B Bresnihan

Summary

Affiliation: St Vincent's University Hospital
Country: Ireland

Publications

  1. ncbi Infection complications associated with the use of biologic agents
    Barry Bresnihan
    Department of Rheumatology, St Vincent s University Hospital, Dublin 4, Ireland
    Rheum Dis Clin North Am 29:185-202. 2003
  2. pmc Effects of anakinra on clinical and radiological outcomes in rheumatoid arthritis
    B Bresnihan
    St Vincent s University Hospital, Dublin 4, Republic of Ireland
    Ann Rheum Dis 61:ii74-7. 2002
  3. ncbi Apolipoprotein A-I infiltration in rheumatoid arthritis synovial tissue: a control mechanism of cytokine production?
    Barry Bresnihan
    Department of Rheumatology, St Vincents University Hospital, Dublin, Ireland
    Arthritis Res Ther 6:R563-6. 2004
  4. ncbi Synovial tissue analysis in clinical trials
    Barry Bresnihan
    Department of Rheumatology, St Vincent s University Hospital, Dublin, Ireland
    J Rheumatol 32:2481-4. 2005
  5. pmc Synovial tissue interleukin-18 expression and the response to treatment in patients with inflammatory arthritis
    T Rooney
    Department of Rheumatology, St Vincent s University Hospital, Elm Park, Dublin 4, Republic of Ireland
    Ann Rheum Dis 63:1393-8. 2004
  6. ncbi A prospective, clinical and radiological study of early psoriatic arthritis: an early synovitis clinic experience
    D Kane
    Department of Rheumatology, St Vincent s University Hospital, Dublin, Ireland
    Rheumatology (Oxford) 42:1460-8. 2003
  7. ncbi Involvement of the nuclear orphan receptor NURR1 in the regulation of corticotropin-releasing hormone expression and actions in human inflammatory arthritis
    E P Murphy
    Department of Rheumatology, Education and Research Center, St. Vincent's University Hospital, Dublin, Ireland
    Arthritis Rheum 44:782-93. 2001
  8. ncbi The effects of treatment with interleukin-1 receptor antagonist on the inflamed synovial membrane in rheumatoid arthritis
    G Cunnane
    Department of Rheumatology, St Vincent's University Hospital, Dublin 4, Ireland
    Rheumatology (Oxford) 40:62-9. 2001
  9. pmc Validated measurement of periarticular bone mineral density at the knee joint by dual energy x ray absorptiometry
    E Murphy
    Department of Rheumatology, St Vincent s University Hospital, Dublin 4, Ireland
    Ann Rheum Dis 60:8-13. 2001
  10. ncbi Decreased CD20 expression in rheumatoid arthritis synovium following 8 weeks of rituximab therapy
    C A E Walsh
    Deptartment of Rheumatology, St Vincent s University Hospital, Dublin, Ireland
    Clin Exp Rheumatol 26:656-8. 2008

