Colm Cunningham

Summary

Affiliation: Trinity College
Country: Ireland

Publications

  1. doi request reprint Microglia and neurodegeneration: the role of systemic inflammation
    Colm Cunningham
    School of Biochemistry and Immunology and Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland
    Glia 61:71-90. 2013
  2. pmc Systemic TNF-α produces acute cognitive dysfunction and exaggerated sickness behavior when superimposed upon progressive neurodegeneration
    Edel Hennessy
    School of Biochemistry and Immunology, Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    Brain Behav Immun 59:233-244. 2017
  3. pmc Interdependent and independent roles of type I interferons and IL-6 in innate immune, neuroinflammatory and sickness behaviour responses to systemic poly I:C
    Carol Murray
    School of Biochemistry and Immunology, Trinity College Dublin, Ireland Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland
    Brain Behav Immun 48:274-86. 2015
  4. doi request reprint Co-morbidity and systemic inflammation as drivers of cognitive decline: new experimental models adopting a broader paradigm in dementia research.
    Colm Cunningham
    Trinity College Institute of Neuroscience and School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Republic of Ireland
    Alzheimers Res Ther 7:33. 2015
  5. pmc Worsening cognitive impairment and neurodegenerative pathology progressively increase risk for delirium
    Daniel H J Davis
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom
    Am J Geriatr Psychiatry 23:403-15. 2015
  6. doi request reprint Early Hippocampal Synaptic Loss Precedes Neuronal Loss and Associates with Early Behavioural Deficits in Three Distinct Strains of Prion Disease.
    Kathryn J Hilton
    School of Biological Sciences, Southampton General Hospital, Southampton, United Kingdom
    PLoS ONE 8:e68062. 2013
  7. pmc Microglia and the urokinase plasminogen activator receptor/uPA system in innate brain inflammation
    Orla Cunningham
    FIRC Institute of Molecular Oncology, 20139 Milan, Italy
    Glia 57:1802-14. 2009
  8. pmc At the extreme end of the psychoneuroimmunological spectrum: delirium as a maladaptive sickness behaviour response
    Colm Cunningham
    School of Biochemistry and Immunology and Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland
    Brain Behav Immun 28:1-13. 2013
  9. pmc Non-steroidal anti-inflammatory drugs and cognitive function: are prostaglandins at the heart of cognitive impairment in dementia and delirium?
    Colm Cunningham
    School of Biochemistry and Immunology and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Republic of Ireland
    J Neuroimmune Pharmacol 7:60-73. 2012
  10. pmc Systemic inflammation and delirium: important co-factors in the progression of dementia
    Colm Cunningham
    School of Biochemistry and Immunology and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Republic of Ireland
    Biochem Soc Trans 39:945-53. 2011

