Anne F McGettrick

Summary

Affiliation: Trinity College
Country: Ireland

Publications

  1. doi request reprint The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation
    Sarah L Doyle
    Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Pearse Street, Dublin 2, Ireland
    Nat Commun 3:707. 2012
  2. doi request reprint Localisation and trafficking of Toll-like receptors: an important mode of regulation
    Anne F McGettrick
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Curr Opin Immunol 22:20-7. 2010
  3. ncbi request reprint Toll-like receptors: key activators of leucocytes and regulator of haematopoiesis
    Anne F McGettrick
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    Br J Haematol 139:185-93. 2007
  4. pmc The GOLD domain-containing protein TMED1 is involved in interleukin-33 signaling
    Dympna J Connolly
    Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 288:5616-23. 2013
  5. ncbi request reprint The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction
    Anne F McGettrick
    Department of Biochemistry, Trinity College Dublin, Dublin, Ireland
    Mol Immunol 41:577-82. 2004
  6. doi request reprint Regulators of TLR4 signaling by endotoxins
    Anne F McGettrick
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Subcell Biochem 53:153-71. 2010
  7. pmc How Metabolism Generates Signals during Innate Immunity and Inflammation
    Anne F McGettrick
    From the School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 288:22893-8. 2013
  8. pmc Nuclear Factor κB2 p52 Protein Has a Role in Antiviral Immunity through IκB Kinase {epsilon}-dependent Induction of Sp1 Protein and Interleukin 15
    Sarah L Doyle
    From the Immunology Research Centre, Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 288:25066-75. 2013
  9. doi request reprint TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway
    Eva M Palsson-McDermott
    School of Biochemistry and Immunology, Trinity College Dublin, Ireland
    Nat Immunol 10:579-86. 2009
  10. pmc Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling
    Anne F McGettrick
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Proc Natl Acad Sci U S A 103:9196-201. 2006

Collaborators

Detail Information

Publications12

  1. doi request reprint The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation
    Sarah L Doyle
    Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Pearse Street, Dublin 2, Ireland
    Nat Commun 3:707. 2012
    ..A TMED homologue, logjam, has a negative role in the Toll and IMD pathways in Drosophila melanogaster; therefore, TMEDs may have a conserved role in the regulation of innate immunity...
  2. doi request reprint Localisation and trafficking of Toll-like receptors: an important mode of regulation
    Anne F McGettrick
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Curr Opin Immunol 22:20-7. 2010
    ..Several proteins, including Triad3A and TAG appear to be involved in the movement of TLR4 to the lysosome for degradation...
  3. ncbi request reprint Toll-like receptors: key activators of leucocytes and regulator of haematopoiesis
    Anne F McGettrick
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    Br J Haematol 139:185-93. 2007
    ..B cells and T cells proliferation and differentiation is influenced by TLR activation and the possible therapeutic benefits of using TLR ligands for the treatment of chronic lymphocytic leukaemia will also be discussed...
  4. pmc The GOLD domain-containing protein TMED1 is involved in interleukin-33 signaling
    Dympna J Connolly
    Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 288:5616-23. 2013
    ..This discovery provides additional support to the concept that the TMED family members are important players in innate immune signaling...
  5. ncbi request reprint The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction
    Anne F McGettrick
    Department of Biochemistry, Trinity College Dublin, Dublin, Ireland
    Mol Immunol 41:577-82. 2004
    ..Different TLRs use different combinations of these adaptors, leading to the activation of common and unique pathways involved in the elimination of the invading microbe...
  6. doi request reprint Regulators of TLR4 signaling by endotoxins
    Anne F McGettrick
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Subcell Biochem 53:153-71. 2010
    ..Several regulatory mechanisms, including localisation of components, splice variants and inhibitory molecules will be discussed in this review...
  7. pmc How Metabolism Generates Signals during Innate Immunity and Inflammation
    Anne F McGettrick
    From the School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 288:22893-8. 2013
    ..These observations cast new light on the role of metabolism during host defense and inflammation. ..
  8. pmc Nuclear Factor κB2 p52 Protein Has a Role in Antiviral Immunity through IκB Kinase {epsilon}-dependent Induction of Sp1 Protein and Interleukin 15
    Sarah L Doyle
    From the Immunology Research Centre, Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 288:25066-75. 2013
    ..Our study identifies NFκB2 as a target for IKKε in antiviral immunity and describes, for the first time, a role for NFκB2 in the regulation of gene expression in response to viral infection. ..
  9. doi request reprint TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway
    Eva M Palsson-McDermott
    School of Biochemistry and Immunology, Trinity College Dublin, Ireland
    Nat Immunol 10:579-86. 2009
    ..Targeting TAG could be useful in the effort to boost the immunostimulatory effect of TLR4 without causing unwanted inflammation...
  10. pmc Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling
    Anne F McGettrick
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Proc Natl Acad Sci U S A 103:9196-201. 2006
    ..We have therefore uncovered a key process in Toll-like receptor 4 signaling, identifying TRAM as the target for PKCepsilon...
  11. ncbi request reprint Dye-ligand affinity chromatography
    Anne F McGettrick
    Department of Biochemistry Trinity College, Dublin, Ireland
    Methods Mol Biol 244:151-7. 2004
  12. pmc The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction
    Daniel C Rowe
    Division of Infectious Disease and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 103:6299-304. 2006
    ....