Clifford C Taggart

Summary

Affiliation: Royal College of Surgeons in Ireland
Country: Ireland

Publications

  1. ncbi Elafin prevents lipopolysaccharide-induced AP-1 and NF-kappaB activation via an effect on the ubiquitin-proteasome pathway
    Marcus W Butler
    Pulmonary Research Division, Department of Medicine, The Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland
    J Biol Chem 281:34730-5. 2006
  2. ncbi The effect of recombinant human lactoferrin on growth and the antibiotic susceptibility of the cystic fibrosis pathogen Burkholderia cepacia complex when cultured planktonically or as biofilms
    Emma M Caraher
    Centre of Microbial Host Interaction, Department of Science, Institute of Technology Tallaght ITT Dublin, Tallaght, Dublin 24, Ireland
    J Antimicrob Chemother 60:546-54. 2007
  3. ncbi Elastolytic proteases: inflammation resolution and dysregulation in chronic infective lung disease
    Clifford C Taggart
    Pulmonary Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
    Am J Respir Crit Care Med 171:1070-6. 2005
  4. ncbi Secretory leucoprotease inhibitor prevents lipopolysaccharide-induced IkappaBalpha degradation without affecting phosphorylation or ubiquitination
    Clifford C Taggart
    Pulmonary Research Division, Department of Medicine, The Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
    J Biol Chem 277:33648-53. 2002
  5. pmc Secretory leucoprotease inhibitor binds to NF-kappaB binding sites in monocytes and inhibits p65 binding
    Clifford C Taggart
    Pulmonary Research Division, Department of Medicine, Education and Research Centre, Beaumont Hospital, Dublin 2, Ireland
    J Exp Med 202:1659-68. 2005
  6. ncbi Viral inhibition of IL-1- and neutrophil elastase-induced inflammatory responses in bronchial epithelial cells
    Tomas P Carroll
    Respiratory Research Division, Royal College of Surgeons in Ireland, Education and Research Center, Beaumont Hospital, Dublin, Ireland
    J Immunol 175:7594-601. 2005
  7. ncbi TLR-induced inflammation in cystic fibrosis and non-cystic fibrosis airway epithelial cells
    Catherine M Greene
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
    J Immunol 174:1638-46. 2005
  8. pmc Elafin, an elastase-specific inhibitor, is cleaved by its cognate enzyme neutrophil elastase in sputum from individuals with cystic fibrosis
    Nicolas Guyot
    Pulmonary Research Division, Department of Medicine, The Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland
    J Biol Chem 283:32377-85. 2008
  9. ncbi Neutrophil elastase up-regulates cathepsin B and matrix metalloprotease-2 expression
    Patrick Geraghty
    Pulmonary Research Division, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
    J Immunol 178:5871-8. 2007
  10. doi Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway
    David A Bergin
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland
    J Biol Chem 283:31736-44. 2008

