Naomi Chadderton

Summary

Affiliation: Trinity College
Country: Ireland

Publications

  1. pmc Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy
    Naomi Chadderton
    School of Genetics and Microbiology, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland
    Eur J Hum Genet 21:62-8. 2013
  2. pmc Improved retinal function in a mouse model of dominant retinitis pigmentosa following AAV-delivered gene therapy
    Naomi Chadderton
    Department of Genetics, Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland
    Mol Ther 17:593-9. 2009
  3. doi request reprint Adeno-associated virus-mediated rhodopsin replacement provides therapeutic benefit in mice with a targeted disruption of the rhodopsin gene
    Arpad Palfi
    Department of Genetics, Trinity College Dublin, Dublin 2, Ireland
    Hum Gene Ther 21:311-23. 2010
  4. pmc RNA interference-mediated suppression and replacement of human rhodopsin in vivo
    Mary O'Reilly
    Smurfit Institute of Genetics, Trinity College, Dublin, Ireland
    Am J Hum Genet 81:127-35. 2007
  5. doi request reprint Efficacy of codelivery of dual AAV2/5 vectors in the murine retina and hippocampus
    Arpad Palfi
    Department of Genetics, Trinity College Dublin, Dublin 2, Ireland
    Hum Gene Ther 23:847-58. 2012
  6. doi request reprint Protection of photoreceptors in a mouse model of RP10
    Lawrence C S Tam
    Department of Genetics, Trinity College Dublin, Dublin 2, Ireland
    Adv Exp Med Biol 664:559-65. 2010
  7. doi request reprint Therapeutic benefit derived from RNAi-mediated ablation of IMPDH1 transcripts in a murine model of autosomal dominant retinitis pigmentosa (RP10)
    Lawrence C S Tam
    The Ocular Genetics Unit, Department of Genetics, Trinity College Dublin, Dublin 2, Ireland
    Hum Mol Genet 17:2084-100. 2008
  8. pmc Suppression and replacement gene therapy for autosomal dominant disease in a murine model of dominant retinitis pigmentosa
    Sophia Millington-Ward
    Department of Genetics, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland
    Mol Ther 19:642-9. 2011
  9. ncbi request reprint A transgenic mouse model for gene therapy of rhodopsin-linked Retinitis Pigmentosa
    Mary O'Reilly
    Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland
    Vision Res 48:386-91. 2008
  10. doi request reprint AAV-mediated chronic over-expression of SNAP-25 in adult rat dorsal hippocampus impairs memory-associated synaptic plasticity
    Alex G McKee
    Applied Neurotherapeutics Research Group, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland
    J Neurochem 112:991-1004. 2010

Collaborators

Detail Information

Publications11

  1. pmc Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy
    Naomi Chadderton
    School of Genetics and Microbiology, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland
    Eur J Hum Genet 21:62-8. 2013
    ..Intraocular injection of AAV-NDI1 overcomes many barriers previously associated with developing therapies for LHON and holds great therapeutic promise for a mitochondrial disorder for which there are no effective therapies...
  2. pmc Improved retinal function in a mouse model of dominant retinitis pigmentosa following AAV-delivered gene therapy
    Naomi Chadderton
    Department of Genetics, Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland
    Mol Ther 17:593-9. 2009
    ..The results demonstrate that RNAi-based mutation-independent suppression and replacement can provide benefit for RHO-adRP and promote the therapeutic approach as potentially beneficial for other autosomal dominantly inherited disorders...
  3. doi request reprint Adeno-associated virus-mediated rhodopsin replacement provides therapeutic benefit in mice with a targeted disruption of the rhodopsin gene
    Arpad Palfi
    Department of Genetics, Trinity College Dublin, Dublin 2, Ireland
    Hum Gene Ther 21:311-23. 2010
    ....
  4. pmc RNA interference-mediated suppression and replacement of human rhodopsin in vivo
    Mary O'Reilly
    Smurfit Institute of Genetics, Trinity College, Dublin, Ireland
    Am J Hum Genet 81:127-35. 2007
    ..Results provide the first in vivo indication that suppression and replacement can provide a therapeutic solution for dominantly inherited disorders such as RHO-linked RP and can be employed to circumvent mutational heterogeneity...
  5. doi request reprint Efficacy of codelivery of dual AAV2/5 vectors in the murine retina and hippocampus
    Arpad Palfi
    Department of Genetics, Trinity College Dublin, Dublin 2, Ireland
    Hum Gene Ther 23:847-58. 2012
    ..The study suggests that codelivery of AAV is an efficient means of expanding the therapeutic application of AAV in neurons...
  6. doi request reprint Protection of photoreceptors in a mouse model of RP10
    Lawrence C S Tam
    Department of Genetics, Trinity College Dublin, Dublin 2, Ireland
    Adv Exp Med Biol 664:559-65. 2010
    ..Here, we report that the use of rAAV2/5 vectors expressing shRNA targeting mutant IMPDH1 prevents photoreceptor degeneration, and preserves synaptic connectivity in a mouse model of RP10...
  7. doi request reprint Therapeutic benefit derived from RNAi-mediated ablation of IMPDH1 transcripts in a murine model of autosomal dominant retinitis pigmentosa (RP10)
    Lawrence C S Tam
    The Ocular Genetics Unit, Department of Genetics, Trinity College Dublin, Dublin 2, Ireland
    Hum Mol Genet 17:2084-100. 2008
    ..These data strongly suggest that an RNAi-mediated approach to therapy for RP10 holds considerable promise for human subjects...
  8. pmc Suppression and replacement gene therapy for autosomal dominant disease in a murine model of dominant retinitis pigmentosa
    Sophia Millington-Ward
    Department of Genetics, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland
    Mol Ther 19:642-9. 2011
    ..Additionally, dual-vector delivery of combined therapeutics represents an exciting approach, which is potentially applicable to other inherited disorders...
  9. ncbi request reprint A transgenic mouse model for gene therapy of rhodopsin-linked Retinitis Pigmentosa
    Mary O'Reilly
    Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland
    Vision Res 48:386-91. 2008
    ..Suppression and replacement, while exemplified by adRP, may also be relevant to many other dominantly inherited diseases with the hallmark of mutational heterogeneity...
  10. doi request reprint AAV-mediated chronic over-expression of SNAP-25 in adult rat dorsal hippocampus impairs memory-associated synaptic plasticity
    Alex G McKee
    Applied Neurotherapeutics Research Group, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland
    J Neurochem 112:991-1004. 2010
    ..Together these studies provide the first evidence that excess SNAP-25 activity, restricted to the adult period, is sufficient to mediate significant deficits in the memory formation process...
  11. doi request reprint Mitochondrial disorders: aetiologies, models systems, and candidate therapies
    G Jane Farrar
    Smurfit Institute of Genetics, School of Genetics and Microbiology, Trinity College Dublin, Dublin 2, Ireland Electronic address
    Trends Genet 29:488-97. 2013
    ..Key advances in these areas are outlined in this review, with a focus on Leber hereditary optic neuropathy (LHON). This exciting field is set to grow exponentially and yield many candidate therapies to treat this class of disease. ..