Kevin J Mitchell

Summary

Affiliation: Trinity College
Country: Ireland

Publications

  1. pmc Mutation of Semaphorin-6A disrupts limbic and cortical connectivity and models neurodevelopmental psychopathology
    Annette E Rünker
    Smurfit Institute of Genetics and Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
    PLoS ONE 6:e26488. 2011
  2. pmc Plxdc2 is a mitogen for neural progenitors
    Suzanne F C Miller-Delaney
    Smurfit Institute of Genetics and Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
    PLoS ONE 6:e14565. 2011
  3. pmc Mutation of Elfn1 in mice causes seizures and hyperactivity
    Jackie Dolan
    Smurfit Institute of Genetics and Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
    PLoS ONE 8:e80491. 2013
  4. pmc What is complex about complex disorders?
    Kevin J Mitchell
    Smurfit Institute of Genetics and Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    Genome Biol 13:237. 2012
  5. pmc Boundary cap cells constrain spinal motor neuron somal migration at motor exit points by a semaphorin-plexin mechanism
    Romke Bron
    MRC Centre for Developmental Neurobiology, King s College London, Guy s Campus, London Bridge, London, SE1 1UL, UK
    Neural Dev 2:21. 2007
  6. doi Curiouser and curiouser: genetic disorders of cortical specialization
    Kevin J Mitchell
    Smurfit Institute of Genetic and Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    Curr Opin Genet Dev 21:271-7. 2011
  7. pmc The genetics of brain wiring: from molecule to mind
    Kevin J Mitchell
    Smurfit Institute of Genetics and Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    PLoS Biol 5:e113. 2007
  8. doi The genetics of neurodevelopmental disease
    Kevin J Mitchell
    Smurfit Institute of Genetics and Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    Curr Opin Neurobiol 21:197-203. 2011
  9. doi Rethinking the genetic architecture of schizophrenia
    K J Mitchell
    Smurfit Institute of Genetics, Trinity College Dublin, Ireland
    Psychol Med 41:19-32. 2011
  10. pmc Following the genes: a framework for animal modeling of psychiatric disorders
    Kevin J Mitchell
    Smurfit Institute of Genetics and Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    BMC Biol 9:76. 2011

