Kingston H G Mills

Summary

Affiliation: Trinity College
Country: Ireland

Publications

  1. doi request reprint Adenylate cycalse toxin of Bordetella pertussis inhibits TLR-induced IRF-1 and IRF-8 activation and IL-12 production and enhances IL-10 through MAPK activation in dendritic cells
    Fionnuala B Hickey
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    J Leukoc Biol 84:234-43. 2008
  2. pmc Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis
    Peter McGuirk
    Immune Regulation Research Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Exp Med 195:221-31. 2002
  3. pmc Retinoic acid expression associates with enhanced IL-22 production by γδ T cells and innate lymphoid cells and attenuation of intestinal inflammation
    Lisa A Mielke
    Immunology Research Centre, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
    J Exp Med 210:1117-24. 2013
  4. pmc Relative contribution of Th1 and Th17 cells in adaptive immunity to Bordetella pertussis: towards the rational design of an improved acellular pertussis vaccine
    Pádraig J Ross
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland
    PLoS Pathog 9:e1003264. 2013
  5. doi request reprint Do we need a new vaccine to control the re-emergence of pertussis?
    Kingston H G Mills
    School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland Electronic address
    Trends Microbiol 22:49-52. 2014
  6. doi request reprint The role of inflammasome-derived IL-1 in driving IL-17 responses
    Kingston H G Mills
    Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
    J Leukoc Biol 93:489-97. 2013
  7. doi request reprint Designer adjuvants for enhancing the efficacy of infectious disease and cancer vaccines based on suppression of regulatory T cell induction
    Kingston H G Mills
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    Immunol Lett 122:108-11. 2009
  8. doi request reprint TLR9 turns the tide on Treg cells
    Kingston H G Mills
    School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    Immunity 29:518-20. 2008
  9. doi request reprint Induction, function and regulation of IL-17-producing T cells
    Kingston H G Mills
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    Eur J Immunol 38:2636-49. 2008
  10. ncbi request reprint Regulatory T cells: friend or foe in immunity to infection?
    Kingston H G Mills
    Immune Regulation Research Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    Nat Rev Immunol 4:841-55. 2004

Detail Information

Publications84

  1. doi request reprint Adenylate cycalse toxin of Bordetella pertussis inhibits TLR-induced IRF-1 and IRF-8 activation and IL-12 production and enhances IL-10 through MAPK activation in dendritic cells
    Fionnuala B Hickey
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    J Leukoc Biol 84:234-43. 2008
    ....
  2. pmc Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis
    Peter McGuirk
    Immune Regulation Research Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Exp Med 195:221-31. 2002
    ..The induction of Tr1 cells after interaction of a pathogen-derived molecule with cells of the innate immune system represents a novel strategy exploited by an infectious pathogen to subvert protective immune responses in vivo...
  3. pmc Retinoic acid expression associates with enhanced IL-22 production by γδ T cells and innate lymphoid cells and attenuation of intestinal inflammation
    Lisa A Mielke
    Immunology Research Centre, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
    J Exp Med 210:1117-24. 2013
    ....
  4. pmc Relative contribution of Th1 and Th17 cells in adaptive immunity to Bordetella pertussis: towards the rational design of an improved acellular pertussis vaccine
    Pádraig J Ross
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland
    PLoS Pathog 9:e1003264. 2013
    ..Our findings demonstrate that alum promotes protective immunity through IL-1β-induced IL-17A production, but also reveal that optimum protection against B. pertussis requires induction of Th1, but not Th2 cells...
  5. doi request reprint Do we need a new vaccine to control the re-emergence of pertussis?
    Kingston H G Mills
    School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland Electronic address
    Trends Microbiol 22:49-52. 2014
    ..Efficacy of Pa could be improved by switching from alum to alternative adjuvants that generate more potent cell mediated immunity. ..
  6. doi request reprint The role of inflammasome-derived IL-1 in driving IL-17 responses
    Kingston H G Mills
    Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
    J Leukoc Biol 93:489-97. 2013
    ..Consequently, inflammasomes are now major drug targets for many autoimmune and chronic inflammatory diseases, as well as autoinflammatory diseases...
