Gary Donohoe

Summary

Affiliation: Trinity College
Country: Ireland

Publications

  1. doi request reprint Does the ability to sustain attention underlie symptom severity in schizophrenia?
    Cara O'Gráda
    Department of Psychiatry, University College Cork, Ireland
    Schizophr Res 107:319-23. 2009
  2. ncbi request reprint Neuropsychological effects of the CSMD1 genome-wide associated schizophrenia risk variant rs10503253
    G Donohoe
    Neuropsychiatric Genetics Group, Department of Psychiatry, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, Dublin, Ireland
    Genes Brain Behav 12:203-9. 2013
  3. doi request reprint Influence of NOS1 on verbal intelligence and working memory in both patients with schizophrenia and healthy control subjects
    Gary Donohoe
    Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity Health Sciences Bldg, St James s Hospital, Dublin 8, Ireland
    Arch Gen Psychiatry 66:1045-54. 2009
  4. pmc The psychosis susceptibility gene ZNF804A: associations, functions, and phenotypes
    Gary Donohoe
    Department of Psychiatry, Trinity College Dublin, Trinity Health Sciences Building, St James s Hospital, Dublin 8, Ireland
    Schizophr Bull 36:904-9. 2010
  5. doi request reprint ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia
    Gary Donohoe
    Neuropsychiatric Genetics Research Group, Trinity College Dublin, Dublin, Ireland
    Neuroimage 54:2132-7. 2011
  6. doi request reprint Neural effects of the CSMD1 genome-wide associated schizophrenia risk variant rs10503253
    Emma J Rose
    Neuropsychiatric Genetics Group and Department of Psychiatry, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, Dublin, Ireland
    Am J Med Genet B Neuropsychiatr Genet 162:530-7. 2013
  7. doi request reprint Are relational style and neuropsychological performance predictors of social attributions in chronic schizophrenia?
    Gary Donohoe
    Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, Dublin 2, Ireland
    Psychiatry Res 161:19-27. 2008
  8. ncbi request reprint Variance in neurocognitive performance is associated with dysbindin-1 in schizophrenia: a preliminary study
    Gary Donohoe
    Department of Psychology and Trinity Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
    Neuropsychologia 45:454-8. 2007
  9. pmc Reduced occipital and prefrontal brain volumes in dysbindin-associated schizophrenia
    Gary Donohoe
    Department of Psychiatry, Neuropsychiatric Genetics Research Group, Trinity College Dublin, Dublin, Ireland
    Neuropsychopharmacology 35:368-73. 2010
  10. ncbi request reprint Chitinase-3-like 1 (CHI3L1) gene and schizophrenia: genetic association and a potential functional mechanism
    Mao Sheng Yang
    Neuropsychiatric Genetics Research Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College Dublin, Ireland
    Biol Psychiatry 64:98-103. 2008

Detail Information

Publications44

  1. doi request reprint Does the ability to sustain attention underlie symptom severity in schizophrenia?
    Cara O'Gráda
    Department of Psychiatry, University College Cork, Ireland
    Schizophr Res 107:319-23. 2009
    ..These data suggest that this component of attention at least partly explains variance in negative symptoms...
  2. ncbi request reprint Neuropsychological effects of the CSMD1 genome-wide associated schizophrenia risk variant rs10503253
    G Donohoe
    Neuropsychiatric Genetics Group, Department of Psychiatry, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, Dublin, Ireland
    Genes Brain Behav 12:203-9. 2013
    ....
  3. doi request reprint Influence of NOS1 on verbal intelligence and working memory in both patients with schizophrenia and healthy control subjects
    Gary Donohoe
    Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity Health Sciences Bldg, St James s Hospital, Dublin 8, Ireland
    Arch Gen Psychiatry 66:1045-54. 2009
    ..Human and animal studies have implicated the gene NOS1 in both cognition and schizophrenia susceptibility...
  4. pmc The psychosis susceptibility gene ZNF804A: associations, functions, and phenotypes
    Gary Donohoe
    Department of Psychiatry, Trinity College Dublin, Trinity Health Sciences Building, St James s Hospital, Dublin 8, Ireland
    Schizophr Bull 36:904-9. 2010
    ..We conclude that ZNF804A is robustly, if modestly, associated with schizophrenia risk, with much work still remaining to elucidate its role in schizophrenia biology...