Collaborators

Detail Information

Publications23

  1. pmc Mutation of Semaphorin-6A disrupts limbic and cortical connectivity and models neurodevelopmental psychopathology
    Annette E Rünker
    Smurfit Institute of Genetics and Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
    PLoS ONE 6:e26488. 2011
    ..The biological data presented here also make these genes plausible candidates to explain human linkage findings for schizophrenia and autism...
  2. pmc Plxdc2 is a mitogen for neural progenitors
    Suzanne F C Miller-Delaney
    Smurfit Institute of Genetics and Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
    PLoS ONE 6:e14565. 2011
    ..They also implicate Plxdc2 as a novel component of the network of signalling molecules known to coordinate proliferation and differentiation in the developing nervous system...
  3. pmc Mutation of Elfn1 in mice causes seizures and hyperactivity
    Jackie Dolan
    Smurfit Institute of Genetics and Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
    PLoS ONE 8:e80491. 2013
    ..These analyses reveal a requirement for Elfn1 in brain function and are suggestive of possible relevance to the etiology and pathophysiology of epilepsy and attention-deficit hyperactivity disorder...
  4. pmc What is complex about complex disorders?
    Kevin J Mitchell
    Smurfit Institute of Genetics and Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    Genome Biol 13:237. 2012
    ..Rather than being polygenic, complex disorders probably represent umbrella terms for collections of conditions caused by rare, recent mutations in any of a large number of different genes...
  5. pmc Boundary cap cells constrain spinal motor neuron somal migration at motor exit points by a semaphorin-plexin mechanism
    Romke Bron
    MRC Centre for Developmental Neurobiology, King s College London, Guy s Campus, London Bridge, London, SE1 1UL, UK
    Neural Dev 2:21. 2007
    ..Here we used RNA interference in the chick embryo together with analysis of null mutant mice to identify possible boundary cap cell ligands, their receptors on motor neurons and cytoplasmic signalling molecules that control this process...
  6. doi Curiouser and curiouser: genetic disorders of cortical specialization
    Kevin J Mitchell
    Smurfit Institute of Genetic and Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    Curr Opin Genet Dev 21:271-7. 2011
    ..Here, I consider recent advances in our understanding of the genetic and neurobiological bases of these conditions and the developmental mechanisms underlying the specialization of cortical areas and networks...
  7. pmc The genetics of brain wiring: from molecule to mind
    Kevin J Mitchell
    Smurfit Institute of Genetics and Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    PLoS Biol 5:e113. 2007
  8. doi The genetics of neurodevelopmental disease
    Kevin J Mitchell
    Smurfit Institute of Genetics and Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    Curr Opin Neurobiol 21:197-203. 2011
    ..They have also converged on specific neurodevelopmental pathways, providing insights into pathogenic mechanisms...
  9. doi Rethinking the genetic architecture of schizophrenia
    K J Mitchell
    Smurfit Institute of Genetics, Trinity College Dublin, Ireland
    Psychol Med 41:19-32. 2011
    ..Here we ask how this discrepancy between theory and data arose and propose a rationalization of the recent evidence base...
  10. pmc Following the genes: a framework for animal modeling of psychiatric disorders
    Kevin J Mitchell
    Smurfit Institute of Genetics and Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    BMC Biol 9:76. 2011
    ....
  11. pmc Semaphorin-6A controls guidance of corticospinal tract axons at multiple choice points
    Annette E Rünker
    Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland
    Neural Dev 3:34. 2008
    ..To assess the involvement of transmembrane semaphorins and their plexin receptors in the guidance of CST axons, we have examined this tract in mutants of Semaphorin-6A (Sema6A), Plexin-A2 (PlxnA2) and Plexin-A4 (PlxnA4)...
  12. ncbi Functional genomics and schizophrenia: endophenotypes and mutant models
    John L Waddington
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Psychiatr Clin North Am 30:365-99. 2007
    ..It examines gene-gene and gene-environment interactions. Finally, it looks at future directions for research...
  13. pmc Specificity and plasticity of thalamocortical connections in Sema6A mutant mice
    Graham E Little
    Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland
    PLoS Biol 7:e98. 2009
    ..These findings emphasize the importance and specificity of cortical cues in establishing thalamocortical connectivity and the spectacular capacity of the early postnatal cortex for remapping initial sensory representations...
  14. doi Differences in early sensory-perceptual processing in synesthesia: a visual evoked potential study
    Kylie J Barnett
    Institute of Neuroscience TCIN, Lloyd Building, Trinity College Dublin, Dublin 2, Ireland
    Neuroimage 43:605-13. 2008
    ..We discuss our results with reference to widespread connectivity differences as a broader phenotype of synesthesia...
  15. doi Colored-speech synaesthesia is triggered by multisensory, not unisensory, perception
    Gary Bargary
    School of Psychology, Trinity College Dublin, Dublin, Ireland
    Psychol Sci 20:529-33. 2009
    ..Our findings indicate that color-speech synaesthesia is triggered only when a significant amount of information processing has occurred and that early sensory activation is not directly linked to the synaesthetic experience...
  16. pmc The extracellular leucine-rich repeat superfamily; a comparative survey and analysis of evolutionary relationships and expression patterns
    Jackie Dolan
    Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland
    BMC Genomics 8:320. 2007
    ....
  17. ncbi Expression of Plxdc2/TEM7R in the developing nervous system of the mouse
    Suzanne F C Miller
    Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland
    Gene Expr Patterns 7:635-44. 2007
    ....
  18. pmc Ohnologs are overrepresented in pathogenic copy number mutations
    Aoife McLysaght
    Smurfit Institute of Genetics, Trinity College, University of Dublin, Dublin 2, Ireland
    Proc Natl Acad Sci U S A 111:361-6. 2014
    ....
  19. doi Synaesthesia and cortical connectivity
    Gary Bargary
    School of Psychology, Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    Trends Neurosci 31:335-42. 2008
    ....
  20. ncbi Familial patterns and the origins of individual differences in synaesthesia
    Kylie J Barnett
    School of Psychology, Trinity College Dublin, Ireland
    Cognition 106:871-93. 2008
    ..Synaesthesia thus provides a good model to explore the interplay of all these factors in the development of cognitive traits in general...
  21. doi Plexin-A2 and its ligand, Sema6A, control nucleus-centrosome coupling in migrating granule cells
    Julie Renaud
    Centre National de la Recherche Scientifique, UMR7102, 9 quai Saint Bernard, Paris F 75005, France
    Nat Neurosci 11:440-9. 2008
    ..This suggests that semaphorin-plexin signaling modulates cell migration by controlling centrosome positioning...