J L Waddington

Summary

Affiliation: Royal College of Surgeons in Ireland
Country: Ireland

Publications

  1. pmc Frontonasal dysmorphology in bipolar disorder by 3D laser surface imaging and geometric morphometrics: comparisons with schizophrenia
    Robin J Hennessy
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Schizophr Res 122:63-71. 2010
  2. ncbi request reprint The new antipsychotics, and their potential for early intervention in schizophrenia
    J L Waddington
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin
    Schizophr Res 28:207-22. 1997
  3. doi request reprint Congenital anomalies and early functional impairments in a prospective birth cohort: risk of schizophrenia-spectrum disorder in adulthood
    John L Waddington
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Br J Psychiatry 192:264-7. 2008
  4. ncbi request reprint Neuroimaging and other neurobiological indices in schizophrenia: relationship to measurement of functional outcome
    John L Waddington
    Molecular and Cellular Therapeutics, Royal College of Surgeons, Dublin, Ireland
    Br J Psychiatry Suppl 50:s52-7. 2007
  5. ncbi request reprint Early cerebro-craniofacial dysmorphogenesis in schizophrenia: a lifetime trajectory model from neurodevelopmental basis to 'neuroprogressive' process
    J L Waddington
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin, Ireland
    J Psychiatr Res 33:477-89. 1999
  6. ncbi request reprint Functional genomics and schizophrenia: endophenotypes and mutant models
    John L Waddington
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Psychiatr Clin North Am 30:365-99. 2007
  7. ncbi request reprint Mortality in schizophrenia. Antipsychotic polypharmacy and absence of adjunctive anticholinergics over the course of a 10-year prospective study
    J L Waddington
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin
    Br J Psychiatry 173:325-9. 1998
  8. ncbi request reprint Phenotypic studies on dopamine receptor subtype and associated signal transduction mutants: insights and challenges from 10 years at the psychopharmacology-molecular biology interface
    John L Waddington
    Institute of Biopharmaceutical Sciences, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Psychopharmacology (Berl) 181:611-38. 2005
  9. ncbi request reprint Comparative, topographically-based evaluation of behavioural phenotype and specification of D(1)-like:D(2) interactions in a line of incipient congenic mice with D(2) dopamine receptor 'knockout'
    J J Clifford
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin, Ireland
    Neuropsychopharmacology 25:527-36. 2001
  10. doi request reprint Phenotypic characterization of cognition and social behavior in mice with heterozygous versus homozygous deletion of catechol-O-methyltransferase
    D Babovic
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Neuroscience 155:1021-9. 2008

Collaborators

Detail Information

Publications76

  1. pmc Frontonasal dysmorphology in bipolar disorder by 3D laser surface imaging and geometric morphometrics: comparisons with schizophrenia
    Robin J Hennessy
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Schizophr Res 122:63-71. 2010
    ..Bipolar disorder and schizophrenia might reflect similar insult(s) acting over slightly differing time-frames or slightly differing insult(s) acting over a similar time-frame...
  2. ncbi request reprint The new antipsychotics, and their potential for early intervention in schizophrenia
    J L Waddington
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin
    Schizophr Res 28:207-22. 1997
    ....
  3. doi request reprint Congenital anomalies and early functional impairments in a prospective birth cohort: risk of schizophrenia-spectrum disorder in adulthood
    John L Waddington
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Br J Psychiatry 192:264-7. 2008
    ..Adversities operating over intrauterine life have been associated with risk of schizophrenia, but the biology of resultant developmental perturbation is poorly understood...
  4. ncbi request reprint Neuroimaging and other neurobiological indices in schizophrenia: relationship to measurement of functional outcome
    John L Waddington
    Molecular and Cellular Therapeutics, Royal College of Surgeons, Dublin, Ireland
    Br J Psychiatry Suppl 50:s52-7. 2007
    ..As understanding of the pathobiology of schizophrenia increases, the challenge is to relate such measures to outcome at a functional level...
  5. ncbi request reprint Early cerebro-craniofacial dysmorphogenesis in schizophrenia: a lifetime trajectory model from neurodevelopmental basis to 'neuroprogressive' process
    J L Waddington
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin, Ireland
    J Psychiatr Res 33:477-89. 1999
    ....
