James Harris

Summary

Affiliation: Trinity College
Country: Ireland

Publications

  1. pmc Th1-Th2 polarisation and autophagy in the control of intracellular mycobacteria by macrophages
    James Harris
    Institute of Molecular Medicine, Trinity College Dublin and St James s Hospital, Dublin 8, Ireland
    Vet Immunol Immunopathol 128:37-43. 2009
  2. doi Autophagy and cytokines
    James Harris
    Immunology Research Centre, School of Biochemistry and Immunology, Trinity College Dublin, College Green, Dublin 2, Ireland
    Cytokine 56:140-4. 2011
  3. doi Autophagy and the immune response to TB
    J Harris
    Adjuvant Research Group, School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Transbound Emerg Dis 56:248-54. 2009
  4. pmc Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation
    James Harris
    Adjuvant Research Group, School of Biochemistry and Immunology, Trinity College Dublin, College Green, Dublin 2, Ireland
    J Biol Chem 286:9587-97. 2011
  5. pmc Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
    Seth L Masters
    Immunology Research Centre, School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    Nat Immunol 11:897-904. 2010
  6. doi The role of inflammasomes in the immunostimulatory effects of particulate vaccine adjuvants
    James Harris
    Adjuvant Research Group, School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    Eur J Immunol 40:634-8. 2010
  7. doi Autophagy and inflammatory diseases
    Sarah A Jones
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland
    Immunol Cell Biol 91:250-8. 2013
  8. doi The role of inflammasome-derived IL-1 in driving IL-17 responses
    Kingston H G Mills
    Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
    J Leukoc Biol 93:489-97. 2013
  9. pmc Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome
    Fiona A Sharp
    Adjuvant Research Group, School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    Proc Natl Acad Sci U S A 106:870-5. 2009
  10. doi Measuring autophagy in macrophages
    James Harris
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    Curr Protoc Immunol . 2009

Collaborators

Detail Information

Publications13

  1. pmc Th1-Th2 polarisation and autophagy in the control of intracellular mycobacteria by macrophages
    James Harris
    Institute of Molecular Medicine, Trinity College Dublin and St James s Hospital, Dublin 8, Ireland
    Vet Immunol Immunopathol 128:37-43. 2009
    ..We discuss how differential modulation of autophagy by Th1 and Th2 cytokines may represent an important feature of the host response to mycobacteria...
  2. doi Autophagy and cytokines
    James Harris
    Immunology Research Centre, School of Biochemistry and Immunology, Trinity College Dublin, College Green, Dublin 2, Ireland
    Cytokine 56:140-4. 2011
    ..This review discusses the potentially pivotal roles of autophagy in the regulation of inflammation and the coordination of innate and adaptive immune responses...
  3. doi Autophagy and the immune response to TB
    J Harris
    Adjuvant Research Group, School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Transbound Emerg Dis 56:248-54. 2009
    ..In addition, the modulation of autophagy by cytokines and pathogen-derived stimuli is discussed...
  4. pmc Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation
    James Harris
    Adjuvant Research Group, School of Biochemistry and Immunology, Trinity College Dublin, College Green, Dublin 2, Ireland
    J Biol Chem 286:9587-97. 2011
    ..These data demonstrate that autophagy controls the production of IL-1β through at least two separate mechanisms: by targeting pro-IL-1β for lysosomal degradation and by regulating activation of the NLRP3 inflammasome...
  5. pmc Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
    Seth L Masters
    Immunology Research Centre, School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    Nat Immunol 11:897-904. 2010
    ..Our findings identify previously unknown mechanisms in the pathogenesis of type 2 diabetes and treatment of pathology caused by IAPP...
  6. doi The role of inflammasomes in the immunostimulatory effects of particulate vaccine adjuvants
    James Harris
    Adjuvant Research Group, School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    Eur J Immunol 40:634-8. 2010
    ..The mechanisms underlying this activation have been partly resolved and the role of NLRP3 in particulate adjuvant-induced adaptive immunity is currently the subject of intense interest...
  7. doi Autophagy and inflammatory diseases
    Sarah A Jones
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland
    Immunol Cell Biol 91:250-8. 2013
    ..This review focuses on the known roles of autophagy in the induction and maintenance of inflammation and on its role in the aetiology and regulation of inflammatory and autoimmune disorders...
  8. doi The role of inflammasome-derived IL-1 in driving IL-17 responses
    Kingston H G Mills
    Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
    J Leukoc Biol 93:489-97. 2013
    ..Consequently, inflammasomes are now major drug targets for many autoimmune and chronic inflammatory diseases, as well as autoinflammatory diseases...
  9. pmc Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome
    Fiona A Sharp
    Adjuvant Research Group, School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    Proc Natl Acad Sci U S A 106:870-5. 2009
    ..Our data demonstrate that uptake of microparticulate adjuvants by DCs activates the NALP3 inflammasome, and this contributes to their enhancing effects on innate and antigen-specific cellular immunity...
  10. doi Measuring autophagy in macrophages
    James Harris
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    Curr Protoc Immunol . 2009
    ..This unit presents protocols for the measurement of autophagy in macrophages...
  11. doi Advanced microscopy: laser scanning confocal microscopy
    Orla Hanrahan
    School of Biochemistry and Immunology, Trinity College Dublin, Ireland
    Methods Mol Biol 784:169-80. 2011
    ..There are practical guidelines about sample preparation for both fixed and living specimens, as well as examples of some of the applications of confocal microscopy...
  12. doi Autophagy regulates IL-23 secretion and innate T cell responses through effects on IL-1 secretion
    Celia Peral de Castro
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin 2, Ireland
    J Immunol 189:4144-53. 2012
    ..These data demonstrate that autophagy has a potentially pivotal role to play in the induction and regulation of inflammatory responses by innate immune cells, largely driven by IL-1 and its consequential effects on IL-23 secretion...
  13. pmc How tumour necrosis factor blockers interfere with tuberculosis immunity
    J Harris
    Adjuvant Research Group, School of Biochemistry and Immunology, and St James s Hospital, Trinity College Dublin, Dublin, Ireland
    Clin Exp Immunol 161:1-9. 2010
    ..This review summarizes some of the reported effects of TNF blockers on immune cell responses in the context of the observed clinical data on TB reactivation in patients on anti-TNF therapy...