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Genomes and GenesSpecies | Thomas FrodlSummaryAffiliation: Trinity College Country: Ireland Publications
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Publications
Interaction of childhood stress with hippocampus and prefrontal cortex volume reduction in major depressionThomas Frodl
Institute of Neuroscience, Department of Psychiatry, Trinity College Dublin, Dublin 2, Ireland
J Psychiatr Res 44:799-807. 2010..Subjects with both, structural brain changes and childhood emotional neglect seem to be at a very high risk to develop a more severe illness course...
Childhood stress, serotonin transporter gene and brain structures in major depressionThomas Frodl
Department of Psychiatry, Institute of Neuroscience, Trinity College, Dublin, Ireland
Neuropsychopharmacology 35:1383-90. 2010..Structural brain changes due to stress represent part of the mechanism by which the illness risk and outcome might be genetically mediated...- Comorbidity of ADHD and Substance Use Disorder (SUD): a neuroimaging perspectiveThomas Frodl
Department of Psychiatry, School of Medicine, Trinity College Dublin, Dublin 2, Ireland
J Atten Disord 14:109-20. 2010..The high comorbidity indicates some shared underlying neurobiological substrates. Knowing these substrates may increase the understanding of the disease and help identify therapeutic processes... - Functional connectivity of emotional processing in depressionAngela Carballedo
Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Integrated Neuroimaging, Trinity Academic Medical Centre, The Adelaide and Meath Hospital incorporating the National Children s Hospital, and St James s Hospital, Trinity College, Dublin, Ireland
J Affect Disord 134:272-9. 2011..orbitofrontal cortex (OFC), anterior cingulate cortex (ACC) and prefrontal cortex (PFC) and that frontal-amygdala connections are altered in major depressive disorder (MDD)... - ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophreniaGary Donohoe
Neuropsychiatric Genetics Research Group, Trinity College Dublin, Dublin, Ireland
Neuroimage 54:2132-7. 2011..Establishing if this represents a discrete molecular pathogenesis with consequences for nosology and treatment will be an important next step in understanding ZNF084A's role in illness risk... - Brain activation predicts treatment improvement in patients with major depressive disorderAndrea C Samson
Department of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Integrated Neuroimaging, The Adelaide and Meath Hospital incorporating the National Children s Hospital AMNCH, and St James s Hospital, Trinity College, Dublin, Ireland
J Psychiatr Res 45:1214-22. 2011..The present investigation suggests the pCC, dmPFC, SFG, caudate nucleus and insula may have a key role as a biological marker for treatment response and predictor for therapeutic success... - Different effects of mirtazapine and venlafaxine on brain activation: an open randomized controlled fMRI studyThomas Frodl
Integrated Neuroimaging, Department of Psychiatry, Trinity College, Dublin, Ireland
J Clin Psychiatry 72:448-57. 2011..The aim of the study was therefore to investigate effects of 2 antidepressants on brain activation and to identify predictors for therapy response... - Altered inhibition of negative emotions in subjects at family risk of major depressive disorderDanuta M Lisiecka
Department of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Adelaide and Meath Hospital Incorporating the National Children s Hospital, Tallaght, Trinity College Dublin, Ireland
J Psychiatr Res 46:181-8. 2012..Overactivation of cingulate cortex and caudate nucleus may indicate a learnt strategy aimed at coping with increased susceptibility to negative information schemata and may have future consequences for therapy... - Neurotrophic tyrosine kinase polymorphism impacts white matter connections in patients with major depressive disorderMelissa L Murphy
Integrated Neuroimaging Group, Department of Psychiatry and Institute of Neuroscience, School of Medicine, Trinity College Dublin, University of Dublin, College Green, Dublin, Ireland
Biol Psychiatry 72:663-70. 2012.... - Brain-derived neurotrophic factor Val66Met polymorphism and early life adversity affect hippocampal volumeAngela Carballedo
Department of Psychiatry and Institute of Neuroscience, University of Dublin, Trinity College Dublin, Dublin, Ireland
Am J Med Genet B Neuropsychiatr Genet 162:183-90. 2013..Our results highlight how relevant stress-gene interactions are for hippocampal volume reductions. Subjects exposed to early life adversity developed smaller hippocampal volumes when they carry the Met-allele of the BDNF polymorphism... - Effect of genetic variant in BICC1 on functional and structural brain changes in depressionRachel Bermingham
Integrated Neuroimaging Group, Department of Psychiatry and Institute of Neuroscience, School of Medicine, Trinity College Dublin, University of Dublin, College Green, Dublin, Ireland
Neuropsychopharmacology 37:2855-62. 2012..These results are suggestive that the minor T-allele of BICC1 has a protective role against MDD and its known structural and functional brain changes. However, this protective effect seems to be lost in the case of co-occurrence of ELA... - Early life adversity is associated with brain changes in subjects at family risk for depressionAngela Carballedo
Department of Psychiatry, Institute of Neuroscience, Adelaide and Meath Hospital incorporating the National Children s Hospital AMNCH, St James s Hospital and Centre of Advanced Medical Imaging CAMI, University Dublin, Trinity College, Ireland
World J Biol Psychiatry 13:569-78. 2012.... - Anterior cingulate cortex gray matter abnormalities in adults with attention deficit hyperactivity disorder: a voxel-based morphometry studyFrancesco Amico
Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Integrated Neuroimaging, Trinity College, Dublin, Ireland
Psychiatry Res 191:31-5. 2011..Volumetric abnormalities in the brain of adult ADHD patients might be less pronounced than those found in children and adolescents, although the role played by chronic stimulant treatment needs further investigation... - Recruitment of the left hemispheric emotional attention neural network in risk for and protection from depressionDanuta M Lisiecka
Department of Psychiatry, University of Dublin, Trinity College, Ireland
J Psychiatry Neurosci 38:117-28. 2013..Emotion processing and attention shifting are functions altered by MDD and family history of the disease; therefore, it is important to recognize the neural correlates of these functions in association with both factors... 
