T J Foster

Summary

Affiliation: Trinity College
Country: Ireland

Publications

  1. ncbi Immune evasion by staphylococci
    Timothy J Foster
    Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Nat Rev Microbiol 3:948-58. 2005
  2. pmc Increased virulence of a fibronectin-binding protein mutant of Staphylococcus aureus in a rat model of pneumonia
    Mary C McElroy
    Rayne Laboratory, Respiratory Medicine, University of Edinburgh, Scotland Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin, Ireland
    Infect Immun 70:3865-73. 2002
  3. pmc Molecular characterization of the interaction of staphylococcal microbial surface components recognizing adhesive matrix molecules (MSCRAMM) ClfA and Fbl with fibrinogen
    Joan A Geoghegan
    Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    J Biol Chem 285:6208-16. 2010
  4. pmc Fibronectin-binding protein B variation in Staphylococcus aureus
    Fiona M Burke
    Department of Microbiology, Moyne Institute of Preventive Medicine, University of Dublin, Trinity College, Dublin, Ireland
    BMC Microbiol 10:160. 2010
  5. pmc Identification of the Staphylococcus aureus MSCRAMM clumping factor B (ClfB) binding site in the alphaC-domain of human fibrinogen
    Evelyn J Walsh
    Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Microbiology 154:550-8. 2008
  6. pmc Genome sequence of Staphylococcus lugdunensis N920143 allows identification of putative colonization and virulence factors
    Simon Heilbronner
    Microbiology Department, Trinity College, Dublin, Ireland
    FEMS Microbiol Lett 322:60-7. 2011
  7. pmc The immune evasion protein Sbi of Staphylococcus aureus occurs both extracellularly and anchored to the cell envelope by binding lipoteichoic acid
    Emma Jane Smith
    Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Mol Microbiol 83:789-804. 2012
  8. pmc Effect of filaggrin breakdown products on growth of and protein expression by Staphylococcus aureus
    Helen Miajlovic
    Moyne Institute of Preventive Medicine, Trinity College, Dublin, Ireland
    J Allergy Clin Immunol 126:1184-90.e3. 2010
  9. pmc Surface proteins that promote adherence of Staphylococcus aureus to human desquamated nasal epithelial cells
    Rebecca M Corrigan
    Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    BMC Microbiol 9:22. 2009
  10. pmc Sequence diversity in the A domain of Staphylococcus aureus fibronectin-binding protein A
    Anthony Loughman
    Department of Microbiology, Moyne Institute of Preventive Medicine, University of Dublin, Trinity College, Dublin, Ireland
    BMC Microbiol 8:74. 2008

Collaborators

Detail Information

Publications70

  1. ncbi Immune evasion by staphylococci
    Timothy J Foster
    Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Nat Rev Microbiol 3:948-58. 2005
    ..In contrast, Staphylococcus epidermidis must rely primarily on cell-surface polymers and the ability to form a biolfilm to survive in the host...
  2. pmc Increased virulence of a fibronectin-binding protein mutant of Staphylococcus aureus in a rat model of pneumonia
    Mary C McElroy
    Rayne Laboratory, Respiratory Medicine, University of Edinburgh, Scotland Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin, Ireland
    Infect Immun 70:3865-73. 2002
    ..Instead, our data suggest that fibronectin-binding proteins decrease the virulence of S. aureus in pneumonia...
  3. pmc Molecular characterization of the interaction of staphylococcal microbial surface components recognizing adhesive matrix molecules (MSCRAMM) ClfA and Fbl with fibrinogen
    Joan A Geoghegan
    Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    J Biol Chem 285:6208-16. 2010
    ..Fbl variant proteins with alanine substitutions in key residues had reduced affinities for fibrinogen. Thus Fbl and ClfA bind the same site in fibrinogen by similar mechanisms...
  4. pmc Fibronectin-binding protein B variation in Staphylococcus aureus
    Fiona M Burke
    Department of Microbiology, Moyne Institute of Preventive Medicine, University of Dublin, Trinity College, Dublin, Ireland
    BMC Microbiol 10:160. 2010
    ..The variation created differences in antigenicity while ligand binding functions were retained. Here, FnBPB variation was examined in both human and bovine isolates and compared to that of FnBPA...
