Richard J Flavin

Summary

Affiliation: Trinity College
Country: Ireland

Publications

  1. pmc Effect of ret/PTC 1 rearrangement on transcription and post-transcriptional regulation in a papillary thyroid carcinoma model
    Susanne Cahill
    Dept of Histopathology, University of Dublin, Trinity College, Dublin, Ireland
    Mol Cancer 5:70. 2006
  2. pmc Effect of BRAFV600E mutation on transcription and post-transcriptional regulation in a papillary thyroid carcinoma model
    Susanne Cahill
    Dept of Histopathology, University of Dublin, Trinity College, Dublin, Ireland
    Mol Cancer 6:21. 2007
  3. pmc ret/PTC-1 expression alters the immunoprofile of thyroid follicular cells
    Karen Denning
    Department of Histopathology, University of Dublin, Trinity College, Dublin, Ireland
    Mol Cancer 7:44. 2008
  4. pmc An integrative model for recurrence in ovarian cancer
    Alexandros Laios
    Department of Obstetrics and Gynaecology, Trinity College Dublin, Trinity Centre for Health Sciences, St, James s Hospital, Dublin 8, Ireland
    Mol Cancer 7:8. 2008
  5. pmc Potential role of miR-9 and miR-223 in recurrent ovarian cancer
    Alexandros Laios
    Department of Obstetrics and Gynaecology, Trinity College Dublin, Trinity Centre for Health Sciences, St, James s Hospital, Dublin 8, Ireland
    Mol Cancer 7:35. 2008
  6. pmc Comparison of miRNA expression patterns using total RNA extracted from matched samples of formalin-fixed paraffin-embedded (FFPE) cells and snap frozen cells
    Jinghuan Li
    Department of Histopathology, University of Dublin, Trinity College, Dublin, Ireland
    BMC Biotechnol 7:36. 2007
  7. pmc Improved RNA quality and TaqMan Pre-amplification method (PreAmp) to enhance expression analysis from formalin fixed paraffin embedded (FFPE) materials
    Jinghuan Li
    Deptment of Histopathology, University of Dublin, Trinity College, Dublin, Ireland
    BMC Biotechnol 8:10. 2008
  8. doi Altered eIF6 and Dicer expression is associated with clinicopathological features in ovarian serous carcinoma patients
    Richard J Flavin
    Department of Histopathology, Trinity College Dublin, Dublin, Ireland
    Mod Pathol 21:676-84. 2008
  9. doi miR-29b expression is associated with disease-free survival in patients with ovarian serous carcinoma
    Richard Flavin
    Department of Histopathology, Trinity College, Dublin, Ireland
    Int J Gynecol Cancer 19:641-7. 2009
  10. doi Potentially important microRNA cluster on chromosome 17p13.1 in primary peritoneal carcinoma
    Richard J Flavin
    Department of Histopathology, Trinity College Dublin, Dublin, Ireland
    Mod Pathol 22:197-205. 2009