  5. doi request reprint ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia
    Gary Donohoe
    Neuropsychiatric Genetics Research Group, Trinity College Dublin, Dublin, Ireland
    Neuroimage 54:2132-7. 2011
    ..Establishing if this represents a discrete molecular pathogenesis with consequences for nosology and treatment will be an important next step in understanding ZNF084A's role in illness risk...
  6. doi request reprint Neural effects of the CSMD1 genome-wide associated schizophrenia risk variant rs10503253
    Emma J Rose
    Neuropsychiatric Genetics Group and Department of Psychiatry, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, Dublin, Ireland
    Am J Med Genet B Neuropsychiatr Genet 162:530-7. 2013
    ..e., executive function); with the relatively deleterious effects of the identified "A" risk allele on brain activity possibly constituting part of the mechanism by which CSMD1 increases schizophrenia risk...
  7. doi request reprint Are relational style and neuropsychological performance predictors of social attributions in chronic schizophrenia?
    Gary Donohoe
    Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, Dublin 2, Ireland
    Psychiatry Res 161:19-27. 2008
    ..This study highlights the importance of relationship style and neuropsychological performance for different aspects of attributional style in schizophrenia...
  8. ncbi request reprint Variance in neurocognitive performance is associated with dysbindin-1 in schizophrenia: a preliminary study
    Gary Donohoe
    Department of Psychology and Trinity Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
    Neuropsychologia 45:454-8. 2007
    ..Our study suggests that the increased risk for schizophrenia associated with dysbindin may be partly mediated by its influence on pre-frontal function...
  9. pmc Reduced occipital and prefrontal brain volumes in dysbindin-associated schizophrenia
    Gary Donohoe
    Department of Psychiatry, Neuropsychiatric Genetics Research Group, Trinity College Dublin, Dublin, Ireland
    Neuropsychopharmacology 35:368-73. 2010
    ..These data provide important evidence of the influence of dysbindin risk variants on brain structure, and suggest a possible mechanism by which disease risk is being increased...
  10. ncbi request reprint Chitinase-3-like 1 (CHI3L1) gene and schizophrenia: genetic association and a potential functional mechanism
    Mao Sheng Yang
    Neuropsychiatric Genetics Research Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College Dublin, Ireland
    Biol Psychiatry 64:98-103. 2008
    ..Gene expression data and association analyses in two Chinese samples implicate chitinase 3-like 1 (CHI3L1), a cellular survival gene, in schizophrenia susceptibility...
  11. ncbi request reprint A dysbindin risk haplotype associated with less severe manic-type symptoms in psychosis
    Aiden Corvin
    Neuropsychiatric Genetics Group, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, Dublin 8, Ireland
    Neurosci Lett 431:146-9. 2008
    ..004), with a trend for higher negative symptom scores. This suggests that risk variation at the dysbindin gene may contribute to a more prototypical SZ presentation with less severe excitement/manic symptoms and more negative symptoms...
  12. ncbi request reprint Dysbindin (DTNBP1) and the biogenesis of lysosome-related organelles complex 1 (BLOC-1): main and epistatic gene effects are potential contributors to schizophrenia susceptibility
    Derek W Morris
    Neuropsychiatric Genetics Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College, Dublin, Ireland
    Biol Psychiatry 63:24-31. 2008
    ....
  13. doi request reprint Is "clinical" insight the same as "cognitive" insight in schizophrenia?
    Gary Donohoe
    Department of Psychiatry, Trinity College Dublin, Dublin, Ireland
    J Int Neuropsychol Soc 15:471-5. 2009
    ..We conclude that while good cognitive insight may not be necessary for good clinical insight, good cognitive awareness is at least partly reliant on the processes involved in clinical insight...
  14. ncbi request reprint Are deficits in executive sub-processes simply reflecting more general cognitive decline in schizophrenia?
    Gary Donohoe
    Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College, Dublin, Ireland
    Schizophr Res 85:168-73. 2006
    ..Schizophrenia is associated with both global and specific cognitive deficits. We sought to investigate whether deficits in executive subcomponents differed in their relationship to global cognitive impairments...
  15. doi request reprint The effect of the neurogranin schizophrenia risk variant rs12807809 on brain structure and function
    Emma J Rose
    Department of Psychiatry, Trinity College Dublin, Ireland
    Twin Res Hum Genet 15:296-303. 2012
    ..Although it remains to be established whether this holds true in larger samples and in patient cohorts, if valid, this suggests a potential mechanism by which NRGN variability might contribute to schizophrenia risk...
