T Frodl

Summary

Affiliation: Trinity College
Country: Ireland

Publications

  1. doi request reprint Amygdala reduction in patients with ADHD compared with major depression and healthy volunteers
    T Frodl
    Department of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience TCIN, Trinity College, University of Dublin, Trinity Centre for Health Sciences, Trinity Academic Medical Centre The Adelaide and Meath Hospital Incorporating the National Children s Hospital AMNCH and St James s Hospital, Dublin 24, Ireland
    Acta Psychiatr Scand 121:111-8. 2010
  2. doi request reprint Meta-analysis of structural MRI studies in children and adults with attention deficit hyperactivity disorder indicates treatment effects
    T Frodl
    Department of Psychiatry, Trinity College Dublin, Ireland
    Acta Psychiatr Scand 125:114-26. 2012
  3. doi request reprint How does the brain deal with cumulative stress? A review with focus on developmental stress, HPA axis function and hippocampal structure in humans
    Thomas Frodl
    Department of Psychiatry, University Dublin, Trinity College, Ireland
    Neurobiol Dis 52:24-37. 2013
  4. pmc Reduced expression of glucocorticoid-inducible genes GILZ and SGK-1: high IL-6 levels are associated with reduced hippocampal volumes in major depressive disorder
    T Frodl
    Department of Psychiatry and Institute of Neuroscience, Adelaide and Meath Hospital incorporating the National Children s Hospital and St James s Hospital, University Dublin, Trinity College, Dublin, Ireland
    Transl Psychiatry 2:e88. 2012
  5. pmc Meta-analysis of diffusion tensor imaging studies shows altered fractional anisotropy occurring in distinct brain areas in association with depression
    Melissa L Murphy
    Department of Psychiatry and Institute of Neuroscience, School of Medicine, Trinity College Dublin, University of Dublin, College Green, Dublin 2, Ireland
    Biol Mood Anxiety Disord 1:3. 2011
  6. doi request reprint Functional connectivity bias of the orbitofrontal cortex in drug-free patients with major depression
    Thomas Frodl
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, Germany
    Biol Psychiatry 67:161-7. 2010
  7. doi request reprint Different effects of mirtazapine and venlafaxine on brain activation: an open randomized controlled fMRI study
    Thomas Frodl
    Integrated Neuroimaging, Department of Psychiatry, Trinity College, Dublin, Ireland
    J Clin Psychiatry 72:448-57. 2011
  8. pmc Effects of early-life adversity on white matter diffusivity changes in patients at risk for major depression
    Thomas Frodl
    Department of Psychiatry, Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    J Psychiatry Neurosci 37:37-45. 2012
  9. doi request reprint Dual-isotope SPECT imaging of striatal dopamine: a comparative study between never-treated and haloperidol-treated first-episode schizophrenic patients
    G J E Schmitt
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 262:183-91. 2012
  10. ncbi request reprint Striatal dopamine transporter availability is associated with the productive psychotic state in first episode, drug-naive schizophrenic patients
    G J E Schmitt
    Department of Psychiatry, Ludwig Maximilians University Munich, 80336, Munchen, Germany
    Eur Arch Psychiatry Clin Neurosci 256:115-21. 2006