Collaborators

Detail Information

Publications31

  1. doi request reprint Microglia and neurodegeneration: the role of systemic inflammation
    Colm Cunningham
    School of Biochemistry and Immunology and Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland
    Glia 61:71-90. 2013
    ..Mechanisms by which microglia might effect neuronal damage and dysfunction, as a consequence of systemic stimulation, will be highlighted...
  2. pmc Systemic TNF-α produces acute cognitive dysfunction and exaggerated sickness behavior when superimposed upon progressive neurodegeneration
    Edel Hennessy
    School of Biochemistry and Immunology, Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    Brain Behav Immun 59:233-244. 2017
    ..The data indicate that acutely elevated TNF-α has robust acute effects on brain function, selectively in the degenerating brain, but more sustained levels may be required to significantly impact on underlying neurodegeneration...
  3. pmc Interdependent and independent roles of type I interferons and IL-6 in innate immune, neuroinflammatory and sickness behaviour responses to systemic poly I:C
    Carol Murray
    School of Biochemistry and Immunology, Trinity College Dublin, Ireland Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland
    Brain Behav Immun 48:274-86. 2015
    ..Hence, we have demonstrated both interdependent and independent roles for IFN-I and IL-6 in systemic inflammation-induced changes in brain function. ..
  4. doi request reprint Co-morbidity and systemic inflammation as drivers of cognitive decline: new experimental models adopting a broader paradigm in dementia research.
    Colm Cunningham
    Trinity College Institute of Neuroscience and School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Republic of Ireland
    Alzheimers Res Ther 7:33. 2015
    ..Detailed study of these pathways will uncover important mechanisms of peripheral inflammation-driven cognitive decline and are already driving clinical initiatives to mitigate AD progression through minimising systemic inflammation...
  5. pmc Worsening cognitive impairment and neurodegenerative pathology progressively increase risk for delirium
    Daniel H J Davis
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom
    Am J Geriatr Psychiatry 23:403-15. 2015
    ..We used humans and mice to address the hypothesis that the severity of underlying neurodegenerative changes and/or cognitive impairment progressively alters delirium risk...
  6. doi request reprint Early Hippocampal Synaptic Loss Precedes Neuronal Loss and Associates with Early Behavioural Deficits in Three Distinct Strains of Prion Disease.
    Kathryn J Hilton
    School of Biological Sciences, Southampton General Hospital, Southampton, United Kingdom
    PLoS ONE 8:e68062. 2013
    ....
  7. pmc Microglia and the urokinase plasminogen activator receptor/uPA system in innate brain inflammation
    Orla Cunningham
    FIRC Institute of Molecular Oncology, 20139 Milan, Italy
    Glia 57:1802-14. 2009
    ..These data are novel and suggest much wider involvement of the uPAR/uPA system in CNS function and pathology than previously supposed...
  8. pmc At the extreme end of the psychoneuroimmunological spectrum: delirium as a maladaptive sickness behaviour response
    Colm Cunningham
    School of Biochemistry and Immunology and Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland
    Brain Behav Immun 28:1-13. 2013
    ..We conclude that, with appropriate caveats, the study of sickness behaviour in the vulnerable brain offers a promising route to uncover the mechanisms of this common and serious unmet medical need...
  9. pmc Non-steroidal anti-inflammatory drugs and cognitive function: are prostaglandins at the heart of cognitive impairment in dementia and delirium?
    Colm Cunningham
    School of Biochemistry and Immunology and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Republic of Ireland
    J Neuroimmune Pharmacol 7:60-73. 2012
    ..We will also discuss how understanding the role of inflammatory mediators in delirious episodes will have major implications for ameliorating the rate of decline in the demented population...
  10. pmc Systemic inflammation and delirium: important co-factors in the progression of dementia
    Colm Cunningham
    School of Biochemistry and Immunology and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Republic of Ireland
    Biochem Soc Trans 39:945-53. 2011
    ..These data suggest that systemic inflammation is a major contributor to the progression of dementia and constitutes an important clinical target...
  11. pmc Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease
    Colm Cunningham
    Department of Biochemistry, Trinity College Institute of Neuroscience, Trinity College Dublin, Republic of Ireland
    Biol Psychiatry 65:304-12. 2009
    ....
  12. pmc Malaise in the water maze: untangling the effects of LPS and IL-1beta on learning and memory
    Colm Cunningham
    School of Biochemistry and Immunology, Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland
    Brain Behav Immun 22:1117-27. 2008
    ....
  13. ncbi request reprint The sickness behaviour and CNS inflammatory mediator profile induced by systemic challenge of mice with synthetic double-stranded RNA (poly I:C)
    Colm Cunningham
    Department of Biochemistry, Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland
    Brain Behav Immun 21:490-502. 2007
    ..These findings demonstrate clear CNS effects of peripheral TLR3 stimulation and will be useful in studying aspects of the effects of systemic viral infection on brain function in both normal and pathological situations...
  14. pmc Systemic challenge with the TLR3 agonist poly I:C induces amplified IFNalpha/beta and IL-1beta responses in the diseased brain and exacerbates chronic neurodegeneration
    Robert Field
    School of Biochemistry and Immunology, Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    Brain Behav Immun 24:996-1007. 2010
    ..That systemic poly I:C accelerates neurodegeneration has implications for the control of systemic viral infection during chronic neurodegeneration and indicates that type I interferon responses in the brain merit further study...
  15. pmc A systematic analysis of the peripheral and CNS effects of systemic LPS, IL-1β, [corrected] TNF-α and IL-6 challenges in C57BL/6 mice
    Donal T Skelly
    School of Biochemistry and Immunology and Trinity College Institute of Neuroscience, Trinity College, Dublin, Republic of Ireland
    PLoS ONE 8:e69123. 2013
    ....
  16. pmc Cyclooxygenase-1-dependent prostaglandins mediate susceptibility to systemic inflammation-induced acute cognitive dysfunction
    Eadaoin W Griffin
    Trinity College Institute of Neuroscience and School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Republic of Ireland
