Research Topics
Species | H GaravanSummaryAffiliation: Trinity College Country: Ireland Publications
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Detail Information
Publications
Comparability of functional MRI response in young and old during inhibitionKristy A Nielson
Department of Psychology, Integrative Neuroscience Research Center, Marquette University, PO Box 1881, Milwaukee, WI 53201 1881, USA
Neuroreport 15:129-33. 2004..We conclude that activation during cognitive inhibition, which was predominantly increased in elders, was not due to vascular confounds or specific changes in hemodynamic coupling...
Prefrontal-subcortical dissociations underlying inhibitory control revealed by event-related fMRIA M Clare Kelly
Department of Psychology and Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland
Eur J Neurosci 19:3105-12. 2004....
Predicting success: patterns of cortical activation and deactivation prior to response inhibitionRobert L Hester
Trinity College, Dublin, Ireland
J Cogn Neurosci 16:776-85. 2004....
Do antisaccade deficits in schizophrenia provide evidence of a specific inhibitory function?Gary Donohoe
Neuropsychiatric Genetics Research Group, Department of Psychiatry, and Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland
J Int Neuropsychol Soc 12:901-6. 2006..We investigated whether variance in antisaccade performance could be better accounted for in terms of a specific inhibitory function...
Menstrual cycle phase modulates cognitive control over male but not female stimuliGloria M P Roberts
School of Psychology and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
Brain Res 1224:79-87. 2008....
Individual differences in the functional neuroanatomy of inhibitory controlHugh Garavan
School of Psychology and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
Brain Res 1105:130-42. 2006..Although response inhibition produces robust activation in a discrete network of brain regions, these results reveal that individual differences impact on the relative contribution made by the nodes of this network...
A validation of event-related FMRI comparisons between users of cocaine, nicotine, or cannabis and control subjectsKevin Murphy
Department of Psychology, Trinity College Dublin, Dublin 2, Ireland
Am J Psychiatry 163:1245-51. 2006..This may be of particular concern in event-related functional magnetic resonance imaging (fMRI), where current analytic techniques search for a specific shape in the hemodynamic response to neuronal activity...
The role of cognitive control in cocaine dependenceHugh Garavan
School of Psychology and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
Neuropsychol Rev 17:337-45. 2007..Combined, these deficits may contribute to the continuation of use in dependent individuals and may qualify as important targets for therapeutic interventions...
Insula and drug cravingsHugh Garavan
School of Psychology and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
Brain Struct Funct 214:593-601. 2010..Finally, some consideration is given to sex differences and developmental processes in craving...
A parametric manipulation of central executive functioningH Garavan
Department of Psychiatry and Biophysics Research Institute, Medical College of Wisconsin, Milwaukee, WI, USA
Cereb Cortex 10:585-92. 2000..Together, these data suggest that a distributed neuroanatomy, rather than a specific and unique locus, underlies this attention switching executive function...
Practice-related functional activation changes in a working memory taskH Garavan
Department of Psychiatry, Medical College of Wisconsin, Milwaukee, WI 53202, USA
Microsc Res Tech 51:54-63. 2000..Further, these data show that the dynamics of functional change can be tracked while a task is being learned and as an important cognitive process becomes more skilled...
A midline dissociation between error-processing and response-conflict monitoringH Garavan
Department of Psychology and Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland
Neuroimage 20:1132-9. 2003..The results suggest that these two action-monitoring processes are distinct and dissociable and are localised along the midline...
Acute effects of cocaine on the neurobiology of cognitive controlHugh Garavan
Institute of Neuroscience, School of Psychology, Trinity College Dublin, Dublin 2, Ireland
Philos Trans R Soc Lond B Biol Sci 363:3267-76. 2008..Furthermore, the effects of cocaine on midline function suggest a dopaminergically mediated intersection between cocaine's acute reinforcing effects and its effects on cognitive control...
Cocaine dependence and attention switching within and between verbal and visuospatial working memoryA Kubler
Department of Psychology and Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
Eur J Neurosci 21:1984-92. 2005....
