A G Bowie

Summary

Affiliation: Trinity College
Country: Ireland

Publications

  1. pmc Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence
    Julianne Stack
    Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Exp Med 201:1007-18. 2005
  2. pmc The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense
    Mary T Harte
    The Cytokine Research Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Exp Med 197:343-51. 2003
  3. pmc Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7
    Leonie Unterholzner
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    PLoS Pathog 7:e1002247. 2011
  4. doi request reprint Removing the TREX1 safety net: oxidized DNA overcomes immune silencing by exonuclease TREX1
    Andrew G Bowie
    School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland Electronic address
    Immunity 39:423-5. 2013
  5. pmc Neuronal Toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro
    Sophie Leow-Dyke
    Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK
    J Neuroinflammation 9:230. 2012
  6. doi request reprint The STING in the tail for cytosolic DNA-dependent activation of IRF3
    Andrew Bowie
    Immunology Research Centre, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
    Sci Signal 5:pe9. 2012
  7. pmc Translational mini-review series on Toll-like receptors: recent advances in understanding the role of Toll-like receptors in anti-viral immunity
    A G Bowie
    School of Biochemistry and Immunology, Trinity College Dublin, Ireland
    Clin Exp Immunol 147:217-26. 2007
  8. doi request reprint TRIM-ing down Tolls
    Andrew G Bowie
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Nat Immunol 9:348-50. 2008
  9. doi request reprint Viral evasion and subversion of pattern-recognition receptor signalling
    Andrew G Bowie
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Nat Rev Immunol 8:911-22. 2008
  10. ncbi request reprint Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries
    A Bowie
    Department of Biochemistry, Trinity College, Dublin, Ireland
    Biochem Pharmacol 59:13-23. 2000

