Research Topics
Genomes and GenesSpecies | Gary DonohoeSummaryAffiliation: Trinity College Country: Ireland Publications
| Collaborators
|
Detail Information
Publications
Does the ability to sustain attention underlie symptom severity in schizophrenia?Cara O'Gráda
Department of Psychiatry, University College Cork, Ireland
Schizophr Res 107:319-23. 2009..These data suggest that this component of attention at least partly explains variance in negative symptoms...- Neuropsychological effects of the CSMD1 genome-wide associated schizophrenia risk variant rs10503253G Donohoe
Neuropsychiatric Genetics Group, Department of Psychiatry, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, Dublin, Ireland
Genes Brain Behav 12:203-9. 2013.... 
The psychosis susceptibility gene ZNF804A: associations, functions, and phenotypesGary Donohoe
Department of Psychiatry, Trinity College Dublin, Trinity Health Sciences Building, St James s Hospital, Dublin 8, Ireland
Schizophr Bull 36:904-9. 2010..We conclude that ZNF804A is robustly, if modestly, associated with schizophrenia risk, with much work still remaining to elucidate its role in schizophrenia biology...- Influence of NOS1 on verbal intelligence and working memory in both patients with schizophrenia and healthy control subjectsGary Donohoe
Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity Health Sciences Bldg, St James s Hospital, Dublin 8, Ireland
Arch Gen Psychiatry 66:1045-54. 2009..Human and animal studies have implicated the gene NOS1 in both cognition and schizophrenia susceptibility... - ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophreniaGary Donohoe
Neuropsychiatric Genetics Research Group, Trinity College Dublin, Dublin, Ireland
Neuroimage 54:2132-7. 2011..Establishing if this represents a discrete molecular pathogenesis with consequences for nosology and treatment will be an important next step in understanding ZNF084A's role in illness risk... 
Variance in neurocognitive performance is associated with dysbindin-1 in schizophrenia: a preliminary studyGary Donohoe
Department of Psychology and Trinity Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
Neuropsychologia 45:454-8. 2007..Our study suggests that the increased risk for schizophrenia associated with dysbindin may be partly mediated by its influence on pre-frontal function...- Are relational style and neuropsychological performance predictors of social attributions in chronic schizophrenia?Gary Donohoe
Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, Dublin 2, Ireland
Psychiatry Res 161:19-27. 2008..This study highlights the importance of relationship style and neuropsychological performance for different aspects of attributional style in schizophrenia... - Reduced occipital and prefrontal brain volumes in dysbindin-associated schizophreniaGary Donohoe
Department of Psychiatry, Neuropsychiatric Genetics Research Group, Trinity College Dublin, Dublin, Ireland
Neuropsychopharmacology 35:368-73. 2010..These data provide important evidence of the influence of dysbindin risk variants on brain structure, and suggest a possible mechanism by which disease risk is being increased... - Chitinase-3-like 1 (CHI3L1) gene and schizophrenia: genetic association and a potential functional mechanismMao Sheng Yang
Neuropsychiatric Genetics Research Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College Dublin, Ireland
Biol Psychiatry 64:98-103. 2008..Gene expression data and association analyses in two Chinese samples implicate chitinase 3-like 1 (CHI3L1), a cellular survival gene, in schizophrenia susceptibility... - A dysbindin risk haplotype associated with less severe manic-type symptoms in psychosisAiden Corvin
Neuropsychiatric Genetics Group, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, Dublin 8, Ireland
Neurosci Lett 431:146-9. 2008..004), with a trend for higher negative symptom scores. This suggests that risk variation at the dysbindin gene may contribute to a more prototypical SZ presentation with less severe excitement/manic symptoms and more negative symptoms... - Dysbindin (DTNBP1) and the biogenesis of lysosome-related organelles complex 1 (BLOC-1): main and epistatic gene effects are potential contributors to schizophrenia susceptibilityDerek W Morris
Neuropsychiatric Genetics Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College, Dublin, Ireland
Biol Psychiatry 63:24-31. 2008.... - Is "clinical" insight the same as "cognitive" insight in schizophrenia?Gary Donohoe
Department of Psychiatry, Trinity College Dublin, Dublin, Ireland
J Int Neuropsychol Soc 15:471-5. 2009..We conclude that while good cognitive insight may not be necessary for good clinical insight, good cognitive awareness is at least partly reliant on the processes involved in clinical insight... - Are deficits in executive sub-processes simply reflecting more general cognitive decline in schizophrenia?Gary Donohoe
Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College, Dublin, Ireland
Schizophr Res 85:168-73. 2006..Schizophrenia is associated with both global and specific cognitive deficits. We sought to investigate whether deficits in executive subcomponents differed in their relationship to global cognitive impairments... - The effect of the neurogranin schizophrenia risk variant rs12807809 on brain structure and functionEmma J Rose
Department of Psychiatry, Trinity College Dublin, Ireland
Twin Res Hum Genet 15:296-303. 2012..Although it remains to be established whether this holds true in larger samples and in patient cohorts, if valid, this suggests a potential mechanism by which NRGN variability might contribute to schizophrenia risk... - D-amino acid oxidase (DAO) genotype and mood symptomatology in schizophreniaAiden Corvin
Neuropsychiatric Genetics Group, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, James s Street, Dublin 8, Ireland
Neurosci Lett 426:97-100. 2007..02, d.f.=2, p=0.01). These data suggest a potential role for DAO in susceptibility to depressive symptoms in schizophrenia, but a more general role for DAO in affective disorders cannot be excluded... - Social cognition in bipolar disorder versus schizophrenia: comparability in mental state decoding deficitsGary Donohoe
Neuropsychiatric Genetics Research Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland
Bipolar Disord 14:743-8. 2012.... - Neurocognition and suicidal behaviour in an Irish population with major psychotic disordersJeanne-Marie Nangle
Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, Ireland
Schizophr Res 85:196-200. 2006..In particular, the preservation of higher executive function may influence the ability to initiate and plan suicidal behaviour... - Early visual processing deficits in dysbindin-associated schizophreniaGary Donohoe
Neuropsychiatric Genetics Group, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, Dublin, Ireland
Biol Psychiatry 63:484-9. 2008..We investigated P1 performance, a component of early visual processing on which both patients and their relatives show deficits, in carriers and noncarriers of a known dysbindin risk haplotype... - Do antisaccade deficits in schizophrenia provide evidence of a specific inhibitory function?Gary Donohoe
Neuropsychiatric Genetics Research Group, Department of Psychiatry, and Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland
J Int Neuropsychol Soc 12:901-6. 2006..We investigated whether variance in antisaccade performance could be better accounted for in terms of a specific inhibitory function... - A NOS1 variant implicated in cognitive performance influences evoked neural responses during a high density EEG study of early visual perceptionTherese O'Donoghue
Neuropsychiatric Genetics Group and Department of Psychiatry, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, Dublin 8, Ireland
Hum Brain Mapp 33:1202-11. 2012..Whether this variant is also associated with variation in early sensory processing remains unclear... - Evidence that specific executive functions predict symptom variance among schizophrenia patients with a predominantly negative symptom profileGary Donohoe
Trinity College, Dublin, Ireland
Cogn Neuropsychiatry 11:13-32. 2006..In particular, it was hoped that this approach could clarify whether negative and positive symptoms of schizophrenia are differentially related to particular aspects of executive/attentional functions... - Replicated genetic evidence supports a role for HOMER2 in schizophreniaWilliam P Gilks
Neuropsychiatric Genetics Research Group, Institute for Molecular Medicine and Department of Psychiatry, Trinity College Dublin, Ireland
Neurosci Lett 468:229-33. 2010..This study supports a role for HOMER2 gene in schizophrenia susceptibility. Further work is required to confirm and elucidate the role of HOMER2 and interacting genes in schizophrenia aetiology... - Functional investigation of a schizophrenia GWAS signal at the CDC42 geneWilliam P Gilks
Neuropsychiatric Genetics Research Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland
World J Biol Psychiatry 13:550-4. 2012..Reduced expression of CDC42 in schizophrenia has previously been reported. Our objective was to test whether the associated SNP affected CDC42 expression... - Are the cognitive deficits associated with impaired insight in schizophrenia specific to executive task performance?Gary Donohoe
Department of Psychology, Trinity College Dublin, Trinity Centre, St James s Hospital, Dublin 8, Ireland
J Nerv Ment Dis 193:803-8. 2005..We conclude that while impaired insight does appear to be associated with executive deficits, this association may not be specific but may instead relate to cognitive deficits more generally... - Childhood stress, serotonin transporter gene and brain structures in major depressionThomas Frodl
Department of Psychiatry, Institute of Neuroscience, Trinity College, Dublin, Ireland
