Sarah L Doyle

Summary

Affiliation: Trinity College
Country: Ireland

Publications

  1. request reprint
    Doyle S, Jefferies C, Feighery C, O Neill L. Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase. J Biol Chem. 2007;282:36953-60 pubmed
    ..Lack of functioning Btk in XLA patients downstream of TLR8 and TLR9 might explain the susceptibility of XLA patients to viral infections. ..
  2. Husebye H, Doyle S. Using Confocal Microscopy to Investigate Intracellular Trafficking of Toll-Like Receptors. Methods Mol Biol. 2016;1390:65-77 pubmed publisher
    ..This chapter details the common methods for determining the subcellular location of TLRs in both live and fixed cells. ..
  3. Doyle S, Shirey K, McGettrick A, Kenny E, Carpenter S, Caffrey B, et al. Nuclear factor ?B2 p52 protein has a role in antiviral immunity through I?B kinase epsilon-dependent induction of Sp1 protein and interleukin 15. J Biol Chem. 2013;288:25066-75 pubmed publisher
    ..Our study identifies NF?B2 as a target for IKK? in antiviral immunity and describes, for the first time, a role for NF?B2 in the regulation of gene expression in response to viral infection. ..

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Detail Information

Publications3

  1. request reprint
    Doyle S, Jefferies C, Feighery C, O Neill L. Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase. J Biol Chem. 2007;282:36953-60 pubmed
    ..Lack of functioning Btk in XLA patients downstream of TLR8 and TLR9 might explain the susceptibility of XLA patients to viral infections. ..
  2. Husebye H, Doyle S. Using Confocal Microscopy to Investigate Intracellular Trafficking of Toll-Like Receptors. Methods Mol Biol. 2016;1390:65-77 pubmed publisher
    ..This chapter details the common methods for determining the subcellular location of TLRs in both live and fixed cells. ..
  3. Doyle S, Shirey K, McGettrick A, Kenny E, Carpenter S, Caffrey B, et al. Nuclear factor ?B2 p52 protein has a role in antiviral immunity through I?B kinase epsilon-dependent induction of Sp1 protein and interleukin 15. J Biol Chem. 2013;288:25066-75 pubmed publisher
    ..Our study identifies NF?B2 as a target for IKK? in antiviral immunity and describes, for the first time, a role for NF?B2 in the regulation of gene expression in response to viral infection. ..