  5. pmc Identification of the Staphylococcus aureus MSCRAMM clumping factor B (ClfB) binding site in the alphaC-domain of human fibrinogen
    Evelyn J Walsh
    Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Microbiology 154:550-8. 2008
    ....
  6. pmc Genome sequence of Staphylococcus lugdunensis N920143 allows identification of putative colonization and virulence factors
    Simon Heilbronner
    Microbiology Department, Trinity College, Dublin, Ireland
    FEMS Microbiol Lett 322:60-7. 2011
    ..It is the only staphylococcal species other than S. aureus that possesses a locus encoding iron-regulated surface determinant (Isd) proteins involved in iron acquisition from haemoglobin...
  7. pmc The immune evasion protein Sbi of Staphylococcus aureus occurs both extracellularly and anchored to the cell envelope by binding lipoteichoic acid
    Emma Jane Smith
    Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Mol Microbiol 83:789-804. 2012
    ..This explains how Sbi partitions with the membrane in fractionation experiments yet is partially exposed on the cell surface. An LTA-defective mutant of S. aureus had reduced levels of Sbi in the cytoplasmic membrane...
  8. pmc Effect of filaggrin breakdown products on growth of and protein expression by Staphylococcus aureus
    Helen Miajlovic
    Moyne Institute of Preventive Medicine, Trinity College, Dublin, Ireland
    J Allergy Clin Immunol 126:1184-90.e3. 2010
    ..Atopic dermatitis is associated with loss-of-function mutations in the filaggrin (FLG) gene, accompanied by reduced levels of filaggrin breakdown products on the skin...
  9. pmc Surface proteins that promote adherence of Staphylococcus aureus to human desquamated nasal epithelial cells
    Rebecca M Corrigan
    Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    BMC Microbiol 9:22. 2009
    ..S. aureus strain Newman defective in IsdA and ClfB exhibited reduced but not completely defective adherence to squamous cells in indicating that other cell surface components might also contribute...
  10. pmc Sequence diversity in the A domain of Staphylococcus aureus fibronectin-binding protein A
    Anthony Loughman
    Department of Microbiology, Moyne Institute of Preventive Medicine, University of Dublin, Trinity College, Dublin, Ireland
    BMC Microbiol 8:74. 2008
    ..aureus were examined to determine the extent of FnBPA A domain variation within the S. aureus population and its effect on ligand binding and immuno-crossreactivity...
  11. doi Colonization and infection of the human host by staphylococci: adhesion, survival and immune evasion
    Timothy J Foster
    Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Vet Dermatol 20:456-70. 2009
    ..By studying the molecular pathogenesis of S. aureus infections markers might be found for investigating S. pseudintermedius infections of dogs...
  12. ncbi Surface protein adhesins of Staphylococcus aureus
    T J Foster
    Microbiology Dept, Moyne Institute of Preventive Medicine, Trinity College, Dublin, Ireland
    Trends Microbiol 6:484-8. 1998
    ..Adherence is mediated by surface protein adhesins (MSCRAMMs). Ligand binding by these fibronectin-, fibrinogen- and collagen-binding proteins occurs by distinct mechanisms that are being investigated at the molecular level...
  13. pmc The Staphylococcus aureus "superbug"
    Timothy J Foster
    Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    J Clin Invest 114:1693-6. 2004
    ..aureus population is clonal and that some strains have enhanced virulence. This is discussed in the context of growing interest in the mechanisms of bacterial colonization, antibiotic resistance, and novel vaccines...
  14. ncbi Loss of clumping factor B fibrinogen binding activity by Staphylococcus aureus involves cessation of transcription, shedding and cleavage by metalloprotease
    F M McAleese
    Microbiology Department, Moyne Institute for Preventive Medicine, Trinity College, Dublin 2, Ireland
    J Biol Chem 276:29969-78. 2001
    ..Cleavage was detected at two sites, one located between residues Ser(197) and Leu(198) and the other between Ala(199) and Val(200). The truncated form of ClfB did not bind fibrinogen...
  15. ncbi The fibrinogen-binding MSCRAMM (clumping factor) of Staphylococcus aureus has a Ca2+-dependent inhibitory site
    D P O'Connell
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Republic of Ireland
    J Biol Chem 273:6821-9. 1998
    ..Mutagenesis studies indicate that the Ca2+-dependent inhibitory site is located within the EF-hand motif at residues 310-321...