Neuropsychopharmacology 35:1383-90. 2010..Structural brain changes due to stress represent part of the mechanism by which the illness risk and outcome might be genetically mediated... - Mental state decoding v. mental state reasoning as a mediator between cognitive and social function in psychosisNicola McGlade
Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity Health Sciences Building, St James s Hospital, Dublin 8, Ireland
Br J Psychiatry 193:77-8. 2008..We discuss these findings in terms of the accumulating evidence that mental state decoding has particular relevance for understanding deficits in social function in schizophrenia... - Investigation of the apolipoprotein-L (APOL) gene family and schizophrenia using a novel DNA pooling strategy for public database SNPsKevin A McGhee
Neuropsychiatric Genetics Group, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, James Street, Dublin 8, Ireland
Schizophr Res 76:231-8. 2005..We found no evidence to support the hypothesis that genetic variation at the APOL genes contributes to SZ susceptibility in our sample... - Social dysfunction in schizophrenia: An investigation of the GAF scale's sensitivity to deficits in social cognitionDeirdre A Robertson
Department of Psychiatry and Neuropsychiatric Genetics Research Group, School of Medicine and Trinity College Institute of Neuroscience, The Trinity Center, St James s Hospital, Dublin 8, Ireland
Schizophr Res 146:363-5. 2013..To investigate this, we assessed whether variation in GAF score was explained by performance on measures of neurocognitive and social cognition, particularly after variation associated with symptom severity had been accounted for... - Effect of genetic variant in BICC1 on functional and structural brain changes in depressionRachel Bermingham
Integrated Neuroimaging Group, Department of Psychiatry and Institute of Neuroscience, School of Medicine, Trinity College Dublin, University of Dublin, College Green, Dublin, Ireland
Neuropsychopharmacology 37:2855-62. 2012..These results are suggestive that the minor T-allele of BICC1 has a protective role against MDD and its known structural and functional brain changes. However, this protective effect seems to be lost in the case of co-occurrence of ELA... - Insulin-like growth factor 1 (IGF1) and its active peptide (1-3)IGF1 enhance the expression of synaptic markers in neuronal circuits through different cellular mechanismsAiden P Corvin
Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, St James Hospital, Dublin 8, Ireland
Neurosci Lett 520:51-6. 2012..The results show that the two molecules increase the expression of synaptic proteins through activating different cellular mechanisms... - The NOS1 variant rs6490121 is associated with variation in prefrontal function and grey matter density in healthy individualsEmma J Rose
Neuropsychiatric Genetics Research Group and Institute of Molecular Medicine, Department of Psychiatry, Trinity College Dublin, Ireland
Neuroimage 60:614-22. 2012..While the mechanisms by which NOS1 may influence brain structure and/or function have not yet been well delineated, these data provide further evidence for a role of NOS1 in risk for schizophrenia via an impact upon cognitive function... - Evidence that health attributions and symptom severity predict insight in schizophreniaGary Donohoe
Department of Adult Psychiatry, Cluain Mhuire Family Center, St John of God's Order, Dublin, Ireland
J Nerv Ment Dis 192:635-7. 2004..This study emphasizes the multifactorial nature of insight and the importance of psychological variables in addition to symptomatology... - Brain vs Behavior: An Effect Size Comparison of Neuroimaging and Cognitive Studies of Genetic Risk for SchizophreniaEmma Jane Rose
To whom correspondence should be addressed Department of Psychiatry, Trinity College Dublin, Trinity Centre for Health Sciences, St James Hospital, Dublin 8, Ireland tel 353 0 18962464, fax 353 0 18963405, E mail
Schizophr Bull 39:518-26. 2013.... - Assessing patients' beliefs about their cancer-related fatigue: validation of an adapted version of the Illness Perception QuestionnaireMaria Margareta Pertl
School of Psychology, Aras an Phiarsaigh, Trinity College Dublin, Dublin 2, Ireland
J Clin Psychol Med Settings 19:293-307. 2012..The scale may be able to be used clinically to identify if patients have inaccurate or unhelpful representations of CRF and to help tailor interventions for persistent fatigue in cancer survivors... - The effects of psychosis risk variants on brain connectivity: a reviewOmar Mothersill
Neuropsychiatric Genetics Group, Department of Psychiatry, Trinity College Dublin Dublin, Ireland
Front Psychiatry 3:18. 2012..These conclusions are limited by methodological considerations, and require further investigation involving larger samples, multiple genes, and novel analysis techniques for confirmation...