Co-ordination within and between verbal and visuospatial working memory: network modulation and anterior frontal recruitmentA Kubler
Department of Psychology and Institute of Neuroscience, Trinity College Dublin, 2, Dublin, Ireland
Neuroimage 20:1298-308. 2003....
Dissociable executive functions in the dynamic control of behavior: inhibition, error detection, and correctionH Garavan
Department of Psychology, Trinity College Dublin, Dublin 2, Ireland
Neuroimage 17:1820-9. 2002..The results highlight how higher cognitive functions responsible for behavioral control can result from the dynamic interplay of distinct cortical systems...
Artifactual fMRI group and condition differences driven by performance confoundsK Murphy
Department of Psychology and Institute of Neuroscience, Trinity College, 2, Dublin, Ireland
Neuroimage 21:219-28. 2004..Consequently, brain-imaging investigations that do not accommodate error contributions to functional signals are at risk of misinterpreting activation patterns...
Beyond common resources: the cortical basis for resolving task interferenceRobert Hester
Department of Psychology and Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland
Neuroimage 23:202-12. 2004....
Prefrontal and midline interactions mediating behavioural controlCatherine Fassbender
School of Psychology and Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
Eur J Neurosci 29:181-7. 2009..These results suggest that prefrontal and midline regions work together to implement cognitive control and reveal that intra-subject variability is reflected in these lateral and midline interactions...
The neural correlates of deficient error awareness in attention-deficit hyperactivity disorder (ADHD)Redmond G O'Connell
Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
Neuropsychologia 47:1149-59. 2009..Our data provide evidence that neuropsychological deficits associated with ADHD can be exacerbated by error processing abnormalities. Error awareness may represent an important cognitive and physiological phenotype for ADHD...
Loss of insight in frontotemporal dementia, corticobasal degeneration and progressive supranuclear palsyB Murray
Trinity College Institute of Neurosciences and Department of Psychology, Trinity College, Dublin, Ireland
Brain 130:753-64. 2007..The results are discussed in terms of neurocognitive models of awareness and different patterns of neurobiological decline in the separate patient groups...
Learning and memory deficits in ecstasy users and their neural correlates during a face-learning taskGloria M P Roberts
School of Psychology and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
Brain Res 1292:71-81. 2009..These ecstasy-specific effects may be related to the vulnerability of isocortical and allocortical regions to the neurotoxic effects of ecstasy...
Inhibitory consequences of memory selectionR B Anderson
Department of Psychology, Bowling Green State University, OH 43403, USA
Acta Psychol (Amst) 96:155-66. 1997..The present finding suggests a complex and perhaps strategy-dependent relationship between memory selection difficulty and NP...
Right hemispheric dominance of inhibitory control: an event-related functional MRI studyH Garavan
Department of Psychiatry, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Proc Natl Acad Sci U S A 96:8301-6. 1999..Contrary to the prominence traditionally given to ventral frontal regions for response inhibition, the results suggest that response inhibition is accomplished by a distributed cortical network...
Evidence of increased activation underlying cognitive control in ecstasy and cannabis usersGloria M P Roberts
School of Psychology and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
Neuroimage 52:429-35. 2010....
Automaticity and reestablishment of executive control-an fMRI studyAndrea Kubler
Trinity College Dublin, Ireland
J Cogn Neurosci 18:1331-42. 2006....
Amygdala response to both positively and negatively valenced stimuliH Garavan
Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
Neuroreport 12:2779-83. 2001..These results clearly demonstrate a role for the amygdala in processing emotional stimuli that extends beyond negative and fearful stimuli...
A topography of executive functions and their interactions revealed by functional magnetic resonance imagingC Fassbender
Department of Psychology and Institute of Neuroscience, Trinity College, Dublin 2, Ireland
Brain Res Cogn Brain Res 20:132-43. 2004..The results reveal that the executive control of behavior can be separated into distinct functions performed by discrete cortical regions...