  16. ncbi Clumping factor B (ClfB), a new surface-located fibrinogen-binding adhesin of Staphylococcus aureus
    D Ni Eidhin
    Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Mol Microbiol 30:245-57. 1998
    ....
  17. ncbi The binding of calcium to the B-repeat segment of SdrD, a cell surface protein of Staphylococcus aureus
    E Josefsson
    Department of Microbiology, Moyne Institute of Preventive Medicine, University of Dublin, Trinity College, Dublin 2, Republic of Ireland
    J Biol Chem 273:31145-52. 1998
    ..The B-repeats may act as rulers or springs that modulate the distance between the interactive A region and the bacterial cell surface...
  18. ncbi Identification of residues in the Staphylococcus aureus fibrinogen-binding MSCRAMM clumping factor A (ClfA) that are important for ligand binding
    O M Hartford
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    J Biol Chem 276:2466-73. 2001
    ..These data suggest that the C terminus of the A region may contain at least part of the Fg-binding site of ClfA and that Glu(526) and Val(527) may be involved in ligand recognition...
  19. ncbi Molecular characterization of the clumping factor (fibrinogen receptor) of Staphylococcus aureus
    D McDevitt
    Microbiology Department, Moyne Institute, Trinity College, Dublin, Ireland
    Mol Microbiol 11:237-48. 1994
    ..Significant homology was found between the ClfA protein and the fibronectin-binding proteins of S. aureus, particularly in the N- and C-termini...
  20. ncbi The Fbe (SdrG) protein of Staphylococcus epidermidis HB promotes bacterial adherence to fibrinogen
    O Hartford
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Microbiology 147:2545-52. 2001
    ..These strains adhered strongly to immobilized fibrinogen. These results confirm that Fbe is a fibrinogen-binding adhesin...
  21. pmc Molecular analysis of the tagF gene, encoding CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase of Staphylococcus epidermidis ATCC 14990
    S N Fitzgerald
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    J Bacteriol 182:1046-52. 2000
    ..This suggests that the tagF gene is essential and that the TagF and other enzymes involved in teichoic acid biosynthesis could be targets for new antistaphylococcal drugs...
  22. ncbi Three new members of the serine-aspartate repeat protein multigene family of Staphylococcus aureus
    E Josefsson
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin, Ireland
    Microbiology 144:3387-95. 1998
    ..The sdr locus was present in all 31 S. aureus strains from human and bovine sources tested by Southern hybridization, although in a few strains it contained two rather than three genes...
  23. doi Elucidating the role of Staphylococcus epidermidis serine-aspartate repeat protein G in platelet activation
    M P Brennan
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
    J Thromb Haemost 7:1364-72. 2009
    ..S. epidermidis induces platelet aggregation by an unknown mechanism. The fibrinogen-binding protein serine-aspartate repeat protein G (SdrG) is present in 67-91% of clinical strains...
  24. ncbi Sequence and mapping of the aroA gene of Staphylococcus aureus 8325-4
    C O'CONNELL
    Microbiology Department, Moyne Institute, Trinity College, Dublin, Ireland
    J Gen Microbiol 139:1449-60. 1993
    ..The PAB independence may explain the finding that the mutant was not attenuated in mouse infection experiments. It was not possible to isolate a null mutant in aroA...
  25. ncbi Molecular cloning and genetic analysis of the determinant for gamma-lysin, a two-component toxin of Staphylococcus aureus
    J Cooney
    Microbiology Department, Moyne Institute, Trinity College, Dublin, Ireland
    J Gen Microbiol 134:2179-88. 1988
    ..The 38 kDa polypeptide is probably an unprocessed precursor. Southern hybridization demonstrated that the hlgA and hlgB genes are closely linked in the chromosome of several strains of S. aureus...
  26. pmc Staphylococcus schleiferi subsp. schleiferi expresses a fibronectin-binding protein
    S J Peacock
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Infect Immun 67:4272-5. 1999
    ..This study provides phenotypic and genotypic evidence for the expression of a cell wall-anchored fibronectin-binding protein by this species...
  27. ncbi Fibrinogen and elastin bind to the same region within the A domain of fibronectin binding protein A, an MSCRAMM of Staphylococcus aureus
    Fiona M Keane
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Mol Microbiol 63:711-23. 2007
    ....
