Thomas Frodl

Summary

Affiliation: Trinity College
Country: Ireland

Publications

  1. ncbi request reprint Is there an association between peripheral immune markers and structural/functional neuroimaging findings?
    Thomas Frodl
    Department of Psychiatry, Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland Adelaide and Meath incorporating the National s Children Hospital, Dublin, Ireland St James s Hospital, Dublin, Ireland Electronic address
    Prog Neuropsychopharmacol Biol Psychiatry 48:295-303. 2014
  2. doi request reprint Comorbidity of ADHD and Substance Use Disorder (SUD): a neuroimaging perspective
    Thomas Frodl
    Department of Psychiatry, School of Medicine, Trinity College Dublin, Dublin 2, Ireland
    J Atten Disord 14:109-20. 2010
  3. ncbi request reprint Interaction of childhood stress with hippocampus and prefrontal cortex volume reduction in major depression
    Thomas Frodl
    Institute of Neuroscience, Department of Psychiatry, Trinity College Dublin, Dublin 2, Ireland
    J Psychiatr Res 44:799-807. 2010
  4. pmc Childhood stress, serotonin transporter gene and brain structures in major depression
    Thomas Frodl
    Department of Psychiatry, Institute of Neuroscience, Trinity College, Dublin, Ireland
    Neuropsychopharmacology 35:1383-90. 2010
  5. doi request reprint Functional connectivity of emotional processing in depression
    Angela Carballedo
    Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Integrated Neuroimaging, Trinity Academic Medical Centre, The Adelaide and Meath Hospital incorporating the National Children s Hospital, and St James s Hospital, Trinity College, Dublin, Ireland
    J Affect Disord 134:272-9. 2011
  6. ncbi request reprint Brain-derived neurotrophic factor Val66Met polymorphism and early life adversity affect hippocampal volume
    Angela Carballedo
    Department of Psychiatry and Institute of Neuroscience, University of Dublin, Trinity College Dublin, Dublin, Ireland
    Am J Med Genet B Neuropsychiatr Genet 162:183-90. 2013
  7. doi request reprint ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia
    Gary Donohoe
    Neuropsychiatric Genetics Research Group, Trinity College Dublin, Dublin, Ireland
    Neuroimage 54:2132-7. 2011
  8. doi request reprint Early life adversity is associated with brain changes in subjects at family risk for depression
    Angela Carballedo
    Department of Psychiatry, Institute of Neuroscience, Adelaide and Meath Hospital incorporating the National Children s Hospital AMNCH, St James s Hospital and Centre of Advanced Medical Imaging CAMI, University Dublin, Trinity College, Ireland
    World J Biol Psychiatry 13:569-78. 2012
  9. doi request reprint Different effects of mirtazapine and venlafaxine on brain activation: an open randomized controlled fMRI study
    Thomas Frodl
    Integrated Neuroimaging, Department of Psychiatry, Trinity College, Dublin, Ireland
    J Clin Psychiatry 72:448-57. 2011
  10. ncbi request reprint Brain activation predicts treatment improvement in patients with major depressive disorder
    Andrea C Samson
    Department of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Integrated Neuroimaging, The Adelaide and Meath Hospital incorporating the National Children s Hospital AMNCH, and St James s Hospital, Trinity College, Dublin, Ireland
    J Psychiatr Res 45:1214-22. 2011

