Aiden Corvin

Summary

Affiliation: Trinity College
Country: Ireland

Publications

  1. ncbi request reprint Are the cognitive deficits associated with impaired insight in schizophrenia specific to executive task performance?
    Gary Donohoe
    Department of Psychology, Trinity College Dublin, Trinity Centre, St James s Hospital, Dublin 8, Ireland
    J Nerv Ment Dis 193:803-8. 2005
  2. pmc Mental state decoding v. mental state reasoning as a mediator between cognitive and social function in psychosis
    Nicola McGlade
    Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity Health Sciences Building, St James s Hospital, Dublin 8, Ireland
    Br J Psychiatry 193:77-8. 2008
  3. doi request reprint What have the genomics ever done for the psychoses?
    M Gill
    Neuropsychiatric Genetics Research Group, Department of Psychiatry, School of Medicine, Trinity College Dublin 8, Ireland
    Psychol Med 40:529-40. 2010
  4. pmc The shock of the new: progress in schizophrenia genomics
    Susan Moore
    Neuropsychiatric Genetics Research Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College, Dublin, Ireland
    Curr Genomics 12:516-24. 2011
  5. pmc Unlocking the treasure trove: from genes to schizophrenia biology
    Shane E McCarthy
    To whom correspondence should be addressed Department of Psychiatry and Neuropsychiatric Genetics Research Group, Institute of Molecular Medicine, Trinity College Dublin, Dublin 2, Ireland tel 353 1 8962467, fax 353 1 8963405, E mail
    Schizophr Bull 40:492-6. 2014
  6. doi request reprint Genome-wide association studies: findings at the major histocompatibility complex locus in psychosis
    Aiden Corvin
    Department of Psychiatry and Neuropsychiatric Genetics Research Group, Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland Electronic address
    Biol Psychiatry 75:276-83. 2014
  7. doi request reprint The cognitive genetics of neuropsychiatric disorders
    A Corvin
    Department of Psychiatry, Trinity College Dublin, Dublin, Ireland
    Curr Top Behav Neurosci 12:579-613. 2012
  8. pmc Two patients walk into a clinic...a genomics perspective on the future of schizophrenia
    Aiden P Corvin
    Department of Psychiatry, Trinity College Dublin, Dublin 2, Ireland
    BMC Biol 9:77. 2011
  9. ncbi request reprint Evidence for association and epistasis at the DAOA/G30 and D-amino acid oxidase loci in an Irish schizophrenia sample
    A Corvin
    Neuropsychiatric Genetics Group, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, James Street, Dublin 8, Ireland
    Am J Med Genet B Neuropsychiatr Genet 144:949-53. 2007
  10. ncbi request reprint D-amino acid oxidase (DAO) genotype and mood symptomatology in schizophrenia
    Aiden Corvin
    Neuropsychiatric Genetics Group, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, James s Street, Dublin 8, Ireland
    Neurosci Lett 426:97-100. 2007

Detail Information

Publications48

  1. ncbi request reprint Are the cognitive deficits associated with impaired insight in schizophrenia specific to executive task performance?
    Gary Donohoe
    Department of Psychology, Trinity College Dublin, Trinity Centre, St James s Hospital, Dublin 8, Ireland
    J Nerv Ment Dis 193:803-8. 2005
    ..We conclude that while impaired insight does appear to be associated with executive deficits, this association may not be specific but may instead relate to cognitive deficits more generally...
  2. pmc Mental state decoding v. mental state reasoning as a mediator between cognitive and social function in psychosis
    Nicola McGlade
    Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity Health Sciences Building, St James s Hospital, Dublin 8, Ireland
    Br J Psychiatry 193:77-8. 2008
    ..We discuss these findings in terms of the accumulating evidence that mental state decoding has particular relevance for understanding deficits in social function in schizophrenia...
  3. doi request reprint What have the genomics ever done for the psychoses?
    M Gill
    Neuropsychiatric Genetics Research Group, Department of Psychiatry, School of Medicine, Trinity College Dublin 8, Ireland
    Psychol Med 40:529-40. 2010
    ..Despite the substantial heritability of the psychoses and their genuine public health burden, the applicability of the genomic approach in psychiatry has been strongly questioned or prematurely dismissed...
  4. pmc The shock of the new: progress in schizophrenia genomics
    Susan Moore
    Neuropsychiatric Genetics Research Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College, Dublin, Ireland
    Curr Genomics 12:516-24. 2011
    ..This review summarizes recent research progress and suggests how the tools of modern genomics and neuroscience can be applied to best understand this devastating disorder...
