Mary Clare Cathcart

Summary

Affiliation: Trinity College
Country: Ireland

Publications

  1. pmc Examination of thromboxane synthase as a prognostic factor and therapeutic target in non-small cell lung cancer
    Mary Clare Cathcart
    Department of Surgery, Institute of Molecular Medicine, Trinity Health Sciences Centre, St James s Hospital, Dublin 8, Ireland
    Mol Cancer 10:25. 2011
  2. ncbi request reprint Thromboxane synthase expression and correlation with VEGF and angiogenesis in non-small cell lung cancer
    Mary Clare Cathcart
    Department of Surgery, Institute of Molecular Medicine, Trinity Health Sciences Centre, St James s Hospital, Dublin 8, Ireland Electronic address
    Biochim Biophys Acta 1842:747-55. 2014
  3. doi request reprint COX-derived prostanoid pathways in gastrointestinal cancer development and progression: novel targets for prevention and intervention
    Mary Clare Cathcart
    Department of Surgery, Institute of Molecular Medicine, Trinity Health Sciences Centre, St James s Hospital, Dublin 8, Ireland
    Biochim Biophys Acta 1825:49-63. 2012
  4. doi request reprint Cyclooxygenase-2-linked attenuation of hypoxia-induced pulmonary hypertension and intravascular thrombosis
    Mary Clare Cathcart
    Department of Molecular and Cellular Therapeutics, Royal College of Surgeons Ireland, Dublin, Ireland
    J Pharmacol Exp Ther 326:51-8. 2008
  5. doi request reprint The role of prostacyclin synthase and thromboxane synthase signaling in the development and progression of cancer
    Mary Clare Cathcart
    Department of Surgery, Trinity Health Sciences Centre, St James s Hospital, Dublin 8, Ireland
    Biochim Biophys Acta 1805:153-66. 2010
  6. doi request reprint Eicosanoid signalling pathways in the development and progression of colorectal cancer: novel approaches for prevention/intervention
    Mary Clare Cathcart
    Department of Surgery, Institute of Molecular Medicine, Trinity Health Sciences Centre, St James s Hospital, Trinity College Dublin, Dublin 8, Ireland
    Cancer Metastasis Rev 30:363-85. 2011
  7. doi request reprint Prostacyclin synthase expression and epigenetic regulation in nonsmall cell lung cancer
    Mary Clare Cathcart
    Department of Clinical Medicine, Translational Cancer Research Group, Institute of Molecular Medicine, Trinity Centre for Health Sciences, St James Hospital, Dublin, Ireland
    Cancer 117:5121-32. 2011
  8. doi request reprint MMP9 expression in oesophageal adenocarcinoma is upregulated with visceral obesity and is associated with poor tumour differentiation
    Emma H Allott
    Department of Surgery, Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland
    Mol Carcinog 52:144-54. 2013
  9. doi request reprint Regulation of EP receptors in non-small cell lung cancer by epigenetic modifications
    Steven G Gray
    Dept of Clinical Medicine, Thoracic Oncology Research Group, Institute of Molecular Medicine, Trinity Centre for Health Sciences, St James s Hospital, Dublin 8, Ireland
    Eur J Cancer 45:3087-97. 2009

Collaborators

Detail Information

Publications9

  1. pmc Examination of thromboxane synthase as a prognostic factor and therapeutic target in non-small cell lung cancer
    Mary Clare Cathcart
    Department of Surgery, Institute of Molecular Medicine, Trinity Health Sciences Centre, St James s Hospital, Dublin 8, Ireland
    Mol Cancer 10:25. 2011
    ..TXS inhibition induces cell death in-vitro, providing a rationale for therapeutic intervention. We aimed to determine the expression profile of TXS in NSCLC and if it is prognostic and/or a survival factor in the disease...
  2. ncbi request reprint Thromboxane synthase expression and correlation with VEGF and angiogenesis in non-small cell lung cancer
    Mary Clare Cathcart
    Department of Surgery, Institute of Molecular Medicine, Trinity Health Sciences Centre, St James s Hospital, Dublin 8, Ireland Electronic address
    Biochim Biophys Acta 1842:747-55. 2014
    ..TXS has been identified as a potential therapeutic target in NSCLC. This study examines a link between TXS expression, angiogenesis, and survival in NSCLC...
  3. doi request reprint COX-derived prostanoid pathways in gastrointestinal cancer development and progression: novel targets for prevention and intervention
    Mary Clare Cathcart
    Department of Surgery, Institute of Molecular Medicine, Trinity Health Sciences Centre, St James s Hospital, Dublin 8, Ireland
    Biochim Biophys Acta 1825:49-63. 2012
    ..I. cancers will also be discussed. Finally, we will highlight the latest pre-clinical technologies as well as avenues for future investigation in this highly topical research field...
  4. doi request reprint Cyclooxygenase-2-linked attenuation of hypoxia-induced pulmonary hypertension and intravascular thrombosis
    Mary Clare Cathcart
    Department of Molecular and Cellular Therapeutics, Royal College of Surgeons Ireland, Dublin, Ireland
    J Pharmacol Exp Ther 326:51-8. 2008
    ..The data provide evidence that endogenous prostaglandins modulate the pulmonary response to hypoxia...
  5. doi request reprint The role of prostacyclin synthase and thromboxane synthase signaling in the development and progression of cancer
    Mary Clare Cathcart
    Department of Surgery, Trinity Health Sciences Centre, St James s Hospital, Dublin 8, Ireland
    Biochim Biophys Acta 1805:153-66. 2010
    ..Finally, we discuss current therapeutic strategies aimed at targeting these enzymes for the prevention/treatment of cancer...
  6. doi request reprint Eicosanoid signalling pathways in the development and progression of colorectal cancer: novel approaches for prevention/intervention
    Mary Clare Cathcart
    Department of Surgery, Institute of Molecular Medicine, Trinity Health Sciences Centre, St James s Hospital, Trinity College Dublin, Dublin 8, Ireland
    Cancer Metastasis Rev 30:363-85. 2011
    ..Finally, novel approaches targeting these arachidonic acid-derived eicosanoids (using pharmacological or natural agents) for chemoprevention and/or treatment of colorectal cancer are outlined...
  7. doi request reprint Prostacyclin synthase expression and epigenetic regulation in nonsmall cell lung cancer
    Mary Clare Cathcart
    Department of Clinical Medicine, Translational Cancer Research Group, Institute of Molecular Medicine, Trinity Centre for Health Sciences, St James Hospital, Dublin, Ireland
    Cancer 117:5121-32. 2011
    ..Prostacyclin synthase (PGIS) metabolizes prostaglandin H(2), into prostacyclin. This study aimed to determine the expression profile of PGIS in nonsmall cell lung cancer (NSCLC) and examine potential mechanisms involved in PGIS regulation...
  8. doi request reprint MMP9 expression in oesophageal adenocarcinoma is upregulated with visceral obesity and is associated with poor tumour differentiation
    Emma H Allott
    Department of Surgery, Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland
    Mol Carcinog 52:144-54. 2013
    ....
  9. doi request reprint Regulation of EP receptors in non-small cell lung cancer by epigenetic modifications
    Steven G Gray
    Dept of Clinical Medicine, Thoracic Oncology Research Group, Institute of Molecular Medicine, Trinity Centre for Health Sciences, St James s Hospital, Dublin 8, Ireland
    Eur J Cancer 45:3087-97. 2009
    ..PGE(2) exerts its effects through the E prostanoid (EP) receptors (EPs1-4)...