Detail Information

Publications32

  1. ncbi request reprint Is there an association between peripheral immune markers and structural/functional neuroimaging findings?
    Thomas Frodl
    Department of Psychiatry, Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland Adelaide and Meath incorporating the National s Children Hospital, Dublin, Ireland St James s Hospital, Dublin, Ireland Electronic address
    Prog Neuropsychopharmacol Biol Psychiatry 48:295-303. 2014
    ..The present paper reviews this research, with particular focus on major depressive disorder (MDD), cognitive impairment in older adults, Alzheimer's disease (AD) and schizophrenia...
  2. doi request reprint Comorbidity of ADHD and Substance Use Disorder (SUD): a neuroimaging perspective
    Thomas Frodl
    Department of Psychiatry, School of Medicine, Trinity College Dublin, Dublin 2, Ireland
    J Atten Disord 14:109-20. 2010
    ..The high comorbidity indicates some shared underlying neurobiological substrates. Knowing these substrates may increase the understanding of the disease and help identify therapeutic processes...
  3. ncbi request reprint Interaction of childhood stress with hippocampus and prefrontal cortex volume reduction in major depression
    Thomas Frodl
    Institute of Neuroscience, Department of Psychiatry, Trinity College Dublin, Dublin 2, Ireland
    J Psychiatr Res 44:799-807. 2010
    ..Subjects with both, structural brain changes and childhood emotional neglect seem to be at a very high risk to develop a more severe illness course...
  4. pmc Childhood stress, serotonin transporter gene and brain structures in major depression
    Thomas Frodl
    Department of Psychiatry, Institute of Neuroscience, Trinity College, Dublin, Ireland
    Neuropsychopharmacology 35:1383-90. 2010
    ..Structural brain changes due to stress represent part of the mechanism by which the illness risk and outcome might be genetically mediated...
  5. doi request reprint Functional connectivity of emotional processing in depression
    Angela Carballedo
    Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Integrated Neuroimaging, Trinity Academic Medical Centre, The Adelaide and Meath Hospital incorporating the National Children s Hospital, and St James s Hospital, Trinity College, Dublin, Ireland
    J Affect Disord 134:272-9. 2011
    ..orbitofrontal cortex (OFC), anterior cingulate cortex (ACC) and prefrontal cortex (PFC) and that frontal-amygdala connections are altered in major depressive disorder (MDD)...
  6. ncbi request reprint Brain-derived neurotrophic factor Val66Met polymorphism and early life adversity affect hippocampal volume
    Angela Carballedo
    Department of Psychiatry and Institute of Neuroscience, University of Dublin, Trinity College Dublin, Dublin, Ireland
    Am J Med Genet B Neuropsychiatr Genet 162:183-90. 2013
    ..Our results highlight how relevant stress-gene interactions are for hippocampal volume reductions. Subjects exposed to early life adversity developed smaller hippocampal volumes when they carry the Met-allele of the BDNF polymorphism...
  7. doi request reprint ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia
    Gary Donohoe
    Neuropsychiatric Genetics Research Group, Trinity College Dublin, Dublin, Ireland
    Neuroimage 54:2132-7. 2011
    ..Establishing if this represents a discrete molecular pathogenesis with consequences for nosology and treatment will be an important next step in understanding ZNF084A's role in illness risk...
  8. doi request reprint Early life adversity is associated with brain changes in subjects at family risk for depression
    Angela Carballedo
    Department of Psychiatry, Institute of Neuroscience, Adelaide and Meath Hospital incorporating the National Children s Hospital AMNCH, St James s Hospital and Centre of Advanced Medical Imaging CAMI, University Dublin, Trinity College, Ireland
    World J Biol Psychiatry 13:569-78. 2012
    ....
  9. doi request reprint Different effects of mirtazapine and venlafaxine on brain activation: an open randomized controlled fMRI study
    Thomas Frodl
    Integrated Neuroimaging, Department of Psychiatry, Trinity College, Dublin, Ireland
    J Clin Psychiatry 72:448-57. 2011
    ..The aim of the study was therefore to investigate effects of 2 antidepressants on brain activation and to identify predictors for therapy response...
  10. ncbi request reprint Brain activation predicts treatment improvement in patients with major depressive disorder
    Andrea C Samson
    Department of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Integrated Neuroimaging, The Adelaide and Meath Hospital incorporating the National Children s Hospital AMNCH, and St James s Hospital, Trinity College, Dublin, Ireland
    J Psychiatr Res 45:1214-22. 2011
    ..The present investigation suggests the pCC, dmPFC, SFG, caudate nucleus and insula may have a key role as a biological marker for treatment response and predictor for therapeutic success...