  5. pmc Unlocking the treasure trove: from genes to schizophrenia biology
    Shane E McCarthy
    To whom correspondence should be addressed Department of Psychiatry and Neuropsychiatric Genetics Research Group, Institute of Molecular Medicine, Trinity College Dublin, Dublin 2, Ireland tel 353 1 8962467, fax 353 1 8963405, E mail
    Schizophr Bull 40:492-6. 2014
    ..We review recent advances in these fields, consider the likely obstacles to progress, and consider strategies as to how these can be overcome...
  6. doi request reprint Genome-wide association studies: findings at the major histocompatibility complex locus in psychosis
    Aiden Corvin
    Department of Psychiatry and Neuropsychiatric Genetics Research Group, Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland Electronic address
    Biol Psychiatry 75:276-83. 2014
    ..Finally, we discuss that these genetic data may be used to understand how the MHC contributes to the complex etiology of schizophrenia. ..
  7. doi request reprint The cognitive genetics of neuropsychiatric disorders
    A Corvin
    Department of Psychiatry, Trinity College Dublin, Dublin, Ireland
    Curr Top Behav Neurosci 12:579-613. 2012
    ..Finally, we review the analysis of whole-genome DNA sequence data and the challenges that this will bring for cognitive genomics research...
  8. pmc Two patients walk into a clinic...a genomics perspective on the future of schizophrenia
    Aiden P Corvin
    Department of Psychiatry, Trinity College Dublin, Dublin 2, Ireland
    BMC Biol 9:77. 2011
    ..This has radical implications for clinical practice, as diagnosis and treatment will be guided by molecular etiology rather than clinical diagnostic criteria...
  9. ncbi request reprint Evidence for association and epistasis at the DAOA/G30 and D-amino acid oxidase loci in an Irish schizophrenia sample
    A Corvin
    Neuropsychiatric Genetics Group, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, James Street, Dublin 8, Ireland
    Am J Med Genet B Neuropsychiatr Genet 144:949-53. 2007
    ..3 (1.4, 60.5). Based on these data, more systematic investigation of genes involved in DAO signaling is required...
  10. ncbi request reprint D-amino acid oxidase (DAO) genotype and mood symptomatology in schizophrenia
    Aiden Corvin
    Neuropsychiatric Genetics Group, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, James s Street, Dublin 8, Ireland
    Neurosci Lett 426:97-100. 2007
    ..02, d.f.=2, p=0.01). These data suggest a potential role for DAO in susceptibility to depressive symptoms in schizophrenia, but a more general role for DAO in affective disorders cannot be excluded...
  11. ncbi request reprint A dysbindin risk haplotype associated with less severe manic-type symptoms in psychosis
    Aiden Corvin
    Neuropsychiatric Genetics Group, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, Dublin 8, Ireland
    Neurosci Lett 431:146-9. 2008
    ..004), with a trend for higher negative symptom scores. This suggests that risk variation at the dysbindin gene may contribute to a more prototypical SZ presentation with less severe excitement/manic symptoms and more negative symptoms...
  12. ncbi request reprint Confirmation and refinement of an 'at-risk' haplotype for schizophrenia suggests the EST cluster, Hs.97362, as a potential susceptibility gene at the Neuregulin-1 locus
    A P Corvin
    Neuropsychiatric Genetics Group, Department of Psychiatry, Institute of Molecular Medicine, Trinity College, Dublin 2, Ireland
    Mol Psychiatry 9:208-13. 2004
    ..0% vs 13.5%; P=0.036). Interestingly, this refined 'at-risk' haplotype is positioned close to an EST cluster of unknown function (Hs.97362) within intron 1 of NRG1...
  13. pmc Neuronal cell adhesion genes: Key players in risk for schizophrenia, bipolar disorder and other neurodevelopmental brain disorders?
    Aiden P Corvin
    Department of Psychiatry Neuropsychiatric Genetics Laboratory, Trinity College, Dublin, Ireland
    Cell Adh Migr 4:511-4. 2010
    ....
  14. ncbi request reprint Cigarette smoking and psychotic symptoms in bipolar affective disorder
    A Corvin
    Department of Psychiatry, Trinity Centre for Health Sciences, St James s Hospital, Dublin, Ireland
    Br J Psychiatry 179:35-8. 2001
    ..An association exists between smoking and schizophrenia, independent of other factors and related to psychotic symptomatology...