  28. doi Staphylococci and staphylococcal infections
    Timothy J Foster
    Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College Dublin, Dublin 2, Ireland
    Expert Rev Anti Infect Ther 8:1337-8. 2010
    ..Sessions comprised keynote lectures along with short talks by junior investigators chosen from submitted abstracts. This article reviews several important developments in the field that were discussed at the conference...
  29. ncbi Fibronectin-binding proteins of Staphylococcus aureus mediate activation of human platelets via fibrinogen and fibronectin bridges to integrin GPIIb/IIIa and IgG binding to the FcgammaRIIa receptor
    J Ross Fitzgerald
    Department of Microbiology, Moyne Institute of Preventive Medicine, University of Dublin, Trinity College, Dublin, Ireland
    Mol Microbiol 59:212-30. 2006
    ..This suggests new avenues for development of therapeutics against vascular infections...
  30. ncbi The role of Staphylococcus aureus surface protein SasG in adherence and biofilm formation
    Rebecca M Corrigan
    Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Microbiology 153:2435-46. 2007
    ..Several clinical isolates expressed SasG at levels similar to those of SH1000 sasG : : pMUTIN4, indicating that the properties described in the laboratory strain SH1000 may be relevant in vivo...
  31. ncbi The N-terminal A domain of fibronectin-binding proteins A and B promotes adhesion of Staphylococcus aureus to elastin
    Fiona M Roche
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    J Biol Chem 279:38433-40. 2004
    ..This interaction was inhibited by soluble elastin peptides, suggesting a specific receptor-ligand interaction...
  32. ncbi Staphylococcus aureus clumping factor B (ClfB) promotes adherence to human type I cytokeratin 10: implications for nasal colonization
    Louise M O'Brien
    Moyne Institute of Preventive Medicine, Department of Microbiology, Trinity College Dublin, Dublin 2, Ireland
    Cell Microbiol 4:759-70. 2002
    ..We also showed that ClfB is transcribed by S. aureus in the human nares. We propose that ClfB is a major determinant in S. aureus nasal colonization...
  33. ncbi The coagulase of Staphylococcus aureus 8325-4. Sequence analysis and virulence of site-specific coagulase-deficient mutants
    P Phonimdaeng
    Department of Microbiology, Moyne Institute, Trinity College, Dublin, Ireland
    Mol Microbiol 4:393-404. 1990
    ..This contradicts findings of several groups using Coa- mutants generated by chemical mutagenesis and suggests that the earlier results were obtained with strains that had suffered additional mutations in virulence-related genes...
  34. doi Staphylococcus pseudintermedius expresses surface proteins that closely resemble those from Staphylococcus aureus
    Joan A Geoghegan
    Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin, Ireland
    Vet Microbiol 138:345-52. 2009
    ..aureus. It is proposed that this is an Sdr protein with B-repeats that has an A domain that binds to fibrinogen. Whether it is the same protein that binds cytokeratin 10 is not clear...
  35. ncbi The Staphylococcus aureus surface protein SasG and its homologues promote bacterial adherence to human desquamated nasal epithelial cells
    Fiona M Roche
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Microbiology 149:2759-67. 2003
    ..These results suggest that SasG, Pls and AAP bind to the same as-yet-unidentified receptor on the surface of nasal epithelial cells. In addition, expression of SasG, like Pls, reduced adherence of S. aureus to fibronectin and fibrinogen...
  36. ncbi Molecular basis for Staphylococcus aureus-mediated platelet aggregate formation under arterial shear in vitro
    Steven W Kerrigan
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
    Arterioscler Thromb Vasc Biol 28:335-40. 2008
    ..Previously, we showed that S. aureus clumping factor A (ClfA) and fibronectin-binding protein A (FnBPA) can stimulate rapid platelet aggregation...
  37. ncbi Characterization of novel LPXTG-containing proteins of Staphylococcus aureus identified from genome sequences
    Fiona M Roche
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Microbiology 149:643-54. 2003
    ..Several IgG samples purified from patients recovering from S. aureus infections had higher titres against Sas proteins than control IgG, suggesting that expression occurred during infection in some patients...
  38. ncbi Multiple mechanisms for the activation of human platelet aggregation by Staphylococcus aureus: roles for the clumping factors ClfA and ClfB, the serine-aspartate repeat protein SdrE and protein A
    Louise O'Brien
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Mol Microbiol 44:1033-44. 2002
    ..aureus. Thus, S. aureus has multiple mechanisms for stimulating platelet aggregation. Such functional redundancy suggests that this phenomenon may be important in the pathogenesis of invasive diseases such as infective endocarditis...