  7. doi request reprint Designer adjuvants for enhancing the efficacy of infectious disease and cancer vaccines based on suppression of regulatory T cell induction
    Kingston H G Mills
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    Immunol Lett 122:108-11. 2009
    ..However, these subunit vaccines lack the danger signals required to activate innate immune responses and must therefore be delivered with potent adjuvants or delivery systems in order to generate protective adaptive immune responses...
  8. doi request reprint TLR9 turns the tide on Treg cells
    Kingston H G Mills
    School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    Immunity 29:518-20. 2008
    ..In this issue of Immunity, Hall et al. (2008) demonstrate that commensal bacterial DNA can suppress Treg cell conversion via TLR9-mediated activation of lamina propria dendritic cells and thus potentially disrupt intestinal homeostasis...
  9. doi request reprint Induction, function and regulation of IL-17-producing T cells
    Kingston H G Mills
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    Eur J Immunol 38:2636-49. 2008
    ....
  10. ncbi request reprint Regulatory T cells: friend or foe in immunity to infection?
    Kingston H G Mills
    Immune Regulation Research Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    Nat Rev Immunol 4:841-55. 2004
    ....
  11. ncbi request reprint Antigen-specific regulatory T cells--their induction and role in infection
    Kingston H G Mills
    Immune Regulation Research Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    Semin Immunol 16:107-17. 2004
    ..Tr1 or Th3 cells are capable of suppressing Th1 and Th2 responses and function in infection to limit pathogen-induced immunopathology, but can also be exploited in therapies for immune-mediated diseases...
  12. ncbi request reprint Toll-like receptor 4-mediated innate IL-10 activates antigen-specific regulatory T cells and confers resistance to Bordetella pertussis by inhibiting inflammatory pathology
    Sarah C Higgins
    Immune Regulation Research Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Immunol 171:3119-27. 2003
    ..pertussis, which both directly, and by promoting the induction of IL-10-secreting type 1 regulatory T cells, may inhibit Th1 responses and limit inflammatory pathology in the lungs during infection with B. pertussis...
  13. ncbi request reprint Inflammasome activation by adenylate cyclase toxin directs Th17 responses and protection against Bordetella pertussis
    Aisling Dunne
    Immunology Research Centre, School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    J Immunol 185:1711-9. 2010
    ..In addition to its known role in subverting host immunity, our findings suggest that CyaA can promote IL-1beta-mediated Th17 cells, which promote clearance of the bacteria from the respiratory tract...
  14. ncbi request reprint Attenuating regulatory T cell induction by TLR agonists through inhibition of p38 MAPK signaling in dendritic cells enhances their efficacy as vaccine adjuvants and cancer immunotherapeutics
    Andrew G Jarnicki
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    J Immunol 180:3797-806. 2008
    ..Our findings suggest that p38 is an important therapeutic target and provides a mechanism to enhance the efficacy of TLR agonists as vaccine adjuvants and cancer immunotherapeutics...
  15. pmc Adenylate cyclase toxin from Bordetella pertussis synergizes with lipopolysaccharide to promote innate interleukin-10 production and enhances the induction of Th2 and regulatory T cells
    Pádraig J Ross
    Immune Regulation Research Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    Infect Immun 72:1568-79. 2004
    ....
  16. doi request reprint Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis
    Aine C Murphy
    Trinity College Institute for Neuroscience, Trinity College, Dublin 2, Ireland
    Brain Behav Immun 24:641-51. 2010
    ..Our findings suggest that T cells which secrete IL-17 or IL-17 and IFN-gamma infiltrate the CNS prior to the onset of clinical symptoms of EAE, where they may mediate CNS inflammation, in part, through microglial activation...
  17. ncbi request reprint Bordetella pertussis adenylate cyclase toxin modulates innate and adaptive immune responses: distinct roles for acylation and enzymatic activity in immunomodulation and cell death
    Aoife P Boyd
    Immune Regulation Research Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Immunol 175:730-8. 2005
    ....
  18. doi request reprint Escherichia coli heat-labile enterotoxin promotes protective Th17 responses against infection by driving innate IL-1 and IL-23 production
    Corinna F Brereton
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    J Immunol 186:5896-906. 2011
    ..Our findings provide clear evidence that LT can promote protective immune responses in part through induction of innate IL-1 and, consequently, Th17 cells...