  6. ncbi request reprint Functional genomics and schizophrenia: endophenotypes and mutant models
    John L Waddington
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Psychiatr Clin North Am 30:365-99. 2007
    ..It examines gene-gene and gene-environment interactions. Finally, it looks at future directions for research...
  7. ncbi request reprint Mortality in schizophrenia. Antipsychotic polypharmacy and absence of adjunctive anticholinergics over the course of a 10-year prospective study
    J L Waddington
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin
    Br J Psychiatry 173:325-9. 1998
    ..Although increased mortality is one of the most consistent and accepted epidemiological findings in schizophrenia, a high rate of suicide appears unable to account fully for this burden which remains poorly understood...
  8. ncbi request reprint Phenotypic studies on dopamine receptor subtype and associated signal transduction mutants: insights and challenges from 10 years at the psychopharmacology-molecular biology interface
    John L Waddington
    Institute of Biopharmaceutical Sciences, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Psychopharmacology (Berl) 181:611-38. 2005
    ..Furthermore, there are poorly understood methodological factors that contribute to inconsistent phenotypic findings between laboratories...
  9. ncbi request reprint Comparative, topographically-based evaluation of behavioural phenotype and specification of D(1)-like:D(2) interactions in a line of incipient congenic mice with D(2) dopamine receptor 'knockout'
    J J Clifford
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin, Ireland
    Neuropsychopharmacology 25:527-36. 2001
    ....
  10. doi request reprint Phenotypic characterization of cognition and social behavior in mice with heterozygous versus homozygous deletion of catechol-O-methyltransferase
    D Babovic
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Neuroscience 155:1021-9. 2008
    ..The data suggest that catechol-O-methyltransferase and neuregulin-1 may influence, respectively, primarily cognitive and social endophenotypes of the overall schizophrenia syndrome...
  11. ncbi request reprint Topographical assessment and pharmacological characterization of orofacial movements in mice: dopamine D(1)-like vs. D(2)-like receptor regulation
    K Tomiyama
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin, Ireland
    Eur J Pharmacol 418:47-54. 2001
    ..This methodology will allow the use of knockout mice to clarify the roles of individual dopamine receptor subtypes in their regulation...
  12. doi request reprint Disruption of thermal nociceptive behaviour in mice mutant for the schizophrenia-associated genes NRG1, COMT and DISC1
    J Walsh
    School of Physiotherapy, Royal College of Surgeons in Ireland, Dublin, Ireland
    Brain Res 1348:114-9. 2010
    ..0mg/kg). These results indicate a differential contribution of NRG1 and DISC1 vis-à-vis COMT to the processing of thermal nociceptive stimuli and extend their phenotypic relationship to psychotic illness...
  13. ncbi request reprint Phenotypic resolution of spontaneous and D1-like agonist-induced orofacial movement topographies in congenic dopamine D1A receptor 'knockout' mice
    K Tomiyama
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Neuropharmacology 42:644-52. 2002
    ....
  14. doi request reprint Schizophrenia-related endophenotypes in heterozygous neuregulin-1 'knockout' mice
    C M P O'Tuathaigh
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Eur J Neurosci 31:349-58. 2010
    ..These data indicate a subtle role for NRG1 in modulating several schizophrenia-relevant processes including the effects of psychotomimetic N-methyl-D-aspartate receptor antagonists...
  15. ncbi request reprint Conservation of behavioural topography to dopamine D1-like receptor agonists in mutant mice lacking the D1A receptor implicates a D1-like receptor not coupled to adenylyl cyclase
    J J Clifford
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin
    Neuroscience 93:1483-9. 1999
    ..These data are consistent with behavioural primacy of a D1-like receptor other than D1A [or D1B] that is coupled to a transduction system other than/additional to adenylyl cyclase...
  16. ncbi request reprint Topographical evaluation of behavioural phenotype in a line of mice with targeted gene deletion of the D2 dopamine receptor
    J J Clifford
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin
    Neuropharmacology 39:382-90. 2000
    ....
