Research Topics
Genomes and Genes
| Clifford C TaggartSummaryAffiliation: Royal College of Surgeons in Ireland Country: Ireland Publications
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Detail Information
Publications
Elafin prevents lipopolysaccharide-induced AP-1 and NF-kappaB activation via an effect on the ubiquitin-proteasome pathwayMarcus W Butler
Pulmonary Research Division, Department of Medicine, The Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland
J Biol Chem 281:34730-5. 2006..These results suggest that inhibition by elafin of lipopolysaccharide-induced AP-1 and NF-kappaB activation occurs via an effect on the ubiquitin-proteasome pathway...- The effect of recombinant human lactoferrin on growth and the antibiotic susceptibility of the cystic fibrosis pathogen Burkholderia cepacia complex when cultured planktonically or as biofilmsEmma M Caraher
Centre of Microbial Host Interaction, Department of Science, Institute of Technology Tallaght ITT Dublin, Tallaght, Dublin 24, Ireland
J Antimicrob Chemother 60:546-54. 2007.... - Secretory leucoprotease inhibitor prevents lipopolysaccharide-induced IkappaBalpha degradation without affecting phosphorylation or ubiquitinationClifford C Taggart
Pulmonary Research Division, Department of Medicine, The Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
J Biol Chem 277:33648-53. 2002..These results suggest that SLPI may be inhibiting proteasomal degradation of NF-kappaB regulatory proteins, an effect that is dependent on the antiprotease activity of SLPI... - Secretory leucoprotease inhibitor binds to NF-kappaB binding sites in monocytes and inhibits p65 bindingClifford C Taggart
Pulmonary Research Division, Department of Medicine, Education and Research Centre, Beaumont Hospital, Dublin 2, Ireland
J Exp Med 202:1659-68. 2005..Therefore, SLPI inhibition of NF-kappaB activation is mediated, in part, by competitive binding to the NF-kappaB consensus-binding site... - Elastolytic proteases: inflammation resolution and dysregulation in chronic infective lung diseaseClifford C Taggart
Pulmonary Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
Am J Respir Crit Care Med 171:1070-6. 2005 - TLR-induced inflammation in cystic fibrosis and non-cystic fibrosis airway epithelial cellsCatherine M Greene
Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
J Immunol 174:1638-46. 2005..This effect was abrogated by expression of dominant-negative versions of MyD88 or Mal, key signal transducers for TLRs, thereby implicating them as potential anti-inflammatory agents for CF... - Elafin, an elastase-specific inhibitor, is cleaved by its cognate enzyme neutrophil elastase in sputum from individuals with cystic fibrosisNicolas Guyot
Pulmonary Research Division, Department of Medicine, The Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland
J Biol Chem 283:32377-85. 2008..aeruginosa infection promotes this effect. Such cleavage may have repercussions on the innate immune function of elafin... - Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathwayDavid A Bergin
Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland
J Biol Chem 283:31736-44. 2008..The data describe a previously unidentified lung metalloprotease meprin alpha, and its role in NE-induced EGFR and TLR4 activation and IL-8 production... - Neutrophil elastase up-regulates cathepsin B and matrix metalloprotease-2 expressionPatrick Geraghty
Pulmonary Research Division, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
J Immunol 178:5871-8. 2007..This has important implications for therapeutic intervention in protease-mediated diseases... - Secretory leucocyte protease inhibitor inhibits interferon-gamma-induced cathepsin S expressionPatrick Geraghty
Pulmonary Research Division, Beaumont Hospital, Royal College of Surgeons in Ireland, Dublin 9, Ireland
J Biol Chem 282:33389-95. 2007..Secretory leukocyte protease inhibitor may prove to be therapeutically important as a potential inhibitor of protease expression in chronic obstructive pulmonary disease... - Functional study of elafin cleaved by Pseudomonas aeruginosa metalloproteinasesNicolas Guyot
Department of Medicine, Pulmonary Research Division, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland
Biol Chem 391:705-16. 2010..In conclusion, this study provides evidence that elafin is susceptible to proteolytic cleavage at alternative sites by P. aeruginosa metalloproteinases, which can affect different biological functions of elafin... - Secretory leucoprotease inhibitor impairs Toll-like receptor 2- and 4-mediated responses in monocytic cellsCatherine M Greene
Respiratory Research Division, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
Infect Immun 72:3684-7. 2004.... - Effect of pro-inflammatory stimuli on mucin expression and inhibition by secretory leucoprotease inhibitorSiobhan Griffin
Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
Cell Microbiol 9:670-9. 2007.... - Respiratory epithelial cells require Toll-like receptor 4 for induction of human beta-defensin 2 by lipopolysaccharideRuth MacRedmond
