Elizabeth K Brint

Summary

Affiliation: Trinity College
Country: Ireland

Publications

  1. ncbi Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2. A role for Jun N-terminal kinase in IL-4 induction
    Elizabeth K Brint
    Cytokine Research Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Biol Chem 277:49205-11. 2002
  2. ncbi ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance
    Elizabeth K Brint
    Department of Biochemistry, Trinity College, Dublin 2, Ireland
    Nat Immunol 5:373-9. 2004
  3. ncbi Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling
    Anne F McGettrick
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Proc Natl Acad Sci U S A 103:9196-201. 2006
  4. ncbi Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL
    Javed A Khan
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Biol Chem 279:31664-70. 2004
  5. ncbi Negative regulation of toll-like receptor-mediated immune responses
    Foo Y Liew
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow G11 6NT, UK
    Nat Rev Immunol 5:446-58. 2005

Detail Information

Publications5

  1. ncbi Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2. A role for Jun N-terminal kinase in IL-4 induction
    Elizabeth K Brint
    Cytokine Research Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Biol Chem 277:49205-11. 2002
    ....
  2. ncbi ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance
    Elizabeth K Brint
    Department of Biochemistry, Trinity College, Dublin 2, Ireland
    Nat Immunol 5:373-9. 2004
    ..Thus, these results provide a molecular explanation for the function of ST2 in T(H)2 responses, as inhibition of TLRs promotes a T(H)2 response, and also identify ST2 as a key regulator of endotoxin tolerance...
  3. ncbi Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling
    Anne F McGettrick
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Proc Natl Acad Sci U S A 103:9196-201. 2006
    ..We have therefore uncovered a key process in Toll-like receptor 4 signaling, identifying TRAM as the target for PKCepsilon...
  4. ncbi Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL
    Javed A Khan
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Biol Chem 279:31664-70. 2004
    ..Deletion mutagenesis studies show that the activation of JNK by IL-1RAPL does not depend on the integrity of its TIR domain, suggesting a distinct mechanism of signaling through this receptor...
  5. ncbi Negative regulation of toll-like receptor-mediated immune responses
    Foo Y Liew
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow G11 6NT, UK
    Nat Rev Immunol 5:446-58. 2005
    ..Here, we discuss the various negative regulatory mechanisms that have evolved to attenuate TLR signalling to maintain this immunological balance...