  19. pmc Regulation of interleukin-1beta by interferon-gamma is species specific, limited by suppressor of cytokine signalling 1 and influences interleukin-17 production
    Seth L Masters
    Immunology Research Centre, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    EMBO Rep 11:640-6. 2010
    ..In mice, IFNgamma decreased IL-1beta and subsequently IL-17, indicating that the adaptive immune response can provide a systemic, but transient, signal to limit inflammation...
  20. doi request reprint Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity
    Caroline E Sutton
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    Immunity 31:331-41. 2009
    ..Our findings demonstrate that gammadelta T cells activated by IL-1beta and IL-23 are an important source of innate IL-17 and IL-21 and provide an alternative mechanism whereby IL-1 and IL-23 may mediate autoimmune inflammation...
  21. doi request reprint Psychological stress suppresses innate IFN-gamma production via glucocorticoid receptor activation: reversal by the anxiolytic chlordiazepoxide
    Niamh M Curtin
    Neuroimmunology Research Group, Department of Physiology, School of Medicine and Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland
    Brain Behav Immun 23:535-47. 2009
    ....
  22. doi request reprint Decreased neuronal CD200 expression in IL-4-deficient mice results in increased neuroinflammation in response to lipopolysaccharide
    Anthony Lyons
    Trinity College Institute for Neuroscience, Trinity College, Dublin 2, Ireland
    Brain Behav Immun 23:1020-7. 2009
    ..These findings suggest that the neuromodulatory effect of IL-4, and in particular its capacity to maintain microglia in a quiescent state, may result from its ability to upregulate CD200 expression on neurons...
  23. ncbi request reprint Depletion of NK cells results in disseminating lethal infection with Bordetella pertussis associated with a reduction of antigen-specific Th1 and enhancement of Th2, but not Tr1 cells
    Patricia Byrne
    Immune Regulation Research Group, Department of Biochemistry, Trinity College, Dublin, Ireland
    Eur J Immunol 34:2579-88. 2004
    ..These findings suggest that NK cells confer resistance to B. pertussis by activating IL-12-mediated production of IFN-gamma, which enhances the anti-bacterial activity of macrophages, but also promotes the differentiation of Th1 cells...
  24. ncbi request reprint Cholera toxin promotes the induction of regulatory T cells specific for bystander antigens by modulating dendritic cell activation
    Ed C Lavelle
    Immune Regulation Research Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Immunol 171:2384-92. 2003
    ....
  25. doi request reprint Caspase-1-processed cytokines IL-1beta and IL-18 promote IL-17 production by gammadelta and CD4 T cells that mediate autoimmunity
    Stephen J Lalor
    School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    J Immunol 186:5738-48. 2011
    ....
  26. doi request reprint Activation of mixed glia by Abeta-specific Th1 and Th17 cells and its regulation by Th2 cells
    K McQuillan
    Trinity College Institute for Neuroscience, Trinity College, Dublin 2, Ireland
    Brain Behav Immun 24:598-607. 2010
    ..These data indicate that Abeta-specific Th1 and Th17 cells induce inflammatory activation of glia, and that this is in part regulated by Th2 cells...
  27. ncbi request reprint TLR4 mediates vaccine-induced protective cellular immunity to Bordetella pertussis: role of IL-17-producing T cells
    Sarah C Higgins
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    J Immunol 177:7980-9. 2006
    ..Our findings also demonstrate that activation of innate immune cells through TLR4 helps to direct the induction of Th1 and Th-17 cells, which mediate protective cellular immunity to B. pertussis...
  28. ncbi request reprint Proinflammatory responses in the murine brain after intranasal delivery of cholera toxin: implications for the use of AB toxins as adjuvants in intranasal vaccines
    Michelle E Armstrong
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    J Infect Dis 192:1628-33. 2005
    ..Our findings suggest that CT can induce proinflammatory mediators in the brain when it is administered intranasally but not parenterally, and they raise concerns about the use of AB toxins as adjuvants in intranasal vaccines...
  29. doi request reprint A conjugated linoleic acid-enriched beef diet attenuates lipopolysaccharide-induced inflammation in mice in part through PPARgamma-mediated suppression of toll-like receptor 4
    Clare M Reynolds
    UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, Ireland
    J Nutr 139:2351-7. 2009
    ..In addition, downregulation of BMDC TLR4 is mediated through induction of PPARgamma...