  16. ncbi request reprint D-amino acid oxidase (DAO) genotype and mood symptomatology in schizophrenia
    Aiden Corvin
    Neuropsychiatric Genetics Group, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, James s Street, Dublin 8, Ireland
    Neurosci Lett 426:97-100. 2007
    ..02, d.f.=2, p=0.01). These data suggest a potential role for DAO in susceptibility to depressive symptoms in schizophrenia, but a more general role for DAO in affective disorders cannot be excluded...
  17. ncbi request reprint Neurocognition and suicidal behaviour in an Irish population with major psychotic disorders
    Jeanne Marie Nangle
    Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, Ireland
    Schizophr Res 85:196-200. 2006
    ..Our aim was to examine the relationship between neurocognitive variables and suicidal behaviour in patients with schizophrenia and schizoaffective disorder...
  18. doi request reprint Social cognition in bipolar disorder versus schizophrenia: comparability in mental state decoding deficits
    Gary Donohoe
    Neuropsychiatric Genetics Research Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland
    Bipolar Disord 14:743-8. 2012
    ....
  19. ncbi request reprint Early visual processing deficits in dysbindin-associated schizophrenia
    Gary Donohoe
    Neuropsychiatric Genetics Group, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, Dublin, Ireland
    Biol Psychiatry 63:484-9. 2008
    ..We investigated P1 performance, a component of early visual processing on which both patients and their relatives show deficits, in carriers and noncarriers of a known dysbindin risk haplotype...
  20. doi request reprint Social dysfunction in schizophrenia: an investigation of the GAF scale's sensitivity to deficits in social cognition
    Deirdre A Robertson
    Department of Psychiatry and Neuropsychiatric Genetics Research Group, School of Medicine and Trinity College Institute of Neuroscience, The Trinity Center, St James s Hospital, Dublin 8, Ireland
    Schizophr Res 146:363-5. 2013
    ..To investigate this, we assessed whether variation in GAF score was explained by performance on measures of neurocognitive and social cognition, particularly after variation associated with symptom severity had been accounted for...
  21. ncbi request reprint Do antisaccade deficits in schizophrenia provide evidence of a specific inhibitory function?
    Gary Donohoe
    Neuropsychiatric Genetics Research Group, Department of Psychiatry, and Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland
    J Int Neuropsychol Soc 12:901-6. 2006
    ..We investigated whether variance in antisaccade performance could be better accounted for in terms of a specific inhibitory function...
  22. doi request reprint A NOS1 variant implicated in cognitive performance influences evoked neural responses during a high density EEG study of early visual perception
    Therese O'Donoghue
    Neuropsychiatric Genetics Group and Department of Psychiatry, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, Dublin 8, Ireland
    Hum Brain Mapp 33:1202-11. 2012
    ..Whether this variant is also associated with variation in early sensory processing remains unclear...
  23. ncbi request reprint Evidence that specific executive functions predict symptom variance among schizophrenia patients with a predominantly negative symptom profile
    Gary Donohoe
    Trinity College, Dublin, Ireland
    Cogn Neuropsychiatry 11:13-32. 2006
    ..In particular, it was hoped that this approach could clarify whether negative and positive symptoms of schizophrenia are differentially related to particular aspects of executive/attentional functions...
  24. doi request reprint Replicated genetic evidence supports a role for HOMER2 in schizophrenia
    William P Gilks
    Neuropsychiatric Genetics Research Group, Institute for Molecular Medicine and Department of Psychiatry, Trinity College Dublin, Ireland
    Neurosci Lett 468:229-33. 2010
    ..This study supports a role for HOMER2 gene in schizophrenia susceptibility. Further work is required to confirm and elucidate the role of HOMER2 and interacting genes in schizophrenia aetiology...
  25. ncbi request reprint Genome-wide schizophrenia variant at MIR137 does not impact white matter microstructure in healthy participants
    Sinead Kelly
    Neuropsychiatric Genetics Group, Department of Psychiatry, Trinity Centre for Health Sciences, St James s Hospital, Dublin 8, Ireland Trinity College Institute for Neuroscience, Trinity College Dublin, Ireland
    Neurosci Lett 574:6-10. 2014
    ....
  26. doi request reprint Functional investigation of a schizophrenia GWAS signal at the CDC42 gene
    William P Gilks
    Neuropsychiatric Genetics Research Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland
    World J Biol Psychiatry 13:550-4. 2012
    ..Reduced expression of CDC42 in schizophrenia has previously been reported. Our objective was to test whether the associated SNP affected CDC42 expression...