Brain structure and function in borderline personality disorderAisling O'Neill
Department of Psychiatry, Institute of Neuroscience, Trinity College, Dublin 2, Ireland
Brain Struct Funct 217:767-82. 2012..We also discuss the limitations of some of the current studies including hindrances due to sample effects and techniques used and the potential of future neuroimaging research in BPD...- Impact of family history and depression on amygdala volumeKarim Saleh
Department of Psychiatry St James s Hospital and Adelaide and Meath Hospital incorporating the National Children s Hospital, Trinity College Dublin, Ireland
Psychiatry Res 203:24-30. 2012..Ultimately, these findings highlight consideration of family history and gender in research and treatment strategies... - Functional anomalies in healthy individuals with a first degree family history of major depressive disorderFrancesco Amico
Department of Psychiatry, Trinity College Dublin, College Green, Dublin 2, Ireland
Biol Mood Anxiety Disord 2:1. 2012..abstract:.. - Effect of hippocampal and amygdala volumes on clinical outcomes in major depression: a 3-year prospective magnetic resonance imaging studyThomas Frodl
Department of Psychiatry, Trinity College Dublin, Ireland
J Psychiatry Neurosci 33:423-30. 2008..We sought to examine the changes in hippocampal and amygdala volumes at baseline and at 3 years after an acute depressive episode, and the impact of reduced hippocampal volumes on the outcome... - Structural MRI correlates for vulnerability and resilience to major depressive disorderFrancesco Amico
Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Integrated Neuroimaging, Trinity Academic Medical Centre The Adelaide and Meath Hospital, incorporating the National Children s Hospital and St James s Hospital, Trinity College, Dublin, Ireland
J Psychiatry Neurosci 36:15-22. 2011..The aim of this study was to investigate whether structural abnormalities are related to risk for the development of MDD... - Reduced occipital and prefrontal brain volumes in dysbindin-associated schizophreniaGary Donohoe
Department of Psychiatry, Neuropsychiatric Genetics Research Group, Trinity College Dublin, Dublin, Ireland
Neuropsychopharmacology 35:368-73. 2010..These data provide important evidence of the influence of dysbindin risk variants on brain structure, and suggest a possible mechanism by which disease risk is being increased... - Altered brain activation during a verbal working memory task in subjects with amnestic mild cognitive impairmentArun L W Bokde
Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Alzheimer Memorial Center, Munich, Germany
J Alzheimers Dis 21:103-18. 2010..The activation differences between groups may be compensatory mechanisms within the MCI group for the effects of the putative AD neuropathology. This has been the first study that has examined verbal working memory in MCI... - Functional connectivity bias of the orbitofrontal cortex in drug-free patients with major depressionThomas Frodl
Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, Germany
Biol Psychiatry 67:161-7. 2010..The aim of this study was to compare the functional connectivity of the OFC during emotion processing in patients with major depression and healthy control subjects... - Tryptophan depletion in depressed patients occurs independent of kynurenine pathway activationMartina M Hughes
Neuroimmunology Research Group, Department of Physiology, School of Medicine and Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland
Brain Behav Immun 26:979-87. 2012..Taken together these data question the ability of the mild inflammatory phenotype observed in depression to induce molecules such as IDO and SERT that could negatively impact upon serotonergic functioning... - Effects of early-life adversity on white matter diffusivity changes in patients at risk for major depressionThomas Frodl
Department of Psychiatry, Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
J Psychiatry Neurosci 37:37-45. 2012.... - Neural correlates of treatment outcome in major depressionDanuta Lisiecka
Department of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Integrated Neuroimaging, The Adelaide and Meath Hospital Incorporating The National Children s Hospital AMiNCH, and St James s Hospital, Trinity College, Dublin, Ireland
Int J Neuropsychopharmacol 14:521-34. 2011..These results indicate that OFC functional connectivity might be useful as a marker for therapy response to mirtazapine and venlafaxine and to reconstruct the differences in their mechanism of action... - Complementary medicine for children and young people who have attention deficit hyperactivity disorderNorbert Skokauskas
Department of Psychiatry, Trinity College, Ireland
Curr Opin Psychiatry 24:291-300. 2011..This article reviews the latest scientific evidence of the effectiveness and safety of these treatments in ADHD...