Collaborators

Detail Information

Publications40

  1. ncbi Infection complications associated with the use of biologic agents
    Barry Bresnihan
    Department of Rheumatology, St Vincent s University Hospital, Dublin 4, Ireland
    Rheum Dis Clin North Am 29:185-202. 2003
    ..Long-term observation will be required to determine the exact nature of the relationship between cytokine inhibition and infection...
  2. pmc Effects of anakinra on clinical and radiological outcomes in rheumatoid arthritis
    B Bresnihan
    St Vincent s University Hospital, Dublin 4, Republic of Ireland
    Ann Rheum Dis 61:ii74-7. 2002
  3. ncbi Apolipoprotein A-I infiltration in rheumatoid arthritis synovial tissue: a control mechanism of cytokine production?
    Barry Bresnihan
    Department of Rheumatology, St Vincents University Hospital, Dublin, Ireland
    Arthritis Res Ther 6:R563-6. 2004
    ....
  4. ncbi Synovial tissue analysis in clinical trials
    Barry Bresnihan
    Department of Rheumatology, St Vincent s University Hospital, Dublin, Ireland
    J Rheumatol 32:2481-4. 2005
    ..This special interest group is working on establishing the evidence to have this endpoint meet the OMERACT filter criteria...
  5. pmc Synovial tissue interleukin-18 expression and the response to treatment in patients with inflammatory arthritis
    T Rooney
    Department of Rheumatology, St Vincent s University Hospital, Elm Park, Dublin 4, Republic of Ireland
    Ann Rheum Dis 63:1393-8. 2004
    ..To measure synovial tissue interleukin-18 (IL-18) expression in patients with inflammatory arthritis, and to identify associations with serum levels, disease activity, and response to treatment...
  6. ncbi A prospective, clinical and radiological study of early psoriatic arthritis: an early synovitis clinic experience
    D Kane
    Department of Rheumatology, St Vincent s University Hospital, Dublin, Ireland
    Rheumatology (Oxford) 42:1460-8. 2003
    ..To determine the clinical presentation and clinical and radiological outcome of early psoriatic arthritis (PsA) at 1 and 2 yr...
  7. ncbi Involvement of the nuclear orphan receptor NURR1 in the regulation of corticotropin-releasing hormone expression and actions in human inflammatory arthritis
    E P Murphy
    Department of Rheumatology, Education and Research Center, St. Vincent's University Hospital, Dublin, Ireland
    Arthritis Rheum 44:782-93. 2001
    ..CONCLUSION: These data demonstrate the involvement of the transcription factor NURR1 in the regulation of CRH expression and activity in human inflammatory arthritis...
  8. ncbi The effects of treatment with interleukin-1 receptor antagonist on the inflamed synovial membrane in rheumatoid arthritis
    G Cunnane
    Department of Rheumatology, St Vincent's University Hospital, Dublin 4, Ireland
    Rheumatology (Oxford) 40:62-9. 2001
    ..CONCLUSION: Treatment of RA with IL-1Ra resulted in reduced mononuclear cell infiltration of synovial membrane, which may represent the in vivo inhibition of biologically relevant IL-1ss-mediated pathogenic effects...
  9. pmc Validated measurement of periarticular bone mineral density at the knee joint by dual energy x ray absorptiometry
    E Murphy
    Department of Rheumatology, St Vincent s University Hospital, Dublin 4, Ireland
    Ann Rheum Dis 60:8-13. 2001
    ..This study aimed at developing a new technique for measurement of periarticular bone density at the knee joint by dual energy x ray absorptiometry (DXA) and assessing the precision of this technique for selected areas around the knee...
  10. ncbi Decreased CD20 expression in rheumatoid arthritis synovium following 8 weeks of rituximab therapy
    C A E Walsh
    Deptartment of Rheumatology, St Vincent s University Hospital, Dublin, Ireland
    Clin Exp Rheumatol 26:656-8. 2008
    ..To characterise the effects of rituximab on synovial tissue of patients with refractory rheumatoid arthritis (RA)...
  11. pmc Synovial tissue inflammation in early and late osteoarthritis
    M J Benito
    Department of Rheumatology, Education and Research Centre, St Vincent s University Hospital, Dublin, Ireland
    Ann Rheum Dis 64:1263-7. 2005
    ..To compare selected immunohistological features of inflammation in synovial tissue from patients with early and late osteoarthritis (OA)...
  12. ncbi Increased bone resorption and failure to respond to antiresorptive therapy in progressive dystrophic calcification
    E Murphy
    Department of Rheumatology, St Vincent s University Hospital, Dublin, Ireland
    Calcif Tissue Int 73:433-40. 2003
    ..Several antiresorptive agents were shown to be ineffective in limiting either bone turnover or clinical progression in one patient...
  13. pmc Synovial tissue hypoxia and inflammation in vivo
    C T Ng
    Dublin Academic Medical Centre, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    Ann Rheum Dis 69:1389-95. 2010
    ....
  14. ncbi Quality of life and economic impact of switching from established infliximab therapy to adalimumab in patients with rheumatoid arthritis
    C A E Walsh
    Department of Rheumatology, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    Rheumatology (Oxford) 46:1148-52. 2007
    ..To evaluate the quality of life and economic impact of switching therapy from infliximab to adalimumab in patients with rheumatoid arthritis (RA)...