  17. ncbi request reprint The psychopharmacology-molecular biology interface: exploring the behavioural roles of dopamine receptor subtypes using targeted gene deletion ('knockout')
    J L Waddington
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin
    Prog Neuropsychopharmacol Biol Psychiatry 25:925-64. 2001
    ..It is being complemented by more systematic phenotypic characterisation at the level of behaviour and additional, molecular biologically-based approaches...
  18. doi request reprint Disruption of exploratory and habituation behavior in mice with mutation of DISC1: an ethologically based analysis
    J Walsh
    School of Physiotherapy, Royal College of Surgeons in Ireland, Dublin, Ireland
    J Neurosci Res 90:1445-53. 2012
    ..This is discussed in the context of the functional role of the gene vis à vis a schizophrenia phenotype as well as the value of ethologically based approaches to behavioral phenotyping...
  19. ncbi request reprint Phenotypic characterization of spatial cognition and social behavior in mice with 'knockout' of the schizophrenia risk gene neuregulin 1
    C M P O'Tuathaigh
    Molecular and Cellular Therapeutics and RCSI Research Institute, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Neuroscience 147:18-27. 2007
    ..These data inform at a novel phenotypic level on the functional role of this gene in the context of its association with risk for schizophrenia...
  20. ncbi request reprint Prospective evaluation of neurological soft signs in first-episode schizophrenia in relation to psychopathology: state versus trait phenomena
    P Whitty
    Stanley Research Unit, Cluain Mhuire Family Centre, Blackrock, Dublin, Ireland
    Psychol Med 33:1479-84. 2003
    ..Although patients with schizophrenia have increased rates of neurological soft signs, few studies have examined prospectively their trait or state characteristics in relation to psychopathology...
  21. doi request reprint Mood congruent psychotic symptoms and specific cognitive deficits in carriers of the novel schizophrenia risk variant at MIR-137
    E Cummings
    Dept of Psychiatry and Neuropsychiatric Genetics Group, Institute of Molecular Medicine, Trinity College Dublin, Dublin 2, Ireland
    Neurosci Lett 532:33-8. 2013
    ..The most significant finding mapped to a micro-RNA, MIR-137, which may be involved in regulating the function of other schizophrenia and bipolar disorder susceptibility genes...
  22. doi request reprint The relationship between insight and neurological dysfunction in first-episode psychosis
    M Hill
    Stanley Research Unit, Cluain Mhuire Family Centre, St John of God Adult Psychiatric Service, Dublin, Ireland
    Eur Psychiatry 27:200-5. 2012
    ..The aim was to examine the relationship between NSS and insight in a sample of 241 first-episode psychosis patients...
  23. ncbi request reprint Essential fatty acids given from conception prevent topographies of motor deficit in a transgenic model of Huntington's disease
    J J Clifford
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Neuroscience 109:81-8. 2002
    ....
  24. ncbi request reprint Topographical Assessment of Ethological and Dopamine Receptor Agonist-Induced Behavioral Phenotype in Mutants with Congenic DARPP-32 'Knockout'
    Rachel E Nally
    Department of Clinical Pharmacology, and Institute of Biopharmaceutical Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland
    Neuropsychopharmacology 28:2055-63. 2003
    ....
  25. ncbi request reprint Susceptibility genes for schizophrenia: characterisation of mutant mouse models at the level of phenotypic behaviour
    Daniela Babovic
    Molecular and Cellular Therapeutics and Research Institute, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Neurosci Biobehav Rev 31:60-78. 2007
    ..We also consider methodological issues that are likely to influence phenotypic effects, as well as the limitations associated with existing molecular techniques...
  26. ncbi request reprint Confirmation and refinement of an 'at-risk' haplotype for schizophrenia suggests the EST cluster, Hs.97362, as a potential susceptibility gene at the Neuregulin-1 locus
    A P Corvin
    Neuropsychiatric Genetics Group, Department of Psychiatry, Institute of Molecular Medicine, Trinity College, Dublin 2, Ireland
    Mol Psychiatry 9:208-13. 2004
    ..0% vs 13.5%; P=0.036). Interestingly, this refined 'at-risk' haplotype is positioned close to an EST cluster of unknown function (Hs.97362) within intron 1 of NRG1...
