Kevin M Malone

Summary

Affiliation: St Vincent's University Hospital
Country: Ireland

Publications

  1. ncbi request reprint Cigarette smoking, suicidal behavior, and serotonin function in major psychiatric disorders
    Kevin M Malone
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, USA
    Am J Psychiatry 160:773-9. 2003
  2. ncbi request reprint Positron emission tomography of regional brain metabolic responses to a serotonergic challenge and lethality of suicide attempts in major depression
    Maria A Oquendo
    Department of Psychiatry, Columbia University, New York, USA
    Arch Gen Psychiatry 60:14-22. 2003
  3. pmc Future suicide attempt and responses to serotonergic challenge
    John G Keilp
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY, USA
    Neuropsychopharmacology 35:1063-72. 2010
  4. pmc Positron emission tomography study of regional brain metabolic responses to a serotonergic challenge in major depressive disorder with and without comorbid lifetime alcohol dependence
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Eur Neuropsychopharmacol 17:608-15. 2007
  5. ncbi request reprint Positron emission tomography of regional brain metabolic responses to a serotonergic challenge in major depressive disorder with and without borderline personality disorder
    Maria A Oquendo
    Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, NY, USA
    Neuropsychopharmacology 30:1163-72. 2005
  6. pmc Regional brain glucose uptake distinguishes suicide attempters from non-attempters in major depression
    M Elizabeth Sublette
    a Departments of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, New York, USA
    Arch Suicide Res 17:434-47. 2013
  7. pmc Regional brain metabolic correlates of self-reported depression severity contrasted with clinician ratings
    Matthew S Milak
    Department of Psychiatry, Columbia University, New York, NY 10032, USA
    J Affect Disord 126:113-24. 2010
  8. ncbi request reprint Neuroanatomic correlates of psychopathologic components of major depressive disorder
    Matthew S Milak
    Departments of Psychiatry and Radiology, Department of Neuroscience, NY State Psychiatric Institute, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Arch Gen Psychiatry 62:397-408. 2005
  9. ncbi request reprint Prolactin response to fenfluramine administration in patients with unipolar and bipolar depression and healthy controls
    Leo Sher
    Department of Neuroscience, New York State Psychiatric Institute, 1051 Riverside Drive, Suite 2917, Box 42, New York, NY 10032, USA
    Psychoneuroendocrinology 28:559-73. 2003
  10. ncbi request reprint Lower CSF homovanillic acid levels in depressed patients with a history of alcoholism
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Neuropsychopharmacology 28:1712-9. 2003