Collaborators

Detail Information

Publications15

  1. pmc Effect of ret/PTC 1 rearrangement on transcription and post-transcriptional regulation in a papillary thyroid carcinoma model
    Susanne Cahill
    Dept of Histopathology, University of Dublin, Trinity College, Dublin, Ireland
    Mol Cancer 5:70. 2006
    ..ret/PTC 1 is an oncogene with constitutive kinase activity implicated in the development of papillary thyroid carcinoma (PTC). This rearrangement leads to aberrant MAPK activation that is implicated in PTC tumourigenesis...
  2. pmc Effect of BRAFV600E mutation on transcription and post-transcriptional regulation in a papillary thyroid carcinoma model
    Susanne Cahill
    Dept of Histopathology, University of Dublin, Trinity College, Dublin, Ireland
    Mol Cancer 6:21. 2007
    ..This mutation leads to aberrant MAPK activation that is implicated in tumourigenesis...
  3. pmc ret/PTC-1 expression alters the immunoprofile of thyroid follicular cells
    Karen Denning
    Department of Histopathology, University of Dublin, Trinity College, Dublin, Ireland
    Mol Cancer 7:44. 2008
    ..The purpose of this study was to observe the immunogenic effect exposure to H.T. and control lymphocyte supernatant would have on normal (Nthy-ori) and ret/PTC-1 (TPC-1) expressing thyroid cell line models...
  4. pmc An integrative model for recurrence in ovarian cancer
    Alexandros Laios
    Department of Obstetrics and Gynaecology, Trinity College Dublin, Trinity Centre for Health Sciences, St, James s Hospital, Dublin 8, Ireland
    Mol Cancer 7:8. 2008
  5. pmc Potential role of miR-9 and miR-223 in recurrent ovarian cancer
    Alexandros Laios
    Department of Obstetrics and Gynaecology, Trinity College Dublin, Trinity Centre for Health Sciences, St, James s Hospital, Dublin 8, Ireland
    Mol Cancer 7:35. 2008
    ..MicroRNAs (miRNAs) are small, noncoding RNAs that negatively regulate gene expression by binding to target mRNAs. miRNAs have not been comprehensively studied in recurrent ovarian cancer, yet an incurable disease...
  6. pmc Comparison of miRNA expression patterns using total RNA extracted from matched samples of formalin-fixed paraffin-embedded (FFPE) cells and snap frozen cells
    Jinghuan Li
    Department of Histopathology, University of Dublin, Trinity College, Dublin, Ireland
    BMC Biotechnol 7:36. 2007
    ..This study analyzed 160 miRNAs in paired snap frozen and FFPE cells to investigate if miRNAs may be successfully detected in archival specimens...
  7. pmc Improved RNA quality and TaqMan Pre-amplification method (PreAmp) to enhance expression analysis from formalin fixed paraffin embedded (FFPE) materials
    Jinghuan Li
    Deptment of Histopathology, University of Dublin, Trinity College, Dublin, Ireland
    BMC Biotechnol 8:10. 2008
    ..Further, it evaluated a novel pre-amplification system (PreAmp) designed to enhance expression analysis from tissue samples using assays with a range of amplicon size (62-164 bp)...
  8. doi Altered eIF6 and Dicer expression is associated with clinicopathological features in ovarian serous carcinoma patients
    Richard J Flavin
    Department of Histopathology, Trinity College Dublin, Dublin, Ireland
    Mod Pathol 21:676-84. 2008
    ..The status of eIF6 and proteins of the microRNA machinery may help predict toxicity and susceptibility to future interfering RNA-based therapy...
  9. doi miR-29b expression is associated with disease-free survival in patients with ovarian serous carcinoma
    Richard Flavin
    Department of Histopathology, Trinity College, Dublin, Ireland
    Int J Gynecol Cancer 19:641-7. 2009
    ....
  10. doi Potentially important microRNA cluster on chromosome 17p13.1 in primary peritoneal carcinoma
    Richard J Flavin
    Department of Histopathology, Trinity College Dublin, Dublin, Ireland
    Mod Pathol 22:197-205. 2009
    ..1 in primary peritoneal carcinoma relative to ovarian serous carcinoma. miR-195 and miR-497 may have potential roles as tumour-suppressor genes in primary peritoneal tumourigenesis...
  11. doi RET/PTC rearrangement occurring in primary peritoneal carcinoma
    Richard Flavin
    Department of Histopathology, Trinity College Medical School, Dublin, Ireland
    Int J Surg Pathol 17:187-97. 2009
    ..These rearrangements may not be directly implicated in tumor growth; rather representing "passenger" mutations reflecting RET instability in secondary tumor subclones...
  12. pmc Geographical mapping of a multifocal thyroid tumour using genetic alteration analysis & miRNA profiling
    Sinead T Aherne
    Department of Histopathology, Trinity College, Dublin, Ireland
    Mol Cancer 7:89. 2008
    ....
  13. ncbi A molecular expression signature distinguishing follicular lesions in thyroid carcinoma using preamplification RT-PCR in archival samples
    Karen M Denning
    Department of Histopathology, Trinity College, University of Dublin, Dublin, Ireland
    Mod Pathol 20:1095-102. 2007
    ..It may have utility for broader use in the setting of fine-needle aspiration cytology and could improve the definitive diagnosis of certain categories of thyroid malignancy...
  14. pmc Suppression of cancer stemness p21-regulating mRNA and microRNA signatures in recurrent ovarian cancer patient samples
    Michael F Gallagher
    Department of Histopathology, University of Dublin, Trinity College, Trinity Centre for Health Sciences, St James Hospital, Dublin 8, Ireland
    J Ovarian Res 5:2. 2012
    ..abstract:..
  15. pmc Regulation of microRNA biosynthesis and expression in 2102Ep embryonal carcinoma stem cells is mirrored in ovarian serous adenocarcinoma patients
    Michael F Gallagher
    Department of Histopathology, University of Dublin, Trinity College, Institute of Molecular Medicine, St James s Hospital, Dublin 8, Ireland
    J Ovarian Res 2:19. 2009
    ....