  27. ncbi request reprint Exploratory and habituation phenotype of heterozygous and homozygous COMT knockout mice
    Daniela Babovic
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
    Behav Brain Res 183:236-9. 2007
    ..Heterozygous COMT deletion is associated with a distinctive phenotype. This differs from that which we have reported previously for heterozygous deletion of the schizophrenia risk gene neuregulin-1...
  28. ncbi request reprint Congenic D1A dopamine receptor mutants: ethologically based resolution of behavioural topography indicates genetic background as a determinant of knockout phenotype
    Fergal N McNamara
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin
    Neuropsychopharmacology 28:86-99. 2003
    ..Genetic background appears to modulate critically the magnitude but not the general nature of the D(1A)-null phenotype, which may involve compensatory processes independent of other D(1)-like or D(2)-like receptors...
  29. ncbi request reprint Ethological resolution of behavioural topography and D1-like versus D2-like agonist responses in congenic D5 dopamine receptor mutants: identification of D5:D2-like interactions
    Gerard J O'Sullivan
    Department of Clinical Pharmacology and Institute of Biopharmaceutical Sciences, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Synapse 55:201-11. 2005
    ..Additionally, they indicate the involvement of phosphoinositide hydrolysis and D(5):D(2)-like interactions in regulating these processes...
  30. ncbi request reprint Mice mutant for genes associated with schizophrenia: common phenotype or distinct endophenotypes?
    Lieve Desbonnet
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Behav Brain Res 204:258-73. 2009
    ..Emphasis is also placed on the importance of studying gene x environment and gene x gene interactions, as well as addressing methodological issues related to genetic modelling and phenotyping strategies...
  31. ncbi request reprint Three-dimensional laser surface imaging and geometric morphometrics resolve frontonasal dysmorphology in schizophrenia
    Robin J Hennessy
    Stanley Research Unit, Molecular and Cellular Therapeutics and RCSI Research Institute, Royal College of Surgeons in Ireland, Dublin
    Biol Psychiatry 61:1187-94. 2007
    ..The brain and face emerge in embryologic intimacy, such that in neurodevelopmental disorders, brain dysmorphogenesis is accompanied by facial dysmorphogenesis...
  32. ncbi request reprint Phenotypic, ethologically based resolution of spontaneous and D(2)-like vs D(1)-like agonist-induced behavioural topography in mice with congenic D(3) dopamine receptor "knockout"
    Fergal N McNamara
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Synapse 46:19-31. 2002
    ..A role for D(3) receptors in inhibitory processes appeared topographically circumscribed and only when baseline levels of behaviour were low...
  33. ncbi request reprint D1-like dopamine receptor-mediated function in congenic mutants with D1 vs. D5 receptor "knockout"
    Gerard J O'Sullivan
    Department of Clinical Pharmacology, Institute of Biopharmaceutical Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland
    J Recept Signal Transduct Res 24:107-16. 2004
    ....
  34. ncbi request reprint Disruption to social dyadic interactions but not emotional/anxiety-related behaviour in mice with heterozygous 'knockout' of the schizophrenia risk gene neuregulin-1
    Colm M P O'Tuathaigh
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Prog Neuropsychopharmacol Biol Psychiatry 32:462-6. 2008
    ..They indicate that NRG1 is involved in the regulation of reciprocal social interaction behaviour and thus suggest a putative role for NRG1 in a schizophrenia-related endophenotype...
  35. ncbi request reprint Facial shape and asymmetry by three-dimensional laser surface scanning covary with cognition in a sexually dimorphic manner
    Robin J Hennessy
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    J Neuropsychiatry Clin Neurosci 18:73-80. 2006
    ..Events over early fetal life may be an important determinant of sexually dimorphic covariance of anterior facial shape and asymmetry with aspects of cognition that involve the anterior brain...
  36. ncbi request reprint 3D morphometrics of craniofacial dysmorphology reveals sex-specific asymmetries in schizophrenia
    Robin J Hennessy
    Stanley Research Unit, Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Schizophr Res 67:261-8. 2004
    ....