    J Neurosci 33:15248-58. 2013
    ..These data contribute to our understanding of how systemic inflammation and ongoing neurodegeneration interact to induce cognitive dysfunction and episodes of delirium. ..
  17. pmc Systemic inflammation induces acute working memory deficits in the primed brain: relevance for delirium
    Carol Murray
    Trinity College Institute of Neuroscience, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    Neurobiol Aging 33:603-616.e3. 2012
    ....
  18. pmc Exacerbation of CNS inflammation and neurodegeneration by systemic LPS treatment is independent of circulating IL-1β and IL-6
    Carol L Murray
    School of Biochemistry and Immunology, Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    J Neuroinflammation 8:50. 2011
    ..Here we investigated whether inhibition of systemic cytokine synthesis using the anti-inflammatory steroid dexamethasone-21-phosphate was sufficient to block any or all of these responses...
  19. pmc Prior pathology in the basal forebrain cholinergic system predisposes to inflammation-induced working memory deficits: reconciling inflammatory and cholinergic hypotheses of delirium
    Robert H Field
    Trinity College Institute of Neuroscience, and School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Republic of Ireland
    J Neurosci 32:6288-94. 2012
    ..These data provide a useful model for examining interactions between acute systemic inflammation and chronic cholinergic hypofunction in delirium and have implications for the recent trial of rivastigmine in sepsis-associated delirium...
  20. pmc Microglia in the degenerating brain are capable of phagocytosis of beads and of apoptotic cells, but do not efficiently remove PrPSc, even upon LPS stimulation
    Martina M Hughes
    Trinity College Institute of Neuroscience and School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Republic of Ireland
    Glia 58:2017-30. 2010
    ..Furthermore, microglia/macrophages remain IL-1β-negative during phagocytosis of apoptotic cells. The data demonstrate that phagocytic activity and pro-inflammatory microglial phenotype do not necessarily correlate...
  21. pmc At the centre of neuronal, synaptic and axonal pathology in murine prion disease: degeneration of neuroanatomically linked thalamic and brainstem nuclei
    Renata Reis
    Trinity College Institute of Neuroscience and School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    Neuropathol Appl Neurobiol 41:780-97. 2015
    ..Synaptic loss and axonal pathology frequently precede neuronal loss and protein aggregation demonstrably spreads along neuroanatomical pathways in many neurodegenerative diseases. The spread of neuronal pathology is less studied...
  22. pmc Astrocytes Are Primed by Chronic Neurodegeneration to Produce Exaggerated Chemokine and Cell Infiltration Responses to Acute Stimulation with the Cytokines IL-1β and TNF-α
    Edel Hennessy
    Trinity College Institute of Neuroscience, School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    J Neurosci 35:8411-22. 2015
    ..These data have significant implications for acute sterile inflammatory insults such as stroke and traumatic brain injury occurring on a background of aging or neurodegeneration. ..
  23. pmc DNA sensors are expressed in astrocytes and microglia in vitro and are upregulated during gliosis in neurodegenerative disease
    Donal J Cox
    Molecular Immunology Group, School, of Biochemistry and Immunology and Immunology Research Centre, Trinity College Dublin, Ireland
    Glia 63:812-25. 2015
    ....
  24. pmc Endogenous IL-1 in cognitive function and anxiety: a study in IL-1RI-/- mice
    Carol L Murray
    School of Biochemistry and Immunology and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Republic of Ireland
    PLoS ONE 8:e78385. 2013
    ..The results argue for a careful evaluation of the roles of endogenous IL-1 in hippocampal and limbic system function. ..
  25. ncbi request reprint Transforming growth factor-beta 1-mediated neuroprotection against excitotoxic injury in vivo
    Delphine Boche
    CNS Inflammation Group, Southampton Neuroscience Group, School of Biological Sciences, University of Southampton, Southampton, Hampshire, UK
    J Cereb Blood Flow Metab 23:1174-82. 2003
    ..We have demonstrated in vivo that the cerebral tolerance phenomenon induced by LPS pretreatment is mediated by TGF-beta 1 cytokine...
  26. pmc Comparison of inflammatory and acute-phase responses in the brain and peripheral organs of the ME7 model of prion disease
    Colm Cunningham
    CNS Inflammation Group, School of Biological Sciences, Bassett Crescent East, Southampton, Hampshire SO16 7PX, United Kingdom
    J Virol 79:5174-84. 2005
    ..We also propose that serum cytokine and APP measurements are not useful during preclinical disease. Possible consequences of the clear chronic elevation of APPs in the CNS are discussed...
  27. ncbi request reprint Cytokines and the ageing brain
    Colm Cunningham
    CNS Inflammation Group, University of Southampton, Bassett Crescent East, SO16 7PX, UK
    Trends Neurosci 25:546-7. 2002
    ..Cytokines and the ageing brain". Held in Palais de Congres, Arcachon, France on 1-3 June 2002...
  28. ncbi request reprint Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration
    Colm Cunningham
    CNS Inflammation Group, School of Biological Sciences, Southampton, Hampshire SO16 7PX, United Kingdom
    J Neurosci 25:9275-84. 2005
    ..The finding that a single acute systemic inflammatory event can induce neuronal death in the CNS has implications for therapy in neurodegenerative diseases...
  29. ncbi request reprint TGFbeta1 regulates the inflammatory response during chronic neurodegeneration
    Delphine Boche
    CNS Inflammation Group, Southampton Neurosciences Group, School of Biological Sciences, University of Southampton, Southampton, SO16 7PX Hampshire, UK
    Neurobiol Dis 22:638-50. 2006
    ..These data suggest that TGFbeta1 plays a critical role in the downregulation of microglial responses minimizing brain inflammation and thus avoiding exacerbation of brain damage...
  30. doi request reprint Systemic inflammation switches the inflammatory cytokine profile in CNS Wallerian degeneration
    Karine Palin
    CNS Inflammation Group, School of Biological Sciences, University of Southampton, Southampton SO16 7PX, UK
    Neurobiol Dis 30:19-29. 2008
    ....
  31. ncbi request reprint Atypical inflammation in the central nervous system in prion disease
    V Hugh Perry
    CNS Inflammation Group, School of Biological Sciences, University of Southampton, Southampton SO16 7PX, UK
    Curr Opin Neurol 15:349-54. 2002
    ..There is also now evidence to suggest that a peripheral infection, and its consequent systemic cytokine expression, may drive central nervous system cytokine expression and perhaps exacerbate disease...