Affiliation: Trinity College
- Cunningham C. Microglia and neurodegeneration: the role of systemic inflammation. Glia. 2013;61:71-90 pubmed publisher..Mechanisms by which microglia might effect neuronal damage and dysfunction, as a consequence of systemic stimulation, will be highlighted. ..
- Cunningham C, Skelly D. Non-steroidal anti-inflammatory drugs and cognitive function: are prostaglandins at the heart of cognitive impairment in dementia and delirium?. J Neuroimmune Pharmacol. 2012;7:60-73 pubmed publisher..We will also discuss how understanding the role of inflammatory mediators in delirious episodes will have major implications for ameliorating the rate of decline in the demented population. ..
- Hennessy E, Gormley S, López Rodríguez A, Murray C, Murray C, Cunningham C. Systemic TNF-? produces acute cognitive dysfunction and exaggerated sickness behavior when superimposed upon progressive neurodegeneration. Brain Behav Immun. 2017;59:233-244 pubmed publisher..The data indicate that acutely elevated TNF-? has robust acute effects on brain function, selectively in the degenerating brain, but more sustained levels may be required to significantly impact on underlying neurodegeneration. ..
- Cunningham C, Campion S, Teeling J, Felton L, Perry V. The sickness behaviour and CNS inflammatory mediator profile induced by systemic challenge of mice with synthetic double-stranded RNA (poly I:C). Brain Behav Immun. 2007;21:490-502 pubmed..These findings demonstrate clear CNS effects of peripheral TLR3 stimulation and will be useful in studying aspects of the effects of systemic viral infection on brain function in both normal and pathological situations. ..
- Cunningham C, Campion S, Lunnon K, Murray C, Woods J, Deacon R, et al. Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease. Biol Psychiatry. 2009;65:304-12 pubmed publisher..These deleterious effects of systemic inflammation have implications for the treatment of chronic neurodegeneration and associated delirium. ..
- Cunningham C, MacLullich A. At the extreme end of the psychoneuroimmunological spectrum: delirium as a maladaptive sickness behaviour response. Brain Behav Immun. 2013;28:1-13 pubmed publisher..We conclude that, with appropriate caveats, the study of sickness behaviour in the vulnerable brain offers a promising route to uncover the mechanisms of this common and serious unmet medical need. ..
- Cunningham C, Sanderson D. Malaise in the water maze: untangling the effects of LPS and IL-1beta on learning and memory. Brain Behav Immun. 2008;22:1117-27 pubmed publisher....