Sarah L Doyle

Summary

Affiliation: Trinity College
Country: Ireland

Publications

  1. ncbi request reprint Toll-like receptors: from the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity
    Sarah L Doyle
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Biochem Pharmacol 72:1102-13. 2006
  2. ncbi request reprint Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase
    Sarah L Doyle
    School of Biochemistry and Immunology, Department of Immunology, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 282:36953-60. 2007
  3. pmc Bruton's tyrosine kinase mediates the synergistic signalling between TLR9 and the B cell receptor by regulating calcium and calmodulin
    Elaine F Kenny
    Immunology Research Centre, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland
    PLoS ONE 8:e74103. 2013
  4. pmc Nuclear factor κB2 p52 protein has a role in antiviral immunity through IκB kinase epsilon-dependent induction of Sp1 protein and interleukin 15
    Sarah L Doyle
    Immunology Research Centre, Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 288:25066-75. 2013
  5. ncbi request reprint Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NFkappaB activation by lipopolysaccharide
    Sarah L Doyle
    Department of Biochemistry and Biotechnology Institute, Trinity College, Dublin 2, Ireland
    J Biol Chem 280:23496-501. 2005
  6. doi request reprint The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation
    Sarah L Doyle
    Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Pearse Street, Dublin 2, Ireland
    Nat Commun 3:707. 2012
  7. pmc IL-10 inhibits miR-155 induction by toll-like receptors
    Claire E McCoy
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 285:20492-8. 2010
  8. pmc Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer
    Luke A J O'Neill
    School of Biochemistry and Immunology, Trinity College Dublin, Ireland
    Pharmacol Rev 61:177-97. 2009
  9. ncbi request reprint MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction
    Pearl Gray
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 281:10489-95. 2006
  10. ncbi request reprint Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation
    Ashley Mansell
    Centre for Functional Genomics and Human Disease, Monash Institute of Medical Research, Monash University, Melbourne, Victoria, Australia
    Nat Immunol 7:148-55. 2006

Detail Information

Publications10

  1. ncbi request reprint Toll-like receptors: from the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity
    Sarah L Doyle
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Biochem Pharmacol 72:1102-13. 2006
    ....
  2. ncbi request reprint Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase
    Sarah L Doyle
    School of Biochemistry and Immunology, Department of Immunology, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 282:36953-60. 2007
    ..Lack of functioning Btk in XLA patients downstream of TLR8 and TLR9 might explain the susceptibility of XLA patients to viral infections...
  3. pmc Bruton's tyrosine kinase mediates the synergistic signalling between TLR9 and the B cell receptor by regulating calcium and calmodulin
    Elaine F Kenny
    Immunology Research Centre, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland
    PLoS ONE 8:e74103. 2013
    ..Downstream of BTK we find that calcium acting via calmodulin is required for this process. These data provide new insights into the role of BTK, an important target for autoimmune diseases, in B cell activation. ..
  4. pmc Nuclear factor κB2 p52 protein has a role in antiviral immunity through IκB kinase epsilon-dependent induction of Sp1 protein and interleukin 15
    Sarah L Doyle
    Immunology Research Centre, Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 288:25066-75. 2013
    ..Our study identifies NFκB2 as a target for IKKε in antiviral immunity and describes, for the first time, a role for NFκB2 in the regulation of gene expression in response to viral infection. ..
  5. ncbi request reprint Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NFkappaB activation by lipopolysaccharide
    Sarah L Doyle
    Department of Biochemistry and Biotechnology Institute, Trinity College, Dublin 2, Ireland
    J Biol Chem 280:23496-501. 2005
    ..This study therefore reveals a novel function for Btk. It is required for the signaling pathway activated by TLR4, which culminates in phosphorylation of p65 on serine 536 promoting transactivation by NFkappaB...
  6. doi request reprint The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation
    Sarah L Doyle
    Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Pearse Street, Dublin 2, Ireland
    Nat Commun 3:707. 2012
    ..A TMED homologue, logjam, has a negative role in the Toll and IMD pathways in Drosophila melanogaster; therefore, TMEDs may have a conserved role in the regulation of innate immunity...
  7. pmc IL-10 inhibits miR-155 induction by toll-like receptors
    Claire E McCoy
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 285:20492-8. 2010
    ..This is the first example of IL-10 playing a role in microRNA function and suggests that through its inhibitory effect on miR-155, IL-10 has the ability to promote anti-inflammatory gene expression...
  8. pmc Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer
    Luke A J O'Neill
    School of Biochemistry and Immunology, Trinity College Dublin, Ireland
    Pharmacol Rev 61:177-97. 2009
    ..Here we review these recent advances and speculate about whether manipulating TLRs is likely to be successful in fighting off different diseases...
  9. ncbi request reprint MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction
    Pearl Gray
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 281:10489-95. 2006
    ..Our study therefore provides the first demonstration of the key role of Mal phosphorylation on tyrosine during signaling by TLR2 and TLR4 and identifies a novel function for Btk as the kinase involved...
  10. ncbi request reprint Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation
    Ashley Mansell
    Centre for Functional Genomics and Human Disease, Monash Institute of Medical Research, Monash University, Melbourne, Victoria, Australia
    Nat Immunol 7:148-55. 2006
    ..The transient activation of Mal and subsequent SOCS-1-mediated degradation is a rapid and selective means of limiting primary innate immune response...