  30. ncbi request reprint Hepatitis C virus-specific Th17 cells are suppressed by virus-induced TGF-beta
    Aileen G Rowan
    School of Biochemistry and Immunology, Trinity College Dublin, Ireland
    J Immunol 181:4485-94. 2008
    ..This may represent a novel immune subversion mechanism by the virus to evade host-protective immune responses. Our findings also suggest that TGF-beta and IL-10 play important roles in constraining the function of Th17 cells in general...
  31. pmc Bordetella pertussis expresses a functional type III secretion system that subverts protective innate and adaptive immune responses
    Neil K Fennelly
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    Infect Immun 76:1257-66. 2008
    ..Our findings suggest that the TTSS subverts innate and adaptive immune responses during infection of the lungs and may be a functionally important virulence factor for B. pertussis infection of humans...
  32. doi request reprint Blocking retinoic acid receptor-α enhances the efficacy of a dendritic cell vaccine against tumours by suppressing the induction of regulatory T cells
    Karen C Galvin
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, 152 160 Pearse St, Dublin 2, Ireland
    Cancer Immunol Immunother 62:1273-82. 2013
    ..Our findings demonstrate that RARα is an important target for the development of effective anti-tumour immunotherapeutics and for improving the efficacy of cancer vaccines...
  33. doi request reprint Alveolar macrophages contribute to respiratory tolerance by inducing FoxP3 expression in naive T cells
    Michelle M Coleman
    Immune Regulation Research Group, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland
    Am J Respir Cell Mol Biol 48:773-80. 2013
    ..Our findings suggest that AMs can mediate tolerance in the lungs of mice and humans via RA and TGF-β₁. These data may have implications in the development of nasal vaccines in the future...
  34. ncbi request reprint IFN-γ Production by amyloid β-specific Th1 cells promotes microglial activation and increases plaque burden in a mouse model of Alzheimer's disease
    Tara C Browne
    Trinity College Institute of Neuroscience, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
    J Immunol 190:2241-51. 2013
    ..Our study suggests that release of IFN-γ from infiltrating Th1 cells significantly accelerates markers of diseases in an animal model of AD...
  35. doi request reprint A novel anti-inflammatory role of NCAM-derived mimetic peptide, FGL
    Eric J Downer
    Trinity College Institute for Neuroscience, Physiology Department, Trinity College, Dublin 2, Ireland
    Neurobiol Aging 31:118-28. 2010
    ..These findings provide the first evidence of a role for FGL as an anti-inflammatory agent and identify a mechanism by which FGL controls microglial activation...
  36. ncbi request reprint Reciprocal effects of Th1 and Treg cell inducing pathogen-associated immunomodulatory molecules on anti-tumor immunity
    Joanne Lysaght
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    Cancer Immunol Immunother 56:1367-79. 2007
    ....
  37. doi request reprint IL-27 mediates the response to IFN-β therapy in multiple sclerosis patients by inhibiting Th17 cells
    Cheryl M Sweeney
    School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    Brain Behav Immun 25:1170-81. 2011
    ..Our findings suggest that IFN-β mediates its therapeutic effects in MS at least in part via the induction of IL-27, and that IL-27 may represent an alternative therapy for MS patients that do not respond to IFN-β...
  38. ncbi request reprint Effects of cholera toxin on innate and adaptive immunity and its application as an immunomodulatory agent
    Ed C Lavelle
    Department of Biochemistry, Trinity College, Dublin, Ireland
    J Leukoc Biol 75:756-63. 2004
    ..Therefore, CT may promote the induction of Th2 and Tr1 cells in part via selective modulation of DC cytokine production and costimulatory molecule expression...
  39. ncbi request reprint Suppression of antitumor immunity by IL-10 and TGF-beta-producing T cells infiltrating the growing tumor: influence of tumor environment on the induction of CD4+ and CD8+ regulatory T cells
    Andrew G Jarnicki
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    J Immunol 177:896-904. 2006
    ..However, CD8+ T regulatory cells expressing IL-10 and TGF-beta are also recruited or activated by the immunosuppressive environment of the lung, where they may suppress the induction of antitumor immunity...