  15. ncbi request reprint Variance in neurocognitive performance is associated with dysbindin-1 in schizophrenia: a preliminary study
    Gary Donohoe
    Department of Psychology and Trinity Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
    Neuropsychologia 45:454-8. 2007
    ..Our study suggests that the increased risk for schizophrenia associated with dysbindin may be partly mediated by its influence on pre-frontal function...
  16. ncbi request reprint Neurocognition and suicidal behaviour in an Irish population with major psychotic disorders
    Jeanne Marie Nangle
    Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, Ireland
    Schizophr Res 85:196-200. 2006
    ..Our aim was to examine the relationship between neurocognitive variables and suicidal behaviour in patients with schizophrenia and schizoaffective disorder...
  17. ncbi request reprint Are deficits in executive sub-processes simply reflecting more general cognitive decline in schizophrenia?
    Gary Donohoe
    Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College, Dublin, Ireland
    Schizophr Res 85:168-73. 2006
    ..Schizophrenia is associated with both global and specific cognitive deficits. We sought to investigate whether deficits in executive subcomponents differed in their relationship to global cognitive impairments...
  18. ncbi request reprint Chitinase-3-like 1 (CHI3L1) gene and schizophrenia: genetic association and a potential functional mechanism
    Mao Sheng Yang
    Neuropsychiatric Genetics Research Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College Dublin, Ireland
    Biol Psychiatry 64:98-103. 2008
    ..Gene expression data and association analyses in two Chinese samples implicate chitinase 3-like 1 (CHI3L1), a cellular survival gene, in schizophrenia susceptibility...
  19. doi request reprint Are relational style and neuropsychological performance predictors of social attributions in chronic schizophrenia?
    Gary Donohoe
    Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, Dublin 2, Ireland
    Psychiatry Res 161:19-27. 2008
    ..This study highlights the importance of relationship style and neuropsychological performance for different aspects of attributional style in schizophrenia...
  20. doi request reprint Neural effects of the CSMD1 genome-wide associated schizophrenia risk variant rs10503253
    Emma J Rose
    Neuropsychiatric Genetics Group and Department of Psychiatry, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, Dublin, Ireland
    Am J Med Genet B Neuropsychiatr Genet 162:530-7. 2013
    ..e., executive function); with the relatively deleterious effects of the identified "A" risk allele on brain activity possibly constituting part of the mechanism by which CSMD1 increases schizophrenia risk...
  21. doi request reprint Influence of NOS1 on verbal intelligence and working memory in both patients with schizophrenia and healthy control subjects
    Gary Donohoe
    Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity Health Sciences Bldg, St James s Hospital, Dublin 8, Ireland
    Arch Gen Psychiatry 66:1045-54. 2009
    ..Human and animal studies have implicated the gene NOS1 in both cognition and schizophrenia susceptibility...
  22. doi request reprint Social cognition in bipolar disorder versus schizophrenia: comparability in mental state decoding deficits
    Gary Donohoe
    Neuropsychiatric Genetics Research Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland
    Bipolar Disord 14:743-8. 2012
    ....
  23. ncbi request reprint Do antisaccade deficits in schizophrenia provide evidence of a specific inhibitory function?
    Gary Donohoe
    Neuropsychiatric Genetics Research Group, Department of Psychiatry, and Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland
    J Int Neuropsychol Soc 12:901-6. 2006
    ..We investigated whether variance in antisaccade performance could be better accounted for in terms of a specific inhibitory function...
  24. ncbi request reprint Investigation of the apolipoprotein-L (APOL) gene family and schizophrenia using a novel DNA pooling strategy for public database SNPs
    Kevin A McGhee
    Neuropsychiatric Genetics Group, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, James Street, Dublin 8, Ireland
    Schizophr Res 76:231-8. 2005
    ..We found no evidence to support the hypothesis that genetic variation at the APOL genes contributes to SZ susceptibility in our sample...
  25. doi request reprint Social dysfunction in schizophrenia: an investigation of the GAF scale's sensitivity to deficits in social cognition
    Deirdre A Robertson
    Department of Psychiatry and Neuropsychiatric Genetics Research Group, School of Medicine and Trinity College Institute of Neuroscience, The Trinity Center, St James s Hospital, Dublin 8, Ireland
    Schizophr Res 146:363-5. 2013
    ..To investigate this, we assessed whether variation in GAF score was explained by performance on measures of neurocognitive and social cognition, particularly after variation associated with symptom severity had been accounted for...