  37. ncbi request reprint Sexually dimorphic changes in the exploratory and habituation profiles of heterozygous neuregulin-1 knockout mice
    Colm M O'Tuathaigh
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin, Ireland
    Neuroreport 17:79-83. 2006
    ..These studies elaborate a pleiotropic role of neuregulin-1 in development, plasticity and function, including sexual dimorphism, by defining the elemental, temporal and sex-specific characteristics of the neuregulin-1 mutant ethogram...
  38. doi request reprint Molecular genetic models related to schizophrenia and psychotic illness: heuristics and challenges
    Colm M P O'Tuathaigh
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St Stephen s Green, Dublin 2, Ireland
    Curr Top Behav Neurosci 7:87-119. 2011
    ....
  39. doi request reprint Age-related behavioural phenotype and cellular characterisation of mice with progressive ablation of D1 dopamine receptor-expressing cells
    Daniela Babovic
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
    Behav Brain Res 206:78-87. 2010
    ..Understanding the mechanistic bases of mitigation vs persistence of individual phenotypes in relation to neural adaptation consequent to cell loss may lead to novel therapeutic strategies for basal ganglia disorders...
  40. pmc Mutant mouse models: genotype-phenotype relationships to negative symptoms in schizophrenia
    Colm M P O'Tuathaigh
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Schizophr Bull 36:271-88. 2010
    ..The breadth and depth of ongoing studies in mutants hold the prospect of addressing these shortcomings...
  41. pmc Chronic adolescent exposure to Δ-9-tetrahydrocannabinol in COMT mutant mice: impact on psychosis-related and other phenotypes
    Colm M P O'Tuathaigh
    Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
    Neuropsychopharmacology 35:2262-73. 2010
    ..These findings illuminate the interaction between genes and adverse environmental exposures over a particular stage of development in the expression of the psychosis phenotype...
  42. pmc Mutant mouse models: phenotypic relationships to domains of psychopathology and pathobiology in schizophrenia
    Colm M P O'Tuathaigh
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Schizophr Bull 36:243-5. 2010
    ....
  43. doi request reprint Mutant models for genes associated with schizophrenia
    Lieve Desbonnet
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Biochem Soc Trans 37:308-12. 2009
    ..Finally, we identify current challenges associated with the use of genetic mutant models and highlight their potential value for exploring gene-gene and gene-environment interactions in relation to schizophrenia...
  44. ncbi request reprint Ethological resolution of behavioral topography and D2-like vs. D1-like agonist responses in congenic D4 dopamine receptor "knockouts": identification of D4:D1-like interactions
    Gerard J O'Sullivan
    Department of Clinical Pharmacology and Research Institute, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Synapse 59:107-18. 2006
    ..These studies identify novel functional roles for the D4 receptor that are distinct from those of closely related D2-like family members and involve interactions with their D1-like counterparts...
  45. ncbi request reprint 3D laser surface scanning and geometric morphometric analysis of craniofacial shape as an index of cerebro-craniofacial morphogenesis: initial application to sexual dimorphism
    Robin J Hennessy
    Stanley Foundation Research Unit, Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Biol Psychiatry 51:507-14. 2002
    ..Digitization technologies now allow 3D recording of craniofacial surface landmarks and modeling of craniofacial shape differences using geometric morphometrics...
  46. ncbi request reprint Comparative phenotypic resolution of spontaneous, D2-like and D1-like agonist-induced orofacial movement topographies in congenic mutants with dopamine D2 vs. D3 receptor "knockout"
    Katsunori Tomiyama
    Department of Clinical Pharmacology and Institute of Biopharmaceutical Sciences, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Synapse 51:71-81. 2004
    ..D2 receptors exert topographically specific regulation of orofacial movements in a manner distinct from their D1A counterparts, while D3 receptors exert only minor regulation of such movements...
  47. ncbi request reprint Topographical evaluation of the phenotype of spontaneous behaviour in mice with targeted gene deletion of the D1A dopamine receptor: paradoxical elevation of grooming syntax
    J J Clifford
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin
    Neuropharmacology 37:1595-602. 1998
    ....
