Mohamed M M Abdel-Latif

Summary

Affiliation: Trinity College
Country: Ireland

Publications

  1. doi request reprint Inflammation and esophageal carcinogenesis
    Mohamed M M Abdel-Latif
    Department of Clinical Medicine, Trinity Centre for Health Sciences, St James s Hospital, Dublin 8, Ireland
    Curr Opin Pharmacol 9:396-404. 2009
  2. doi request reprint A new mechanism of gastric epithelial injury induced by acid exposure: the role of Egr-1 and ERK signaling pathways
    Mohamed M M Abdel-Latif
    Department of Clinical Medicine and Institute of Molecular Medicine, Trinity Centre for Health Sciences, St James s Hospital, Dublin 8, Ireland
    J Cell Biochem 108:249-60. 2009
  3. doi request reprint Potential role of NF-kappaB in esophageal adenocarcinoma: as an emerging molecular target
    Mohamed M M Abdel-Latif
    Department of Clinical Surgery, Trinity Centre for Health Sciences, St James s Hospital, Dublin 8, Ireland
    J Surg Res 153:172-80. 2009
  4. ncbi request reprint Helicobacter pylori extract induces nuclear factor-kappa B, activator protein-1, and cyclooxygenase-2 in esophageal epithelial cells
    Mohamed M M Abdel-Latif
    Department of Surgery and Clinical Medicine, Trinity Centre for Health Sciences, St James s Hospital, Dublin, Ireland
    J Gastrointest Surg 10:551-62. 2006
  5. ncbi request reprint Vitamin C enhances chemosensitization of esophageal cancer cells in vitro
    M M M Abdel-Latif
    Department of Surgery, Trinity Centre for Health Sciences, St James s Hospital, Dublin, Ireland
    J Chemother 17:539-49. 2005
  6. pmc Caffeic acid phenethyl ester modulates Helicobacter pylori-induced nuclear factor-kappa B and activator protein-1 expression in gastric epithelial cells
    Mohamed M M Abdel-Latif
    Department of Clinical Medicine, Dublin Molecular Medicine Centre and Trinity Centre for Health Sciences, St James s Hospital, Dublin 8, Ireland
    Br J Pharmacol 146:1139-47. 2005
  7. ncbi request reprint Activated nuclear factor-kappa B and cytokine profiles in the esophagus parallel tumor regression following neoadjuvant chemoradiotherapy
    M M M Abdel-Latif
    Department of Clinical Surgery, Trinity Centre for Health Sciences, St James s Hospital, Dublin, Ireland
    Dis Esophagus 18:246-52. 2005
  8. pmc NF-kappaB activation in esophageal adenocarcinoma: relationship to Barrett's metaplasia, survival, and response to neoadjuvant chemoradiotherapy
    Mohamed M M Abdel-Latif
    Department of Clinical Surgery, Trinity Centre for Health Sciences, St James s Hospital and Trinity College Dublin, Dublin 8, Ireland
    Ann Surg 239:491-500. 2004
  9. pmc Deoxycholate induces COX-2 expression via Erk1/2-, p38-MAPK and AP-1-dependent mechanisms in esophageal cancer cells
    Eileen Looby
    Department of Clinical Medicine and Institute of Molecular Medicine, Trinity Centre for Health Sciences, Trinity College Dublin, St James s Hospital, Dublin 8, Ireland
    BMC Cancer 9:190. 2009
  10. ncbi request reprint Low pH and Helicobacter pylori increase nuclear factor kappa B binding in gastric epithelial cells: a common pathway for epithelial cell injury?
    Dermot O'Toole
    Department of Clinical Medicine, Trinity Centre for Health Sciences, St James s Hospital, Dublin 8, Ireland
    J Cell Biochem 96:589-98. 2005

