Tim Downing

Summary

Affiliation: Trinity College
Country: Ireland

Publications

  1. pmc Evidence of balanced diversity at the chicken interleukin 4 receptor alpha chain locus
    Tim Downing
    Smurfit Institute of Genetics, Trinity College, University of Dublin, Dublin, Ireland
    BMC Evol Biol 9:136. 2009
  2. doi request reprint Contrasting evolution of diversity at two disease-associated chicken genes
    Tim Downing
    Smurfit Institute of Genetics, Trinity College, University of Dublin, Dublin, Ireland
    Immunogenetics 61:303-14. 2009
  3. ncbi request reprint The differential evolutionary dynamics of avian cytokine and TLR gene classes
    Tim Downing
    Smurfit Institute of Genetics, Dublin, Ireland
    J Immunol 184:6993-7000. 2010
  4. pmc Genome-wide association analysis of avian resistance to Campylobacter jejuni colonization identifies risk locus spanning the CDH13 gene
    Sarah Connell
    Smurfit Institute of Genetics, University of Dublin, Trinity College, Dublin, Ireland
    G3 (Bethesda) 3:881-90. 2013
  5. pmc Evidence of the adaptive evolution of immune genes in chicken
    Tim Downing
    Smurfit Institute of Genetics, Trinity College, University of Dublin, Ireland
    BMC Res Notes 2:254. 2009
  6. doi request reprint The avian Toll-Like receptor pathway--subtle differences amidst general conformity
    Paul Cormican
    School of Biochemistry and Immunology, Trinity College, University of Dublin, Dublin 2, Ireland
    Dev Comp Immunol 33:967-73. 2009

Detail Information

Publications6

  1. pmc Evidence of balanced diversity at the chicken interleukin 4 receptor alpha chain locus
    Tim Downing
    Smurfit Institute of Genetics, Trinity College, University of Dublin, Dublin, Ireland
    BMC Evol Biol 9:136. 2009
    ..Signatures of selection detected by inter-species comparison may then be investigated at the population level in global chicken populations to highlight potentially relevant functional polymorphisms...
  2. doi request reprint Contrasting evolution of diversity at two disease-associated chicken genes
    Tim Downing
    Smurfit Institute of Genetics, Trinity College, University of Dublin, Dublin, Ireland
    Immunogenetics 61:303-14. 2009
    ....
  3. ncbi request reprint The differential evolutionary dynamics of avian cytokine and TLR gene classes
    Tim Downing
    Smurfit Institute of Genetics, Dublin, Ireland
    J Immunol 184:6993-7000. 2010
    ..Analyses also indicated that a general pattern of high variability has been enhanced by widespread genetic exchange between chicken and red JF, and possibly between chicken and gray JF at TLR1LA and TLR2A...
  4. pmc Genome-wide association analysis of avian resistance to Campylobacter jejuni colonization identifies risk locus spanning the CDH13 gene
    Sarah Connell
    Smurfit Institute of Genetics, University of Dublin, Trinity College, Dublin, Ireland
    G3 (Bethesda) 3:881-90. 2013
    ....
  5. pmc Evidence of the adaptive evolution of immune genes in chicken
    Tim Downing
    Smurfit Institute of Genetics, Trinity College, University of Dublin, Ireland
    BMC Res Notes 2:254. 2009
    ..Pathogen challenges are likely to have driven the selective forces that have shaped variation at chicken immune genes, and continue to restrict diversity in this functional class...
  6. doi request reprint The avian Toll-Like receptor pathway--subtle differences amidst general conformity
    Paul Cormican
    School of Biochemistry and Immunology, Trinity College, University of Dublin, Dublin 2, Ireland
    Dev Comp Immunol 33:967-73. 2009
    ..These findings contribute to the characterization of the differing immune response systems that have evolved in individual vertebrate species in response to their microbiological environment...