Sarah L Doyle

Summary

Affiliation: Trinity College
Country: Ireland

Publications

  1. ncbi Toll-like receptors: from the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity
    Sarah L Doyle
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Biochem Pharmacol 72:1102-13. 2006
  2. ncbi Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase
    Sarah L Doyle
    School of Biochemistry and Immunology, Department of Immunology, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 282:36953-60. 2007
  3. ncbi Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NFkappaB activation by lipopolysaccharide
    Sarah L Doyle
    Department of Biochemistry and Biotechnology Institute, Trinity College, Dublin 2, Ireland
    J Biol Chem 280:23496-501. 2005
  4. ncbi The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation
    Sarah L Doyle
    Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Pearse Street, Dublin 2, Ireland
    Nat Commun 3:707. 2012
  5. ncbi Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer
    Luke A J O'Neill
    School of Biochemistry and Immunology, Trinity College Dublin, Ireland
    Pharmacol Rev 61:177-97. 2009
  6. ncbi IL-10 inhibits miR-155 induction by toll-like receptors
    Claire E McCoy
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 285:20492-8. 2010
  7. ncbi MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction
    Pearl Gray
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 281:10489-95. 2006
  8. ncbi Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation
    Ashley Mansell
    Centre for Functional Genomics and Human Disease, Monash Institute of Medical Research, Monash University, Melbourne, Victoria, Australia
    Nat Immunol 7:148-55. 2006

Collaborators

Detail Information

Publications8

  1. ncbi Toll-like receptors: from the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity
    Sarah L Doyle
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Biochem Pharmacol 72:1102-13. 2006
    ....
  2. ncbi Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase
    Sarah L Doyle
    School of Biochemistry and Immunology, Department of Immunology, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 282:36953-60. 2007
    ..Lack of functioning Btk in XLA patients downstream of TLR8 and TLR9 might explain the susceptibility of XLA patients to viral infections...
  3. ncbi Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NFkappaB activation by lipopolysaccharide
    Sarah L Doyle
    Department of Biochemistry and Biotechnology Institute, Trinity College, Dublin 2, Ireland
    J Biol Chem 280:23496-501. 2005
    ..This study therefore reveals a novel function for Btk. It is required for the signaling pathway activated by TLR4, which culminates in phosphorylation of p65 on serine 536 promoting transactivation by NFkappaB...
  4. ncbi The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation
    Sarah L Doyle
    Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Pearse Street, Dublin 2, Ireland
    Nat Commun 3:707. 2012
    ..A TMED homologue, logjam, has a negative role in the Toll and IMD pathways in Drosophila melanogaster; therefore, TMEDs may have a conserved role in the regulation of innate immunity...
  5. ncbi Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer
    Luke A J O'Neill
    School of Biochemistry and Immunology, Trinity College Dublin, Ireland
    Pharmacol Rev 61:177-97. 2009
    ..Here we review these recent advances and speculate about whether manipulating TLRs is likely to be successful in fighting off different diseases...
  6. ncbi IL-10 inhibits miR-155 induction by toll-like receptors
    Claire E McCoy
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 285:20492-8. 2010
    ..This is the first example of IL-10 playing a role in microRNA function and suggests that through its inhibitory effect on miR-155, IL-10 has the ability to promote anti-inflammatory gene expression...
  7. ncbi MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction
    Pearl Gray
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 281:10489-95. 2006
    ..Our study therefore provides the first demonstration of the key role of Mal phosphorylation on tyrosine during signaling by TLR2 and TLR4 and identifies a novel function for Btk as the kinase involved...
  8. ncbi Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation
    Ashley Mansell
    Centre for Functional Genomics and Human Disease, Monash Institute of Medical Research, Monash University, Melbourne, Victoria, Australia
    Nat Immunol 7:148-55. 2006
    ..The transient activation of Mal and subsequent SOCS-1-mediated degradation is a rapid and selective means of limiting primary innate immune response...