Naomi Chadderton

Summary

Affiliation: Trinity College
Country: Ireland

Publications

  1. pmc Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy
    Naomi Chadderton
    School of Genetics and Microbiology, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland
    Eur J Hum Genet 21:62-8. 2013
  2. pmc Improved retinal function in a mouse model of dominant retinitis pigmentosa following AAV-delivered gene therapy
    Naomi Chadderton
    Department of Genetics, Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland
    Mol Ther 17:593-9. 2009
  3. doi request reprint Adeno-associated virus-mediated rhodopsin replacement provides therapeutic benefit in mice with a targeted disruption of the rhodopsin gene
    Arpad Palfi
    Department of Genetics, Trinity College Dublin, Dublin 2, Ireland
    Hum Gene Ther 21:311-23. 2010
  4. pmc RNA interference-mediated suppression and replacement of human rhodopsin in vivo
    Mary O'Reilly
    Smurfit Institute of Genetics, Trinity College, Dublin, Ireland
    Am J Hum Genet 81:127-35. 2007
  5. doi request reprint Efficacy of codelivery of dual AAV2/5 vectors in the murine retina and hippocampus
    Arpad Palfi
    Department of Genetics, Trinity College Dublin, Dublin 2, Ireland
    Hum Gene Ther 23:847-58. 2012
  6. doi request reprint Therapeutic benefit derived from RNAi-mediated ablation of IMPDH1 transcripts in a murine model of autosomal dominant retinitis pigmentosa (RP10)
    Lawrence C S Tam
    The Ocular Genetics Unit, Department of Genetics, Trinity College Dublin, Dublin 2, Ireland
    Hum Mol Genet 17:2084-100. 2008
  7. doi request reprint Protection of photoreceptors in a mouse model of RP10
    Lawrence C S Tam
    Department of Genetics, Trinity College Dublin, Dublin 2, Ireland
    Adv Exp Med Biol 664:559-65. 2010
  8. pmc Suppression and replacement gene therapy for autosomal dominant disease in a murine model of dominant retinitis pigmentosa
    Sophia Millington-Ward
    Department of Genetics, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland
    Mol Ther 19:642-9. 2011
  9. ncbi request reprint A transgenic mouse model for gene therapy of rhodopsin-linked Retinitis Pigmentosa
    Mary O'Reilly
    Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland
    Vision Res 48:386-91. 2008
  10. doi request reprint AAV-mediated chronic over-expression of SNAP-25 in adult rat dorsal hippocampus impairs memory-associated synaptic plasticity
    Alex G McKee
    Applied Neurotherapeutics Research Group, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland
    J Neurochem 112:991-1004. 2010

Collaborators

Detail Information

Publications12

  1. pmc Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy
    Naomi Chadderton
    School of Genetics and Microbiology, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland
    Eur J Hum Genet 21:62-8. 2013
    ..Intraocular injection of AAV-NDI1 overcomes many barriers previously associated with developing therapies for LHON and holds great therapeutic promise for a mitochondrial disorder for which there are no effective therapies...
  2. pmc Improved retinal function in a mouse model of dominant retinitis pigmentosa following AAV-delivered gene therapy
    Naomi Chadderton
    Department of Genetics, Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland
    Mol Ther 17:593-9. 2009
    ..The results demonstrate that RNAi-based mutation-independent suppression and replacement can provide benefit for RHO-adRP and promote the therapeutic approach as potentially beneficial for other autosomal dominantly inherited disorders...
  3. doi request reprint Adeno-associated virus-mediated rhodopsin replacement provides therapeutic benefit in mice with a targeted disruption of the rhodopsin gene
    Arpad Palfi
    Department of Genetics, Trinity College Dublin, Dublin 2, Ireland
    Hum Gene Ther 21:311-23. 2010
    ....
  4. pmc RNA interference-mediated suppression and replacement of human rhodopsin in vivo
    Mary O'Reilly
    Smurfit Institute of Genetics, Trinity College, Dublin, Ireland
    Am J Hum Genet 81:127-35. 2007
    ..Results provide the first in vivo indication that suppression and replacement can provide a therapeutic solution for dominantly inherited disorders such as RHO-linked RP and can be employed to circumvent mutational heterogeneity...
  5. doi request reprint Efficacy of codelivery of dual AAV2/5 vectors in the murine retina and hippocampus
    Arpad Palfi
    Department of Genetics, Trinity College Dublin, Dublin 2, Ireland
    Hum Gene Ther 23:847-58. 2012
    ..The study suggests that codelivery of AAV is an efficient means of expanding the therapeutic application of AAV in neurons...
  6. doi request reprint Therapeutic benefit derived from RNAi-mediated ablation of IMPDH1 transcripts in a murine model of autosomal dominant retinitis pigmentosa (RP10)
    Lawrence C S Tam
    The Ocular Genetics Unit, Department of Genetics, Trinity College Dublin, Dublin 2, Ireland
    Hum Mol Genet 17:2084-100. 2008
    ..These data strongly suggest that an RNAi-mediated approach to therapy for RP10 holds considerable promise for human subjects...
  7. doi request reprint Protection of photoreceptors in a mouse model of RP10
    Lawrence C S Tam
    Department of Genetics, Trinity College Dublin, Dublin 2, Ireland
    Adv Exp Med Biol 664:559-65. 2010
    ..Here, we report that the use of rAAV2/5 vectors expressing shRNA targeting mutant IMPDH1 prevents photoreceptor degeneration, and preserves synaptic connectivity in a mouse model of RP10...
  8. pmc Suppression and replacement gene therapy for autosomal dominant disease in a murine model of dominant retinitis pigmentosa
    Sophia Millington-Ward
    Department of Genetics, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland
    Mol Ther 19:642-9. 2011
    ..Additionally, dual-vector delivery of combined therapeutics represents an exciting approach, which is potentially applicable to other inherited disorders...
  9. ncbi request reprint A transgenic mouse model for gene therapy of rhodopsin-linked Retinitis Pigmentosa
    Mary O'Reilly
    Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland
    Vision Res 48:386-91. 2008
    ..Suppression and replacement, while exemplified by adRP, may also be relevant to many other dominantly inherited diseases with the hallmark of mutational heterogeneity...
  10. doi request reprint AAV-mediated chronic over-expression of SNAP-25 in adult rat dorsal hippocampus impairs memory-associated synaptic plasticity
    Alex G McKee
    Applied Neurotherapeutics Research Group, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland
    J Neurochem 112:991-1004. 2010
    ..Together these studies provide the first evidence that excess SNAP-25 activity, restricted to the adult period, is sufficient to mediate significant deficits in the memory formation process...
  11. doi request reprint Mitochondrial disorders: aetiologies, models systems, and candidate therapies
    G Jane Farrar
    Smurfit Institute of Genetics, School of Genetics and Microbiology, Trinity College Dublin, Dublin 2, Ireland
    Trends Genet 29:488-97. 2013
    ..Key advances in these areas are outlined in this review, with a focus on Leber hereditary optic neuropathy (LHON). This exciting field is set to grow exponentially and yield many candidate therapies to treat this class of disease. ..
  12. doi request reprint CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression
    Chris M Egan
    The Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland
    Dev Cell 26:223-36. 2013
    ..These findings provide insights into the regulatory role of CHD5 during neurogenesis and suggest how inactivation of this candidate tumor suppressor might contribute to neuroblastoma...