  39. ncbi Clumping factor A of Staphylococcus aureus inhibits phagocytosis by human polymorphonuclear leucocytes
    Judy Higgins
    Moyne Institute of Preventive Medicine, Trinity College Dublin, Dublin 2, Ireland
    FEMS Microbiol Lett 258:290-6. 2006
    ..ClfA inhibited phagocytosis in the absence of fibrinogen, and showed enhanced inhibition in the presence of fibrinogen...
  40. ncbi Clumping factor B, a fibrinogen-binding MSCRAMM (microbial surface components recognizing adhesive matrix molecules) adhesin of Staphylococcus aureus, also binds to the tail region of type I cytokeratin 10
    Evelyn J Walsh
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 279:50691-9. 2004
    ..We provide an explanation for the molecular basis for S. aureus adherence to the squamous epithelium and suggest that nasal colonization might be prevented by reagents that inhibit this interaction...
  41. ncbi Characterization of the fibrinogen-binding surface protein Fbl of Staphylococcus lugdunensis
    Jennifer Mitchell
    Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Microbiology 150:3831-41. 2004
    ..Nevertheless Fbl had a tenfold lower affinity for fibrinogen, suggesting that sequence differences that occur elsewhere in the protein, possibly in beta-strand E of domain N2, affect ligand binding...
  42. pmc Role of surface protein SasG in biofilm formation by Staphylococcus aureus
    Joan A Geoghegan
    Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    J Bacteriol 192:5663-73. 2010
    ..Extensively purified recombinant B domain protein is very labile, and we propose that cleavage occurs spontaneously at labile peptide bonds and that this is necessary for biofilm formation...
  43. ncbi The elastin-binding protein of Staphylococcus aureus (EbpS) is expressed at the cell surface as an integral membrane protein and not as a cell wall-associated protein
    Robert Downer
    Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    J Biol Chem 277:243-50. 2002
    ..Finally, expression of EbpS was correlated with the ability of cells to grow to a higher density in liquid culture, suggesting that EbpS may have a role in regulating cell growth...
  44. pmc Both complement- and fibrinogen-dependent mechanisms contribute to platelet aggregation mediated by Staphylococcus aureus clumping factor B
    Helen Miajlovic
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Infect Immun 75:3335-43. 2007
    ..However, bacteria expressing ClfB Q235A caused platelet aggregation in a complement-dependent manner which required specific anti-ClfB antibodies...
  45. ncbi The N-terminal A domain of Staphylococcus aureus fibronectin-binding protein A binds to tropoelastin
    Fiona M Keane
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Biochemistry 46:7226-32. 2007
    ..The data indicate novel interactions between tropoelastin and FnBPA that include the use of surface charges. These results demonstrate that FnBPA is capable of directly binding tropoelastin prior to its incorporation into elastin...
  46. ncbi Analysis of mutations in the Staphylococcus aureus clfB promoter leading to increased expression
    Fionnuala M McAleese
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Microbiology 149:99-109. 2003
    ..Therefore, mutations in the clfB promoter that cause changes in the -35 region produce a stronger promoter that is capable of increased transcription and, as a result, increased expression of ClfB...
  47. doi Direct interaction of iron-regulated surface determinant IsdB of Staphylococcus aureus with the GPIIb/IIIa receptor on platelets
    Helen Miajlovic
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College Dublin, Dublin 2, Ireland
    Microbiology 156:920-8. 2010
    ..Antibodies to the platelet integrin GPIIb/IIIa inhibited platelet adhesion by IsdB-expressing strains, as did antagonists of GPIIb/IIIa. Surface plasmon resonance demonstrated that recombinant IsdB interacts directly with GPIIb/IIIa...
  48. ncbi Roles for fibrinogen, immunoglobulin and complement in platelet activation promoted by Staphylococcus aureus clumping factor A
    Anthony Loughman
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Mol Microbiol 57:804-18. 2005
    ..The fibrinogen-independent pathway required IgG and complement deposition to trigger platelet aggregation...
  49. pmc The Sbi protein is a multifunctional immune evasion factor of Staphylococcus aureus
    Emma Jane Smith
    Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Infect Immun 79:3801-9. 2011
    ..Both the secreted and envelope-associated forms of Sbi contributed to immune evasion. The IgG-binding domains contributed only when Sbi was attached to the cell, while only the secreted C3-binding domains were biologically active...
