Michael J Gibney
Affiliation: Trinity College
- Strategies for altering population intakes of fats and fatty acidsM J Gibney
Institute of European Food Studies, Trinity College, Dublin, Republic of Ireland
Proc Nutr Soc 58:189-91. 1999..A new set of 'interim attainable dietary guidelines', based on prevailing dietary intakes, must be the basis for establishing sensible food-based dietary guidelines...
- Approaches to assessment of exposure to food- and supplement-derived amino acidsMichael J Gibney
Institute of European Food Studies, Department of Clinical Medicine, Trinity Centre for Health Sciences, St James s Hospital, Dublin 8, Ireland
J Nutr 134:1660S-1663S; discussion 1664S-1666S, 1667S-1672S. 2004..Using multiple iterations and perhaps bootstrapping on some elements of the model, fully worst-case model scenarios of exposure could be computed...
- Metabolomics in human nutrition: opportunities and challengesMichael J Gibney
Nutrition Unit, Department of Clinical Medicine, Trinity College, Dublin, Ireland
Am J Clin Nutr 82:497-503. 2005..The purpose of the present review was to highlight some early challenges that need to be addressed if metabolomics is to realize its great potential in human nutrition...
- Diet, genes and disease: implications for nutrition policyMichael J Gibney
Institute of European Food Studies, Department of Biochemistry, Trinity College, Dublin, Republic of Ireland
Proc Nutr Soc 63:491-500. 2004..Once accepted in clinical nutrition, the diet-gene interaction will filter into the prevention of disease in public health nutrition...
- Nutrition, physical activity and health status in Europe: an overviewM J Gibney
Department of Clinical Medicine and Institute of European Food Studies, St James Hospital, Dublin, Ireland
Public Health Nutr 2:329-33. 1999..Such diets are most successful and yield the most favourable metabolic profile when there is an adequate level of physical activity...
- Dietary intake methods for estimating food additive intakeM J Gibney
Nutriscan Ltd, Institute of European Food Studies, Trinity College, IRL Dublin, Ireland
Regul Toxicol Pharmacol 30:S31-3. 1999....
- The effect of dietary supplementation using isomeric blends of conjugated linoleic acid on lipid metabolism in healthy human subjectsEnda J Noone
Unit of Nutrition, Department of Clinical Medicine, Trinity Centre for Health Sciences, St James s Hospital, Dublin, Republic of Ireland
Br J Nutr 88:243-51. 2002..The study confirms that some of the cardio-protective effects of CLA that were shown in animal studies are relevant to man...
- Dietary intake patterns are reflected in metabolomic profiles: potential role in dietary assessment studiesAifric O'Sullivan
Institute of Food and Health, University College Dublin, Dublin, Ireland
Am J Clin Nutr 93:314-21. 2011..It has been suggested that metabolomics could play a role in dietary assessment and identification of novel biomarkers of dietary intake...
- The relationship between aerobic fitness level and metabolic profiles in healthy adultsCiara Morris
UCD Institute of Food and Health, University College Dublin, Belfield, Dublin, Ireland
Mol Nutr Food Res 57:1246-54. 2013..This study aimed to examine the relationship between fitness level, substrate oxidation rates, and the metabolic profile...
- Identification of differential responses to an oral glucose tolerance test in healthy adultsCiara Morris
UCD Institute of Food and Health, University College Dublin, Belfield, Dublin, Rep of Ireland UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, Rep of Ireland
PLoS ONE 8:e72890. 2013..This study examined whether metabolic phenotyping could identify differential responders to an oral glucose tolerance test (OGTT) and examined the phenotypic basis of the response...
- Within-person variation in the postprandial lipemic response of healthy adultsMiriam F Ryan
Institute of Food and Health, University College Dublin Belfield, Dublin, Ireland
Am J Clin Nutr 97:261-7. 2013..Objectives: The objectives were to quantify within-person variation in triacylglycerol response by means of a novel variation score (S(v)) and to explore the phenotypic and genotypic factors associated with this score...
- An investigation into the relationship between the metabolic profile of follicular fluid, oocyte developmental potential, and implantation outcomeMartina Wallace
UCD Conway Institute, UCD School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin, Ireland
Fertil Steril 97:1078-84.e1-8. 2012..To determine whether metabolomic analysis of follicular fluid could prove a useful noninvasive technique for the selection of viable oocytes and embryos...
- Biochemical and metabolomic phenotyping in the identification of a vitamin D responsive metabotype for markers of the metabolic syndromeAifric O'Sullivan
UCD Institute of Food and Health, University College Dublin, Dublin, Ireland
Mol Nutr Food Res 55:679-90. 2011..Metabolic phenotyping promises to be a useful tool in human intervention studies. This study examined whether metabolic phenotyping could identify responders to vitamin D supplementation in terms of the metabolic syndrome...
- The metabolic syndrome: the crossroads of diet and geneticsHelen M Roche
Nutrigenomics Research Group, Department of Clinical Medicine, Institute of Molecular Medicine, Trinity College Dublin, Dublin 8, Republic of Ireland
Proc Nutr Soc 64:371-7. 2005....