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Cigarette smoking, suicidal behavior, and serotonin function in major psychiatric disorders
    Kevin M Malone
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, USA
    Am J Psychiatry 160:773-9. 2003
    ..The authors hypothesized that the relationship that may exist between cigarette smoking and suicidal behavior may be associated with lower serotonin function and the presence of impulsive/aggressive traits...
  2. ncbi request reprint Positron emission tomography of regional brain metabolic responses to a serotonergic challenge and lethality of suicide attempts in major depression
    Maria A Oquendo
    Department of Psychiatry, Columbia University, New York, USA
    Arch Gen Psychiatry 60:14-22. 2003
    ..Postmortem studies of serotonin receptors in suicides localize changes to the ventral prefrontal cortex (PFC). We studied serotonergic response in ventral PFC in depressed patients surviving a high-lethality suicide attempt...
  3. pmc Future suicide attempt and responses to serotonergic challenge
    John G Keilp
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY, USA
    Neuropsychopharmacology 35:1063-72. 2010
    ..Results suggest that blunted cortisol and unfavorable acute mood response to serotonergic challenge, in the context of the general activating effects of these drugs, may be a risk factor for later suicide attempt...
  4. pmc Positron emission tomography study of regional brain metabolic responses to a serotonergic challenge in major depressive disorder with and without comorbid lifetime alcohol dependence
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Eur Neuropsychopharmacol 17:608-15. 2007
    ..The fact that the observed group difference disappeared after the fenfluramine challenge suggests that serotonergic mechanisms play a role in the observed differences between the groups...
  5. ncbi request reprint Positron emission tomography of regional brain metabolic responses to a serotonergic challenge in major depressive disorder with and without borderline personality disorder
    Maria A Oquendo
    Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, NY, USA
    Neuropsychopharmacology 30:1163-72. 2005
    ..Controlling for the presence of BPD in future imaging studies of mood disorders may elucidate similarities and differences in regional serotonergic function in these two often comorbid disorders...
  6. pmc Regional brain glucose uptake distinguishes suicide attempters from non-attempters in major depression
    M Elizabeth Sublette
    a Departments of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, New York, USA
    Arch Suicide Res 17:434-47. 2013
    ..After fenfluramine, relatively hypometabolic areas enlarged, and no hypermetabolic areas were detected. Distinct rCMRglu patterns may be serotonin-sensitive biomarkers of suicide risk...
  7. pmc Regional brain metabolic correlates of self-reported depression severity contrasted with clinician ratings
    Matthew S Milak
    Department of Psychiatry, Columbia University, New York, NY 10032, USA
    J Affect Disord 126:113-24. 2010
    ....
  8. ncbi request reprint Neuroanatomic correlates of psychopathologic components of major depressive disorder
    Matthew S Milak
    Departments of Psychiatry and Radiology, Department of Neuroscience, NY State Psychiatric Institute, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Arch Gen Psychiatry 62:397-408. 2005
    ..The HDRS comprises distinct symptom clusters that may be associated with different patterns of regional brain glucose metabolism...
  9. ncbi request reprint Prolactin response to fenfluramine administration in patients with unipolar and bipolar depression and healthy controls
    Leo Sher
    Department of Neuroscience, New York State Psychiatric Institute, 1051 Riverside Drive, Suite 2917, Box 42, New York, NY 10032, USA
    Psychoneuroendocrinology 28:559-73. 2003
    ..The lack of difference in the response to fenfluramine administration between unipolar and bipolar depressed patients may indicate that overall serotonergic function in unipolar and bipolar depressed patients is similarly impaired...
  10. ncbi request reprint Lower CSF homovanillic acid levels in depressed patients with a history of alcoholism
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Neuropsychopharmacology 28:1712-9. 2003
    ..Low CSF HVA suggests that impaired dopaminergic activity is associated with a history of alcoholism in persons with current MDE...
  11. ncbi request reprint Association of comorbid posttraumatic stress disorder and major depression with greater risk for suicidal behavior
    Maria A Oquendo
    New York State Psychiatric Institute, Columbia University, New York, 10032, USA
    Am J Psychiatry 160:580-2. 2003
    ..The authors' goal was to examine the effect of comorbid PTSD and major depressive episode on suicidal behavior...
  12. pmc Plasma polyunsaturated fatty acids and regional cerebral glucose metabolism in major depression
    M Elizabeth Sublette
    Department of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, Columbia University, 1051 Riverside Drive, Unit 42, New York, NY 10032, USA
    Prostaglandins Leukot Essent Fatty Acids 80:57-64. 2009
    ..This pilot study is the first to demonstrate fatty acid and regionally specific correlations in the brain between plasma PUFA and rCMRglu in humans...
  13. ncbi request reprint Impulsivity, gender, and response to fenfluramine challenge in borderline personality disorder
    Paul H Soloff
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA, USA
    Psychiatry Res 119:11-24. 2003