  40. ncbi request reprint Intranasal immunization with genetically detoxified diphtheria toxin induces T cell responses in humans: enhancement of Th2 responses and toxin-neutralizing antibodies by formulation with chitosan
    Edel A McNeela
    Immune Regulation Research Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    Vaccine 22:909-14. 2004
    ..Furthermore, our findings demonstrate that mucosal subunit vaccines with appropriate delivery systems have considerable potential for booster immunization of adults...
  41. doi request reprint Inhibition of ERK MAPK suppresses IL-23- and IL-1-driven IL-17 production and attenuates autoimmune disease
    Corinna F Brereton
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    J Immunol 183:1715-23. 2009
    ....
  42. pmc A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis
    Caroline Sutton
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    J Exp Med 203:1685-91. 2006
    ..Tumor necrosis factor alpha also synergized with IL-23 to enhance IL-17 production, and this was IL-1 dependent. Our findings demonstrate that IL-1 functions upstream of IL-17 to promote pathogenic ThIL-17 cells in EAE...
  43. ncbi request reprint Psychological stress increases expression of IL-10 and its homolog IL-19 via beta-adrenoceptor activation: reversal by the anxiolytic chlordiazepoxide
    Niamh M Curtin
    Neuroimmunology Research Group, Department of Physiology, School of Medicine and Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland
    Brain Behav Immun 23:371-9. 2009
    ..The findings suggest that stress enhances the production of immunosuppressive cytokines, which may impact on stress-related disease processes...
  44. doi request reprint IL-1F5 mediates anti-inflammatory activity in the brain through induction of IL-4 following interaction with SIGIRR/TIR8
    Ceire Costelloe
    Trinity College Institute for Neuroscience, Trinity College, Dublin, Ireland
    J Neurochem 105:1960-9. 2008
    ..In contrast to its effects in brain tissue, IL-1F5 did not attenuate LPS-induced changes, or up-regulated IL-4 in macrophages or dendritic cells, suggesting that the effect is confined to the brain...
  45. ncbi request reprint Therapeutic vaccination with dendritic cells pulsed with tumor-derived Hsp70 and a COX-2 inhibitor induces protective immunity against B16 melanoma
    Deirdre Toomey
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    Vaccine 26:3540-9. 2008
    ..Our findings provide a novel immunotherapeutic approach against cancer based on attenuation of COX-2-mediated immunosuppression using in vitro modulated DC...
  46. doi request reprint Immunotherapy with PI3K inhibitor and Toll-like receptor agonist induces IFN-γ+IL-17+ polyfunctional T cells that mediate rejection of murine tumors
    Neil A Marshall
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland
    Cancer Res 72:581-91. 2012
    ..These findings suggest important uses for PI3K inhibitors in heightening responses to cancer immunotherapy and immunochemotherapy...
  47. doi request reprint Therapeutic potential of targeting IL-17
    Sarah A Jones
    School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland
    Nat Immunol 13:1022-5. 2012
    ..A June 2012 meeting in Dublin, Ireland, showcased advances in the understanding of the role of IL-17 and related cytokines in host immunity and how these cytokines have been successfully targeted for the treatment of autoimmunity...
  48. doi request reprint Gene silencing of TGF-β1 enhances antitumor immunity induced with a dendritic cell vaccine by reducing tumor-associated regulatory T cells
    Helen Conroy
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Room 4 04, Pearse Street, Dublin 2, Ireland
    Cancer Immunol Immunother 61:425-31. 2012
    ..Our findings suggest that transient suppression of TGF-β1 may be a promising approach for enhancing the efficacy of tumor vaccines in humans...
  49. doi request reprint The role of regulatory T cells in respiratory infections and allergy and asthma
    Peter McGuirk
    School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    Curr Allergy Asthma Rep 10:21-8. 2010
    ....
  50. ncbi request reprint Hepatitis C virus non-structural protein 4 suppresses Th1 responses by stimulating IL-10 production from monocytes
    Miriam T Brady
    Immune Regulation Research Group, Department of Biochemistry, Trinity College, Dublin, Ireland
    Eur J Immunol 33:3448-57. 2003
    ..Our data suggest that HCV subverts cellular immunity by inducing IL-10 and inhibiting IL-12 production by monocytes, which in turn inhibits the activation of DC that drive the differentiation of Th1 cells...