  50. doi An improved tetracycline-inducible expression vector for Staphylococcus aureus
    Rebecca M Corrigan
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Plasmid 61:126-9. 2009
    ..This variant of pALC2073 thus offers almost complete repression when uninduced and high levels of expression when induced...
  51. ncbi Staphylococcus aureus protein A binding to von Willebrand factor A1 domain is mediated by conserved IgG binding regions
    Maghnus O'Seaghdha
    Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    FEBS J 273:4831-41. 2006
    ..This indicated that both vWF regions recognized a region on helices I and II that overlapped the IgG Fc binding site...
  52. ncbi Corneal pathogenesis of Staphylococcus aureus strain Newman
    Joseph J Dajcs
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University LSU Health Sciences Center, New Orleans, Louisiana 70112 1393, USA
    Invest Ophthalmol Vis Sci 43:1109-15. 2002
    ..To determine the pathogenic role of gamma- and alpha-toxin in a rabbit model of Staphylococcus aureus keratitis...
  53. pmc Functional blocking of Staphylococcus aureus adhesins following growth in ex vivo media
    Ruth C Massey
    Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    Infect Immun 70:5339-45. 2002
    ..These findings have important implications for future studies of S. aureus adhesins...
  54. pmc Expression of the biofilm-associated protein interferes with host protein receptors of Staphylococcus aureus and alters the infective process
    Carme Cucarella
    Unit of Biochemistry, Department of Basic Biomedical Science, Cardenal Herrera C E U University, 46113 Moncada, Valencia, Spain
    Infect Immun 70:3180-6. 2002
    ..Taken together, these results strongly suggest that the expression of the Bap protein interferes with functional properties of the MSCRAMM proteins, preventing initial bacterial attachment to host tissues and cellular internalization...
  55. pmc Fibrinogen binding sites P336 and Y338 of clumping factor A are crucial for Staphylococcus aureus virulence
    Elisabet Josefsson
    Department of Rheumatology and Inflammation Research, University of Gothenburg, Goteborg, Sweden
    PLoS ONE 3:e2206. 2008
    ..aureus to provoke disease manifestations, and that the vaccine potential of recombinant ClfA is improved by removing its ability to bind fibrinogen...
  56. ncbi Activation of syndecan-1 ectodomain shedding by Staphylococcus aureus alpha-toxin and beta-toxin
    Pyong Woo Park
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    J Biol Chem 279:251-8. 2004
    ..Because shedding of these ectodomains has been implicated in promoting bacterial pathogenesis, activation of ectodomain shedding by alpha-toxin and beta-toxin may be a previously unknown virulence mechanism of S. aureus...
  57. ncbi The role of Staphylococcus aureus adhesins in the pathogenesis of ventricular assist device-related infections
    Carlos Arrecubieta
    Division of Infectious Diseases, Department of Medicine, Columbia University, New York, New York 10032, USA
    J Infect Dis 193:1109-19. 2006
    ..Finally, we demonstrate that ClfA, FnBPA, and FnBPB mediate bacterial infection of implanted murine intra-aortic polyurethane patches...
  58. ncbi SdrF, a Staphylococcus epidermidis surface protein, binds type I collagen
    Carlos Arrecubieta
    Division of Infectious Diseases, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 282:18767-76. 2007
    ..Antibodies directed against the B domain significantly reduce in vitro adherence of S. epidermidis to immobilized collagen...
  59. ncbi Phase-variable expression of the biofilm-associated protein (Bap) in Staphylococcus aureus
    M Angeles Tormo
    Centro de Investigación y Tecnología Animal, Instituto Valenciano de Investigaciones Agrarias CITA IVIA, Apdo 187, 12 400 Segorbe, Castellon, Spain
    Microbiology 153:1702-10. 2007
    ..The absence of Bap correlated with increased adherence to fibrinogen and fibronectin. It is possible that S. aureus can detach from a biofilm by switching to a Bap-negative state...
  60. ncbi Nasal colonization by Staphylococcus aureus
    Timothy J Foster
    Nat Med 10:447; author reply 447. 2004
  61. ncbi Staphylococcus aureus protein A activates TNFR1 signaling through conserved IgG binding domains
    Marisa I Gomez
    Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 281:20190-6. 2006
    ....