Collaborators

Detail Information

Publications27

  1. ncbi Elafin prevents lipopolysaccharide-induced AP-1 and NF-kappaB activation via an effect on the ubiquitin-proteasome pathway
    Marcus W Butler
    Pulmonary Research Division, Department of Medicine, The Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland
    J Biol Chem 281:34730-5. 2006
    ..These results suggest that inhibition by elafin of lipopolysaccharide-induced AP-1 and NF-kappaB activation occurs via an effect on the ubiquitin-proteasome pathway...
  2. ncbi The effect of recombinant human lactoferrin on growth and the antibiotic susceptibility of the cystic fibrosis pathogen Burkholderia cepacia complex when cultured planktonically or as biofilms
    Emma M Caraher
    Centre of Microbial Host Interaction, Department of Science, Institute of Technology Tallaght ITT Dublin, Tallaght, Dublin 24, Ireland
    J Antimicrob Chemother 60:546-54. 2007
    ....
  3. ncbi Elastolytic proteases: inflammation resolution and dysregulation in chronic infective lung disease
    Clifford C Taggart
    Pulmonary Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
    Am J Respir Crit Care Med 171:1070-6. 2005
  4. ncbi Secretory leucoprotease inhibitor prevents lipopolysaccharide-induced IkappaBalpha degradation without affecting phosphorylation or ubiquitination
    Clifford C Taggart
    Pulmonary Research Division, Department of Medicine, The Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
    J Biol Chem 277:33648-53. 2002
    ..These results suggest that SLPI may be inhibiting proteasomal degradation of NF-kappaB regulatory proteins, an effect that is dependent on the antiprotease activity of SLPI...
  5. pmc Secretory leucoprotease inhibitor binds to NF-kappaB binding sites in monocytes and inhibits p65 binding
    Clifford C Taggart
    Pulmonary Research Division, Department of Medicine, Education and Research Centre, Beaumont Hospital, Dublin 2, Ireland
    J Exp Med 202:1659-68. 2005
    ..Therefore, SLPI inhibition of NF-kappaB activation is mediated, in part, by competitive binding to the NF-kappaB consensus-binding site...
  6. ncbi Viral inhibition of IL-1- and neutrophil elastase-induced inflammatory responses in bronchial epithelial cells
    Tomas P Carroll
    Respiratory Research Division, Royal College of Surgeons in Ireland, Education and Research Center, Beaumont Hospital, Dublin, Ireland
    J Immunol 175:7594-601. 2005
    ..These findings identify vaccinia virus proteins as possible therapeutic agents for the manifestations of several inflammatory lung diseases...
  7. ncbi TLR-induced inflammation in cystic fibrosis and non-cystic fibrosis airway epithelial cells
    Catherine M Greene
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
    J Immunol 174:1638-46. 2005
    ..This effect was abrogated by expression of dominant-negative versions of MyD88 or Mal, key signal transducers for TLRs, thereby implicating them as potential anti-inflammatory agents for CF...
  8. pmc Elafin, an elastase-specific inhibitor, is cleaved by its cognate enzyme neutrophil elastase in sputum from individuals with cystic fibrosis
    Nicolas Guyot
    Pulmonary Research Division, Department of Medicine, The Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland
    J Biol Chem 283:32377-85. 2008
    ..aeruginosa infection promotes this effect. Such cleavage may have repercussions on the innate immune function of elafin...
  9. ncbi Neutrophil elastase up-regulates cathepsin B and matrix metalloprotease-2 expression
    Patrick Geraghty
    Pulmonary Research Division, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
    J Immunol 178:5871-8. 2007
    ..This has important implications for therapeutic intervention in protease-mediated diseases...
  10. doi Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway
    David A Bergin
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland
    J Biol Chem 283:31736-44. 2008
    ..The data describe a previously unidentified lung metalloprotease meprin alpha, and its role in NE-induced EGFR and TLR4 activation and IL-8 production...
  11. ncbi Secretory leucocyte protease inhibitor inhibits interferon-gamma-induced cathepsin S expression
    Patrick Geraghty
    Pulmonary Research Division, Beaumont Hospital, Royal College of Surgeons in Ireland, Dublin 9, Ireland
    J Biol Chem 282:33389-95. 2007
    ..Secretory leukocyte protease inhibitor may prove to be therapeutically important as a potential inhibitor of protease expression in chronic obstructive pulmonary disease...
  12. pmc Functional study of elafin cleaved by Pseudomonas aeruginosa metalloproteinases
    Nicolas Guyot
    Department of Medicine, Pulmonary Research Division, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland
    Biol Chem 391:705-16. 2010
    ..In conclusion, this study provides evidence that elafin is susceptible to proteolytic cleavage at alternative sites by P. aeruginosa metalloproteinases, which can affect different biological functions of elafin...
  13. pmc Secretory leucoprotease inhibitor impairs Toll-like receptor 2- and 4-mediated responses in monocytic cells
    Catherine M Greene
    Respiratory Research Division, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
    Infect Immun 72:3684-7. 2004
    ....
  14. ncbi Effect of pro-inflammatory stimuli on mucin expression and inhibition by secretory leucoprotease inhibitor
    Siobhan Griffin
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