  48. ncbi request reprint Dimensions of psychopathology in bipolar disorder versus other affective and non-affective psychoses among an epidemiologically complete population
    P J Scully
    Jonathan Swift Clinic, St James s Hospital, Dublin, Ireland
    Bipolar Disord 4:43-4. 2002
  49. ncbi request reprint Relationship of orofacial movements to behavioural repertoire as assessed topographically over the course of 6-month haloperidol treatment followed by 4-month withdrawal
    Ian E J De Souza
    Department of Anatomy, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Psychopharmacology (Berl) 169:28-34. 2003
    ..Given their common action to block dopamine D2-like receptors, VCMs may be related to changes in dopaminergic function; if so, other typical dopamine-mediated behaviours might be altered also...
  50. ncbi request reprint SK&F 83822 distinguishes adenylyl cyclase from phospholipase C-coupled dopamine D1-like receptors: behavioural topography
    Gerard J O'Sullivan
    Department of Clinical Pharmacology and Institute of Biopharmaceutical Sciences, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Eur J Pharmacol 486:273-80. 2004
    ..For example, the seizure and vacuous chewing responses appear to involve dopamine D1-like receptors that stimulate adenylyl cyclase, while intense grooming involves those which do not...
  51. ncbi request reprint Ethologically based resolution of D2-like dopamine receptor agonist-versus antagonist-induced behavioral topography in dopamine- and adenosine 3',5'-monophosphate-regulated phosphoprotein of 32 kDa "knockout" mutants congenic on the C57BL/6 gene
    Rachel E Nally
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    J Pharmacol Exp Ther 310:1281-7. 2004
    ..Critically, the present data indicate that phenotypic effects of a given gene deletion using an agonist acting on the system disrupted cannot be generalized to a corresponding antagonist, and vice versa...
  52. pmc Facial surface analysis by 3D laser scanning and geometric morphometrics in relation to sexual dimorphism in cerebral--craniofacial morphogenesis and cognitive function
    Robin J Hennessy
    Stanley Research Unit, Department of Clinical Pharmacology, and Research Institute, Royal College of Surgeons in Ireland, Dublin, Ireland
    J Anat 207:283-95. 2005
    ....
  53. pmc Neurological signs and involuntary movements in schizophrenia: intrinsic to and informative on systems pathobiology
    Peter F Whitty
    Department of Psychiatry, The Adelaide and Meath Hospital, Tallaght, Dublin, Ireland
    Schizophr Bull 35:415-24. 2009
    ....
  54. ncbi request reprint Dysbindin (DTNBP1) and the biogenesis of lysosome-related organelles complex 1 (BLOC-1): main and epistatic gene effects are potential contributors to schizophrenia susceptibility
    Derek W Morris
    Neuropsychiatric Genetics Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College, Dublin, Ireland
    Biol Psychiatry 63:24-31. 2008
    ....
  55. doi request reprint Nonadherence to medication four years after a first episode of psychosis and associated risk factors
    Michele Hill
    St John of God Adult Psychiatric Service, Cluain Mhuire Family Centre, Dublin, Ireland
    Psychiatr Serv 61:189-92. 2010
    ..This study examined concurrent associations and predictors at first indication of nonadherence to antipsychotic medication four years after a first episode of psychosis...
  56. doi request reprint Beyond the critical period: longitudinal study of 8-year outcome in first-episode non-affective psychosis
    Niall Crumlish
    Stanley Research Unit, Cluain Mhuire Family Centre, St John of God Adult Psychiatric Service, Dublin, Ireland
    Br J Psychiatry 194:18-24. 2009
    ..Thus, interventions that shorten the duration of untreated psychosis (DUP) and arrest early deterioration may have long-term benefits...
  57. pmc Dopamine D1 vs D5 receptor-dependent induction of seizures in relation to DARPP-32, ERK1/2 and GluR1-AMPA signalling
    Gerard J O'Sullivan
    Molecular and Cellular Therapeutics and RCSI Research Institute, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Neuropharmacology 54:1051-61. 2008
    ..These findings indicate that D(1), and to a lesser extent D(5), receptor coupling to DARPP-32, ERK1/2 and glutamatergic signalling is involved in mediating the convulsant effects of SKF 83822...