Collaborators

Detail Information

Publications42

  1. pmc Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence
    Julianne Stack
    Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Exp Med 201:1007-18. 2005
    ..Importantly, VV lacking the A46R gene was attenuated in a murine intranasal model, demonstrating the importance of A46R for VV virulence...
  2. pmc The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense
    Mary T Harte
    The Cytokine Research Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Exp Med 197:343-51. 2003
    ..This study reveals a novel mechanism used by VV to suppress the host immunity. We demonstrate viral disabling of TLRs, providing further evidence for an important role for this family of receptors in the antiviral response...
  3. pmc Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7
    Leonie Unterholzner
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    PLoS Pathog 7:e1002247. 2011
    ..Thus C6 contributes to VACV virulence and might do so via the inhibition of PRR-induced activation of IRF3 and IRF7...
  4. doi request reprint Removing the TREX1 safety net: oxidized DNA overcomes immune silencing by exonuclease TREX1
    Andrew G Bowie
    School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland Electronic address
    Immunity 39:423-5. 2013
    ..In this issue of Immunity, Gehrke et al. (2013) show that oxidized DNA is resistant to degradation by TREX1 and thus has heightened immunostimulatory capacity. ..
  5. pmc Neuronal Toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro
    Sophie Leow-Dyke
    Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK
    J Neuroinflammation 9:230. 2012
    ..Although neurons have been reported to express TLR4, the function of TLR4 activation in neurons remains unknown...
  6. doi request reprint The STING in the tail for cytosolic DNA-dependent activation of IRF3
    Andrew Bowie
    Immunology Research Centre, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
    Sci Signal 5:pe9. 2012
    ..Thus, STING directs TBK1 to activate IRF3 in DNA-sensing pathways...
  7. pmc Translational mini-review series on Toll-like receptors: recent advances in understanding the role of Toll-like receptors in anti-viral immunity
    A G Bowie
    School of Biochemistry and Immunology, Trinity College Dublin, Ireland
    Clin Exp Immunol 147:217-26. 2007
    ....
  8. doi request reprint TRIM-ing down Tolls
    Andrew G Bowie
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Nat Immunol 9:348-50. 2008
  9. doi request reprint Viral evasion and subversion of pattern-recognition receptor signalling
    Andrew G Bowie
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Nat Rev Immunol 8:911-22. 2008
    ....
  10. ncbi request reprint Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries
    A Bowie
    Department of Biochemistry, Trinity College, Dublin, Ireland
    Biochem Pharmacol 59:13-23. 2000
    ..In future, when a role for oxidative stress in a pathway is postulated, the challenge will be to show which particular kinases or adaptor molecules, if any, are redox-modulated...
  11. ncbi request reprint Vitamin C inhibits NF-kappa B activation by TNF via the activation of p38 mitogen-activated protein kinase
    A G Bowie
    Department of Biochemistry, Trinity College, Dublin, Ireland
    J Immunol 165:7180-8. 2000
    ..The results identify p38 as an intracellular target for high dose vitamin C...
  12. pmc A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling
    A Bowie
    Department of Biochemistry and National Pharmaceutical Biotechnology Centre, Trinity College, Dublin 2, Ireland
    Proc Natl Acad Sci U S A 97:10162-7. 2000
    ..Therefore, A46R and A52R are likely to represent a mechanism used by vaccinia virus of suppressing TIR domain-dependent intracellular signaling...
  13. ncbi request reprint The interleukin-1 receptor/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial products
    A Bowie
    Department of Biochemistry and the National Pharmaceutical Biotechnology Centre, Trinity College Dublin, Ireland
    J Leukoc Biol 67:508-14. 2000
    ..Signaling pathways activated via the TIR domain trigger the activation of downstream kinases, and transcription factors such as NF-kappaB, and involve the adaptor protein MyD88, which itself contains a TIR domain...
  14. doi request reprint Insights from vaccinia virus into Toll-like receptor signalling proteins and their regulation by ubiquitin: role of IRAK-2
    Andrew G Bowie
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Biochem Soc Trans 36:449-52. 2008
    ..Further, I demonstrate how understanding one molecular mechanism whereby vaccinia virus inhibits NF-kappaB activation has led to a revealing of a key role for IRAK-2 in TRAF-6-mediated NF-kappaB activation...
  15. ncbi request reprint Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction
    K A Fitzgerald
    Department of Biochemistry, Trinity College, Dublin 2, Ireland
    Nature 413:78-83. 2001
    ..Mal associates with TLR-4. Mal is therefore an adapter in TLR-4 signal transduction...
  16. ncbi request reprint Ras, protein kinase C zeta, and I kappa B kinases 1 and 2 are downstream effectors of CD44 during the activation of NF-kappa B by hyaluronic acid fragments in T-24 carcinoma cells
    K A Fitzgerald
    Department of Biochemistry, Trinity College, Dublin, Ireland
    J Immunol 164:2053-63. 2000
    ..Taken together, these studies establish a novel signal transduction cascade emanating from CD44 to Ras, PKC zeta, and I kappa B kinase 1 and 2...
  17. ncbi request reprint The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
    Luke A J O'Neill
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Nat Rev Immunol 7:353-64. 2007
    ..These new insights allow for a detailed description of the function of the five TIR-domain-containing adaptors in the initiation of TLR signalling...
  18. ncbi request reprint Viral inhibition of IL-1- and neutrophil elastase-induced inflammatory responses in bronchial epithelial cells
    Tomas P Carroll
    Respiratory Research Division, Royal College of Surgeons in Ireland, Education and Research Center, Beaumont Hospital, Dublin, Ireland
    J Immunol 175:7594-601. 2005
    ..These findings identify vaccinia virus proteins as possible therapeutic agents for the manifestations of several inflammatory lung diseases...
  19. ncbi request reprint The role of Toll-like receptors in the host response to viruses
    Andrew G Bowie
    Department of Biochemistry, Trinity College, Dublin 2, Ireland
    Mol Immunol 42:859-67. 2005
    ..Secondly, TLRs trigger anti-viral signalling pathways leading to the induction of the interferon response. Thirdly, viral immune strategies employed against TLRs have been identified...
  20. doi request reprint Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule
    Tatyana Lysakova-Devine
    Immunology Research Centre, School of Biochemistry and Immunology, Trinity College Dublin, Ireland
    J Immunol 185:4261-71. 2010
    ..Overall, we demonstrate for the first time disruption of a specific TLR signaling pathway by a short virally derived peptide...
  21. doi request reprint Sensing and signaling in antiviral innate immunity
    Luke A J O'Neill
    Immunology Research Centre, School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Curr Biol 20:R328-33. 2010
    ..Furthermore, new complexities in the signaling pathways activated by these receptors continue to be revealed. Together, these new insights are leading to therapeutically useful information in the fight against viruses...
