Claire E McCoy

Summary

Affiliation: Trinity College
Country: Ireland

Publications

  1. ncbi request reprint The role of toll-like receptors in macrophages
    Claire E McCoy
    Department of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Front Biosci 13:62-70. 2008
  2. doi request reprint Glucocorticoids inhibit IRF3 phosphorylation in response to Toll-like receptor-3 and -4 by targeting TBK1 activation
    Claire E McCoy
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 283:14277-85. 2008
  3. pmc IL-10 inhibits miR-155 induction by toll-like receptors
    Claire E McCoy
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 285:20492-8. 2010
  4. pmc The Role of Ets2 Transcription Factor in the Induction of MicroRNA-155 (miR-155) by Lipopolysaccharide and Its Targeting by Interleukin-10
    Susan R Quinn
    From the School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 289:4316-25. 2014
  5. doi request reprint MicroRNAs: the fine-tuners of Toll-like receptor signalling
    Luke A O'Neill
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    Nat Rev Immunol 11:163-75. 2011
  6. pmc miR-19a: an effective regulator of SOCS3 and enhancer of JAK-STAT signalling
    Aideen S Collins
    School of Biochemistry and Immunology, Trinity College, University of Dublin, Dublin, Ireland
    PLoS ONE 8:e69090. 2013
  7. pmc MSK1 activity is controlled by multiple phosphorylation sites
    Claire E McCoy
    MRC Protein Phosphorylation Unit, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 387:507-17. 2005
  8. pmc Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS
    Claire E McCoy
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 402:491-501. 2007

Detail Information

Publications8

  1. ncbi request reprint The role of toll-like receptors in macrophages
    Claire E McCoy
    Department of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Front Biosci 13:62-70. 2008
    ..Since their discovery, it has become clear that Toll-like receptors (TLRs) can play a major role in these macrophage functions. This review will describe the TLRs, their signalling pathways and their role in macrophage function...
  2. doi request reprint Glucocorticoids inhibit IRF3 phosphorylation in response to Toll-like receptor-3 and -4 by targeting TBK1 activation
    Claire E McCoy
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 283:14277-85. 2008
    ..Our study, therefore, demonstrates that TBK1 is a target for dexamethasone, common to both TLR3 and TLR4 signaling...
  3. pmc IL-10 inhibits miR-155 induction by toll-like receptors
    Claire E McCoy
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 285:20492-8. 2010
    ..This is the first example of IL-10 playing a role in microRNA function and suggests that through its inhibitory effect on miR-155, IL-10 has the ability to promote anti-inflammatory gene expression...
  4. pmc The Role of Ets2 Transcription Factor in the Induction of MicroRNA-155 (miR-155) by Lipopolysaccharide and Its Targeting by Interleukin-10
    Susan R Quinn
    From the School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 289:4316-25. 2014
    ..We have thus identified Ets2 as a key novel regulator in both the positive and negative control of miR-155 in the inflammatory response. ..
  5. doi request reprint MicroRNAs: the fine-tuners of Toll-like receptor signalling
    Luke A O'Neill
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    Nat Rev Immunol 11:163-75. 2011
    ..miRNAs are also proving to be an important link between the innate and adaptive immune systems, and their dysregulation might have a role in the pathogenesis of inflammatory diseases...
  6. pmc miR-19a: an effective regulator of SOCS3 and enhancer of JAK-STAT signalling
    Aideen S Collins
    School of Biochemistry and Immunology, Trinity College, University of Dublin, Dublin, Ireland
    PLoS ONE 8:e69090. 2013
    ..These results reveal a novel mechanism by which miR-19a may augment JAK-STAT signal transduction via control of SOCS3 expression and are fundamental to the understanding of inflammatory regulation. ..
  7. pmc MSK1 activity is controlled by multiple phosphorylation sites
    Claire E McCoy
    MRC Protein Phosphorylation Unit, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 387:507-17. 2005
    ..This is in contrast with the closely related RSK (p90 ribosomal S6 kinase) proteins, whose activity requires phosphorylation by PDK1 (3-phosphoinositide-dependent protein kinase 1) in addition to phosphorylation by ERK1/2...
  8. pmc Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS
    Claire E McCoy
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 402:491-501. 2007
    ....