Detail Information

Publications30

  1. doi request reprint Amygdala reduction in patients with ADHD compared with major depression and healthy volunteers
    T Frodl
    Department of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience TCIN, Trinity College, University of Dublin, Trinity Centre for Health Sciences, Trinity Academic Medical Centre The Adelaide and Meath Hospital Incorporating the National Children s Hospital AMNCH and St James s Hospital, Dublin 24, Ireland
    Acta Psychiatr Scand 121:111-8. 2010
    ..The aim of this study was to investigate whether in adult patients with ADHD hippocampal or amygdala volumes differs from that in healthy controls and patients with major depression (MD)...
  2. doi request reprint Meta-analysis of structural MRI studies in children and adults with attention deficit hyperactivity disorder indicates treatment effects
    T Frodl
    Department of Psychiatry, Trinity College Dublin, Ireland
    Acta Psychiatr Scand 125:114-26. 2012
    ..The aim of this study was to perform a meta-analysis of MRI voxel-based morphometry (VBM) and manual tracing studies to identify the differences between adults and children with ADHD as well as between treated and untreated individuals...
  3. doi request reprint How does the brain deal with cumulative stress? A review with focus on developmental stress, HPA axis function and hippocampal structure in humans
    Thomas Frodl
    Department of Psychiatry, University Dublin, Trinity College, Ireland
    Neurobiol Dis 52:24-37. 2013
    ....
  4. pmc Reduced expression of glucocorticoid-inducible genes GILZ and SGK-1: high IL-6 levels are associated with reduced hippocampal volumes in major depressive disorder
    T Frodl
    Department of Psychiatry and Institute of Neuroscience, Adelaide and Meath Hospital incorporating the National Children s Hospital and St James s Hospital, University Dublin, Trinity College, Dublin, Ireland
    Transl Psychiatry 2:e88. 2012
    ..Further studies need to explore the possible clinical usefulness of such a blood biomarker, for example, for diagnosis or prediction of therapy response...
  5. pmc Meta-analysis of diffusion tensor imaging studies shows altered fractional anisotropy occurring in distinct brain areas in association with depression
    Melissa L Murphy
    Department of Psychiatry and Institute of Neuroscience, School of Medicine, Trinity College Dublin, University of Dublin, College Green, Dublin 2, Ireland
    Biol Mood Anxiety Disord 1:3. 2011
    ..In conclusion, our meta-analysis revealed a significant reduction in fractional anisotropy values in the left superior longitudinal fasciculus, which may ultimately play an important role in the pathology of depression...
  6. doi request reprint Functional connectivity bias of the orbitofrontal cortex in drug-free patients with major depression
    Thomas Frodl
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, Germany
    Biol Psychiatry 67:161-7. 2010
    ..The aim of this study was to compare the functional connectivity of the OFC during emotion processing in patients with major depression and healthy control subjects...
  7. doi request reprint Different effects of mirtazapine and venlafaxine on brain activation: an open randomized controlled fMRI study
    Thomas Frodl
    Integrated Neuroimaging, Department of Psychiatry, Trinity College, Dublin, Ireland
    J Clin Psychiatry 72:448-57. 2011
    ..The aim of the study was therefore to investigate effects of 2 antidepressants on brain activation and to identify predictors for therapy response...
  8. pmc Effects of early-life adversity on white matter diffusivity changes in patients at risk for major depression
    Thomas Frodl
    Department of Psychiatry, Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    J Psychiatry Neurosci 37:37-45. 2012
    ....
  9. doi request reprint Dual-isotope SPECT imaging of striatal dopamine: a comparative study between never-treated and haloperidol-treated first-episode schizophrenic patients
    G J E Schmitt
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 262:183-91. 2012
    ..The data obtained with the new dual-isotope SPECT technique reveal a direct effect of haloperidol at the D2 and DAT receptor level...
  10. ncbi request reprint Striatal dopamine transporter availability is associated with the productive psychotic state in first episode, drug-naive schizophrenic patients
    G J E Schmitt