Detail Information

Publications10

  1. doi request reprint Inflammation and esophageal carcinogenesis
    Mohamed M M Abdel-Latif
    Department of Clinical Medicine, Trinity Centre for Health Sciences, St James s Hospital, Dublin 8, Ireland
    Curr Opin Pharmacol 9:396-404. 2009
    ..Understanding the molecular pathways involved in inflammation-associated esophageal tumorigenesis could enable the development of targeted therapies and offer a better therapeutic treatment in esophageal cancer...
  2. doi request reprint A new mechanism of gastric epithelial injury induced by acid exposure: the role of Egr-1 and ERK signaling pathways
    Mohamed M M Abdel-Latif
    Department of Clinical Medicine and Institute of Molecular Medicine, Trinity Centre for Health Sciences, St James s Hospital, Dublin 8, Ireland
    J Cell Biochem 108:249-60. 2009
    ..Our results also demonstrate that exposure to acid induces Egr-1 via MEK-ERK1/2 pathway. These data suggest that Egr-1 activation might play a crucial role in gastric mucosal inflammation and associated epithelial injury...
  3. doi request reprint Potential role of NF-kappaB in esophageal adenocarcinoma: as an emerging molecular target
    Mohamed M M Abdel-Latif
    Department of Clinical Surgery, Trinity Centre for Health Sciences, St James s Hospital, Dublin 8, Ireland
    J Surg Res 153:172-80. 2009
    ..In this review, we have attempted to highlight the possible role of NF-kappaB in esophageal adenocarcinoma and discuss the anticancer strategy with NF-kappaB as a promising molecular target in esophageal cancer therapy...
  4. ncbi request reprint Helicobacter pylori extract induces nuclear factor-kappa B, activator protein-1, and cyclooxygenase-2 in esophageal epithelial cells
    Mohamed M M Abdel-Latif
    Department of Surgery and Clinical Medicine, Trinity Centre for Health Sciences, St James s Hospital, Dublin, Ireland
    J Gastrointest Surg 10:551-62. 2006
    ..The induction of such transcription factors may play a role in the specific immune response within Barrett's mucosa and may indirectly cause inflammation of the gastric cardia and the distal esophagus...
  5. ncbi request reprint Vitamin C enhances chemosensitization of esophageal cancer cells in vitro
    M M M Abdel-Latif
    Department of Surgery, Trinity Centre for Health Sciences, St James s Hospital, Dublin, Ireland
    J Chemother 17:539-49. 2005
    ..The data suggest that vitamin C supplementation may improve the efficacy of chemotherapy for esophageal cancer...
  6. pmc Caffeic acid phenethyl ester modulates Helicobacter pylori-induced nuclear factor-kappa B and activator protein-1 expression in gastric epithelial cells
    Mohamed M M Abdel-Latif
    Department of Clinical Medicine, Dublin Molecular Medicine Centre and Trinity Centre for Health Sciences, St James s Hospital, Dublin 8, Ireland
    Br J Pharmacol 146:1139-47. 2005
    ..The inhibition of such transcription by CAPE could result in suppression of many genes during H. pylori-induced inflammation, and also provide new insights into the anti-cancer and anti-inflammatory properties of CAPE...
  7. ncbi request reprint Activated nuclear factor-kappa B and cytokine profiles in the esophagus parallel tumor regression following neoadjuvant chemoradiotherapy
    M M M Abdel-Latif
    Department of Clinical Surgery, Trinity Centre for Health Sciences, St James s Hospital, Dublin, Ireland
    Dis Esophagus 18:246-52. 2005
    ..The study suggests that monitoring of molecular and cytokine patterns in patients undergoing this neoadjuvant regimen may help subselect the cohort that derives most benefit from the multimodal approach...
  8. pmc NF-kappaB activation in esophageal adenocarcinoma: relationship to Barrett's metaplasia, survival, and response to neoadjuvant chemoradiotherapy
    Mohamed M M Abdel-Latif
    Department of Clinical Surgery, Trinity Centre for Health Sciences, St James s Hospital and Trinity College Dublin, Dublin 8, Ireland
    Ann Surg 239:491-500. 2004
    ....
  9. pmc Deoxycholate induces COX-2 expression via Erk1/2-, p38-MAPK and AP-1-dependent mechanisms in esophageal cancer cells
    Eileen Looby
    Department of Clinical Medicine and Institute of Molecular Medicine, Trinity Centre for Health Sciences, Trinity College Dublin, St James s Hospital, Dublin 8, Ireland
    BMC Cancer 9:190. 2009
    ..The aim of this study was to investigate DCA-stimulated COX-2 signaling pathways and their possible contribution to deregulated cell survival and apoptosis in esophageal adenocarcinoma cells...
  10. ncbi request reprint Low pH and Helicobacter pylori increase nuclear factor kappa B binding in gastric epithelial cells: a common pathway for epithelial cell injury?
    Dermot O'Toole
    Department of Clinical Medicine, Trinity Centre for Health Sciences, St James s Hospital, Dublin 8, Ireland
    J Cell Biochem 96:589-98. 2005
    ..Similar to H. pylori, low pH potently and independently augments NF-kappaB nuclear binding in AGS cells and such activation appears to be mediated through MEK1-dependant signaling pathways...