Kevin J Mitchell

Summary

Affiliation: Trinity College
Country: Ireland

Publications

  1. pmc What is complex about complex disorders?
    Kevin J Mitchell
    Smurfit Institute of Genetics and Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    Genome Biol 13:237. 2012
  2. pmc Boundary cap cells constrain spinal motor neuron somal migration at motor exit points by a semaphorin-plexin mechanism
    Romke Bron
    MRC Centre for Developmental Neurobiology, King s College London, Guy s Campus, London Bridge, London, SE1 1UL, UK
    Neural Dev 2:21. 2007
  3. pmc The extracellular leucine-rich repeat superfamily; a comparative survey and analysis of evolutionary relationships and expression patterns
    Jackie Dolan
    Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland
    BMC Genomics 8:320. 2007
  4. doi Rethinking the genetic architecture of schizophrenia
    K J Mitchell
    Smurfit Institute of Genetics, Trinity College Dublin, Ireland
    Psychol Med 41:19-32. 2011
  5. doi Curiouser and curiouser: genetic disorders of cortical specialization
    Kevin J Mitchell
    Smurfit Institute of Genetic and Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    Curr Opin Genet Dev 21:271-7. 2011
  6. pmc Following the genes: a framework for animal modeling of psychiatric disorders
    Kevin J Mitchell
    Smurfit Institute of Genetics and Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    BMC Biol 9:76. 2011
  7. doi The genetics of neurodevelopmental disease
    Kevin J Mitchell
    Smurfit Institute of Genetics and Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    Curr Opin Neurobiol 21:197-203. 2011
  8. pmc The genetics of brain wiring: from molecule to mind
    Kevin J Mitchell
    Smurfit Institute of Genetics and Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    PLoS Biol 5:e113. 2007
  9. pmc Mutation of Semaphorin-6A disrupts limbic and cortical connectivity and models neurodevelopmental psychopathology
    Annette E Rünker
    Smurfit Institute of Genetics and Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
    PLoS ONE 6:e26488. 2011
  10. ncbi Functional genomics and schizophrenia: endophenotypes and mutant models
    John L Waddington
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Psychiatr Clin North Am 30:365-99. 2007

Collaborators

Detail Information

Publications14

  1. pmc What is complex about complex disorders?
    Kevin J Mitchell
    Smurfit Institute of Genetics and Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    Genome Biol 13:237. 2012
    ..Rather than being polygenic, complex disorders probably represent umbrella terms for collections of conditions caused by rare, recent mutations in any of a large number of different genes...
  2. pmc Boundary cap cells constrain spinal motor neuron somal migration at motor exit points by a semaphorin-plexin mechanism
    Romke Bron
    MRC Centre for Developmental Neurobiology, King s College London, Guy s Campus, London Bridge, London, SE1 1UL, UK
    Neural Dev 2:21. 2007
    ..Here we used RNA interference in the chick embryo together with analysis of null mutant mice to identify possible boundary cap cell ligands, their receptors on motor neurons and cytoplasmic signalling molecules that control this process...
  3. pmc The extracellular leucine-rich repeat superfamily; a comparative survey and analysis of evolutionary relationships and expression patterns
    Jackie Dolan
    Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland
    BMC Genomics 8:320. 2007
    ....
  4. doi Rethinking the genetic architecture of schizophrenia
    K J Mitchell
    Smurfit Institute of Genetics, Trinity College Dublin, Ireland
    Psychol Med 41:19-32. 2011
    ..Here we ask how this discrepancy between theory and data arose and propose a rationalization of the recent evidence base...
  5. doi Curiouser and curiouser: genetic disorders of cortical specialization
    Kevin J Mitchell
    Smurfit Institute of Genetic and Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    Curr Opin Genet Dev 21:271-7. 2011
    ..Here, I consider recent advances in our understanding of the genetic and neurobiological bases of these conditions and the developmental mechanisms underlying the specialization of cortical areas and networks...
  6. pmc Following the genes: a framework for animal modeling of psychiatric disorders
    Kevin J Mitchell
    Smurfit Institute of Genetics and Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    BMC Biol 9:76. 2011
    ....
  7. doi The genetics of neurodevelopmental disease
    Kevin J Mitchell
    Smurfit Institute of Genetics and Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    Curr Opin Neurobiol 21:197-203. 2011
    ..They have also converged on specific neurodevelopmental pathways, providing insights into pathogenic mechanisms...
  8. pmc The genetics of brain wiring: from molecule to mind
    Kevin J Mitchell
    Smurfit Institute of Genetics and Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    PLoS Biol 5:e113. 2007
  9. pmc Mutation of Semaphorin-6A disrupts limbic and cortical connectivity and models neurodevelopmental psychopathology
    Annette E Rünker
    Smurfit Institute of Genetics and Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
    PLoS ONE 6:e26488. 2011
    ..The biological data presented here also make these genes plausible candidates to explain human linkage findings for schizophrenia and autism...
  10. ncbi Functional genomics and schizophrenia: endophenotypes and mutant models
    John L Waddington
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Psychiatr Clin North Am 30:365-99. 2007
    ..It examines gene-gene and gene-environment interactions. Finally, it looks at future directions for research...
  11. pmc Semaphorin-6A controls guidance of corticospinal tract axons at multiple choice points
    Annette E Rünker
    Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland
    Neural Dev 3:34. 2008
    ..To assess the involvement of transmembrane semaphorins and their plexin receptors in the guidance of CST axons, we have examined this tract in mutants of Semaphorin-6A (Sema6A), Plexin-A2 (PlxnA2) and Plexin-A4 (PlxnA4)...
  12. doi Differences in early sensory-perceptual processing in synesthesia: a visual evoked potential study
    Kylie J Barnett
    Institute of Neuroscience TCIN, Lloyd Building, Trinity College Dublin, Dublin 2, Ireland
    Neuroimage 43:605-13. 2008
    ..We discuss our results with reference to widespread connectivity differences as a broader phenotype of synesthesia...
  13. ncbi Expression of Plxdc2/TEM7R in the developing nervous system of the mouse
    Suzanne F C Miller
    Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland
    Gene Expr Patterns 7:635-44. 2007
    ....
  14. doi Plexin-A2 and its ligand, Sema6A, control nucleus-centrosome coupling in migrating granule cells
    Julie Renaud
    Centre National de la Recherche Scientifique, UMR7102, 9 quai Saint Bernard, Paris F 75005, France
    Nat Neurosci 11:440-9. 2008
    ..This suggests that semaphorin-plexin signaling modulates cell migration by controlling centrosome positioning...