Rachel M McLoughlin
Affiliation: Trinity College
- Longitudinal relationship of early life immunomodulatory T cell phenotype and function to development of allergic sensitization in an urban cohortR M McLoughlin
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
Clin Exp Allergy 42:392-404. 2012..Immunomodulatory T cells are thought to influence development of allergy and asthma, but early life longitudinal data on their phenotype and function are lacking...
- Influence of gastrointestinal commensal bacteria on the immune responses that mediate allergy and asthmaRachel M McLoughlin
School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
J Allergy Clin Immunol 127:1097-107; quiz 1108-9. 2011....
- Relative contribution of Th1 and Th17 cells in adaptive immunity to Bordetella pertussis: towards the rational design of an improved acellular pertussis vaccinePádraig J Ross
Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland
PLoS Pathog 9:e1003264. 2013..Our findings demonstrate that alum promotes protective immunity through IL-1β-induced IL-17A production, but also reveal that optimum protection against B. pertussis requires induction of Th1, but not Th2 cells...
- Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4Edel A McNeela
Adjuvant Research Group, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
PLoS Pathog 6:e1001191. 2010..Furthermore, NLRP3 was required for protective immunity against respiratory infection with S. pneumoniae. These results add significantly to our understanding of the interactions between PLY and the immune system...