Seth L Masters

Summary

Affiliation: Trinity College
Country: Ireland

Publications

  1. pmc Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
    Seth L Masters
    Immunology Research Centre, School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    Nat Immunol 11:897-904. 2010
  2. doi request reprint Disease-associated amyloid and misfolded protein aggregates activate the inflammasome
    Seth L Masters
    Immunology Research Centre, Inflammation Research Group, School of Biochemistry and Immunology, Trinity College Dublin, Ireland
    Trends Mol Med 17:276-82. 2011
  3. doi request reprint The inflammasome in atherosclerosis and type 2 diabetes
    Seth L Masters
    Immunology Research Centre, Inflammation Research Group, School of Biochemistry and Immunology, Trinity College Dublin, Ireland
    Sci Transl Med 3:81ps17. 2011
  4. doi request reprint Cutting edge: miR-223 and EBV miR-BART15 regulate the NLRP3 inflammasome and IL-1β production
    Moritz Haneklaus
    Inflammation Research Group and Immunology Research Centre, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 4, Ireland
    J Immunol 189:3795-9. 2012
  5. pmc Regulation of interleukin-1beta by interferon-gamma is species specific, limited by suppressor of cytokine signalling 1 and influences interleukin-17 production
    Seth L Masters
    Immunology Research Centre, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    EMBO Rep 11:640-6. 2010

Detail Information

Publications5

  1. pmc Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
    Seth L Masters
    Immunology Research Centre, School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    Nat Immunol 11:897-904. 2010
    ..Our findings identify previously unknown mechanisms in the pathogenesis of type 2 diabetes and treatment of pathology caused by IAPP...
  2. doi request reprint Disease-associated amyloid and misfolded protein aggregates activate the inflammasome
    Seth L Masters
    Immunology Research Centre, Inflammation Research Group, School of Biochemistry and Immunology, Trinity College Dublin, Ireland
    Trends Mol Med 17:276-82. 2011
    ..This review discusses the basic research behind these findings and the potential for new therapeutic interventions this affords...
  3. doi request reprint The inflammasome in atherosclerosis and type 2 diabetes
    Seth L Masters
    Immunology Research Centre, Inflammation Research Group, School of Biochemistry and Immunology, Trinity College Dublin, Ireland
    Sci Transl Med 3:81ps17. 2011
    ..Therapeutics that target IL-1β in clinical trials for type 2 diabetes might also decrease the incidence of atherosclerosis...
  4. doi request reprint Cutting edge: miR-223 and EBV miR-BART15 regulate the NLRP3 inflammasome and IL-1β production
    Moritz Haneklaus
    Inflammation Research Group and Immunology Research Centre, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 4, Ireland
    J Immunol 189:3795-9. 2012
    ..Therefore, we have identified both the first endogenous miRNA that limits NLRP3 inflammatory capacity during myeloid cell development and also a viral miRNA that takes advantage of this, limiting inflammation for its own purposes...
  5. pmc Regulation of interleukin-1beta by interferon-gamma is species specific, limited by suppressor of cytokine signalling 1 and influences interleukin-17 production
    Seth L Masters
    Immunology Research Centre, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    EMBO Rep 11:640-6. 2010
    ..In mice, IFNgamma decreased IL-1beta and subsequently IL-17, indicating that the adaptive immune response can provide a systemic, but transient, signal to limit inflammation...