    ..Impulsivity and aggression were inversely related to delta-prolactin and peak-prolactin responses among male but not female subjects. Gender differences in central serotonergic function may contribute to variations in impulsivity in BPD...
  14. ncbi request reprint Clinical impact of a 2-week psychotropic medication washout in unipolar depressed inpatients
    Michael F Grunebaum
    The Mental Health Clinical Research Center for the Study of Suicidal Behavior, Department of Neuroscience, New York State Psychiatric Institute, 1051 Riverside Drive, Box 42, New York, NY 10032, USA
    J Affect Disord 75:291-6. 2003
    ..We studied the impact of a short-term medication washout in unipolar depressed patients consecutively admitted to hospital for neuroimaging and cerebrospinal fluid (CSF) studies...
  15. pmc Serotonergic responses in depressed patients with or without a history of alcohol use disorders and healthy controls
    Leo Sher
    Department of Psychiatry, Columbia University, and New York State Psychiatric Institute, New York, NY 10032, USA
    Eur Neuropsychopharmacol 18:692-9. 2008
    ..The difference in prolactin responses between MDD/AUD and MDD only could be attributed to higher aggression scores in the MDD/AUD group compared to the MDD group...
  16. ncbi request reprint Platelet 5-HT2A receptor subresponsivity and lethality of attempted suicide in depressed in-patients
    Kevin M Malone
    Department of Psychiatry, Columbia University, New York, NY, USA
    Int J Neuropsychopharmacol 10:335-43. 2007
    ..05). A seasonal effect was also observed. High-lethality suicidal acts are associated with more 5-HT2A receptors but impaired signal transduction...
  17. pmc Polyunsaturated fatty acid associations with dopaminergic indices in major depressive disorder
    M Elizabeth Sublette
    Department of Psychiatry, Columbia University, New York, NY, USA
    Int J Neuropsychopharmacol 17:383-91. 2014
    ..The robust relationship of omega-3 PUFAs with dopaminergic but not serotonergic indices suggests that omega-6:omega-3 balance may impact depression pathophysiology through effects on the dopaminergic system...
  18. ncbi request reprint Response of cortical metabolic deficits to serotonergic challenge in familial mood disorders
    Lawrence S Kegeles
    Department of Psychiatry, Columbia University, New York, NY, USA
    Am J Psychiatry 160:76-82. 2003
    ..The authors applied a dl-fenfluramine challenge method to study metabolic response in this region to serotonergic challenge in familial major depression...
  19. ncbi request reprint Substance abuse disorder and major depression are associated with the human 5-HT1B receptor gene (HTR1B) G861C polymorphism
    Yung Yu Huang
    Department of Neuroscience, New York State Psychiatric Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Neuropsychopharmacology 28:163-9. 2003
    ..This preliminary result will need replication, given the limitations of association studies...
  20. ncbi request reprint Adequacy of antidepressant treatment after discharge and the occurrence of suicidal acts in major depression: a prospective study
    Maria A Oquendo
    New York State Psychiatric Institute, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Am J Psychiatry 159:1746-51. 2002
    ..The authors prospectively studied the adequacy of antidepressant treatment and its impact on suicidal acts in the 2 years after hospitalization for major depression...
  21. ncbi request reprint Stress in Irish dentists: developing effective coping strategies
    Cathryn Rogers
    Department of Psychiatry, Psychotherapy and Mental Health Research, St Vincent s University Hospital, and School of Medicine and Medical Science, University College Dublin, Elm Park, Dublin 4
    J Ir Dent Assoc 55:304-7. 2009
    ..Peer support is central to meeting this challenge...
  22. ncbi request reprint Is there circannual variation of human platelet 5-HT(2A) binding in depression?
    Vadim D Khait
    Department of Neuroscience, New York State Psychiatric Institute, Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
    J Affect Disord 71:249-58. 2002
    ..Seasonal variations in onset of mood disorders and in serotonergic function are reported, but their relationship is unclear...
  23. ncbi request reprint High-lethality status in patients with borderline personality disorder
    Paul H Soloff
    University of Pittsburgh, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    J Pers Disord 19:386-99. 2005
    ..These characteristics resemble profiles of patients who complete suicide, are not specific for BPD, and do not include impulsivity, aggression, or severity of BPD criteria...
  24. pmc Classification trees distinguish suicide attempters in major psychiatric disorders: a model of clinical decision making
    J John Mann
    Department of Neuroscience, New York State Psychiatric Institute, New York 10032, USA
    J Clin Psychiatry 69:23-31. 2008
    ..Hypothetical decision trees to identify recent and remote suicide attempters, weighted to increase sensitivity, were generated for psychiatric patients using correlates of past suicidal behavior...
  25. ncbi request reprint Suicide among regular-duty military personnel: a retrospective case-control study of occupation-specific risk factors for workplace suicide
    Martin J Mahon
    Department of Psychiatry and Mental Health Research, St Vincent s University Hospital and University College Dublin, Elm Park, Dublin 4, Ireland
    Am J Psychiatry 162:1688-96. 2005
    ..The purpose of this study was to examine the epidemiology, phenomenology, and occupation-specific risk factors for suicide among regular-duty military personnel as a model for other professions at risk for workplace suicide...