  51. doi request reprint CD39+Foxp3+ regulatory T Cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis
    Jean M Fletcher
    School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    J Immunol 183:7602-10. 2009
    ....
  52. doi request reprint TLR-dependent T cell activation in autoimmunity
    Kingston H G Mills
    Immunology Research Centre and School of Biochemistry and Immunology, Trinity College Dublin, Ireland
    Nat Rev Immunol 11:807-22. 2011
    ..This leads to pro-inflammatory cytokine production and T cell activation, which are now considered to be major factors in the development of autoimmunity...
  53. doi request reprint Infection with a helminth parasite attenuates autoimmunity through TGF-beta-mediated suppression of Th17 and Th1 responses
    Kevin P Walsh
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    J Immunol 183:1577-86. 2009
    ..hepatica-induced TGF-beta plays a critical role in bystander suppression of autoantigen-specific Th1 and Th17 responses that mediate autoimmune diseases...
  54. ncbi request reprint Conjugated linoleic acid suppresses NF-kappa B activation and IL-12 production in dendritic cells through ERK-mediated IL-10 induction
    Christine E Loscher
    Department of Clinical Medicine, Institute of Molecular Medicine, Dublin, Ireland
    J Immunol 175:4990-8. 2005
    ....
  55. doi request reprint CD11c+CD8alpha+ dendritic cells promote protective immunity to respiratory infection with Bordetella pertussis
    Padraic J Dunne
    Trinity College Dublin, Ireland
    J Immunol 183:400-10. 2009
    ..These findings demonstrate that CD11c(+)CD8alpha(+) and CD11c(+)CD103(+)DC play a protective role in mediating immunity to B. pertussis infection in the respiratory tract...
  56. ncbi request reprint Role of interleukin-4 in regulation of age-related inflammatory changes in the hippocampus
    Yvonne Nolan
    Physiology Department, Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland
    J Biol Chem 280:9354-62. 2005
    ..We propose that interplay between pro-inflammatory and anti-inflammatory responses impact significantly on synaptic function in the hippocampus of the aged rat...
  57. ncbi request reprint Innate IL-10 promotes the induction of Th2 responses with plasmid DNA expressing HIV gp120
    Lyn M Daly
    Immune Regulation Research Group, Department of Biochemistry, Trinity College, Dublin, Ireland
    Vaccine 23:963-74. 2005
    ....
  58. doi request reprint Osteoarthritis-associated basic calcium phosphate crystals induce pro-inflammatory cytokines and damage-associated molecules via activation of Syk and PI3 kinase
    Clare C Cunningham
    Immunology Research Centre, School of Biochemistry and Immunology, Trinity College Dublin, Ireland
    Clin Immunol 144:228-36. 2012
    ..We therefore identify Syk and PI3 kinase as potential novel targets for the treatment of BCP-related pathologies...
  59. doi request reprint The immunoregulatory role of CD4⁺ FoxP3⁺ CD25⁻ regulatory T cells in lungs of mice infected with Bordetella pertussis
    Michelle M Coleman
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    FEMS Immunol Med Microbiol 64:413-24. 2012
    ..Our findings suggest that IL-10-producing CD4(+) FoxP3(+) CD25(-) T cells represent an important regulatory cell in the lung...
  60. doi request reprint Immunology meets neuroscience--opportunities for immune intervention in neurodegenerative diseases
    Marina A Lynch
    Trinity Institute for Neuroscience, Trinity College, Dublin, Ireland
    Brain Behav Immun 26:1-10. 2012
    ....
  61. ncbi request reprint Induction and detection of T-cell responses
    Kingston H G Mills
    Immune Regulation Research Group, Department of Biochemistry, Trinity College, Dublin, Ireland
    Methods Mol Med 87:255-78. 2003
  62. ncbi request reprint Regulatory cells and the control of respiratory infection
    Peter McGuirk
    Department of Biochemistry, Trinity College, Dublin 2, Ireland
    Curr Allergy Asthma Rep 5:51-5. 2005
    ....
  63. ncbi request reprint CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: a role for IL-4
    Anthony Lyons
    Trinity College Institute for Neuroscience, Physiology Department, Trinity College, Dublin 2, Ireland
    J Neurosci 27:8309-13. 2007
    ..Our findings provide the first demonstration of a role for IL-4 in modulating CD200 expression and suggest a mechanism for regulation of microglial activation in the intact CNS under inflammatory conditions...