Executive dysfunction in cocaine addiction: evidence for discordant frontal, cingulate, and cerebellar activityRobert Hester
Department of Psychology and Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
J Neurosci 24:11017-22. 2004..The results reveal a neuroanatomical basis for this dysexecutive component to addiction, supporting the suggested importance cognitive functions may play in prolonging abuse or predisposing users toward relapse...
Cingulate hypoactivity in cocaine users during a GO-NOGO task as revealed by event-related functional magnetic resonance imagingJacqueline N Kaufman
Medical College of Wisconsin, Department of Psychiatry, Milwaukee, Wisconsin 53226, USA
J Neurosci 23:7839-43. 2003..The results suggest that addiction may be accompanied by a disruption of brain structures critical for the higher-order, cognitive control of behavior...
Serial attention within working memoryH Garavan
Medical College of Wisconsin, Milwaukee 53226, USA
Mem Cognit 26:263-76. 1998..This internal focus of attention is a subset of WM (Cowan, 1988). Alternative visual and conceptual repetition-priming and memory retrieval explanations for the cost involved in switching between items in WM are addressed...
The anterior cingulate and error avoidanceElena Magno
Institute of Neuroscience and School of Psychology, Trinity College Dublin, Dublin 2, Ireland
J Neurosci 26:4769-73. 2006..These results reveal that the functional role of the cingulate is not particular to errors but instead is related to an evaluative function concerned with on-line behavioral adjustment in the service of avoiding losses...
Structural and functional brain correlates of subclinical psychotic symptoms in 11-13 year old schoolchildrenSarah Jacobson
School of Psychology and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
Neuroimage 49:1875-85. 2010....
Executive function and error detection: The effect of motivation on cingulate and ventral striatum activityCristina Simões-Franklin
Trinity College Dublin, Ireland
Hum Brain Mapp 31:458-69. 2010..This study suggests that there is a motivational influence on cognitive processes in the ACC and nucleus accumbens and hints at a dissociation between tonic proactive activity and phasic reactive error-related activity...
The role of cingulate cortex in the detection of errors with and without awareness: a high-density electrical mapping studyRedmond G O'Connell
Department of Psychology and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
Eur J Neurosci 25:2571-9. 2007..These findings may be particularly important in the context of clinical studies in which a proper understanding of self-monitoring deficits requires an explicit measurement of error awareness...
Functional developmental changes underlying response inhibition and error-detection processesWouter Braet
School of Psychology and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
Neuropsychologia 47:3143-51. 2009..Instead, the neurodevelopmental trajectory of these important executive functions may reveal the basis for the immature executive functioning of the young adolescent...
Increased ventral striatal BOLD activity during non-drug reward anticipation in cannabis usersLiam Nestor
School of Psychology and Institute of Neuroscience, Trinity College Dublin, Ireland
Neuroimage 49:1133-43. 2010....
Deficits in learning and memory: parahippocampal hyperactivity and frontocortical hypoactivity in cannabis usersLiam Nestor
Department of Psychology and Institute of Neuroscience, Trinity College, University of Dublin, Ireland
Neuroimage 40:1328-39. 2008..Hypoactivity in frontal and temporal cortices, and relative hyperactivity in the parahippocampus identify functional deficits and compensatory processes in cannabis users...
Static images of novel, moveable objects learned through touch activate visual area hMT+Jason S Chan
School of Psychology and Institute of Neuroscience, Trinity College Dublin, Dublin, Republic of Ireland
Neuroimage 49:1708-16. 2010....
Flexible cognitive control: effects of individual differences and brief practice on a complex cognitive taskA M Clare Kelly
School of Psychology and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
Neuroimage 31:866-86. 2006..These results raise the possibility that a fundamental human ability, reflexive cognitive control, is amenable to practice...
The functional neuroanatomical correlates of response variability: evidence from a response inhibition taskMark A Bellgrove
Department of Psychology, Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
Neuropsychologia 42:1910-6. 2004....
Individual differences discriminate event-related potentials but not performance during response inhibitionRichard A P Roche
Department of Psychology and Trinity College Institute of Neuroscience, University of Dublin, Trinity College, 2 Dublin, Ireland
Exp Brain Res 160:60-70. 2005....
