Martin Caffrey

Summary

Affiliation: Trinity College
Country: Ireland

Publications

  1. pmc Membrane protein structure determination using crystallography and lipidic mesophases: recent advances and successes
    Martin Caffrey
    Membrane Structural and Functional Biology Group, School of Medicine and School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    Biochemistry 51:6266-88. 2012
  2. pmc Crystallizing membrane proteins for structure-function studies using lipidic mesophases
    Martin Caffrey
    Membrane Structural and Functional Biology Group, School of Biochemistry and Immunology, and School of Medicine, Trinity College Dublin, Ireland
    Biochem Soc Trans 39:725-32. 2011
  3. pmc Crystal structure of the integral membrane diacylglycerol kinase
    Dianfan Li
    School of Biochemistry and Immunology and School of Medicine, Trinity College Dublin, Dublin 2, Ireland
    Nature 497:521-4. 2013
  4. pmc Crystallizing transmembrane peptides in lipidic mesophases
    Nicole Höfer
    Membrane Structural and Functional Biology Group, School of Biochemistry and Immunology, and School of Medicine, Trinity College, Dublin, Ireland
    Biophys J 99:L23-5. 2010
  5. pmc Lipid cubic phase as a membrane mimetic for integral membrane protein enzymes
    Dianfan Li
    Schools of Medicine and Biochemistry and Immunology, Trinity College, Dublin, Ireland
    Proc Natl Acad Sci U S A 108:8639-44. 2011
  6. pmc Crystallizing membrane proteins using lipidic mesophases
    Martin Caffrey
    Membrane Structural and Functional Biology Group, University of Limerick, Limerick, Ireland
    Nat Protoc 4:706-31. 2009

Collaborators

Detail Information

Publications6

  1. pmc Membrane protein structure determination using crystallography and lipidic mesophases: recent advances and successes
    Martin Caffrey
    Membrane Structural and Functional Biology Group, School of Medicine and School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    Biochemistry 51:6266-88. 2012
    ..In this work, these assorted advances are outlined along with a summary of the membrane proteins that have yielded to the method. The prospects for and the challenges that must be overcome to further develop the method are described...
  2. pmc Crystallizing membrane proteins for structure-function studies using lipidic mesophases
    Martin Caffrey
    Membrane Structural and Functional Biology Group, School of Biochemistry and Immunology, and School of Medicine, Trinity College Dublin, Ireland
    Biochem Soc Trans 39:725-32. 2011
    ..In the present article, these assorted advances are outlined, along with a summary of the membrane proteins that have yielded to the method. The challenges that must be overcome to develop the method further are described...
  3. pmc Crystal structure of the integral membrane diacylglycerol kinase
    Dianfan Li
    School of Biochemistry and Immunology and School of Medicine, Trinity College Dublin, Dublin 2, Ireland
    Nature 497:521-4. 2013
    ..They are, however, at variance with a published solution NMR model in that domain swapping, a key feature of the solution form, is not observed in the crystal structures...
  4. pmc Crystallizing transmembrane peptides in lipidic mesophases
    Nicole Höfer
    Membrane Structural and Functional Biology Group, School of Biochemistry and Immunology, and School of Medicine, Trinity College, Dublin, Ireland
    Biophys J 99:L23-5. 2010
    ..This result suggests that the in meso method should be considered as a viable means for high-resolution structure determination of integral membrane peptides, many of which are predicted to be coded for in the human genome...
  5. pmc Lipid cubic phase as a membrane mimetic for integral membrane protein enzymes
    Dianfan Li
    Schools of Medicine and Biochemistry and Immunology, Trinity College, Dublin, Ireland
    Proc Natl Acad Sci U S A 108:8639-44. 2011
    ..Because of its open, bicontinuous nature, the cubic phase offers the added benefit that the protein is accessible for assay from both sides of the membrane...
  6. pmc Crystallizing membrane proteins using lipidic mesophases
    Martin Caffrey
    Membrane Structural and Functional Biology Group, University of Limerick, Limerick, Ireland
    Nat Protoc 4:706-31. 2009
    ..Methods for harvesting microcrystals are also described. The time required to prepare the protein-loaded mesophase and to set up a crystallization plate manually is about 1 h...