  58. ncbi request reprint No evidence for association of the dysbindin gene [DTNBP1] with schizophrenia in an Irish population-based study
    Derek W Morris
    Neuropsychiatric Genetics Group, Department of Genetics, Trinity College, 2, Dublin, Ireland
    Schizophr Res 60:167-72. 2003
    ..No evidence was found to suggest an association between the DTNBP1 gene and schizophrenia in our sample. Possible reasons for these findings are discussed...
  59. ncbi request reprint Suicidality in first episode psychosis
    Mary Clarke
    Stanley Research Unit, Department of Adult Psychiatry, Hospitaller Order of St John of God, Cluain Mhuire Service, Blackrock, Dublin, Ireland
    Schizophr Res 86:221-5. 2006
    ..Four years later 18% had made a suicide attempt and 3% completed suicide. Suicide attempts prior to presentation were associated with a longer duration of untreated psychosis...
  60. ncbi request reprint Untreated illness and outcome of psychosis
    Mary Clarke
    Department of Psychiatry, University College Dublin, and Stanley Resuearch Unit, Cluain Mhuire Family Centre, St John of God Adult Psychiatric Service, Dublin, Ireland
    Br J Psychiatry 189:235-40. 2006
    ..There has been controversy as to whether early intervention in psychosis can improve the outcome of the disorder...
  61. ncbi request reprint Confirming RGS4 as a susceptibility gene for schizophrenia
    Derek W Morris
    Neuropsychiatric Genetics Group, Department of Genetics, Trinity College, Dublin, Ireland
    Am J Med Genet B Neuropsychiatr Genet 125:50-3. 2004
    ..The same haplotype is in excess in the Caucasian schizophrenia sample used by Chowdari et al. [2002: Hum Mol Genet 11: 1373-1380]. This study provides further support for the contribution of RGS4 to schizophrenia susceptibility...
  62. doi request reprint Chitinase-3-like 1 (CHI3L1) gene and schizophrenia: genetic association and a potential functional mechanism
    Mao Sheng Yang
    Neuropsychiatric Genetics Research Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College Dublin, Ireland
    Biol Psychiatry 64:98-103. 2008
    ..Gene expression data and association analyses in two Chinese samples implicate chitinase 3-like 1 (CHI3L1), a cellular survival gene, in schizophrenia susceptibility...
  63. ncbi request reprint Topographical effects of D1-like dopamine receptor agonists on orofacial movements in mice and their differential regulation via oppositional versus synergistic D1-like: D2-like interactions: cautionary observations on SK&F 82958 as an anomalous agent
    Yasuyuki Makihara
    Department of Pharmacology, Nihon University School of Dentistry, Tokyo, Japan
    J Psychopharmacol 18:484-95. 2004
    ..Additionally, results obtained using SK&F 82958 as a probe for D1-like mechanisms should be treated with considerable caution until they are confirmed using other D1-like agonists...
  64. ncbi request reprint Essential conservation of D1 mutant phenotype at the level of individual topographies of behaviour in mice lacking both D1 and D3 dopamine receptors
    John Y F Wong
    Neurosciences Group, Monash University Department of Medicine, Level 5, Block E, Monash Medical Centre, 246 Clayton Road, 3168 Clayton, Victoria, Australia
    Psychopharmacology (Berl) 167:167-73. 2003
    ..In the absence of agonists and antagonists evidencing appropriate selectivities, individual and interactive properties of D(1) and D(3) dopamine receptors would be illuminated most powerfully by their co-deletion...
  65. ncbi request reprint Investigation of the apolipoprotein-L (APOL) gene family and schizophrenia using a novel DNA pooling strategy for public database SNPs
    Kevin A McGhee
    Neuropsychiatric Genetics Group, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, James Street, Dublin 8, Ireland
    Schizophr Res 76:231-8. 2005
    ..We found no evidence to support the hypothesis that genetic variation at the APOL genes contributes to SZ susceptibility in our sample...
  66. ncbi request reprint Longitudinal assessment of psychopathological domains over late-stage schizophrenia in relation to duration of initially untreated psychosis: 3-year prospective study in a long-term inpatient population
    David J Meagher
    Department of Psychiatry, Midwestern Regional Hospital, Limerick, Ireland
    Psychiatry Res 126:217-27. 2004
    ..It would appear that as years of chronic, refractory illness accrue, psychomotor poverty becomes more sharply delineated and dominant within the overall structure of psychopathology, and its prominence is predicted enduringly by DUP...