Variance in neurocognitive performance is associated with dysbindin-1 in schizophrenia: a preliminary studyGary Donohoe
Department of Psychology and Trinity Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
Neuropsychologia 45:454-8. 2007..Our study suggests that the increased risk for schizophrenia associated with dysbindin may be partly mediated by its influence on pre-frontal function...
EEG alpha power changes reflect response inhibition deficits after traumatic brain injury (TBI) in humansRichard A P Roche
Department of Psychology and Trinity College Institute of Neuroscience, University of Dublin, Trinity College, Dublin 2, Ireland
Neurosci Lett 362:1-5. 2004..We conclude that abnormal activity in the structures damaged in this group may render such patients less capable of maintaining a state of alpha desynchronisation compared to controls, resulting in poorer performance on the task...
Mapping the functional anatomy of task preparation: priming task-appropriate brain networksCatherine Fassbender
Department of Psychology and Institute of Neuroscience, Trinity College, Dublin, Ireland
Hum Brain Mapp 27:819-27. 2006..These results suggest that cue periods allow participants to prime task-relevant areas within the brain and highlight the importance of left DLPFC in top-down control...
Deriving the optimal number of events for an event-related fMRI study based on the spatial extent of activationKevin Murphy
Department of Psychology and Institute of Neuroscience, Trinity College, Dublin 2, Ireland
Neuroimage 27:771-7. 2005..The experimental validity of the %AUC technique to identify active brain regions while minimising false positive levels is demonstrated in a group study with 25 participants...
Neural correlates of high and craving during cocaine self-administration using BOLD fMRIRobert C Risinger
Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Neuroimage 26:1097-108. 2005..This study provides the first evidence in humans that changes in subjective state surrounding cocaine self-administration reflect neural activity of the endogenous reward system...
Neurocognitive insights into substance abuseHugh Garavan
Department of Psychology and Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland
Trends Cogn Sci 9:195-201. 2005....
Neural mechanisms involved in error processing: a comparison of errors made with and without awarenessRobert Hester
Department of Psychology and Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland
Neuroimage 27:602-8. 2005..Instead, it appears, irrespective of awareness, to detect information about stimuli/responses that requires interpretation in other brain regions for strategic implementation of post-error adjustments of behaviour...
Working memory and executive function: the influence of content and load on the control of attentionRobert Hester
Trinity College, Dublin, Ireland
Mem Cognit 33:221-33. 2005....
Individual differences in error processing: a review and reanalysis of three event-related fMRI studies using the GO/NOGO taskRobert Hester
Department of Psychology and Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland
Cereb Cortex 14:986-94. 2004..Furthermore, this response is, in part, influenced by individual differences in both demographic characteristics and behavioural performance...
Early visual sensory deficits as endophenotypes for schizophrenia: high-density electrical mapping in clinically unaffected first-degree relativesSherlyn Yeap
Cognitive Neurophysiology Laboratory, St Vincent's Hospital, Fairview, and Trinity College Institute of Neuroscience, Department of Psychology, Dublin, Ireland
Arch Gen Psychiatry 63:1180-8. 2006..The efficacy of using P1 amplitude as an endophenotype is underscored by the observation of a large effect size (d=0.9) over scalp sites where the deficit was maximal...
Multiple neuronal networks mediate sustained attentionNatalia S Lawrence
Medical College of Wisconsin, USA
J Cogn Neurosci 15:1028-38. 2003....
On people's understanding of the diagnostic implications of probabilistic dataM E Doherty
Department of Psychology, Bowling Green State University, OH 43403, USA
Mem Cognit 24:644-54. 1996..Possible relations to other laboratory inference tasks and to clinical judgment are discussed...
An empirical investigation into the number of subjects required for an event-related fMRI studyKevin Murphy
Department of Psychology and Institute of Neuroscience, Trinity College, Dublin 2, Ireland
Neuroimage 22:879-85. 2004..The reported analyses, by quantifying the spatial reproducibility for various sample sizes performing a typical event-related cognitive task, thus provide an empirical measure of the disparity to be expected in comparing activation maps...