  26. doi request reprint Allelic expression imbalance of the schizophrenia susceptibility gene CHI3L1: evidence of cis-acting variation and tissue specific regulation
    Matthew James Hill
    Neuropsychiatric Genetics Research Group, Trinity College Dublin, Institute of Molecular Medicine, Ireland
    Psychiatr Genet 21:281-6. 2011
    ..To identify cis-acting regulatory variants influencing the expression of the schizophrenia susceptibility gene chitinase 3-like 1 gene (CHI3L1) in human lymphoblasts and post-mortem brain tissue...
  27. pmc The psychosis susceptibility gene ZNF804A: associations, functions, and phenotypes
    Gary Donohoe
    Department of Psychiatry, Trinity College Dublin, Trinity Health Sciences Building, St James s Hospital, Dublin 8, Ireland
    Schizophr Bull 36:904-9. 2010
    ..We conclude that ZNF804A is robustly, if modestly, associated with schizophrenia risk, with much work still remaining to elucidate its role in schizophrenia biology...
  28. ncbi request reprint Evidence that specific executive functions predict symptom variance among schizophrenia patients with a predominantly negative symptom profile
    Gary Donohoe
    Trinity College, Dublin, Ireland
    Cogn Neuropsychiatry 11:13-32. 2006
    ..In particular, it was hoped that this approach could clarify whether negative and positive symptoms of schizophrenia are differentially related to particular aspects of executive/attentional functions...
  29. doi request reprint Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility
    C O'Dushlaine
    Department of Psychiatry, Trinity College Dublin, Dublin, Ireland
    Mol Psychiatry 16:286-92. 2011
    ..Similar pathways have also emerged from a pathway analysis of autism, suggesting that mechanisms involved in neuronal cell adhesion may contribute broadly to neurodevelopmental psychiatric phenotypes...
  30. doi request reprint A NOS1 variant implicated in cognitive performance influences evoked neural responses during a high density EEG study of early visual perception
    Therese O'Donoghue
    Neuropsychiatric Genetics Group and Department of Psychiatry, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, Dublin 8, Ireland
    Hum Brain Mapp 33:1202-11. 2012
    ..Whether this variant is also associated with variation in early sensory processing remains unclear...
  31. pmc Population structure and genome-wide patterns of variation in Ireland and Britain
    Colm T O'Dushlaine
    Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College, Dublin, Ireland
    Eur J Hum Genet 18:1248-54. 2010
    ..These results are consistent with our understanding of the population history of Europe and promote Ireland and Scotland as relatively homogenous resources for genetic mapping of rare variants...
  32. ncbi request reprint The SNP ratio test: pathway analysis of genome-wide association datasets
    Colm O'Dushlaine
    Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, Ireland
    Bioinformatics 25:2762-3. 2009
    ..We applied the SRT to a Parkinson's disease GWAS dataset, using the KEGG database, revealing significance for Parkinson's disease and related pathways...
  33. ncbi request reprint Variability in Working Memory Performance Explained by Epistasis vs Polygenic Scores in the ZNF804A Pathway
    Kristin K Nicodemus
    Neuropsychiatric Genetics Group, Department of Psychiatry, Trinity College Dublin, St James Hospital, Dublin, Ireland2Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland
    JAMA Psychiatry 71:778-85. 2014
    ..Of particular importance was the relative contribution of the polygenic score vs epistasis in variation explained...
  34. doi request reprint Effects of a novel schizophrenia risk variant rs7914558 at CNNM2 on brain structure and attributional style
    Emma Jane Rose
    Emma Jane Rose, PhD, Neuropsychiatric Genetics Group, Department of Psychiatry and Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland, and TSTPP MEGEH, RTI International, Baltimore, Maryland, USA April Hargreaves, MSc, Derek Morris, PhD, Ciara Fahey, MSc, Daniela Tropea, PhD, Elizabeth Cummings, MD, Neuropsychiatric Genetics Group, Department of Psychiatry, Trinity College Dublin, Ireland Carlo Caltagirone, MD, IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology and Department of Neuroscience, Tor Vergata University, Rome, Italy Paola Bossù, PhD, Chiara Chiapponi, PhD, Fabrizio Piras, PhD, Gianfranco Spalletta, MD, PhD, IRCCS Santa Lucia Foundation, Tsu National Hospital
    Br J Psychiatry 204:115-21. 2014
    ..A single nucleotide polymorphism (rs7914558) within the cyclin M2 (CNNM2) gene was recently identified as a common risk variant for schizophrenia. The mechanism by which CNNM2 confers risk is unknown...