  15. ncbi The safety and efficacy of interleukin-1 receptor antagonist in the treatment of rheumatoid arthritis
    B Bresnihan
    St. Vincent's University Hospital, Dublin, Ireland
    Semin Arthritis Rheum 30:17-20. 2001
    ..No serious adverse events attributable to IL-1ra treatment were observed. CONCLUSIONS: These studies suggest an important role for IL-1ra as a novel therapeutic agent in the treatment of RA...
  16. pmc Increased serum cartilage oligomeric matrix protein levels and decreased patellar bone mineral density in patients with chondromalacia patellae
    E Murphy
    Department of Rheumatology, St Vincent s University Hospital, Dublin, Ireland
    Ann Rheum Dis 61:981-5. 2002
    ..Chondromalacia patellae is a potentially disabling disorder characterised by features of patellar cartilage degradation...
  17. doi Comparison of interferon {gamma} release assays and conventional screening tests before tumour necrosis factor {alpha} blockade in patients with inflammatory arthritis
    J Martin
    Departments of Rheumatology, Respiratory Medicine and Radiology, St Vincent s University Hospital, Dublin 4, Ireland
    Ann Rheum Dis 69:181-5. 2010
    ....
  18. ncbi Synovial tissue protease gene expression and joint erosions in early rheumatoid arthritis
    G Cunnane
    St Vincent's University Hospital, Dublin, Ireland
    Arthritis Rheum 44:1744-53. 2001
    ..This is the first study to demonstrate features of early synovial pathophysiology that may identify patients at increased risk of developing new joint erosions...
  19. ncbi Disease-modifying anti-rheumatic drug therapy and structural damage in early rheumatoid arthritis
    R H Mullan
    Department of Rheumatology, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    Clin Exp Rheumatol 21:S158-64. 2003
    ..To date, no DMARD combination has totally arrested joint damage in all patients with early RA. Future randomised controlled trials should always include prospective radiographic data as a primary outcome measure...
  20. ncbi Clinical and radiological effects of anakinra in patients with rheumatoid arthritis
    B Bresnihan
    Department of Rheumatology, St Vincent s University Hospital, Dublin, Ireland
    Rheumatology (Oxford) 42:ii22-8. 2003
    ..Furthermore, an initial study indicates that anakinra retards the progression of radiographic joint damage. Such clinical findings suggest that anakinra is an important addition to the rheumatology treatment armamentarium...
  21. ncbi A classification study of clinical subsets in an inception cohort of early psoriatic peripheral arthritis--'DIP or not DIP revisited'
    D Kane
    Department of Rheumatology, St Vincent s University Hospital, Dublin, Ireland
    Rheumatology (Oxford) 42:1469-76. 2003
    ....
  22. ncbi Psoriasis predicts a poor short-term outcome in patients with spondylarthropathy
    L Stafford
    Department of Rheumatology, St. Vincent's Hospital, Dublin 4, Ireland
    Arthritis Rheum 45:485-93. 2001
    ..Although the clinical presentations are indistinguishable, PsS has a more aggressive clinical course with a poorer functional and radiologic outcome...
  23. ncbi Early joint erosions and serum levels of matrix metalloproteinase 1, matrix metalloproteinase 3, and tissue inhibitor of metalloproteinases 1 in rheumatoid arthritis
    G Cunnane
    St Vincent s University Hospital, Dublin, Ireland
    Arthritis Rheum 44:2263-74. 2001
    ..To further evaluate the roles of matrix metalloproteinase 1 (MMP-1), MMP-3, and tissue inhibitor of metalloproteinases 1 (TIMP-1) in the pathogenesis of joint inflammation and articular erosions in early inflammatory arthritis...
  24. ncbi Anakinra as a new therapeutic option in rheumatoid arthritis: clinical results and perspectives
    B Bresnihan
    Rheumatology Department, St Vincent s University Hospital, Dublin, Ireland
    Clin Exp Rheumatol 20:S32-4. 2002
    ..Anakinra, a new biologic approach to the treatment of RA, results in significant improvements in the signs and symptoms, has beneficial effects on functional status, and on the rate of progressive structural joint damage...
  25. ncbi Corticotropin-releasing hormone signaling in synovial tissue from patients with early inflammatory arthritis is mediated by the type 1 alpha corticotropin-releasing hormone receptor
    A N McEvoy
    St Vincent's University Hospital, Dublin, Ireland
    Arthritis Rheum 44:1761-7. 2001
    ..CONCLUSION: Our findings suggest that CRH signaling, via CRH-R1alpha, may play a role in both the vascular changes and the pathologic mechanisms associated with joint inflammation in human arthritis...
  26. ncbi Psoriatic arthritis joint fluids are characterized by CD8 and CD4 T cell clonal expansions appear antigen driven
    P J Costello
    Department of Rheumatology, Education and Research Centre, St Vincent s University Hospital, Dublin, Ireland
    J Immunol 166:2878-86. 2001
    ..The findings support a model of psoriatic arthritis inflammation involving extensive and selective Ag, likely autoantigen, driven intra-articular CD4, and CD8 T cell clonal expansions...
  27. ncbi The prospect of treating rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist
    B Bresnihan