    Cell Microbiol 9:670-9. 2007
    ....
  15. ncbi Z alpha1-antitrypsin polymerizes in the lung and acts as a neutrophil chemoattractant
    Alan T Mulgrew
    Department of Medicine, Respiratory Research Division, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
    Chest 125:1952-7. 2004
    ....
  16. pmc Respiratory epithelial cells require Toll-like receptor 4 for induction of human beta-defensin 2 by lipopolysaccharide
    Ruth MacRedmond
    Department of Respiratory Research, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland
    Respir Res 6:116. 2005
    ..Here we provide evidence for the critical role of Toll-like receptor 4 (TLR4) in lipopolysaccharide (LPS)-induced HBD2 expression by human A549 epithelial cells...
  17. ncbi Loss of microbicidal activity and increased formation of biofilm due to decreased lactoferrin activity in patients with cystic fibrosis
    Mark P Rogan
    Pulmonary Research Division, Department of Medicine, The Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland
    J Infect Dis 190:1245-53. 2004
    ..Loss of such a vital innate immunity protein clearly has important implications for the pathogenesis of chronic P. aeruginosa lung infection in patients with CF...
  18. ncbi Activation of endoplasmic reticulum-specific stress responses associated with the conformational disease Z alpha 1-antitrypsin deficiency
    Matthew W Lawless
    Respiratory Research Division, Royal College of Surgeons in Ireland, Education and Research Center, Beaumont Hospital, Dublin, Ireland
    J Immunol 172:5722-6. 2004
    ..These findings have important implications for the design of future therapeutics for Z A1AT liver disease and may also impact on drug design for other conformational diseases...
  19. ncbi Endotoxin up-regulates interleukin-18: potential role for gram-negative colonization in sarcoidosis
    Deirdre M Kelly
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
    Am J Respir Crit Care Med 172:1299-307. 2005
    ..Previously we demonstrated a role for interleukin-18 in sarcoidosis. Here we examine the regulation of interleukin-18 in this condition...
  20. pmc Antimicrobial proteins and polypeptides in pulmonary innate defence
    Mark P Rogan
    Pulmonary Research Division, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
    Respir Res 7:29. 2006
    ..The potential therapeutic applications of these proteins and peptides in combating infection and preventing inflammation are the subject of ongoing research that holds much promise for the future...
  21. doi Delivery of rSLPI in a liposomal carrier for inhalation provides protection against cathepsin L degradation
    Aileen M Gibbons
    School of Pharmacy, Royal College of Surgeons in Ireland, Dublin, Ireland
    J Microencapsul 26:513-22. 2009
    ..Liposome encapsulation of rSLPI therefore improves stability and potentially reduces the level and frequency of dosing required for therapeutic effect after inhalation...
  22. ncbi Inactivation of human beta-defensins 2 and 3 by elastolytic cathepsins
    Clifford C Taggart
    Pulmonary Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Center, Beaumont Hospital, Dublin, Ireland
    J Immunol 171:931-7. 2003
    ..In chronic lung diseases associated with infection, overexpression of cathepsins may lead to increased degradation of HBD-2 and -3, thereby favoring bacterial infection and colonization...
  23. ncbi Tauroursodeoxycholic acid inhibits apoptosis induced by Z alpha-1 antitrypsin via inhibition of Bad
    Stanley D W Miller
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland
    Hepatology 46:496-503. 2007
    ..CONCLUSION: These data show that caspase-4 is not essential for ZAAT-induced apoptosis in HEK293 cells and implicates P-I-3-kinase and Bad as potential therapeutic targets for the liver disease associated with ZAAT deficiency...
  24. ncbi Neutrophil elastase up-regulates interleukin-8 via toll-like receptor 4
    James M Devaney
    Respiratory Research, Department of Medicine, RCSI Education and Research Centre, Smurfit Building, Beaumont Hospital, Dublin 9, Ireland
    FEBS Lett 544:129-32. 2003
    ..Furthermore, a TLR4 neutralising antibody abrogates NE-induced IL-8 production, and induces tolerance to a secondary lipopolysaccharide stimulus. These data implicate TLR4 in NE induced IL-8 expression in bronchial epithelium...
  25. ncbi Neutrophil elastase up-regulates human beta-defensin-2 expression in human bronchial epithelial cells
    Siobhan Griffin
    Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
    FEBS Lett 546:233-6. 2003
    ..An increase in HBD-2 protein expression was observed in primary NHBE cells after incubation with NE as assessed by laser scanning cytometry. In conclusion, NE up-regulates HBD-2 expression in bronchial epithelial cells...
  26. pmc The prevalence of alpha-1 antitrypsin deficiency in Ireland
    Tomas P Carroll
    Department of Medicine, Royal College of Surgeons in Ireland Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
    Respir Res 12:91. 2011
    ....
  27. ncbi Innate host defense functions of secretory leucoprotease inhibitor
    Sinead Weldon
    School of Medicine and Dentistry, Queen s University Belfast, Belfast, Northern Ireland
    Exp Lung Res 33:485-91. 2007
    ..In the course of this review, the authors highlight the findings from a range of studies that illustrate the multiple functions of SLPI and its role in the resolution of the immune response...