  27. doi request reprint Effects of MIR137 on fronto-amygdala functional connectivity
    Omar Mothersill
    Neuropsychiatric Genetics Group, Department of Psychiatry, Trinity College Dublin, Ireland Trinity College Institute for Neuroscience, Trinity College Dublin, Ireland
    Neuroimage 90:189-95. 2014
    ..Following this evidence, we investigated the effects of MIR137 genotype on neuronal activity during face processing...
  28. doi request reprint Effects of a novel schizophrenia risk variant rs7914558 at CNNM2 on brain structure and attributional style
    Emma Jane Rose
    Emma Jane Rose, PhD, Neuropsychiatric Genetics Group, Department of Psychiatry and Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland, and TSTPP MEGEH, RTI International, Baltimore, Maryland, USA April Hargreaves, MSc, Derek Morris, PhD, Ciara Fahey, MSc, Daniela Tropea, PhD, Elizabeth Cummings, MD, Neuropsychiatric Genetics Group, Department of Psychiatry, Trinity College Dublin, Ireland Carlo Caltagirone, MD, IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology and Department of Neuroscience, Tor Vergata University, Rome, Italy Paola Bossù, PhD, Chiara Chiapponi, PhD, Fabrizio Piras, PhD, Gianfranco Spalletta, MD, PhD, IRCCS Santa Lucia Foundation, Tsu National Hospital
    Br J Psychiatry 204:115-21. 2014
    ..A single nucleotide polymorphism (rs7914558) within the cyclin M2 (CNNM2) gene was recently identified as a common risk variant for schizophrenia. The mechanism by which CNNM2 confers risk is unknown...
  29. pmc Brain vs behavior: an effect size comparison of neuroimaging and cognitive studies of genetic risk for schizophrenia
    Emma Jane Rose
    Department of Psychiatry, Trinity College Dublin, Trinity Centre for Health Sciences, St James Hospital, Dublin 8, Ireland
    Schizophr Bull 39:518-26. 2013
    ....
  30. pmc Mental state decoding v. mental state reasoning as a mediator between cognitive and social function in psychosis
    Nicola McGlade
    Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity Health Sciences Building, St James s Hospital, Dublin 8, Ireland
    Br J Psychiatry 193:77-8. 2008
    ..We discuss these findings in terms of the accumulating evidence that mental state decoding has particular relevance for understanding deficits in social function in schizophrenia...
  31. ncbi request reprint Are the cognitive deficits associated with impaired insight in schizophrenia specific to executive task performance?
    Gary Donohoe
    Department of Psychology, Trinity College Dublin, Trinity Centre, St James s Hospital, Dublin 8, Ireland
    J Nerv Ment Dis 193:803-8. 2005
    ..We conclude that while impaired insight does appear to be associated with executive deficits, this association may not be specific but may instead relate to cognitive deficits more generally...
  32. doi request reprint Attention network hypoconnectivity with default and affective network hyperconnectivity in adults diagnosed with attention-deficit/hyperactivity disorder in childhood
    Hazel McCarthy
    Neuroimaging Group, Department of Psychiatry, Trinity College Dublin, Dublin, Ireland2Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
    JAMA Psychiatry 70:1329-37. 2013
    ..The correlation patterns in spontaneous neural fluctuations at rest are known as resting-state functional connectivity (RSFC) and could characterize ADHD-specific connectivity changes...
  33. ncbi request reprint Investigation of the apolipoprotein-L (APOL) gene family and schizophrenia using a novel DNA pooling strategy for public database SNPs
    Kevin A McGhee
    Neuropsychiatric Genetics Group, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, James Street, Dublin 8, Ireland
    Schizophr Res 76:231-8. 2005
    ..We found no evidence to support the hypothesis that genetic variation at the APOL genes contributes to SZ susceptibility in our sample...
  34. pmc Childhood stress, serotonin transporter gene and brain structures in major depression
    Thomas Frodl
    Department of Psychiatry, Institute of Neuroscience, Trinity College, Dublin, Ireland
    Neuropsychopharmacology 35:1383-90. 2010
    ..Structural brain changes due to stress represent part of the mechanism by which the illness risk and outcome might be genetically mediated...