  35. pmc An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis
    Derek W Morris
    Department of Psychiatry and Neuropsychiatric Genetics Research Group, Institute of Molecular Medicine, Trinity College Dublin, Dublin 2, Ireland
    Hum Mol Genet 23:3316-26. 2014
    ..We demonstrate that PAK7 is developmentally co-expressed with another known psychosis risk gene (DISC1) suggesting a potential molecular mechanism involving aberrant synapse development and plasticity...
  36. ncbi request reprint Genome-wide association studies: a primer
    A Corvin
    Department of Psychiatry, Trinity College Dublin, Dublin, Ireland
    Psychol Med 40:1063-77. 2010
    ..We dissect the GWAS methodology into its components and provide a brief description with citations and links to reviews that cover the topic in detail...
  37. ncbi request reprint Stage 2 of the Wellcome Trust UK-Irish bipolar affective disorder sibling-pair genome screen: evidence for linkage on chromosomes 6q16-q21, 4q12-q21, 9p21, 10p14-p12 and 18q22
    D Lambert
    Department of Genetics, Trinity College Dublin, Dublin, Republic of Ireland
    Mol Psychiatry 10:831-41. 2005
    ..Our scan also provides support for linkage (MLS> or =1.5) at several other regions that have been implicated in meta-analyses of bipolar disorder and/or schizophrenia including 9p21, 10p14-p12 and 18q22...
  38. pmc Genes predict village of origin in rural Europe
    Colm O'Dushlaine
    Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, Dublin, Ireland
    Eur J Hum Genet 18:1269-70. 2010
    ..After excluding close kin and inbreeding, village of origin could still be predicted correctly on the basis of genetic data for 89-100% of individuals...
  39. doi request reprint The Letter-Number Sequencing Test and its association with potential to work among people with psychotic illness
    A Murtagh
    St John of God Hospital Stillorgan, Dublin, Ireland
    Eur Psychiatry 25:101-4. 2010
    ..Letter-number sequencing may warrant further investigation as a clinically useful tool to inform decisions around vocational rehabilitation...
  40. ncbi request reprint Total serum cholesterol in relation to psychological correlates in parasuicide
    M Garland
    Department of Psychiatry, St Vincent s University Hospital, Dublin, Ireland
    Br J Psychiatry 177:77-83. 2000
    ..Low cholesterol may act as a peripheral marker for parasuicide...
  41. ncbi request reprint Sibling pairs with affective disorders: resemblance of demographic and clinical features
    E O'Mahony
    Department of Psychiatry, Trinity College Dublin and St James Hospital, Dublin, Republic of Ireland
    Psychol Med 32:55-61. 2002
    ..The aim of the study was to identify clinical characteristics that had a high degree of familiality...
  42. ncbi request reprint Dysbindin (DTNBP1) and the biogenesis of lysosome-related organelles complex 1 (BLOC-1): main and epistatic gene effects are potential contributors to schizophrenia susceptibility
    Derek W Morris
    Neuropsychiatric Genetics Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College, Dublin, Ireland
    Biol Psychiatry 63:24-31. 2008
    ....
  43. ncbi request reprint Variance in facial recognition performance associated with BDNF in schizophrenia
    Gary Donohoe
    Am J Med Genet B Neuropsychiatr Genet 144:578-9. 2007
  44. ncbi request reprint Bipolar affective puerperal psychosis: genome-wide significant evidence for linkage to chromosome 16
    Ian Jones
    Department of Psychological Medicine, Henry Wellcome Building, Wales School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN UK
    Am J Psychiatry 164:1099-104. 2007
    ..The authors conducted a search by systematic whole genome linkage scan for loci influencing vulnerability to bipolar affective puerperal psychosis...
  45. ncbi request reprint Genomewide linkage scan in schizoaffective disorder: significant evidence for linkage at 1q42 close to DISC1, and suggestive evidence at 22q11 and 19p13
    Marian L Hamshere
    Department of Psychological Medicine, School of Medicine, Cardiff University, Wales
    Arch Gen Psychiatry 62:1081-8. 2005
    ..However, twin data suggest that, in addition to genes with specificity for these phenotypes, there exist genes that simultaneously influence susceptibility to schizophrenia, bipolar disorder, and schizoaffective disorder...
  46. ncbi request reprint Psychiatric genetics in the post-genome age
    Aiden Corvin
    Br J Psychiatry 182:95-6. 2003
  47. ncbi request reprint Schizophrenia and velocardio-facial syndrome
    Aiden Corvin
    Lancet 360:721-2; author reply 722. 2002