  64. doi request reprint Autophagy regulates IL-23 secretion and innate T cell responses through effects on IL-1 secretion
    Celia Peral de Castro
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin 2, Ireland
    J Immunol 189:4144-53. 2012
    ..These data demonstrate that autophagy has a potentially pivotal role to play in the induction and regulation of inflammatory responses by innate immune cells, largely driven by IL-1 and its consequential effects on IL-23 secretion...
  65. ncbi request reprint Pathogen-specific regulatory T cells provoke a shift in the Th1/Th2 paradigm in immunity to infectious diseases
    Peter McGuirk
    Immune Regulation Research Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    Trends Immunol 23:450-5. 2002
    ..These observations have significant implications for our understanding of the role of T cells in immunity to infectious diseases and for the development of new therapies for immune-mediated disorders...
  66. ncbi request reprint Molecules of infectious agents as immunomodulatory drugs
    Ed C Lavelle
    Immune Regulation Research Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    Curr Top Med Chem 4:499-508. 2004
    ..This short review, describes representative microbial immunomodulators, their modes of action and the potential for therapeutic application...
  67. ncbi request reprint TLR based therapeutics
    Aisling Dunne
    School of Biochemistry and Immunology, and Immunology Research Centre, Trinity College Dublin, Ireland
    Curr Opin Pharmacol 11:404-11. 2011
    ..Some have shown to be efficacious in pre-clinical models, and have now entered clinical trials...
  68. ncbi request reprint Interleukin-1 receptor antagonist exerts agonist activity in the hippocampus independent of the interleukin-1 type I receptor
    Christine E Loscher
    Immune Regulation Research Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Neuroimmunol 137:117-24. 2003
    ..These data, taken together with our findings that IL-1ra binds to hippocampal synaptosomes in the absence of IL-1RI, provide evidence that IL-1ra exerts agonist activity in the hippocampus independent of IL-1RI...
  69. pmc Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
    Seth L Masters
    Immunology Research Centre, School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    Nat Immunol 11:897-904. 2010
    ..Our findings identify previously unknown mechanisms in the pathogenesis of type 2 diabetes and treatment of pathology caused by IAPP...
  70. pmc Lack of interleukin-1 receptor I (IL-1RI) protects mice from high-fat diet-induced adipose tissue inflammation coincident with improved glucose homeostasis
    Fiona C McGillicuddy
    Nutrigenomics Research Group, University College Dublin Conway Institute, School of Public Health and Population Science, University College Dublin, Dublin, Ireland
    Diabetes 60:1688-98. 2011
    ..We hypothesized that lack of IL-1RI may ameliorate HFD-induced IR by attenuating adipose tissue inflammation...
  71. ncbi request reprint Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1 beta on long term potentiation in rat dentate gyrus
    Aine Kelly
    Trinity College Institute of Neuroscience, Department of Physiology, Dublin 2, Ireland
    J Biol Chem 278:19453-62. 2003
    ..The evidence is consistent with the idea that the LPS-induced impairment in LTP is mediated by IL-1 beta and is a consequence of activation of p38...
  72. ncbi request reprint CD4 T helper type 1 and regulatory T cells induced against the same epitopes on the core protein in hepatitis C virus-infected persons
    Angus J MacDonald
    Immune Regulation Research Group, Department of Biochemistry, Trinity College Dublin, Ireland
    J Infect Dis 185:720-7. 2002
    ..These findings demonstrate that T helper type 1 and regulatory T cells are induced against the same epitopes on the core protein during HCV infection...
  73. ncbi request reprint IL-1beta-dependent neurological effects of the whole cell pertussis vaccine: a role for IL-1-associated signalling components in vaccine reactogenicity
    Michelle E Armstrong
    Immune Regulation Research Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Neuroimmunol 136:25-33. 2003
    ..These results suggest that the neurological effects of Pw are associated with central activation of IL-1beta and IL-1-associated signalling components...
  74. ncbi request reprint IL-17-producing γδ T cells and innate lymphoid cells
    Caroline E Sutton
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland
    Eur J Immunol 42:2221-31. 2012
    ..Evidence is emerging that these newly recognised sources of IL-17 play both pathological and protective roles in inflammatory diseases as discussed in this article...
