated...
  16. pmc Uncoupling protein 2 polymorphisms as risk factors for NTDs
    Adam Mitchell
    Molecular Pathogenesis Section, Genome Technology Branch, National Human Genome Research Institute, 50 South Drive, Bethesda, MD 20892 8004, USA
    Birth Defects Res A Clin Mol Teratol 85:156-60. 2009
    ..Interestingly, a previous study found that a common UCP2 compound homozygous genotype was associated with a threefold increase in NTD risk...
  17. pmc Construction of a high resolution linkage disequilibrium map to evaluate common genetic variation in TP53 and neural tube defect risk in an Irish population
    Faith Pangilinan
    Molecular Pathogenesis Section, Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland 20892 8004, USA
    Am J Med Genet A 146:2617-25. 2008
    ..86 [1.16-2.96], P = 0.01) and the TT genotype of rs1614984 (RR = 0.58 [0.37-0.91], P = 0.02). As multiple comparisons were made, these cannot be considered definitive positive findings and additional investigation is required...
  18. ncbi request reprint Polymorphisms within the vitamin B12 dependent methylmalonyl-coA mutase are not risk factors for neural tube defects
    Anne Parle-McDermott
    Department of Biochemistry, Trinity College Dublin, Dublin, Ireland
    Mol Genet Metab 80:463-8. 2003
    ..002; H532R, P</=0.001; V671I, P=0.006). In conclusion, common variants in the mutase gene do not appear to be risk factors for NTDs but their allele frequencies are significantly different between ethnic groups...
  19. doi request reprint Associations between holotranscobalamin, vitamin B12, homocysteine and depressive symptoms in community-dwelling elders
    D J Robinson
    School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    Int J Geriatr Psychiatry 26:307-13. 2011
    ..Both vitamin B12 and homocysteine may exert an effect via vascular mechanisms; it is possible that other mechanisms apply. Holotranscobalamin is a novel, more accurate measure of tissue vitamin B12...
  20. ncbi request reprint Elevated plasma homocysteine in early pregnancy: a risk factor for the development of severe preeclampsia
    A M Cotter
    Department of Biochemistry, Trinity College, Dublin, and Coombe Women's Hospital, Ireland
    Am J Obstet Gynecol 185:781-5. 2001
    ..An elevated plasma homocysteine level in early pregnancy can increase the risk of developing severe preeclampsia by almost threefold...
  21. ncbi request reprint Methionine synthase: high-resolution mapping of the human gene and evaluation as a candidate locus for neural tube defects
    L C Brody
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA
    Mol Genet Metab 67:324-33. 1999
    ..A lack of association was also observed for the D1919G missense mutation within the gene. Our results suggest that inherited variation in the MS gene does not contribute to NTD risk in this population...
  22. ncbi request reprint The methylenetetrahydrofolate reductase (MTHFR) gene in colorectal cancer: role in tumor development and significance of allelic loss in tumor progression
    B M Ryan
    Department of Gastroenterology and Clinical Medicine, St James s Hospital and Trinity College, Dublin, Ireland
    Int J Gastrointest Cancer 30:105-11. 2001
    ..We investigated whether this functional polymorphism modulates the risk of developing CRC...
  23. ncbi request reprint The 19-bp deletion polymorphism in intron-1 of dihydrofolate reductase (DHFR) may decrease rather than increase risk for spina bifida in the Irish population
    Anne Parle-McDermott
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    Am J Med Genet A 143:1174-80. 2007
    ..5-fold) associated with the 19-bp intron deletion polymorphism, but this was not significant. In conclusion, the DHFR intron 19-bp deletion allele may be a protective NTD genetic factor by increasing DHFR mRNA levels in pregnant women...
  24. ncbi request reprint The MTHFR 1298CC and 677TT genotypes have opposite associations with red cell folate levels
    Anne Parle-McDermott
    School of Biochemistry and Immunology, Trinity College Dublin, Ireland
    Mol Genet Metab 88:290-4. 2006
    ..Thus, these two common polymorphisms change a metabolic phenotype in opposite directions suggesting that their cancer protective associations are by different mechanisms...
  25. ncbi request reprint Confirmation of the R653Q polymorphism of the trifunctional C1-synthase enzyme as a maternal risk for neural tube defects in the Irish population
    Anne Parle-McDermott
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    Eur J Hum Genet 14:768-72. 2006
    ..We have established that the MTHFD1 1958G>A polymorphism has a significant role in influencing a mother's risk of having an NTD-affected pregnancy in the Irish population...
  26. ncbi request reprint Maternal and fetal plasma homocysteine concentrations at birth: the influence of folate, vitamin B12, and the 5,10-methylenetetrahydrofolate reductase 677C-->T variant
    Anne M Molloy
    Department of Clinical Medicine, Trinity College Dublin, Ireland
    Am J Obstet Gynecol 186:499-503. 2002
    ..The purpose of this study was to determine the nutritional and genetic factors that influence fetal plasma homocysteine concentrations...