  67. ncbi request reprint Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia
    Nadine Norton
    Department of Psychological Medicine, Wales School of Medicine, Heath Park, Cardiff CF14 4XN, Wales, UK
    Am J Med Genet B Neuropsychiatr Genet 141:96-101. 2006
    ....
  68. ncbi request reprint First-episode schizophrenia, bipolar disorder and other psychoses in a rural Irish catchment area: incidence and gender in the Cavan-Monaghan study at 5 years
    Paul J Scully
    Stanley Research Unit, St Davnet s Hospital, Monaghan, Ireland
    Br J Psychiatry Suppl 43:s3-9. 2002
    ..The potential of first-episode studies in schizophrenia is maximised through systematic epidemiological, clinical and biological comparisons between homogeneous populations of the psychoses...
  69. ncbi request reprint Schizophrenia, schizoaffective and bipolar disorder within an epidemiologically complete, homogeneous population in rural Ireland: small area variation in rate
    Paul J Scully
    Stanley Research Unit, St Davnet s Hospital, Monaghan, Ireland
    Schizophr Res 67:143-55. 2004
    ..Under these conditions, small area variations in bipolar disorder may be limited...
  70. ncbi request reprint Is the duration of untreated psychosis temporally stable?
    Deirdre Jackson
    DETECT Early Intervention in Psychosis Service, 1 Marine Terrace, Dun Laoghaire, Co Dublin, Ireland
    Eur Psychiatry 23:97-9. 2008
    ..Patients were diagnosed by Structured Clinical Interview for DSM (SCID) and we determined the DUP using the Beiser Scale. The DUP of the 240 participants did not differ significantly between study periods...
  71. ncbi request reprint Topographical resolution of jaw movements mediated by cyclase- vs. non-cyclase-coupled dopamine D(1)-like receptors: studies with SK&F 83822
    Satoshi Fujita
    Department of Pharmacology, Nihon University School of Dentistry, 1 8 13, Kanda Surugadai, Chiyoda ku, Tokyo 101 8310, Japan
    Eur J Pharmacol 538:94-100. 2006
    ....
  72. ncbi request reprint Neurochemical changes in dopamine D1, D3 and D1/D3 receptor knockout mice
    John Y F Wong
    Neurosciences Group, Monash University, Department of Medicine, Monash Medical Centre, Level 5 Block E, 246 Clayton Road, Clayton, Victoria 3168, Australia
    Eur J Pharmacol 472:39-47. 2003
    ..Upregulated dopamine D2-like binding and enkephalin in D1(-/-) mice may be due to decreased dopamine turnover. Upregulated enkephalin in D1(-/-) mice is dependent on functional dopamine D3 receptors...
  73. ncbi request reprint Prospective analysis of premature mortality in schizophrenia in relation to health service engagement: a 7.5-year study within an epidemiologically complete, homogeneous population in rural Ireland
    Maria G Morgan
    Stanley Research Unit, St Davnet s Hospital, Monaghan, Ireland
    Psychiatry Res 117:127-35. 2003
    ....
  74. ncbi request reprint Disruption of orofacial movement topographies in congenic mutants with dopamine D5 but not D4 receptor or DARPP-32 transduction 'knockout'
    Katsunori Tomiyama
    Nihon University Advanced Research Institute for the Sciences and Humanities, Tokyo 102, Japan
    Eur Neuropsychopharmacol 16:437-45. 2006
    ..In assuming that the well-recognised role of the D(1)-like family in regulating orofacial movements involves primarily D(1) receptors, a role for their D(5) counterparts may have been overlooked...
  75. ncbi request reprint Differential involvement of cyclase- versus non-cyclase-coupled D1-like dopamine receptors in orofacial movement topography in mice: studies with SKF 83822
    Yasuyuki Makihara
    Department of Pharmacology and Dental Research Centre, Nihon University School of Dentistry, Tokyo 101 8310, Japan
    Neurosci Lett 415:6-10. 2007
    ..They are regulated differentially by AC- and/or PLC-dependent processes and these processes involve distinct D1-like:D2-like interactions...