Padraic G Fallon
Affiliation: Trinity College
Saunders S, Moran T, Floudas A, Wurlod F, Kaszlikowska A, Salimi M, et al
. Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity. J Allergy Clin Immunol. 2016;137:482-91 pubmed publisher
..This study provides new insights into our understanding of the atopic march, with innate immunity initiating dermatitis and the adaptive immunity required for subsequent development of compromised lung function. ..
Hams E, Bermingham R, Wurlod F, Hogan A, O Shea D, Preston R, et al
. The helminth T2 RNase Ï‰1 promotes metabolic homeostasis in an IL-33- and group 2 innate lymphoid cell-dependent mechanism. FASEB J. 2016;30:824-35 pubmed publisher
..We demonstrate a novel mechanism for RNase-mediated release of IL-33 inducing ILC2-dependent improvements in the metabolic status of obese animals. ..
Barr M, Gray S, Gately K, Hams E, Fallon P, Davies A, et al
. Vascular endothelial growth factor is an autocrine growth factor, signaling through neuropilin-1 in non-small cell lung cancer. Mol Cancer. 2015;14:45 pubmed publisher
Walsh P, Fallon P. The emergence of the IL-36 cytokine family as novel targets for inflammatory diseases. Ann N Y Acad Sci. 2016;: pubmed publisher
..Given these emerging roles, strategies to specifically target the expression and activity of the IL-36 family have the potential to uncover novel therapeutic approaches aimed at treating inflammatory diseases in humans. ..
Schwartz C, Hams E, Fallon P. Helminth Modulation of Lung Inflammation. Trends Parasitol. 2018;34:388-403 pubmed publisher
..In this review, we focus on the impact of helminth infections on pulmonary immunity, especially with regard to homeostatic lung function, pulmonary viral and bacterial (co)infections, and asthma. ..
Floudas A, Saunders S, Moran T, Schwartz C, Hams E, Fitzgerald D, et al
. IL-17 Receptor A Maintains and Protects the Skin Barrier To Prevent Allergic Skin Inflammation. J Immunol. 2017;199:707-717 pubmed publisher
..This study describes a previously unappreciated protective role for IL-17RA signaling in regulation of the skin barrier and maintenance of skin immune homeostasis. ..
Floudas A, Amu S, Fallon P. New Insights into IL-10 Dependent and IL-10 Independent Mechanisms of Regulatory B Cell Immune Suppression. J Clin Immunol. 2016;36 Suppl 1:25-33 pubmed publisher
..Here we provide an overview of the complexity of Breg cell populations and address the newly discovered IL-10 independent mechanisms of Breg cell expansion and immune-suppression. ..
Schwartz C, Khan A, Floudas A, Saunders S, Hams E, Rodewald H, et al
. ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control. J Exp Med. 2017;214:2507-2521 pubmed publisher