- Acute postprandial effect of hydrogenated fish oil, palm oil and lard on plasma cholesterol, triacylglycerol and non-esterified fatty acid metabolism in normocholesterolaemic malesMarie M Cantwell
Department of Biological Sciences, Dublin Institute of Technology, Kevin Street, Dublin 8, Republic of Ireland
Br J Nutr 95:787-94. 2006..The absence of a higher postprandial response following ingestion of PHFO could be as a result of reduced absorption and increased oxidation of long-chain fatty acids (both cis and trans isomers)...
- Analysis of meal patterns with the use of supervised data mining techniques--artificial neural networks and decision treesAine P Hearty
Institute of Food and Health, University College Dublin, Dublin, Ireland
Am J Clin Nutr 88:1632-42. 2008..At present, the analysis of dietary patterns is based on the intake of individual foods. This article demonstrates how a coding system at the meal level might be analyzed by using data mining techniques...
- Acute-on-chronic effects of fatty acids on intestinal triacylglycerol-rich lipoprotein metabolismIrene L Black
Unit of Nutrition, Department of Clinical Medicine, Trinity Health Sciences Centre, St James s Hospital, Dublin, 8, Ireland
Br J Nutr 88:661-9. 2002....
- Effect of acute dietary standardization on the urinary, plasma, and salivary metabolomic profiles of healthy humansMarianne C Walsh
Nutrition Unit, Division of Clinical and Molecular Medicine, Trinity College, Dublin, Ireland
Am J Clin Nutr 84:531-9. 2006..Metabolomics in human nutrition research is faced with the challenge that changes in metabolic profiles resulting from diet may be difficult to differentiate from normal physiologic variation...
- Isomer-dependent metabolic effects of conjugated linoleic acid: insights from molecular markers sterol regulatory element-binding protein-1c and LXRalphaHelen M Roche
Molecular Nutrition, Department of Clinical Medicine, Trinity Centre for Health Sciences, St James s Hospital, Dublin 8, Ireland
Diabetes 51:2037-44. 2002..The ameliorative effect of c9,t11-CLA on lipid metabolism may be ascribed to reduced synthesis and cleavage of hepatic SREBP-1, which in turn may be regulated by hepatic LXRalpha expression...
- Conjugated linoleic acid and atherosclerosis: no effect on molecular markers of cholesterol homeostasis in THP-1 macrophagesSinead Weldon
Department of Clinical Medicine, Unit of Nutrition, Trinity Centre for Health Sciences, St James s Hospital, James s Street, Dublin 8, Ireland
Atherosclerosis 174:261-73. 2004..Thus, altered cholesterol homeostasis in the macrophage may not explain the anti-atherogenic effects of CLA observed in vivo...
- Influence of acute phytochemical intake on human urinary metabolomic profilesMarianne C Walsh
Centre for Food and Health, School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Dublin 4, Ireland
Am J Clin Nutr 86:1687-93. 2007..Diversity in dietary intake contributes to variation in human metabolomic profiles and artifacts from acute dietary intake can affect metabolomics data...
- Comparison of different nutrient profiling schemes to a new reference method using dietary surveysCaroline Quinio
French Food Safety Agency Afssa, Paris, France
Eur J Nutr 46:37-46. 2007..However, further improvement of the "indicator foods" approach is needed if it is to serve as a "gold standard"...
- Development and validation of a food-frequency questionnaire for the determination of detailed fatty acid intakesMarie M Cantwell
Department of Biological Sciences, Dublin Institute of Technology, Republic of Ireland
Public Health Nutr 8:97-107. 2005..To validate a fat intake questionnaire (FIQ) developed to assess habitual dietary intake while focusing on the assessment of detailed fatty acid intake including total trans unsaturated fatty acids (TUFA)...
- Chronic but not acute treatment with conjugated linoleic acid (CLA) isomers (trans-10, cis-12 CLA and cis-9, trans-11 CLA) affects lipid metabolism in Caco-2 cellsIrene L Black
Smurfit Institute of Genetics, Trinity College Dublin, Ireland
J Nutr 132:2167-73. 2002..In conclusion, chronic t10,c12-CLA supplementation modulated intestinal TRL metabolism, by increasing cellular de novo TAG synthesis but had no effect on de novo TAG secretion in Caco-2 cells...
- A new reference method for the validation of the nutrient profiling schemes using dietary surveysJean Luc Volatier
French Food Safety Agency Afssa, Maisons Alfort, France
Eur J Nutr 46:29-36. 2007..Further work is needed to build a list of indicator foods that could be considered as a "gold standard."..
- Personalised nutrition: status and perspectivesHans Georg Joost
German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, Nuthetal, Germany
Br J Nutr 98:26-31. 2007..These issues need to be addressed before genotyping can become an acceptable method to guide nutritional recommendations...
- The case for strategic international alliances to harness nutritional genomics for public and personal healthJim Kaput
Center of Excellence in Nutritional Genomics, University of California, Davis, CA 95616, USA
Br J Nutr 94:623-32. 2005....