  11. doi request reprint Attention network hypoconnectivity with default and affective network hyperconnectivity in adults diagnosed with attention-deficit/hyperactivity disorder in childhood
    Hazel McCarthy
    Neuroimaging Group, Department of Psychiatry, Trinity College Dublin, Dublin, Ireland2Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
    JAMA Psychiatry 70:1329-37. 2013
    ..The correlation patterns in spontaneous neural fluctuations at rest are known as resting-state functional connectivity (RSFC) and could characterize ADHD-specific connectivity changes...
  12. ncbi request reprint Altered inhibition of negative emotions in subjects at family risk of major depressive disorder
    Danuta M Lisiecka
    Department of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Adelaide and Meath Hospital Incorporating the National Children s Hospital, Tallaght, Trinity College Dublin, Ireland
    J Psychiatr Res 46:181-8. 2012
    ..Overactivation of cingulate cortex and caudate nucleus may indicate a learnt strategy aimed at coping with increased susceptibility to negative information schemata and may have future consequences for therapy...
  13. doi request reprint Neurotrophic tyrosine kinase polymorphism impacts white matter connections in patients with major depressive disorder
    Melissa L Murphy
    Integrated Neuroimaging Group, Department of Psychiatry and Institute of Neuroscience, School of Medicine, Trinity College Dublin, University of Dublin, College Green, Dublin, Ireland
    Biol Psychiatry 72:663-70. 2012
    ....
  14. pmc Recruitment of the left hemispheric emotional attention neural network in risk for and protection from depression
    Danuta M Lisiecka
    Department of Psychiatry, University of Dublin, Trinity College, Ireland
    J Psychiatry Neurosci 38:117-28. 2013
    ..Emotion processing and attention shifting are functions altered by MDD and family history of the disease; therefore, it is important to recognize the neural correlates of these functions in association with both factors...
  15. pmc Effect of genetic variant in BICC1 on functional and structural brain changes in depression
    Rachel Bermingham
    Integrated Neuroimaging Group, Department of Psychiatry and Institute of Neuroscience, School of Medicine, Trinity College Dublin, University of Dublin, College Green, Dublin, Ireland
    Neuropsychopharmacology 37:2855-62. 2012
    ..These results are suggestive that the minor T-allele of BICC1 has a protective role against MDD and its known structural and functional brain changes. However, this protective effect seems to be lost in the case of co-occurrence of ELA...
  16. ncbi request reprint Magnetic resonance imaging in patients with borderline personality disorder: a study of volumetric abnormalities
    Aisling O'Neill
    Department of Psychiatry, University of Dublin, Trinity College, Dublin 2, Ireland
    Psychiatry Res 213:1-10. 2013
    ....
  17. pmc Effect of childhood maltreatment on brain structure in adult patients with major depressive disorder and healthy participants
    Aisling Chaney
    Department of Psychiatry, Institute of Neuroscience, Adelaide and Meath Hospital incorporating the National Children s Hospital AMNCH, Dublin 24, University Dublin, Trinity College, Dublin, Dublin, Ireland
    J Psychiatry Neurosci 39:50-9. 2014
    ..The aim of this study was to investigate whether patients with MDD and a history of childhood maltreatment display more structural changes than patients without childhood maltreatment or healthy controls...
  18. pmc Reduced occipital and prefrontal brain volumes in dysbindin-associated schizophrenia
    Gary Donohoe
    Department of Psychiatry, Neuropsychiatric Genetics Research Group, Trinity College Dublin, Dublin, Ireland
    Neuropsychopharmacology 35:368-73. 2010
    ..These data provide important evidence of the influence of dysbindin risk variants on brain structure, and suggest a possible mechanism by which disease risk is being increased...
  19. pmc Structural MRI correlates for vulnerability and resilience to major depressive disorder
    Francesco Amico
    Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Integrated Neuroimaging, Trinity Academic Medical Centre The Adelaide and Meath Hospital, incorporating the National Children s Hospital and St James s Hospital, Trinity College, Dublin, Ireland
    J Psychiatry Neurosci 36:15-22. 2011
    ..The aim of this study was to investigate whether structural abnormalities are related to risk for the development of MDD...
  20. doi request reprint Impact of family history and depression on amygdala volume
    Karim Saleh
    Department of Psychiatry St James s Hospital and Adelaide and Meath Hospital incorporating the National Children s Hospital, Trinity College Dublin, Ireland
    Psychiatry Res 203:24-30. 2012
    ..Ultimately, these findings highlight consideration of family history and gender in research and treatment strategies...
  21. doi request reprint Anterior cingulate cortex gray matter abnormalities in adults with attention deficit hyperactivity disorder: a voxel-based morphometry study
    Francesco Amico
    Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Integrated Neuroimaging, Trinity College, Dublin, Ireland
    Psychiatry Res 191:31-5. 2011
    ..Volumetric abnormalities in the brain of adult ADHD patients might be less pronounced than those found in children and adolescents, although the role played by chronic stimulant treatment needs further investigation...
  22. ncbi request reprint Brain structure and function in borderline personality disorder
    Aisling O'Neill
    Department of Psychiatry, Institute of Neuroscience, Trinity College, Dublin 2, Ireland
    Brain Struct Funct 217:767-82. 2012
    ..We also discuss the limitations of some of the current studies including hindrances due to sample effects and techniques used and the potential of future neuroimaging research in BPD...
  23. pmc Functional anomalies in healthy individuals with a first degree family history of major depressive disorder
    Francesco Amico
    Department of Psychiatry, Trinity College Dublin, College Green, Dublin 2, Ireland
    Biol Mood Anxiety Disord 2:1. 2012
    ..abstract:..
  24. pmc Effect of hippocampal and amygdala volumes on clinical outcomes in major depression: a 3-year prospective magnetic resonance imaging study
    Thomas Frodl
    Department of Psychiatry, Trinity College Dublin, Ireland
    J Psychiatry Neurosci 33:423-30. 2008
    ..We sought to examine the changes in hippocampal and amygdala volumes at baseline and at 3 years after an acute depressive episode, and the impact of reduced hippocampal volumes on the outcome...
  25. ncbi request reprint Altered brain activation during a verbal working memory task in subjects with amnestic mild cognitive impairment
    Arun L W Bokde
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Alzheimer Memorial Center, Munich, Germany
    J Alzheimers Dis 21:103-18. 2010
    ..The activation differences between groups may be compensatory mechanisms within the MCI group for the effects of the putative AD neuropathology. This has been the first study that has examined verbal working memory in MCI...
  26. doi request reprint Functional connectivity bias of the orbitofrontal cortex in drug-free patients with major depression
    Thomas Frodl
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, Germany
    Biol Psychiatry 67:161-7. 2010
    ..The aim of this study was to compare the functional connectivity of the OFC during emotion processing in patients with major depression and healthy control subjects...
  27. doi request reprint Tryptophan depletion in depressed patients occurs independent of kynurenine pathway activation
    Martina M Hughes
    Neuroimmunology Research Group, Department of Physiology, School of Medicine and Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland
    Brain Behav Immun 26:979-87. 2012
    ..Taken together these data question the ability of the mild inflammatory phenotype observed in depression to induce molecules such as IDO and SERT that could negatively impact upon serotonergic functioning...
  28. ncbi request reprint Neuroimaging markers for the prediction of treatment response to Methylphenidate in ADHD
    Norbert Skokauskas
    Department of Psychiatry, Trinity College Dublin, Ireland Department of Psychiatry and Developmental Psychology, University of Nagoya, Japan Department of Psychiatry, Children s University Hospital, Dublin, Ireland Electronic address
    Eur J Paediatr Neurol 17:543-51. 2013
    ..Methylphenidate is one the most commonly used medication to treat ADHD, however up to 30% of patients do not respond to it...
  29. pmc Effects of early-life adversity on white matter diffusivity changes in patients at risk for major depression
    Thomas Frodl
    Department of Psychiatry, Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    J Psychiatry Neurosci 37:37-45. 2012
    ....
  30. doi request reprint Neural correlates of treatment outcome in major depression
    Danuta Lisiecka
    Department of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Integrated Neuroimaging, The Adelaide and Meath Hospital Incorporating The National Children s Hospital AMiNCH, and St James s Hospital, Trinity College, Dublin, Ireland
    Int J Neuropsychopharmacol 14:521-34. 2011
    ..These results indicate that OFC functional connectivity might be useful as a marker for therapy response to mirtazapine and venlafaxine and to reconstruct the differences in their mechanism of action...
  31. doi request reprint How does the brain deal with cumulative stress? A review with focus on developmental stress, HPA axis function and hippocampal structure in humans
    Thomas Frodl
    Department of Psychiatry, University Dublin, Trinity College, Ireland
    Neurobiol Dis 52:24-37. 2013
    ....
  32. doi request reprint Complementary medicine for children and young people who have attention deficit hyperactivity disorder
    Norbert Skokauskas
    Department of Psychiatry, Trinity College, Ireland
    Curr Opin Psychiatry 24:291-300. 2011
    ..This article reviews the latest scientific evidence of the effectiveness and safety of these treatments in ADHD...