  27. ncbi request reprint Evaluation of transcobalamin II polymorphisms as neural tube defect risk factors in an Irish population
    Deborah A Swanson
    Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Birth Defects Res A Clin Mol Teratol 73:239-44. 2005
    ..TCII levels are altered in the amniotic fluid of pregnancies affected by NTDs. Given this evidence, inherited variants in genes involved in vitamin B(12) trafficking such as TCII are candidate NTD risk factors...
  28. ncbi request reprint Reduced folate carrier polymorphisms and neural tube defect risk
    Valerie B O'Leary
    Department of Biochemistry, Trinity College Dublin, Ireland
    Mol Genet Metab 87:364-9. 2006
    ..The previously unstudied 61 bp tandem repeat, however, has a possible protective NTD effect in our Irish population. This requires confirmation in other studies...
  29. ncbi request reprint Analysis of methionine synthase reductase polymorphisms for neural tube defects risk association
    Valerie B O'Leary
    Department of Biochemistry, Trinity College Dublin, Dublin, Ireland
    Mol Genet Metab 85:220-7. 2005
    ..The frequencies of I22M and K350R differed significantly between the two groups (p = 0.0005 and p = 0.0001, respectively). Our findings do not support an important role for these MTRR variants in NTDs...
  30. ncbi request reprint Analysis of the human folate receptor beta gene for an association with neural tube defects
    Valerie B O'Leary
    Department of Biochemistry, Trinity College Dublin, Dublin, Ireland
    Mol Genet Metab 79:129-33. 2003
    ..Highly significant allele frequency differences were observed between populations. In conclusion, SNP rs651646 within the FRbeta gene is polymorphic but is not associated with neural tube defects within the Irish population...
  31. ncbi request reprint Analysis of the MTHFR 1298A-->C and 677C-->T polymorphisms as risk factors for neural tube defects
    Anne Parle-McDermott
    Department of Biochemistry, Trinity College Dublin, Dublin, Ireland
    J Hum Genet 48:190-3. 2003
    ..Our findings do not support a role for the 1298A-->C polymorphism in NTDs (OR 0.85 (95% CI 0.49-1.47), p= 0.55), nor do we observe a combined effect with the 677C-->T polymorphism...
  32. ncbi request reprint A polymorphism in the MTHFD1 gene increases a mother's risk of having an unexplained second trimester pregnancy loss
    Anne Parle-McDermott
    Department of Biochemistry, Trinity College Dublin, Dublin, Ireland
    Mol Hum Reprod 11:477-80. 2005
    ..Neither showed evidence of significantly affecting the maternal risk of having a second trimester pregnancy loss. In conclusion, the MTHFD1 1958AA genotype may be an important maternal risk factor to consider during pregnancy...
  33. ncbi request reprint Screening for new MTHFR polymorphisms and NTD risk
    Valerie B O'Leary
    Department of Biochemistry, Trinity College Dublin, Dublin, Ireland
    Am J Med Genet A 138:99-106. 2005
    ..This is the first NTD association study of both R594Q and the novel P39P. The association with NTD risk reported for these SNPs is driven by the linkage disequilibrium with the A222V (677C->T) NTD risk factor...
  34. ncbi request reprint Low-dose folic acid lowers plasma homocysteine levels in women of child-bearing age
    S Daly
    Coombe Womens Hospital, Dublin, Ireland
    QJM 95:733-40. 2002
    ..Dose-finding studies are needed before the outcomes of these trials, to establish the benefits and risks of folic acid consumption over the widest intake range likely to be encountered...
  35. pmc Testing reported associations of genetic risk factors for oral clefts in a large Irish study population
    Tonia C Carter
    Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Birth Defects Res A Clin Mol Teratol 88:84-93. 2010
    ....
  36. ncbi request reprint MTHFD1 R653Q polymorphism is a maternal genetic risk factor for severe abruptio placentae
    Anne Parle-McDermott
    Department of Biochemistry, Trinity College Dublin, Dublin, Ireland
    Am J Med Genet A 132:365-8. 2005
    ..We conclude that women who are 'QQ' homozygote for the MTHFD1 1258G --> A (R653Q) polymorphism are almost three times more likely to develop severe abruptio placentae during their pregnancy than women who are 'RQ' or 'RR.'..
  37. pmc Folate-related gene polymorphisms as risk factors for cleft lip and cleft palate
    James L Mills
    Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Birth Defects Res A Clin Mol Teratol 82:636-43. 2008
    ..This study examined four SNPs related to folate metabolism (MTHFR 677 C-->T, MTHFR 1298 A-->C, MTHFD1 1958 G-->A, and TC II 776 C-->G) in a large Irish population to clarify their relationship with clefts...
