Sinead M Miggin

Summary

Affiliation: Trinity College
Country: Ireland

Publications

  1. ncbi request reprint New insights into the regulation of TLR signaling
    Sinead M Miggin
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    J Leukoc Biol 80:220-6. 2006
  2. pmc NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1
    Sinead M Miggin
    School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    Proc Natl Acad Sci U S A 104:3372-7. 2007
  3. ncbi request reprint Interferon regulatory factor-3-mediated activation of the interferon-sensitive response element by Toll-like receptor (TLR) 4 but not TLR3 requires the p65 subunit of NF-kappa
    Claudia Wietek
    Department of Biochemistry, Trinity College, Dublin, Ireland
    J Biol Chem 278:50923-31. 2003
  4. ncbi request reprint Investigation of the mechanisms of G protein: effector coupling by the human and mouse prostacyclin receptors. Identification of critical species-dependent differences
    Sinead M Miggin
    Department of Biochemistry, Conway Institute of Biomolecular and Biomedical Research, Merville House, University College Dublin, Belfield, Dublin 4, Ireland
    J Biol Chem 277:27053-64. 2002
  5. ncbi request reprint Palmitoylation of the human prostacyclin receptor. Functional implications of palmitoylation and isoprenylation
    Sinead M Miggin
    Department of Biochemistry, Conway Institute of Biomolecular and Biomedical Research, Merville House, University College Dublin, Belfield, Dublin 4, Ireland
    J Biol Chem 278:6947-58. 2003

Detail Information

Publications5

  1. ncbi request reprint New insights into the regulation of TLR signaling
    Sinead M Miggin
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    J Leukoc Biol 80:220-6. 2006
    ..Here, we describe recent advances that have been made in our understanding of how TLR signaling is regulated at the biochemical level...
  2. pmc NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1
    Sinead M Miggin
    School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    Proc Natl Acad Sci U S A 104:3372-7. 2007
    ..This functional interaction reveals an important aspect of the coordination between TLRs and caspase-1 during the innate response to pathogens...
  3. ncbi request reprint Interferon regulatory factor-3-mediated activation of the interferon-sensitive response element by Toll-like receptor (TLR) 4 but not TLR3 requires the p65 subunit of NF-kappa
    Claudia Wietek
    Department of Biochemistry, Trinity College, Dublin, Ireland
    J Biol Chem 278:50923-31. 2003
    ..Finally, p65 promoted transactivation of gene expression by IRF-3. These results therefore indicate that IRF-3-mediated activation of the ISRE by TLR4 but not TLR3 requires the p65 subunit of NF-kappa B...
  4. ncbi request reprint Investigation of the mechanisms of G protein: effector coupling by the human and mouse prostacyclin receptors. Identification of critical species-dependent differences
    Sinead M Miggin
    Department of Biochemistry, Conway Institute of Biomolecular and Biomedical Research, Merville House, University College Dublin, Belfield, Dublin 4, Ireland
    J Biol Chem 277:27053-64. 2002
    ..Collectively, our data highlight critical differences in signaling by the mIP and hIP that are regulated by their differential phosphorylation by PKA and PKC together with contextual sequence differences surrounding those sites...
  5. ncbi request reprint Palmitoylation of the human prostacyclin receptor. Functional implications of palmitoylation and isoprenylation
    Sinead M Miggin
    Department of Biochemistry, Conway Institute of Biomolecular and Biomedical Research, Merville House, University College Dublin, Belfield, Dublin 4, Ireland
    J Biol Chem 278:6947-58. 2003
    ....