Patterns of normal human brain plasticity after practice and their implications for neurorehabilitationClare Kelly
School of Psychology and Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland
Arch Phys Med Rehabil 87:S20-9. 2006....
Human functional neuroimaging of brain changes associated with practiceA M Clare Kelly
Department of Psychology and Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland
Cereb Cortex 15:1089-102. 2005..Finally, we suggest that functional and effective connectivity analyses may make important contributions to our understanding of changes in functional anatomy occurring as a result of practice on tasks...
A functional MRI study of the influence of practice on component processes of working memorySusan M Landau
Henry H Wheeler Brain Imaging Center, Helen Wills Neuroscience Institute, and Department of Psychology, University of California at Berkeley, 3210 Tolman Hall 1650, Berkeley, CA 94720 1650, USA
Neuroimage 22:211-21. 2004..Our results suggest that practice influences particular component processes of WM differently, and that the efficiency of these processes may not be captured by performance measures alone...
Differences in the functional neuroanatomy of inhibitory control across the adult life spanKristy A Nielson
Department of Psychology and the Integrative Neuroscience Research Center, Marquette University and Medical College of Wisconsin, Milwaukee 53201, USA
Psychol Aging 17:56-71. 2002..The results are consistent with a compensatory interpretation and extend the aging neuroimaging literature into the cognitive domain of inhibition...
Are auditory-evoked frequency and duration mismatch negativity deficits endophenotypic for schizophrenia? High-density electrical mapping in clinically unaffected first-degree relatives and first-episode and chronic schizophreniaElena Magno
The Cognitive Neurophysiology Laboratory, St Vincent s Hospital, Dublin, Ireland
Biol Psychiatry 64:385-91. 2008..The aim of this study was to investigate the extent to which dysfunction in MMN generation might represent an endophenotypic marker for schizophrenia...
Avoiding another mistake: error and posterror neural activity associated with adaptive posterror behavior changeRobert Hester
Queensland Brain Institute, University of Queensland, St Lucia, Queensland 4072, Australia
Cogn Affect Behav Neurosci 7:317-26. 2007..Implications of this discrepancy for the flexibility of cognitive control are discussed...
Dissociable mechanisms of cognitive control in prefrontal and premotor cortexChristopher D Chambers
Institute of Cognitive Neuroscience, University College London, London, UK
J Neurophysiol 98:3638-47. 2007..The observed double dissociation of neurodisruptive effects between the right IFG and right dPM further implies that response inhibition and execution rely on distinct neural processes despite activating a common cortical network...
Post-error behavior in active cocaine users: poor awareness of errors in the presence of intact performance adjustmentsRobert Hester
Department of Psychology, School of Behavioural Sciences, University of Melbourne, Melbourne, Vic, Australia
Neuropsychopharmacology 32:1974-84. 2007....
Executive "brake failure" following deactivation of human frontal lobeChristopher D Chambers
University of Melbourne, Melbourne, Australia
J Cogn Neurosci 18:444-55. 2006..These findings confirm and extend recent reports that the inferior frontal gyrus is vital for mediating response inhibition...
Regional specificity and practice: dynamic changes in object and spatial working memorySusan M Landau
Henry H Wheeler Brain Imaging Center, Helen Wills Neuroscience Institute, and Department of Psychology, University of California, Berkeley, Berkeley, CA 94720 3192, USA
Brain Res 1180:78-89. 2007....
Neural mechanisms for response selection: comparing selection of responses and items from working memoryRobert Hester
Department of Psychology, University of Melbourne, Melbourne, Australia
Neuroimage 34:446-54. 2007....
A consistent attentional bias for drug-related material in active cocaine users across word and picture versions of the emotional Stroop taskRobert Hester
Cognitive Neuroscience Laboratory, Department of Psychology, University of Melbourne, Parkville, Vic, Australia
Drug Alcohol Depend 81:251-7. 2006..These results provide corroborating evidence for cognitive biases being a hallmark of substance dependence...