    Department of Psychiatry, Ludwig Maximilians University Munich, 80336, Munchen, Germany
    Eur Arch Psychiatry Clin Neurosci 256:115-21. 2006
    ..Association of DAT availability and the acute psychotic syndrome is now demonstrated in a large cohort of first episode, never treated schizophrenic patients...
  11. ncbi request reprint Dual-isotope SPECT imaging of striatal dopamine: first episode, drug naïve schizophrenic patients
    G J E Schmitt
    Department of Psychiatry, Ludwig Maximilians University Munich, Nussbaumstr 7, 80336 Munchen, Germany
    Schizophr Res 101:133-41. 2008
    ..Additionally, relations between radioligand binding to DAT and D(2) and positive symptoms were assessed...
  12. ncbi request reprint Effects of treatment with the atypical neuroleptic quetiapine on working memory function: a functional MRI follow-up investigation
    E M Meisenzahl
    Dept of Psychiatry, Ludwig Maximilians University of Munich, Nussbaumstrasse 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 256:522-31. 2006
    ..The presented study evaluated the impact of a neuroleptic steady state treatment with quetiapine on the altered working memory activation patterns in schizophrenia...
  13. ncbi request reprint Adhesio interthalamica in male patients with schizophrenia
    E M Meisenzahl
    Department of Psychiatry and Radiology, Ludwig Maximilians University, Munich, Germany
    Am J Psychiatry 157:823-5. 2000
    ..The authors investigated whether absence of the adhesio interthalamica in patients with schizophrenia constitutes a marker of early developmental neuropathological changes...
  14. ncbi request reprint Dipole localization of P300 and normal aging
    T Frodl
    Dept of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Brain Topogr 13:3-9. 2000
    ..Age affected both P300 subcomponents' latencies. Therefore, the functionally different alteration of P300 subcomponents might be the reason for P300 topography changes with the P300 maximum more frontally in older age...
  15. doi request reprint Striatal D2/D3 receptor occupancy, clinical response and side effects with amisulpride: an iodine-123-iodobenzamide SPET study
    E M Meisenzahl
    Department of Psychiatry, LMU University of Munich, Munich, Germany
    Pharmacopsychiatry 41:169-75. 2008
    ..Amisulpride appears to be an effective atypical agent for treating schizophrenia in a dose-dependent manner...
  16. doi request reprint Neuroimaging genetics: new perspectives in research on major depression?
    T Frodl
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Acta Psychiatr Scand 118:363-72. 2008
    ..To enhance our understanding of both the interaction between the brain, behaviour and genetics and of biological mechanisms in mood disorders neuroimaging genetics provide a good opportunity...
  17. ncbi request reprint Cerebral differences in explicit and implicit emotional processing--an fMRI study
    J Scheuerecker
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Neuropsychobiology 56:32-9. 2007
    ..Our data partially confirm the hypothesis of different neural substrates for the processing of implicit and explicit emotional stimuli...
  18. doi request reprint Reduced gray matter brain volumes are associated with variants of the serotonin transporter gene in major depression
    T Frodl
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University of Munich, Munich, Germany
    Mol Psychiatry 13:1093-101. 2008
    ..Patients with depression show reduced GM volumes, particularly when they are homozygous for the L(A)-allele, suggesting that these patients are more vulnerable for morphological changes during depressive episodes...
  19. ncbi request reprint Digitized analysis of abnormal hand-motor performance in schizophrenic patients
    P Tigges
    Department of Psychiatry, Ludwig Maximilians University Munich, Clinical Neurophysiology Section, Nussbaumstrasse 7, D 80336, Munich, Germany
    Schizophr Res 45:133-43. 2000
    ..Our findings show NSS in schizophrenic patients, independently of neuroleptics. Further, the hypothesis of lateralization of cerebral structures generating NSS towards the right hemisphere in schizophrenia is supported...
  20. ncbi request reprint The effect of the skull on event-related P300
    T Frodl
    Laboratory for Neuroimaging of Functional Psychosis, Department of Psychiatry, Ludwig Maximilians University Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    Clin Neurophysiol 112:1773-6. 2001
