Aiden Corvin

..We conclude that while impaired insight does appear to be associated with executive deficits, this association may not be specific but may instead relate to cognitive deficits more generally...

..We discuss these findings in terms of the accumulating evidence that mental state decoding has particular relevance for understanding deficits in social function in schizophrenia...

..Despite the substantial heritability of the psychoses and their genuine public health burden, the applicability of the genomic approach in psychiatry has been strongly questioned or prematurely dismissed...

..Finally, we review the analysis of whole-genome DNA sequence data and the challenges that this will bring for cognitive genomics research...

..0% vs 13.5%; P=0.036). Interestingly, this refined 'at-risk' haplotype is positioned close to an EST cluster of unknown function (Hs.97362) within intron 1 of NRG1...

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..004), with a trend for higher negative symptom scores. This suggests that risk variation at the dysbindin gene may contribute to a more prototypical SZ presentation with less severe excitement/manic symptoms and more negative symptoms...

..3 (1.4, 60.5). Based on these data, more systematic investigation of genes involved in DAO signaling is required...

..This has radical implications for clinical practice, as diagnosis and treatment will be guided by molecular etiology rather than clinical diagnostic criteria...

..02, d.f.=2, p=0.01). These data suggest a potential role for DAO in susceptibility to depressive symptoms in schizophrenia, but a more general role for DAO in affective disorders cannot be excluded...

..An association exists between smoking and schizophrenia, independent of other factors and related to psychotic symptomatology...

..Our study suggests that the increased risk for schizophrenia associated with dysbindin may be partly mediated by its influence on pre-frontal function...

..In particular, the preservation of higher executive function may influence the ability to initiate and plan suicidal behaviour...

..Schizophrenia is associated with both global and specific cognitive deficits. We sought to investigate whether deficits in executive subcomponents differed in their relationship to global cognitive impairments...

..This study highlights the importance of relationship style and neuropsychological performance for different aspects of attributional style in schizophrenia...

..Gene expression data and association analyses in two Chinese samples implicate chitinase 3-like 1 (CHI3L1), a cellular survival gene, in schizophrenia susceptibility...

..Human and animal studies have implicated the gene NOS1 in both cognition and schizophrenia susceptibility...

..We investigated whether variance in antisaccade performance could be better accounted for in terms of a specific inhibitory function...

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..To identify cis-acting regulatory variants influencing the expression of the schizophrenia susceptibility gene chitinase 3-like 1 gene (CHI3L1) in human lymphoblasts and post-mortem brain tissue...

..We conclude that ZNF804A is robustly, if modestly, associated with schizophrenia risk, with much work still remaining to elucidate its role in schizophrenia biology...

..We found no evidence to support the hypothesis that genetic variation at the APOL genes contributes to SZ susceptibility in our sample...

..In particular, it was hoped that this approach could clarify whether negative and positive symptoms of schizophrenia are differentially related to particular aspects of executive/attentional functions...

..Similar pathways have also emerged from a pathway analysis of autism, suggesting that mechanisms involved in neuronal cell adhesion may contribute broadly to neurodevelopmental psychiatric phenotypes...

..Whether this variant is also associated with variation in early sensory processing remains unclear...

..We applied the SRT to a Parkinson's disease GWAS dataset, using the KEGG database, revealing significance for Parkinson's disease and related pathways. AVAILABILITY: https://sourceforge.net/projects/snpratiotest/..

..These results are consistent with our understanding of the population history of Europe and promote Ireland and Scotland as relatively homogenous resources for genetic mapping of rare variants...

..To investigate this, we assessed whether variation in GAF score was explained by performance on measures of neurocognitive and social cognition, particularly after variation associated with symptom severity had been accounted for...

..Our scan also provides support for linkage (MLS> or =1.5) at several other regions that have been implicated in meta-analyses of bipolar disorder and/or schizophrenia including 9p21, 10p14-p12 and 18q22...

..We dissect the GWAS methodology into its components and provide a brief description with citations and links to reviews that cover the topic in detail...

..After excluding close kin and inbreeding, village of origin could still be predicted correctly on the basis of genetic data for 89-100% of individuals...

..Letter-number sequencing may warrant further investigation as a clinically useful tool to inform decisions around vocational rehabilitation...

..Low cholesterol may act as a peripheral marker for parasuicide...

..Further research may establish the extent to which these findings are mediated by genetic and/or environmental factors...

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..The authors conducted a search by systematic whole genome linkage scan for loci influencing vulnerability to bipolar affective puerperal psychosis...

..Our results provide strong support for a model of schizophrenia pathogenesis that includes the effects of multiple rare structural variants, both genome-wide and at specific loci...

..Follow-up of this region should use samples enriched for cases of schizoaffective disorder. Our findings have similar implications for the search for genetic variation on chromosome 22q11 that influences susceptibility to psychosis...