- Doyle S, Jefferies C, Feighery C, O Neill L. Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase. J Biol Chem. 2007;282:36953-60 pubmed..Lack of functioning Btk in XLA patients downstream of TLR8 and TLR9 might explain the susceptibility of XLA patients to viral infections. ..
- Husebye H, Doyle S. Using Confocal Microscopy to Investigate Intracellular Trafficking of Toll-Like Receptors. Methods Mol Biol. 2016;1390:65-77 pubmed publisher..This chapter details the common methods for determining the subcellular location of TLRs in both live and fixed cells. ..
- Doyle S, Shirey K, McGettrick A, Kenny E, Carpenter S, Caffrey B, et al. Nuclear factor ?B2 p52 protein has a role in antiviral immunity through I?B kinase epsilon-dependent induction of Sp1 protein and interleukin 15. J Biol Chem. 2013;288:25066-75 pubmed publisher..Our study identifies NF?B2 as a target for IKK? in antiviral immunity and describes, for the first time, a role for NF?B2 in the regulation of gene expression in response to viral infection. ..