  38. pmc A polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase is a maternal genetic risk factor for neural tube defects: report of the Birth Defects Res
    Lawrence C Brody
    Genome Technology Branch, National Human Genome Research Institute, Bethesda, MD, USA
    Am J Hum Genet 71:1207-15. 2002
    ..003). We conclude that genetic variation in the MTHFD1 gene is associated with an increase in the genetically determined risk that a woman will bear a child with NTD and that the gene may be associated with decreased embryo survival...
  39. ncbi request reprint Elevated plasma homocysteine in early pregnancy: a risk factor for the development of nonsevere preeclampsia
    Amanda M Cotter
    Department of Biochemistry, Trinity College Dublin and Coombe Women s Hospital, Dublin, Ireland
    Am J Obstet Gynecol 189:391-4; discussion 394-6. 2003
    ..The aim of this study was to determine whether an elevated plasma homocysteine in early pregnancy is also associated with the development of nonsevere preeclampsia...
  40. pmc Impact of the MTHFR C677T polymorphism on risk of neural tube defects: case-control study
    Peadar N Kirke
    Child Health Epidemiology Division, Health Research Board, Dublin 2, Ireland
    BMJ 328:1535-6. 2004
  41. doi request reprint Folate and vitamin B12 status in relation to cognitive impairment and anaemia in the setting of voluntary fortification in the UK
    Robert Clarke
    Clinical Trial Service Unit, University of Oxford, Oxford, UK
    Br J Nutr 100:1054-9. 2008
    ..88)). There was no evidence of modification by high folate status of the associations of low B12 with anaemia or cognitive impairment in the setting of voluntary fortification, but periodic surveys are needed to monitor fortification...
  42. ncbi request reprint Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C->T polymorphism
    Helene McNulty
    Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland
    Circulation 113:74-80. 2006
    ....
  43. ncbi request reprint Maternal homocysteine before conception and throughout pregnancy predicts fetal homocysteine and birth weight
    Michelle M Murphy
    Unit of Preventive Medicine and Public Health, Rovira i Virgili University, Reus, Spain
    Clin Chem 50:1406-12. 2004
    ..Increased homocysteine has been associated with pregnancy complications...
  44. ncbi request reprint Determining bioavailability of food folates in a controlled intervention study
    Mary P Hannon-Fletcher
    Northern Ireland Centre for Food and Health and the School of Hotel, Leisure, and Tourism, University of Ulster, Coleraine, United Kingdom
    Am J Clin Nutr 80:911-8. 2004
    ..However, many published reports on folate bioavailability are problematic because of several confounding factors...
  45. ncbi request reprint Effect of a voluntary food fortification policy on folate, related B vitamin status, and homocysteine in healthy adults
    Leane Hoey
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, United Kingdom
    Am J Clin Nutr 86:1405-13. 2007
    ..Thus, it is virtually nonexistent in Europe, albeit many countries allow food fortification on a voluntary basis...
  46. pmc Homocysteine concentration, related B vitamins, and betaine in pregnant women recruited to the Seychelles Child Development Study
    Julie Mw Wallace
    Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, Coleraine, United Kingdom
    Am J Clin Nutr 87:391-7. 2008
    ..Both folate and betaine are important predictors of total homocysteine (tHcy) during pregnancy. However, studies to date have only been undertaken in populations with Western dietary patterns...
  47. ncbi request reprint Nutrition and metabolism
    Anne M Molloy
    Curr Opin Lipidol 18:372-4. 2007
  48. ncbi request reprint Detection of vitamin B12 deficiency in older people by measuring vitamin B12 or the active fraction of vitamin B12, holotranscobalamin
    Robert Clarke
    Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom
    Clin Chem 53:963-70. 2007
    ..Concentrations of this active component, carried on holotranscobalamin (holoTC), may be of greater relevance than total vitamin B(12)...
  49. ncbi request reprint The effect of docosahexaenoic acid and folic acid supplementation on placental apoptosis and proliferation
    Mario Klingler
    Dr von Hauner Children s Hospital, Ludwig Maximilians University of Munich, Munich, Germany
    Br J Nutr 96:182-90. 2006
    ..A defined combination of DHA and 5-MTHF may, however, affect placental proliferation...
  50. ncbi request reprint Nutrition and metabolism
    Anne M Molloy
    Curr Opin Lipidol 17:477-9. 2006
  51. ncbi request reprint Longitudinal study of the effect of pregnancy on maternal and fetal cobalamin status in healthy women and their offspring
    Michelle M Murphy
    Unitat de Medicina Preventiva i Salut P├║blica, IRCIS, Facultat de Medicina i Ciencies de la Salut, Universitat Rovira i Virgili, Reus, 43201 Spain
    J Nutr 137:1863-7. 2007
    ..707, 0.682, respectively; P < 0.01). The moderate increases observed in the cobalamin biomarker, MMA, during pregnancy may indicate a functional depletion in intracellular cobalamin status...