  62. ncbi The interaction of bacterial pathogens with platelets
    J Ross Fitzgerald
    Centre for Infectious Diseases, The Chancellor s Building, New Royal Infirmary, University of Edinburgh, Edinburgh EH16 4SB, Scotland, UK
    Nat Rev Microbiol 4:445-57. 2006
    ..Here, we review the nature of the interactions between platelets and bacteria, and the role of these interactions in the pathogenesis of endocarditis and other cardiovascular diseases...
  63. ncbi FbsA, a fibrinogen-binding protein from Streptococcus agalactiae, mediates platelet aggregation
    Giampiero Pietrocola
    University of Pavia, Department of Biochemistry, Viale Taramelli 3 B 27100 Pavia, Italy
    Blood 105:1052-9. 2005
    ..These findings indicate that FbsA is a crucial factor in S agalactiae-induced platelet aggregation and may therefore play an important role in S agalactiae-induced endocarditis...
  64. pmc Localized tufts of fibrils on Staphylococcus epidermidis NCTC 11047 are comprised of the accumulation-associated protein
    Miriam A Banner
    Faculty of Life Sciences, 1 800 Stopford Building, The University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom
    J Bacteriol 189:2793-804. 2007
    ..We therefore propose that full-length Aap is expressed on cells of S. epidermidis NCTC 11047 as tufts of short fibrils and that fibril expression is regulated at a posttranscriptional level...
  65. ncbi Staphylococcus aureus clumping factor A binds to complement regulator factor I and increases factor I cleavage of C3b
    Pamela S Hair
    Department of Pediatrics, George L Wright, Jr, Center for Biomedical Proteomics, Eastern Virginia Medical School, Norfolk, Virginia, USA
    J Infect Dis 198:125-33. 2008
    ..rClfA and the shed ClfA fragment increased factor I cleavage of C3b into inactive C3b. Our findings describe a new S. aureus mechanism for modification of host complement activities...
  66. ncbi Capsular polysaccharide masks clumping factor A-mediated adherence of Staphylococcus aureus to fibrinogen and platelets
    Allison L Risley
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Infect Dis 196:919-27. 2007
    ..Our goals were to determine whether expression of capsular polysaccharide (CP) affected ClfA-mediated adherence of S. aureus and to assess whether the length of the ClfA repeat region influenced this interaction...
  67. ncbi Sip, an integrase protein with excision, circularization and integration activities, defines a new family of mobile Staphylococcus aureus pathogenicity islands
    Carles Ubeda
    Department of Chemistry, Biochemistry and Molecular Biology, Cardenal Herrera CEU University, Edificio Seminario, 46113 Moncada, Valencia, Spain
    Mol Microbiol 49:193-210. 2003
    ..aureus in an intramammary gland infection model. Finally, different bovine isolates of S. aureus were found to carry islands related to SaPIbov2, suggesting the existence of a family of related pathogenicity islands...
  68. pmc A novel Staphylococcus aureus biofilm phenotype mediated by the fibronectin-binding proteins, FnBPA and FnBPB
    Eoghan O'Neill
    School of Biomolecular and Biomedical Science, University College Dublin, Ardmore House, Belfield, Dublin 4, Ireland
    J Bacteriol 190:3835-50. 2008
    ..These data identify a novel S. aureus biofilm phenotype promoted by FnBPA and FnBPB which is apparently independent of the known ligand-binding activities of these multifunctional surface proteins...
  69. pmc Interaction of human complement with Sbi, a staphylococcal immunoglobulin-binding protein: indications of a novel mechanism of complement evasion by Staphylococcus aureus
    Julia D Burman
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
    J Biol Chem 283:17579-93. 2008
    ..As such, our data suggest that Sbi helps mediate bacterial evasion of complement via a novel mechanism, namely futile fluid-phase consumption...
  70. ncbi Growth phase-dependent production of a cell wall-associated elastinolytic cysteine proteinase by Staphylococcus epidermidis
    Aneta Oleksy
    Department of Microbiology, Faculty of Biotechnology, Jagiellonian University, 30 387 Krakow, Poland
    Biol Chem 385:525-35. 2004
    ..This enzyme, with elastinolytic properties, as well as the ability to cleave alpha1PI, fibrinogen and fibronectin, may possibly contribute to the invasiveness and pathogenic potential of S. epidermidis...