Department of Respiratory Research, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland
Respir Res 6:116. 2005..Here we provide evidence for the critical role of Toll-like receptor 4 (TLR4) in lipopolysaccharide (LPS)-induced HBD2 expression by human A549 epithelial cells... - Activation of endoplasmic reticulum-specific stress responses associated with the conformational disease Z alpha 1-antitrypsin deficiencyMatthew W Lawless
Respiratory Research Division, Royal College of Surgeons in Ireland, Education and Research Center, Beaumont Hospital, Dublin, Ireland
J Immunol 172:5722-6. 2004..These findings have important implications for the design of future therapeutics for Z A1AT liver disease and may also impact on drug design for other conformational diseases... - Z alpha1-antitrypsin polymerizes in the lung and acts as a neutrophil chemoattractantAlan T Mulgrew
Department of Medicine, Respiratory Research Division, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
Chest 125:1952-7. 2004.... - Antimicrobial proteins and polypeptides in pulmonary innate defenceMark P Rogan
Pulmonary Research Division, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
Respir Res 7:29. 2006..The potential therapeutic applications of these proteins and peptides in combating infection and preventing inflammation are the subject of ongoing research that holds much promise for the future... - Loss of microbicidal activity and increased formation of biofilm due to decreased lactoferrin activity in patients with cystic fibrosisMark P Rogan
Pulmonary Research Division, Department of Medicine, The Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland
J Infect Dis 190:1245-53. 2004..Loss of such a vital innate immunity protein clearly has important implications for the pathogenesis of chronic P. aeruginosa lung infection in patients with CF... - Delivery of rSLPI in a liposomal carrier for inhalation provides protection against cathepsin L degradationAileen M Gibbons
School of Pharmacy, Royal College of Surgeons in Ireland, Dublin, Ireland
J Microencapsul 26:513-22. 2009..Liposome encapsulation of rSLPI therefore improves stability and potentially reduces the level and frequency of dosing required for therapeutic effect after inhalation... - Tauroursodeoxycholic acid inhibits apoptosis induced by Z alpha-1 antitrypsin via inhibition of BadStanley D W Miller
Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland
Hepatology 46:496-503. 2007..CONCLUSION: These data show that caspase-4 is not essential for ZAAT-induced apoptosis in HEK293 cells and implicates P-I-3-kinase and Bad as potential therapeutic targets for the liver disease associated with ZAAT deficiency... - Neutrophil elastase up-regulates human beta-defensin-2 expression in human bronchial epithelial cellsSiobhan Griffin
Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
FEBS Lett 546:233-6. 2003..An increase in HBD-2 protein expression was observed in primary NHBE cells after incubation with NE as assessed by laser scanning cytometry. In conclusion, NE up-regulates HBD-2 expression in bronchial epithelial cells... - Endotoxin up-regulates interleukin-18: potential role for gram-negative colonization in sarcoidosisDeirdre M Kelly
Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
Am J Respir Crit Care Med 172:1299-307. 2005..This study shows that gram-negative bacteria may contribute to this effect by upregulating interleukin-18 expression... - Neutrophil elastase up-regulates interleukin-8 via toll-like receptor 4James M Devaney
Respiratory Research, Department of Medicine, RCSI Education and Research Centre, Smurfit Building, Beaumont Hospital, Dublin 9, Ireland
FEBS Lett 544:129-32. 2003..Furthermore, a TLR4 neutralising antibody abrogates NE-induced IL-8 production, and induces tolerance to a secondary lipopolysaccharide stimulus. These data implicate TLR4 in NE induced IL-8 expression in bronchial epithelium... - Inactivation of human beta-defensins 2 and 3 by elastolytic cathepsinsClifford C Taggart
Pulmonary Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Center, Beaumont Hospital, Dublin, Ireland
J Immunol 171:931-7. 2003..In chronic lung diseases associated with infection, overexpression of cathepsins may lead to increased degradation of HBD-2 and -3, thereby favoring bacterial infection and colonization... - The prevalence of alpha-1 antitrypsin deficiency in IrelandTomas P Carroll
Department of Medicine, Royal College of Surgeons in Ireland Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
Respir Res 12:91. 2011.... - Innate host defense functions of secretory leucoprotease inhibitorSinead Weldon
School of Medicine and Dentistry, Queen s University Belfast, Belfast, Northern Ireland
Exp Lung Res 33:485-91. 2007..In the course of this review, the authors highlight the findings from a range of studies that illustrate the multiple functions of SLPI and its role in the resolution of the immune response...