    ..The aim of the present study was to investigate this influence of skull and scalp thicknesses on event-related P300 potentials...
  21. ncbi request reprint Corpus callosum and P300 in schizophrenia
    T Frodl
    Laboratory of Clinical Neurophysiology, Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336, Munich, Germany
    Schizophr Res 49:107-19. 2001
    ..The results are discussed in terms of the possibility that abnormalities in interhemispheric transfer may underlie the mechanisms of schizophrenia...
  22. doi request reprint Structural brain alterations at different stages of schizophrenia: a voxel-based morphometric study
    E M Meisenzahl
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstr 7, 80336 Munich, Germany
    Schizophr Res 104:44-60. 2008
    ..Furthermore, our data suggest that in the advanced stages of schizophrenia additional cortical and subcortical brain areas become involved in the disease process. Longitudinal data will be required to further test this hypothesis...
  23. doi request reprint 5-HT1A receptor gene C -1019 G polymorphism and amygdala volume in borderline personality disorder
    T Zetzsche
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Genes Brain Behav 7:306-13. 2008
    ..Future research is recommended to clarify possible interactions between this functional polymorphism and symptoms, course and treatment responses in this disorder...
  24. ncbi request reprint Loudness dependence of auditory evoked potentials in obsessive-compulsive disorder: a pilot study
    M T Carrillo-de-la-Peña
    Department of Psychiatry, Section of Clinical Neurophysiology and Outpatient Clinic for Obsessive Compulsive Disorder, Ludwig Maximilians Universitat, Munich, Germany
    Psychiatry Res 93:209-16. 2000
    ..These findings do not support the hypothesis of a serotonergic dysfunction in OCD patients...
  25. ncbi request reprint P300 and symptom improvement in schizophrenia
    J Gallinat
    Department of Psychiatry, Laboratory of Clinical Psychophysiology, Free University Berlin, Eschenallee 3, 14050 Berlin, Germany
    Psychopharmacology (Berl) 158:55-65. 2001
    ..A reduced amplitude of the auditory evoked P300 was interpreted as a trait marker of schizophrenia but reports about correlations between schizophrenic psychopathology and P300 amplitude indicate also a state character...
  26. doi request reprint Reduced fractional anisotropy in the uncinate fasciculus in patients with major depression carrying the met-allele of the Val66Met brain-derived neurotrophic factor genotype
    A Carballedo
    Department of Psychiatry, Institute of Neuroscience, University of Dublin, Trinity College Dublin, Dublin, Ireland
    Am J Med Genet B Neuropsychiatr Genet 159:537-48. 2012
    ....
  27. ncbi request reprint Markers from event-related potential subcomponents and reaction time for information processing dysfunction in schizophrenia
    T Frodl
    Department of Psychiatry, , Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 248:307-13. 1998
    ..The input-related processing stages (N100 and P200) were not altered, whereas later, the deviant and task-related processes (N200, frontal P300, parietal P300 and reaction time) were significantly prolonged in schizophrenia...
  28. ncbi request reprint The striatal dopamine transporter in first-episode, drug-naive schizophrenic patients: evaluation by the new SPECT-ligand[99mTc]TRODAT-1
    G J E Schmitt
    Department of Psychiatry, Ludwig Maximilians University Munich, Munich, Germany
    J Psychopharmacol 19:488-93. 2005
    ..in a comparable patient sample. [99mTc]TRODAT-1 seems to be a valuable new SPECT-ligand in the evaluation of the presynaptic site of the striatal dopaminergic synapse in schizophrenia...
  29. doi request reprint Identifying a consistent pattern of neural function in attention deficit hyperactivity disorder: a meta-analysis
    H McCarthy
    Department of Psychiatry, Integrated Neuroimaging, Trinity College Dublin, Dublin, Republic of Ireland
    Psychol Med 44:869-80. 2014
    ..To identify a consistent pattern of neural dysfunction in ADHD, a meta-analysis of fMRI studies using Go/no-go, Stop and N-back tasks was undertaken...
  30. ncbi request reprint Thalamic volume in first-episode and chronic schizophrenic subjects: a volumetric MRI study
    U W Preuss
    Department of Psychiatry, Psychiatrische Klinik und Poliklinik, Ludwig Maximilians Universitat Munchen, Nussbaumstr 7, 80336 Munchen, Germany
    Schizophr Res 73:91-101. 2005
    ....