  22. doi request reprint Evaluating the role of Toll-like receptors in diseases of the central nervous system
    Michael Carty
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Biochem Pharmacol 81:825-37. 2011
    ..This review aims to examine the recent literature on TLRs in the CNS thus demonstrating their importance in a range of infectious and non-infectious diseases of the brain...
  23. ncbi request reprint The Toll-IL-1 receptor adaptor family grows to five members
    Luke A J O'Neill
    Cytokine Research Group, Department of Biochemistry, Trinity College, Dublin, Ireland
    Trends Immunol 24:286-90. 2003
    ..It is probable that differential use of adaptors will help explain the distinct pathways activated by TLRs during host defence...
  24. ncbi request reprint An arms race: innate antiviral responses and counteracting viral strategies
    M Schroder
    Viral Immune Evasion Group, School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Biochem Soc Trans 35:1512-4. 2007
    ..Here, we discuss viral evasion proteins that specifically interfere with TLR and/or RLH signalling...
  25. ncbi request reprint Evasion of innate immunity by vaccinia virus
    I R Haga
    Department of Biochemistry, Trinity College, Dublin 2, Ireland
    Parasitology 130:S11-25. 2005
    ....
  26. doi request reprint Activation of host pattern recognition receptors by viruses
    Kiva Brennan
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Curr Opin Microbiol 13:503-7. 2010
    ..Another novel mechanism of viral DNA recognition unveiled, leading to proinflammatory cytokine production, involves the PYHIN family member AIM2...
  27. ncbi request reprint Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptors
    Gary DiPerna
    Viral Immune Evasion Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Biol Chem 279:36570-8. 2004
    ..Furthermore, N1L inhibited IRF3 signaling, which is also regulated by TBK1. These studies define a role for N1L as an immunomodulator of innate immunity by targeting components of NF-kappaB and IRF3 signaling pathways...
  28. pmc Recent insights into the role of Toll-like receptors in viral infection
    M Carty
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    Clin Exp Immunol 161:397-406. 2010
    ....
  29. ncbi request reprint The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling
    Michael Carty
    School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    Nat Immunol 7:1074-81. 2006
    ..Thus, the fifth mammalian TIR adaptor SARM is a negative regulator of Toll-like receptor signaling...
  30. ncbi request reprint Modulation of innate immune signalling pathways by viral proteins
    Orla Mulhern
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    Adv Exp Med Biol 666:49-63. 2009
    ..In this chapter we outline the signalling pathways that respond to viral infection and the various methods that viruses utilize to evade detection and modulate the innate immune response to favour their survival...
  31. ncbi request reprint Viral appropriation of apoptotic and NF-kappaB signaling pathways
    Andrew G Bowie
    Viral Immune Evasion Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Cell Biochem 91:1099-108. 2004
    ..Here, modulation of apoptotic and NF-kappaB signal transduction pathways are examined as examples of common pathways appropriated in contrasting ways by herpesviruses and poxviruses...
  32. pmc IFI16 is an innate immune sensor for intracellular DNA
    Leonie Unterholzner
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    Nat Immunol 11:997-1004. 2010
    ..IFI16 (p204) is the first PYHIN protein to our knowledge shown to be involved in IFN-β induction. Thus, the PYHIN proteins IFI16 and AIM2 form a new family of innate DNA sensors we call 'AIM2-like receptors' (ALRs)...
  33. ncbi request reprint The interplay between viruses and innate immune signaling: recent insights and therapeutic opportunities
    Leonie Unterholzner
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Biochem Pharmacol 75:589-602. 2008
    ..Further, the viral proteins themselves or derivatives of them may be of use therapeutically to curtail inflammation and autoimmunity...
  34. doi request reprint Unexpected roles for DEAD-box protein 3 in viral RNA sensing pathways
    Orla Mulhern
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Eur J Immunol 40:933-5. 2010
    ..This further emphasises the importance of DDX3 in anti-viral immunity, and is consistent with the idea that viruses target DDX3 for immune evasion...
  35. pmc Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation
    Martina Schröder
    Viral Immune Evasion Group, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    EMBO J 27:2147-57. 2008
    ..Therefore, this study shows for the first time the involvement of a DEAD box helicase in TBK1/IKKepsilon-mediated IRF activation and Ifnb promoter induction...
  36. ncbi request reprint Vaccinia virus protein A52R activates p38 mitogen-activated protein kinase and potentiates lipopolysaccharide-induced interleukin-10
    Geraldine Maloney
    Viral Immune Evasion Group, School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 280:30838-44. 2005
    ..A52R-mediated enhancement of TLR-induced IL-10 may be important to virulence, given the role of IL-10 in immunoregulation...
  37. ncbi request reprint IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination
    Sinead E Keating
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 282:33435-43. 2007
    ..Further, IRAK-2 loss-of-function mutants, which could not activate NFkappaB, were incapable of promoting TRAF6 ubiquitination. Thus we propose that IRAK-2 plays a more central role than IRAK-1 in TLR signaling to NFkappaB...
  38. ncbi request reprint TLR3 in antiviral immunity: key player or bystander?
    Martina Schröder
    Viral Immune Evasion Group, Department of Biochemistry, Trinity College Dublin, College Green, Dublin 2, Ireland
    Trends Immunol 26:462-8. 2005
    ..Also, recent research concerning the expression profile of TLR3, its evasion by viruses and a potential role in crosspriming is addressed, which reveals a clearer appreciation of the contribution of TLR3 to antiviral immunity...
  39. doi request reprint Characterisation of viral proteins that inhibit Toll-like receptor signal transduction
    Julianne Stack
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Methods Mol Biol 517:217-35. 2009
    ..Again, complexes recovered from the beads are analysed by Western blotting...
  40. ncbi request reprint Viral activation of macrophages through TLR-dependent and -independent pathways
    Lene Malmgaard
    Department of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark
    J Immunol 173:6890-8. 2004
    ....
  41. pmc Activation of innate defense against a paramyxovirus is mediated by RIG-I and TLR7 and TLR8 in a cell-type-specific manner
    Jesper Melchjorsen
    Department of Medical Microbiology and Immunology, University of Aarhus, Denmark
    J Virol 79:12944-51. 2005
    ..Therefore, there appears to be a large degree of cell-type specificity in the mechanisms used by the host to recognize infecting viruses...
  42. ncbi request reprint Nucleotide-binding oligomerization domain-1 and epidermal growth factor receptor: critical regulators of beta-defensins during Helicobacter pylori infection
    Parjeet K Boughan
    Infectious Diseases and Microbiology Unit, Institute of Child Health, 30 Guildford St, London WC1N 1EH, United Kingdom
    J Biol Chem 281:11637-48. 2006
    ....