  35. pmc Effect of genetic variant in BICC1 on functional and structural brain changes in depression
    Rachel Bermingham
    Integrated Neuroimaging Group, Department of Psychiatry and Institute of Neuroscience, School of Medicine, Trinity College Dublin, University of Dublin, College Green, Dublin, Ireland
    Neuropsychopharmacology 37:2855-62. 2012
    ..These results are suggestive that the minor T-allele of BICC1 has a protective role against MDD and its known structural and functional brain changes. However, this protective effect seems to be lost in the case of co-occurrence of ELA...
  36. ncbi request reprint Variability in Working Memory Performance Explained by Epistasis vs Polygenic Scores in the ZNF804A Pathway
    Kristin K Nicodemus
    Neuropsychiatric Genetics Group, Department of Psychiatry, Trinity College Dublin, St James Hospital, Dublin, Ireland2Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland
    JAMA Psychiatry 71:778-85. 2014
    ..Of particular importance was the relative contribution of the polygenic score vs epistasis in variation explained...
  37. doi request reprint Insulin-like growth factor 1 (IGF1) and its active peptide (1-3)IGF1 enhance the expression of synaptic markers in neuronal circuits through different cellular mechanisms
    Aiden P Corvin
    Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, St James Hospital, Dublin 8, Ireland
    Neurosci Lett 520:51-6. 2012
    ..The results show that the two molecules increase the expression of synaptic proteins through activating different cellular mechanisms...
  38. ncbi request reprint No evidence that runs of homozygosity are associated with schizophrenia in an Irish genome-wide association dataset
    Elizabeth A Heron
    Department of Psychiatry and Neuropsychiatric Genetics Research Group, School of Medicine, The Trinity Centre for Health Sciences, St James s Hospital, Dublin 8, Ireland Electronic address
    Schizophr Res 154:79-82. 2014
    ..There was no genome-wide excess of ROH in cases compared to controls (p=0.7986). No consensus ROH at individual loci showed association with schizophrenia after genome-wide correction. ..
  39. ncbi request reprint Evidence that health attributions and symptom severity predict insight in schizophrenia
    Gary Donohoe
    Department of Adult Psychiatry, Cluain Mhuire Family Center, St John of God s Order, Dublin, Ireland
    J Nerv Ment Dis 192:635-7. 2004
    ..This study emphasizes the multifactorial nature of insight and the importance of psychological variables in addition to symptomatology...
  40. doi request reprint The NOS1 variant rs6490121 is associated with variation in prefrontal function and grey matter density in healthy individuals
    Emma J Rose
    Neuropsychiatric Genetics Research Group and Institute of Molecular Medicine, Department of Psychiatry, Trinity College Dublin, Ireland
    Neuroimage 60:614-22. 2012
    ..While the mechanisms by which NOS1 may influence brain structure and/or function have not yet been well delineated, these data provide further evidence for a role of NOS1 in risk for schizophrenia via an impact upon cognitive function...
  41. ncbi request reprint An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis
    Derek W Morris
    Department of Psychiatry and Neuropsychiatric Genetics Research Group, Institute of Molecular Medicine, Trinity College Dublin, Dublin 2, Ireland
    Hum Mol Genet 23:3316-26. 2014
    ..We demonstrate that PAK7 is developmentally co-expressed with another known psychosis risk gene (DISC1) suggesting a potential molecular mechanism involving aberrant synapse development and plasticity...
  42. doi request reprint Analysis of the hexanucleotide repeat expansion and founder haplotype at C9ORF72 in an Irish psychosis case-control sample
    Ciara Fahey
    Neuropsychiatric Genetics Research Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland
    Neurobiol Aging 35:1510.e1-5. 2014
    ..714, p < 0.001). Our study provides further evidence to bolster the claim that carriers of the repeat expansion at C9ORF72 arose from a single common founder...
  43. doi request reprint Assessing patients' beliefs about their cancer-related fatigue: validation of an adapted version of the Illness Perception Questionnaire
    Maria Margareta Pertl
    School of Psychology, Aras an Phiarsaigh, Trinity College Dublin, Dublin 2, Ireland
    J Clin Psychol Med Settings 19:293-307. 2012
    ..The scale may be able to be used clinically to identify if patients have inaccurate or unhelpful representations of CRF and to help tailor interventions for persistent fatigue in cancer survivors...
  44. pmc The effects of psychosis risk variants on brain connectivity: a review
    Omar Mothersill
    Neuropsychiatric Genetics Group, Department of Psychiatry, Trinity College Dublin Dublin, Ireland
    Front Psychiatry 3:18. 2012
    ..These conclusions are limited by methodological considerations, and require further investigation involving larger samples, multiple genes, and novel analysis techniques for confirmation...