  75. doi request reprint Caspase-1-processed IL-1 family cytokines play a vital role in driving innate IL-17
    Lara S Dungan
    School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    Cytokine 56:126-32. 2011
    ..Caspase-1 processed IL-1 family cytokines therefore play a vital role in the innate immune response and induction of IL-17 from innate immune cells which functions to fight infections and promote autoimmunity...
  76. doi request reprint Influence of gastrointestinal commensal bacteria on the immune responses that mediate allergy and asthma
    Rachel M McLoughlin
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    J Allergy Clin Immunol 127:1097-107; quiz 1108-9. 2011
    ....
  77. doi request reprint Targeting regulatory T cells in cancer
    William L Byrne
    Cork Cancer Research Centre, Mercy University Hospital and Leslie C Quick Jnr Laboratory, University College Cork, Cork, Ireland
    Cancer Res 71:6915-20. 2011
    ..Emerging technologies, such as RNA interference and tetramer-based targeting, may have the potential to improve selectivity and efficacy...
  78. ncbi request reprint TLR, NLR Agonists, and Other Immune Modulators as Infectious Disease Vaccine Adjuvants
    Sarah C Higgins
    School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    Curr Infect Dis Rep 12:4-12. 2010
    ....
  79. ncbi request reprint Inhibition of matrix metalloproteinases ameliorates blood-brain barrier disruption and neuropathological lesions caused by avirulent Semliki Forest virus infection
    Brian Keogh
    Immune Regulation Research Group, Biochemistry Department, Trinity College, Dublin 2, Ireland
    Vet Immunol Immunopathol 94:185-90. 2003
    ..Low levels of neuronal necrosis and demyelination in GM6001-treated mice correlated with localisation of fibrinogen staining to thin-walled blood vessels and less intense staining of the perivascular neuropil...
  80. ncbi request reprint Live vectors: are safe but effective vaccines possible?
    Kingston H G Mills
    Immune Regulation Research Group, Dept of Biochemistry, Trinity College, Dublin 2, Ireland
    Drug Discov Today 7:854-5. 2002
  81. pmc Protective levels of diphtheria-neutralizing antibody induced in healthy volunteers by unilateral priming-boosting intranasal immunization associated with restricted ipsilateral mucosal secretory immunoglobulin a
    Kingston H G Mills
    Immune Regulation Research Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    Infect Immun 71:726-32. 2003
    ..However, a restricted sIgA response suggests that care must be taken in the priming-boosting strategy and clinical sampling techniques when evaluating such vaccines for the induction of local mucosal immunity...
  82. ncbi request reprint Nitroreductase-based therapy of prostate cancer, enhanced by raising expression of heat shock protein 70, acts through increased anti-tumour immunity
    Kai S Lipinski
    Immune Regulation Research Group, Department of Biochemistry, Trinity College, Dublin, Ireland
    Cancer Immunol Immunother 55:347-54. 2006
    ..Protection was CD4+ and CD8+ T cell-dependent and was associated with tumour-specific CTL, IFNgamma and IL-5 responses. The use of such a cytotoxic and immunomodulatory gene combination in cancer therapy warrants further pursuit...
  83. pmc Prevention of experimental colitis by parenteral administration of a pathogen-derived immunomodulatory molecule
    Henri Braat
    Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Gut 56:351-7. 2007
    ..Hypothesis: Injection of FHA would ameliorate disease in a T cell-dependent model of colitis via the induction of anti-inflammatory cytokines and regulatory T cells...
  84. pmc Phase I evaluation of intranasal trivalent inactivated influenza vaccine with nontoxigenic Escherichia coli enterotoxin and novel biovector as mucosal adjuvants, using adult volunteers
    Iain Stephenson
    Infectious Diseases Unit, Leicester Royal Infirmary, Leicester LE1 5WW, United Kingdom
    J Virol 80:4962-70. 2006
    ..The addition of the biovector to the vaccine given with 30 microg LTK63 enhanced mucosal IgA responses to A/Duck/Singapore (H5N3) (P=0.0491) and B/Guandong (P=0.0028) but not to A/Panama (H3N2). All vaccines were well tolerated...