    Department of Rheumatology, St Vincent's University Hospital, Dublin, Ireland
    BioDrugs 15:87-97. 2001
    ..These observations suggest that rhu-IL-1Ra has a potential role as a novel therapeutic modality in the future management of RA...
  28. pmc Sonography and subclinical synovitis
    B Bresnihan
    Department of Rheumatology, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    Ann Rheum Dis 63:333-4. 2004
  29. doi An audit of hospital based outpatient infusions and a pilot program of community-based monoclonal antibody infusions
    J P Doran
    Department of Rheumatology, St Vincent s University Hospital, Dublin, Ireland
    Ir J Med Sci 178:497-501. 2009
    ..Infliximab, a chimeric monoclonal antibody to tumour necrosis factor alpha, is administered as an intravenous infusion requiring a costly hospital day case or inpatient admission...
  30. ncbi The role of ultrasonography in the diagnosis and management of idiopathic plantar fasciitis
    D Kane
    Department of Rheumatology, St Vincent's University Hospital, Dublin 4, Ireland
    Rheumatology (Oxford) 40:1002-8. 2001
    ..Ultrasound-guided injection is effective in the management of plantar fasciitis but is not more effective than palpation-guided injection. Ultrasonography may be used as an objective measure of response to treatment in plantar fasciitis...
  31. pmc Serum interleukin 18 and interleukin 18 binding protein in rheumatoid arthritis
    B Bresnihan
    Department of Rheumatology, St Vincents University Hospital, Dublin, Ireland
    Ann Rheum Dis 61:726-9. 2002
    ..To measure serum interleukin 18 (IL18) and IL18 binding protein (IL18BP) levels in patients with inflammatory arthropathies, and to identify associations with disease status and the response to treatment...
  32. ncbi Treating early rheumatoid arthritis in the younger patient
    B Bresnihan
    Department of Rheumatology, St. Vincents University Hospital, Dublin, Ireland
    J Rheumatol Suppl 62:4-9. 2001
    ..Leflunomide must be discontinued for 2 years before attempting conception; this time can be shortened if the patient opts for drug washout...
  33. pmc Synovial tissue macrophages: a sensitive biomarker for response to treatment in patients with rheumatoid arthritis
    J J Haringman
    Division of Clinical Immunology and Rheumatology, F4 218, Academic Medical Centre University of Amsterdam, Meibergdreef 9, NL 1105 AZ Amsterdam, The Netherlands
    Ann Rheum Dis 64:834-8. 2005
    ..Previous work identified synovial sublining macrophage numbers as a potential biomarker for clinical efficacy in rheumatoid arthritis...
  34. pmc Differential expression of syndecans and glypicans in chronically inflamed synovium
    A M Patterson
    Leopold Muller Arthritis Research Centre, Institute for Science and Technology in Medicine, Medical School, Keele University at Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, Shropshire, UK
    Ann Rheum Dis 67:592-601. 2008
    ..Membrane-bound heparan sulphate proteoglycans (HSPGs) act as co-receptors and presenters of cytokines and are involved in cell-matrix and cell-cell adhesion...
  35. ncbi Women with established rheumatoid arthritis perceive pain as the predominant impairment of health status
    P Minnock
    Rheumatology Rehabilitation, Our Lady s Hospice, Harold s Cross, Dublin 6, Ireland
    Rheumatology (Oxford) 42:995-1000. 2003
    ..The aim of this study was to characterize perceptions of health and well-being in women with established rheumatoid arthritis (RA)...
  36. ncbi Consistency in assessing the Disease Activity Score-28 in routine clinical practice
    C A E Walsh
    Ann Rheum Dis 67:135-6. 2008
  37. pmc Suprascapular nerve block (using bupivacaine and methylprednisolone acetate) in chronic shoulder pain
    E M Shanahan
    Rheumatology Research Unit, Repatriation General Hospital, Daw Park South Australia, Australia 5041
    Ann Rheum Dis 62:400-6. 2003
    ..There have been no large randomised placebo controlled trials examining the efficacy of suprascapular nerve block for shoulder pain in arthritis and/or degenerative disease using pain and disability end points...
  38. ncbi Downregulation of the inhibitor of apoptosis protein survivin in keratinocytes and endothelial cells in psoriasis skin following infliximab therapy
    T Markham
    Department of Dermatology, Merlin Park Hospital, University of Galway, Galway, Ireland
    Br J Dermatol 155:1191-6. 2006
    ..Survivin, an inhibitor of apoptosis protein (IAP), has been implicated in endothelial cell stability, through inhibition of apoptosis and in cell proliferation...
  39. pmc Standardisation of synovial tissue infiltrate analysis: how far have we come? How much further do we need to go?
    M D Smith
    Rheumatology Research Unit, Repatriation General Hospital, Adelaide, South Australia
    Ann Rheum Dis 65:93-100. 2006
    ....
  40. ncbi Expression of the pro-inflammatory protein S100A12 (EN-RAGE) in rheumatoid and psoriatic arthritis
    D Foell
    Department of Pediatrics, University of Munster, Munster, Germany
    Rheumatology (Oxford) 42:1383-9. 2003
    ..S100A12 (EN-RAGE) is secreted by activated granulocytes and binds to the receptor for advanced glycation end products, which induces nuclear factor (NF)-kappaB-dependent activation of endothelium...